{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:18:46Z","timestamp":1783696726425,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1053\/j.gastro.2005.07.054","type":"journal-article","created":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T12:17:46Z","timestamp":1131625066000},"page":"1400-1413","source":"Crossref","is-referenced-by-count":94,"title":["Unexpected Role of Surface Transglutaminase Type II in Celiac Disease"],"prefix":"10.1053","volume":"129","author":[{"given":"Luigi","family":"Maiuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ciacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Ricciardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Raia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Rispo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Issekutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Quaratino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Londei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2005.07.054_bib1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2005.07.054_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0950-3528(95)90030-6","article-title":"The humoral immune system in coeliac disease","volume":"9","author":"Maki","year":"1995","journal-title":"Baillieres Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.054_bib3","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0016-5085(98)70007-1","article-title":"Autoantibodies to tissue transglutaminase as predictors of celiac disease","volume":"115","author":"Dieterich","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archinte.163.3.286","article-title":"Prevalence of celiac disease in at-risk and not-at-risk groups in the United States","volume":"163","author":"Fasano","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.gastro.2005.07.054_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.immunol.18.1.53","article-title":"Molecular basis of celiac disease","volume":"18","author":"Sollid","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2005.07.054_bib7","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"van de Wal","year":"1998","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ni754","article-title":"Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP","volume":"3","author":"Manoury","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib9","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.1074129","article-title":"Structural basis for gluten intolerance in celiac sprue","volume":"297","author":"Shan","year":"2002","journal-title":"Science"},{"key":"10.1053\/j.gastro.2005.07.054_bib10","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"van de Wal","year":"1998","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib11","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1073\/pnas.0306885101","article-title":"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease","volume":"101","author":"Kim","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2005.07.054_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0968-0004(02)02182-5","article-title":"Transglutaminase 2","volume":"27","author":"Fesus","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1053\/j.gastro.2005.07.054_bib13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jcp.1041490304","article-title":"Localization of cellular transglutaminase on the extracellular matrix after wounding","volume":"149","author":"Upchurch","year":"1991","journal-title":"J Cell Physiol"},{"key":"10.1053\/j.gastro.2005.07.054_bib14","doi-asserted-by":"crossref","first-page":"11991","DOI":"10.1074\/jbc.273.20.11991","article-title":"Distinct nuclear localization and activity of tissue transglutaminase","volume":"273","author":"Lesort","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2005.07.054_bib15","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1021\/bi00175a024","article-title":"Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers","volume":"33","author":"Martinez","year":"1994","journal-title":"Biochemistry"},{"key":"10.1053\/j.gastro.2005.07.054_bib16","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.148.4.825","article-title":"Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin","volume":"148","author":"Akimov","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2005.07.054_bib17","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1242\/jcs.114.16.2989","article-title":"Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin","volume":"114","author":"Akimov","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1053\/j.gastro.2005.07.054_bib18","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1053\/gast.1996.v110.pm8613040","article-title":"Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients","volume":"110","author":"Maiuri","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0140-6736(03)13803-2","article-title":"Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease","volume":"362","author":"Maiuri","year":"2003","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.07.054_bib20","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1021\/bi00199a039","article-title":"Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives","volume":"33","author":"Freund","year":"1994","journal-title":"Biochemistry"},{"key":"10.1053\/j.gastro.2005.07.054_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1006\/exer.1997.0463","article-title":"Novel inhibitors against the transglutaminase-catalysed crosslinking of lens proteins","volume":"66","author":"Lorand","year":"1998","journal-title":"Exp Eye Res"},{"key":"10.1053\/j.gastro.2005.07.054_bib22","doi-asserted-by":"crossref","first-page":"10911","DOI":"10.1073\/pnas.190204697","article-title":"Fully competent dendritic cells as inducers of T cell anergy in autoimmunity","volume":"97","author":"Quaratino","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2005.07.054_bib23","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1053\/gast.2000.18149","article-title":"Interleukin 15 mediates epithelial changes in celiac disease","volume":"119","author":"Maiuri","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib24","doi-asserted-by":"crossref","first-page":"16567","DOI":"10.1074\/jbc.M109836200","article-title":"Analysis of tissue transglutaminase function in the migration of Swiss 3T3 fibroblasts","volume":"277","author":"Balklava","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2005.07.054_bib25","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.4049\/jimmunol.171.6.3179","article-title":"Identification