{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:04Z","timestamp":1790740624444,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1053\/j.gastro.2004.05.029","type":"journal-article","created":{"date-parts":[[2004,8,6]],"date-time":"2004-08-06T19:54:42Z","timestamp":1091822082000},"page":"582-594","source":"Crossref","is-referenced-by-count":136,"title":["Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis -infected mice"],"prefix":"10.1053","volume":"127","author":[{"given":"Sachiyo","family":"Nomura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Leys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey B.","family":"Vartapetian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Goldenring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2004.05.029_BIB1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<18::AID-IJC5>3.0.CO;2-M","article-title":"Estimates of the worldwide mortality from 25 cancers in 1990","volume":"83","author":"Pisani","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric cancer","volume":"325","author":"Parsonnet","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2004.05.029_BIB3","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/cncr.10375","article-title":"Patterns of gastric atrophy in intestinal type gastric carcinoma","volume":"94","author":"El-Zimaity","year":"2002","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB4","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2004.05.029_BIB5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1097-0029(20000315)48:6<313::AID-JEMT1>3.0.CO;2-Y","article-title":"Role of Helicobacter pylori gastritis in gastric atrophy, intestinal metaplasia and gastric neoplasia","volume":"48","author":"Smith","year":"2000","journal-title":"Microsc Res Tech"},{"key":"10.1053\/j.gastro.2004.05.029_BIB6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ijc.2910570306","article-title":"Intestinal metaplasia types and the risk of gastric cancer","volume":"57","author":"Filipe","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.1999.00002.x","article-title":"Exploring the link between Helicobacter pylori and gastric cancer","volume":"13","author":"Kuipers","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2004.05.029_BIB8","first-page":"639","article-title":"Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma","volume":"79","author":"Schmidt","year":"1999","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2004.05.029_BIB9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0016-5085(98)70581-5","article-title":"Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection","volume":"114","author":"Wang","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.05.029_BIB10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/gast.1996.v110.pm8536852","article-title":"Hypertrophic gastropathy in Helicobacter felis-infected wild type C57BL\/6 mice and p53 hemizygous transgenic mice","volume":"110","author":"Fox","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.05.029_BIB11","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0016-5085(00)70361-1","article-title":"Reversible drug-induced oxyntic atrophy in rats","volume":"118","author":"Goldenring","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.05.029_BIB12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0016-5085(00)70412-4","article-title":"Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer","volume":"118","author":"Wang","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.05.029_BIB13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/01.LAB.0000022225.45996.21","article-title":"Association of spasmolytic polypeptide expressing metaplasia (SPEM) with carcinogen administration and oxyntic atrophy in rats","volume":"82","author":"Yamaguchi","year":"2002","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2004.05.029_BIB14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02892834","article-title":"The morphology and cell kinetics of pseudopyloric glands","volume":"39","author":"Hattori","year":"1982","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1023\/A:1017920220149","article-title":"Identificiation of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies","volume":"47","author":"Yamaguchi","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2004.05.029_BIB16","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1022564027468","article-title":"Spasmolytic polypeptide expressing metaplasia (SPEM) associated with gastric cancer in Iceland","volume":"48","author":"Halldorsdottir","year":"2003","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2004.05.029_BIB17","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/01.LAB.0000085190.99749.15","article-title":"Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer","volume":"83","author":"Dhar","year":"2003","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2004.05.029_BIB18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/08977199609034571","article-title":"Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-a","volume":"13","author":"Goldenring","year":"1996","journal-title":"Growth Factors"},{"key":"10.1053\/j.gastro.2004.05.029_BIB19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/geno.1996.0177","article-title":"The IMAGE Consortium","volume":"33","author":"Lennon","year":"1996","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2004.05.029_BIB20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-1759(02)00098-4","article-title":"Sensing prothymosin \u03b1 origin, mutations and conformation with monoclonal antibodies","volume":"266","author":"Sukhacheva","year":"2002","journal-title":"J Immunol Methods"},{"key":"10.1053\/j.gastro.2004.05.029_BIB21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00508649","article-title":"Chromogranin A, B and C immunoreactivities of mammalian endocrine cells. Distribution, distinction from costored hormones\/prohormones and relationship with the argyrophil component of secretory granules","volume":"85","author":"Rindi","year":"1986","journal-title":"Histochemistry"},{"key":"10.1053\/j.gastro.2004.05.029_BIB22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s004280100477","article-title":"Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis","volume":"439","author":"Kirchner","year":"2001","journal-title":"Virchows Arch"},{"key":"10.1053\/j.gastro.2004.05.029_BIB23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.genet.36.042902.092433","article-title":"Xist RNA and the mechanism of X chromosome inactivation","volume":"36","author":"Plath","year":"2002","journal-title":"Annu Rev Genet"},{"key":"10.1053\/j.gastro.2004.05.029_BIB24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-4827(02)00047-2","article-title":"Apoptosis-related fragmentation, translocation, and properties of human prothymosin \u03b1","volume":"284","author":"Evstafieva","year":"2003","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2004.05.029_BIB25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s002689910072","article-title":"Significance of plasma thymosin \u03b11 measurements in gastric cancer patients","volume":"24","author":"Mitani","year":"2000","journal-title":"World J Surg"},{"key":"10.1053\/j.gastro.2004.05.029_BIB26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/0046-8177(94)90057-4","article-title":"Barrett\u2019s esophagus, dysplasia, and adenocarcinoma","volume":"25","author":"Haggitt","year":"1994","journal-title":"Hum Pathol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB27","doi-asserted-by":"crossref","first-page":"14819","DOI":"10.1073\/pnas.192574799","article-title":"Molecular