{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:21:16Z","timestamp":1791166876129,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1053\/j.gastro.2004.09.048","type":"journal-article","created":{"date-parts":[[2005,7,29]],"date-time":"2005-07-29T18:31:14Z","timestamp":1122661874000},"page":"1733-1738","source":"Crossref","is-referenced-by-count":176,"title":["Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma"],"prefix":"10.1053","volume":"127","author":[{"given":"Yen-Hsuan","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hwei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Jan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Yuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Horng","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiou-Hwei","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Ming","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keh-Sung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Shinn","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2004.09.048_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1440-1746.1998.tb00685.x","article-title":"Chronic hepatitis virus infection in children","volume":"13","author":"Chang","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0168-8278(98)80337-1","article-title":"Precore stop codon mutant in chronic hepatitis B virus infection in children","volume":"28","author":"Chang","year":"1998","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/jhep.2000.8529","article-title":"Long-term follow-up study of core gene deletion mutants in children with chronic hepatitis B virus infection","volume":"32","author":"Ni","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib4","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1099\/0022-1317-69-10-2575","article-title":"Typing hepatitis B virus by homology in nucleotide sequence","volume":"69","author":"Okamoto","year":"1988","journal-title":"J Gen Virol"},{"key":"10.1053\/j.gastro.2004.09.048_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1099\/0022-1317-81-1-67","article-title":"A new genotype of hepatitis B virus","volume":"81","author":"Stuyver","year":"2000","journal-title":"J Gen Virol"},{"key":"10.1053\/j.gastro.2004.09.048_bib6","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1099\/0022-1317-83-8-2059","article-title":"Genotype H","volume":"83","author":"Arauz-Ruiz","year":"2002","journal-title":"J Gen Virol"},{"key":"10.1053\/j.gastro.2004.09.048_bib7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/hep.510290352","article-title":"Different hepatitis B genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion","volume":"29","author":"Chan","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1086\/314688","article-title":"Core promoter mutations and genotypes in relation to viral replication and liver damage in east Asian hepatitis B virus carriers","volume":"179","author":"Lindh","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1053\/j.gastro.2004.09.048_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/jhep.2003.50098","article-title":"Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma","volume":"37","author":"Yuen","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/jhep.2003.50036","article-title":"Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease","volume":"37","author":"Sumi","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1440-1746.2002.02737.x","article-title":"Hepatitis B viral genotypes","volume":"17","author":"Kao","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib12","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0168-8278(00)80135-X","article-title":"Hepatitis B genotypes and the response to interferon therapy","volume":"33","author":"Kao","year":"2000","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0016-5085(00)70261-7","article-title":"Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B","volume":"118","author":"Kao","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.09.048_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00005176-200210000-00006","article-title":"Histologic activity of childhood chronic hepatitis B related to viremia levels, genotypes, mutations, and epidemiologic factors","volume":"35","author":"S\u00f6derstr\u00f6m","year":"2002","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2004.09.048_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/jhep.2003.50098","article-title":"Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma","volume":"37","author":"Yuen","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib16","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/gast.2002.33588","article-title":"Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C","volume":"122","author":"Chu","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2004.09.048_bib17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1053\/jhep.2001.28188","article-title":"Acute exacerbations of chronic hepatitis B are rarely associated with superinfection of hepatitis B virus","volume":"34","author":"Kao","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib18","first-page":"1387","article-title":"The significance of spontaneous hepatitis B e antigen seroconversion in childhood","volume":"22","author":"Chang","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7326\/0003-4819-135-9-200111060-00009","article-title":"Hepatitis B virus infection in children and adolescents in a hyperendemic area","volume":"135","author":"Ni","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2004.09.048_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.510310136","article-title":"Grading and staging: the histopathological lesions of chronic hepatitis: the Knodell histologic activity index and beyond","volume":"31","author":"Brunt","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/JCM.39.1.362-364.2001","article-title":"Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers","volume":"39","author":"Naito","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1053\/j.gastro.2004.09.048_bib22","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1086\/516458","article-title":"Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus\u2014large scale analysis using a new genotyping method","volume":"175","author":"Lindh","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1053\/j.gastro.2004.09.048_bib23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2004.06.031","article-title":"Combined real time PCR quantification and signature single nucleotide polymorphism genotyping of hepatitis B virus in one-tube reaction","volume":"41","author":"Yeh","year":"2004","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib24","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1440-1746.2003.02976.x","article-title":"Hepatitis flares and hepatitis B e antigen seroconversion","volume":"18","author":"Liaw","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/BF02256028","article-title":"Molecular epidemiology of hepatitis B viral serotypes and genotypes in Taiwan","volume":"9","author":"Liu","year":"2002","journal-title":"J Biomed Sci"},{"key":"10.1053\/j.gastro.2004.09.048_bib26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jmv.10534","article-title":"Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers","volume":"72","author":"Kao","year":"2004","journal-title":"J Med Virol"},{"key":"10.1053\/j.gastro.2004.09.048_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/hep.1840120406","article-title":"Changes of serum hepatitis B virus DNA and transaminase level in the natural course of chronic hepatitis B virus infection in children","volume":"12","author":"Lee","year":"1990","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2004.09.048_bib28","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1128\/JCM.40.4.1207-1209.2002","article-title":"Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection","volume":"40","author":"Kao","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1053\/j.gastro.2004.09.048_bib29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1440-1746.1987.tb00162.x","article-title":"Hepatitis B e antigen and its antibody in chronic type B hepatitis","volume":"2","author":"Chen","year":"1987","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2004.09.048_bib30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1203\/01.PDR.0000136282.20470.87","article-title":"Longitudinal study on mutation profiles of core promoter and precore regions of hepatitis B virus genome in children","volume":"56","author":"Ni","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2004.09.048_bib31","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/1097-0142(19891201)64:11<2377::AID-CNCR2820641130>3.0.CO;2-8","article-title":"Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma","volume":"64","author":"Chang","year":"1989","journal-title":"Cancer"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508504016270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508504016270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T16:28:38Z","timestamp":1552148918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508504016270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0016508504016270"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2004.09.048","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}