of tissue transglutaminase as a novel molecule involved in human CD8+ T cell transendothelial migration","volume":"171","author":"Mohan","year":"2003","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib26","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1053\/gast.2000.20232","article-title":"Modulation of barrier function during Fas-mediated apoptosis in human intestinal epithelial cells","volume":"119","author":"Abreu","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib27","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1136\/gut.48.3.418","article-title":"FAS engagement drives apoptosis of enterocytes of coeliac patients","volume":"48","author":"Maiuri","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.07.054_bib28","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1053\/gast.2002.35355","article-title":"Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease","volume":"123","author":"Forsberg","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib29","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2144\/02334bm10","article-title":"Pseudogene-free amplification of human GAPDH cDNA","volume":"33","author":"Lehmann","year":"2002","journal-title":"Biotechniques"},{"key":"10.1053\/j.gastro.2005.07.054_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1053\/j.gastro.2005.07.054_bib31","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1111\/j.1572-0241.2003.07582.x","article-title":"Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease","volume":"98","author":"Esposito","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.054_bib32","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I","article-title":"T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase","volume":"31","author":"Molberg","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2005.07.054_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/gut.51.2.177","article-title":"Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ","volume":"51","author":"Esposito","year":"2002","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.07.054_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1309\/UV54-BHP3-A66B-0QUD","article-title":"Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease","volume":"115","author":"Ciccocioppo","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/j.gastro.2005.07.054_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.52.2.218","article-title":"Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function","volume":"52","author":"Clemente","year":"2003","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.07.054_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-5793(03)00236-9","article-title":"Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway","volume":"540","author":"Giovannini","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2005.07.054_bib37","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/73200","article-title":"In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope","volume":"6","author":"Anderson","year":"2000","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2005.07.054_bib38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0016-5085(03)01047-3","article-title":"Interleukin 15","volume":"125","author":"Mention","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib39","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0016-5085(03)01049-7","article-title":"Alterations of the intestinal transport and processing of gliadin peptides in celiac disease","volume":"125","author":"Matysiak-Budnik","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.07.054_bib40","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1572-0241.2004.04157.x","article-title":"Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease","volume":"99","author":"Forsberg","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.054_bib41","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/sj.gt.3302041","article-title":"Celiac disease","volume":"10","author":"Londei","year":"2003","journal-title":"Gene Ther"},{"key":"10.1053\/j.gastro.2005.07.054_bib42","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1182\/blood.V98.5.1567","article-title":"Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin","volume":"98","author":"Akimov","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2005.07.054_bib43","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1136\/gut.32.11.1412","article-title":"Increase in gamma\/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease","volume":"32","author":"Maki","year":"1991","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.07.054_bib44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.cdd.4400987","article-title":"Rho GTPase signalling pathways in the morphological changes associated with apoptosis","volume":"9","author":"Coleman","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1053\/j.gastro.2005.07.054_bib45","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00251-002-0504-2","article-title":"Variant mannose-binding lectin alleles are associated with celiac disease","volume":"54","author":"Boniotto","year":"2002","journal-title":"Immunogenetics"},{"key":"10.1053\/j.gastro.2005.07.054_bib46","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1111\/j.1572-0241.2003.08761.x","article-title":"The association between mannan-binding lectin gene alleles and celiac disease","volume":"98","author":"Iltanen","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.07.054_bib47","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00251-004-0724-8","article-title":"MICA response to gliadin in intestinal mucosa from celiac patients","volume":"56","author":"Martin-Pagola","year":"2004","journal-title":"Immunogenetics"},{"key":"10.1053\/j.gastro.2005.07.054_bib48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"Hue","year":"2004","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2005.07.054_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505015647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505015647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T10:20:22Z","timestamp":1683282022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508505015647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0016508505015647"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2005.07.054","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}