characterization of mouse gastric epithelial progenitor cells","volume":"99","author":"Mills","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2004.05.029_BIB28","doi-asserted-by":"crossref","first-page":"7088","DOI":"10.1128\/MCB.17.12.7088","article-title":"Nucleolar KKE\/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis","volume":"17","author":"Gautier","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB29","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1128\/MCB.22.19.6663-6668.2002","article-title":"Purified box C\/D snoRNPs are able to reproduce site-specific 2\u2019-O-methylation of target RNA in vitro","volume":"22","author":"Galardi","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB30","doi-asserted-by":"crossref","first-page":"12914","DOI":"10.1073\/pnas.231490998","article-title":"Position within the host intron is critical for efficient processing of box C\/D snoRNAs in mammalian cells","volume":"98","author":"Hirose","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2004.05.029_BIB31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0169-328X(97)00262-3","article-title":"Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia\/reoxygenation","volume":"53","author":"Imai","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1053\/j.gastro.2004.05.029_BIB32","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1091\/mbc.10.11.3909","article-title":"The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)","volume":"10","author":"Hartmann","year":"1999","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2004.05.029_BIB33","doi-asserted-by":"crossref","first-page":"24569","DOI":"10.1074\/jbc.271.40.24569","article-title":"SRPK1 and Clk\/Sty protein kinases show distinct substrate specificities for serine\/arginine-rich splicing factors","volume":"271","author":"Colwill","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2004.05.029_BIB34","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1128\/MCB.19.10.6991","article-title":"The protein kinase Clk\/Sty directly modulates SR protein activity","volume":"19","author":"Prasad","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1072530","article-title":"\u201cStemness\u201d","volume":"298","author":"Ramalho-Santos","year":"2002","journal-title":"Science"},{"key":"10.1053\/j.gastro.2004.05.029_BIB36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/72799","article-title":"A genome-wide survey of RAS transformation targets","volume":"24","author":"Zuber","year":"2000","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2004.05.029_BIB37","doi-asserted-by":"crossref","first-page":"9504","DOI":"10.1073\/pnas.90.20.9504","article-title":"Expression of \u03b1-thymosins in human tissues in normal and abnormal growth","volume":"90","author":"Tsitsiloni","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2004.05.029_BIB38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0006-291X(03)01520-1","article-title":"Rapid discovery and identification of a tissue-specific tumor biomarker from 39 human cancer cell lines using the SELDI Protein Chip platform","volume":"309","author":"Shiwa","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2004.05.029_BIB39","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0959-8049(05)80433-2","article-title":"Tissue concentrations of prothymosin \u03b1","volume":"29A","author":"Dominguez","year":"1993","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1054\/bjoc.1999.0968","article-title":"Tumour prothymosin \u03b1 content, a potential prognostic marker for primary breast cancer","volume":"82","author":"Magdalena","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB41","first-page":"2821","article-title":"Prothymosin-\u03b1 mRNA expresssion correlates with that of c-myc in human colon cancer","volume":"8","author":"Mori","year":"1993","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2004.05.029_BIB42","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/bjc.1997.533","article-title":"Over expression of hepatic prothymosin \u03b1, a novel marker for human hepatocellular carcinoma","volume":"76","author":"Wu","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2004.05.029_BIB43","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s005950170040","article-title":"Expression of the prothymosin-\u03b1 gene as a prognostic factor in lung cancer","volume":"31","author":"Sasaki","year":"2001","journal-title":"Surg Today"},{"key":"10.1053\/j.gastro.2004.05.029_BIB44","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ar.1092360202","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach. I. Identification of proliferative cell types and pinpointing of the stem cells","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2004.05.029_BIB45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1076807","article-title":"Distinctive roles of PHAP proteins and prothymosin-\u03b1 in a death regulatory pathway","volume":"299","author":"Jiang","year":"2003","journal-title":"Science"},{"key":"10.1053\/j.gastro.2004.05.029_BIB46","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1074\/jbc.M008560200","article-title":"Prothymosin \u03b1 functions as a cellular oncoprotein by inducing transformation of rodent fibroblasts in vitro","volume":"276","author":"Orre","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2004.05.029_BIB47","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1016\/S0960-9822(99)80151-1","article-title":"X-chromosome inactivation","volume":"9","author":"Lyon","year":"1999","journal-title":"Curr Biol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB48","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/351329a0","article-title":"Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome","volume":"351","author":"Brockdorff","year":"1991","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2004.05.029_BIB49","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(92)90519-I","article-title":"The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus","volume":"71","author":"Brockdorff","year":"1992","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2004.05.029_BIB50","first-page":"581","article-title":"X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status","volume":"151","author":"Looijenga","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2004.05.029_BIB51","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng1192-192","article-title":"X inactivation in mammalian testis is correlated with inactive X-specific transcription","volume":"2","author":"Richler","year":"1992","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2004.05.029_BIB52","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ng1192-196","article-title":"Expression of the X-inactivation-associated gene XIST during spermatogenesis","volume":"2","author":"Salido","year":"1992","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2004.05.029_BIB53","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1097-2765(00)80248-8","article-title":"A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation","volume":"5","author":"Wutz","year":"2000","journal-title":"Mol Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508504009217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508504009217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T01:57:57Z","timestamp":1549331877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508504009217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0016508504009217"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2004.05.029","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}