{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:48:12Z","timestamp":1768888092742,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1053\/j.gastro.2005.07.042","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T09:39:54Z","timestamp":1126085994000},"page":"1117-1120","source":"Crossref","is-referenced-by-count":24,"title":["Inflammatory Bowel Disease Extending Its Reach"],"prefix":"10.1053","volume":"129","author":[{"suffix":"Jr","given":"Edward V.","family":"Loftus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2005.07.042_bib1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1053\/j.gastro.2005.06.021","article-title":"The clustering of other chronic inflammatory diseases in inflammatory bowel disease","volume":"129","author":"Bernstein","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib2","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1053\/j.gastro.2005.06.022","article-title":"Increased risk of demyelinating diseases in patients with inflammatory bowel disease","volume":"129","author":"Gupta","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib3","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/oxfordjournals.aje.a009735","article-title":"Epidemiology of Crohn\u2019s disease and ulcerative colitis in a central Canadian province","volume":"149","author":"Bernstein","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2005.07.042_bib4","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1572-0241.2001.03756.x","article-title":"The prevalence of extraintestinal diseases in inflammatory bowel disease","volume":"96","author":"Bernstein","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.042_bib5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z","article-title":"Cancer risk in patients with inflammatory bowel disease","volume":"91","author":"Bernstein","year":"2001","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2005.07.042_bib6","doi-asserted-by":"crossref","first-page":"795","DOI":"10.7326\/0003-4819-133-10-200011210-00012","article-title":"The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study","volume":"133","author":"Bernstein","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2005.07.042_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-0037-1615600","article-title":"The incidence of deep venous thrombosis and pulmonary embolism among patients with inflammatory bowel disease","volume":"85","author":"Bernstein","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.gastro.2005.07.042_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/pds.698","article-title":"Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease","volume":"11","author":"Lewis","year":"2002","journal-title":"Pharmacoepidemiol Drug Safety"},{"key":"10.1053\/j.gastro.2005.07.042_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1053\/gast.2001.28703","article-title":"Inflammatory bowel disease is not associated with an increased risk of lymphoma","volume":"121","author":"Lewis","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1053\/j.gastro.2003.12.003","article-title":"Seasonal variation in flares of inflammatory bowel disease","volume":"126","author":"Lewis","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib11","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1542-3565(05)00020-0","article-title":"Antibiotic use and the risk of flare of inflammatory bowel diseas","volume":"3","author":"Aberra","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.07.042_bib12","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1053\/j.gastro.2003.09.029","article-title":"Mortality in inflammatory bowel disease","volume":"125","author":"Card","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.2003.026799","article-title":"Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use","volume":"53","author":"Card","year":"2004","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.07.042_bib14","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1053\/j.gastro.2004.03.016","article-title":"5-aminosalicylic acids and the risk of renal disease","volume":"126","author":"Van Staa","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib15","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1212\/WNL.54.12.2307","article-title":"Multiple sclerosis and antecedent infections","volume":"54","author":"Marrie","year":"2000","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2005.07.042_bib16","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1212\/01.WNL.0000138433.61870.82","article-title":"Recombinant hepatitis B vaccine and the risk of multiple sclerosis","volume":"63","author":"Hernan","year":"2004","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2005.07.042_bib17","doi-asserted-by":"crossref","first-page":"9979","DOI":"10.1073\/pnas.95.17.9979","article-title":"Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases","volume":"95","author":"Becker","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2005.07.042_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00054725-200303000-00004","article-title":"Pulmonary manifestations of inflammatory bowel disease","volume":"9","author":"Storch","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2005.07.042_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00000478-200302000-00010","article-title":"Noninfectious lung pathology in patients with Crohn\u2019s disease","volume":"27","author":"Casey","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2005.07.042_bib20","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/0016-5085(92)90029-X","article-title":"Survival and causes of death in patients with inflammatory bowel disease","volume":"103","author":"Ekbom","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib21","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/gast.1996.v110.pm8613037","article-title":"Survival and cause-specific mortality in inflammatory bowel disease","volume":"110","author":"Persson","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib22","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1053\/j.gastro.2003.09.036","article-title":"Survival and cause-specific mortality in ulcerative colitis","volume":"125","author":"Winther","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.042_bib23","first-page":"4","article-title":"Association of ulcerative colitis with multiple sclerosis","volume":"2","author":"Rang","year":"1982","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.07.042_bib24","doi-asserted-by":"crossref","first-page":"802","DOI":"10.4065\/75.8.802","article-title":"Concurrence of inflammatory bowel disease and multiple sclerosis","volume":"75","author":"Kimura","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"10.1053\/j.gastro.2005.07.042_bib25","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1191\/1352458504ms1087oa","article-title":"A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic","volume":"10","author":"Edwards","year":"2004","journal-title":"Multiple Sclerosis"},{"key":"10.1053\/j.gastro.2005.07.042_bib26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0140-6736(95)90013-6","article-title":"Focal white-matter lesions in brain of patients with inflammatory bowel disease","volume":"345","author":"Geissler","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.07.042_bib27","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/brain\/awh429","article-title":"Peripheral neuropathy in patients with inflammatory bowel disease","volume":"128","author":"Gondim","year":"2005","journal-title":"Brain"},{"key":"10.1053\/j.gastro.2005.07.042_bib28","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1002\/1529-0131(200112)44:12<2862::AID-ART474>3.0.CO;2-W","article-title":"Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides","volume":"44","author":"Mohan","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2005.07.042_bib29","first-page":"985","article-title":"Retrobulbar optic neuritis associated with infliximab","volume":"120","author":"Foroozan","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1053\/j.gastro.2005.07.042_bib30","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1572-0241.2003.07727.x","article-title":"Avoiding infliximab in the treatment of Crohn\u2019s disease in patients with multiple sclerosis","volume":"98","author":"Nanavati","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.042_bib31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/bmj.326.7389.579","article-title":"Bilateral anterior toxic optic neuropathy and the use of infliximab","volume":"326","author":"ten Tusscher","year":"2003","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2005.07.042_bib32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archopht.122.5.793","article-title":"Infliximab-associated retrobulbar optic neuritis","volume":"122","author":"Mejico","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"10.1053\/j.gastro.2005.07.042_bib33","doi-asserted-by":"crossref","first-page":"W34","DOI":"10.7326\/0003-4819-140-8-200404200-00037-w4","article-title":"Retrobulbar optic neuritis associated with infliximab in a patient with Crohn disease","volume":"140","author":"Strong","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2005.07.042_bib34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00054725-200401000-00004","article-title":"Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn\u2019s disease","volume":"10","author":"Thomas","year":"2004","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2005.07.042_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1212\/WNL.53.3.457","article-title":"TNF neutralization in MS","volume":"53","year":"1999","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2005.07.042_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJMoa051782","article-title":"Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis","volume":"353","author":"Kleinschmidt-DeMasters","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2005.07.042_bib37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1056\/NEJMoa051847","article-title":"Progressive multifocal leukoencephalopathy in a patient treated with natalizumab","volume":"353","author":"Langer-Gould","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2005.07.042_bib38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1056\/NEJMoa051586","article-title":"Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn\u2019s disease","volume":"353","author":"Van Assche","year":"2005","journal-title":"N Engl J Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505015507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505015507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T20:58:19Z","timestamp":1553029099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508505015507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0016508505015507"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2005.07.042","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}