{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:41:12Z","timestamp":1775241672885,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1053\/j.gastro.2005.10.050","type":"journal-article","created":{"date-parts":[[2006,2,10]],"date-time":"2006-02-10T07:29:59Z","timestamp":1139556599000},"page":"521-531","source":"Crossref","is-referenced-by-count":81,"title":["Endothelial Progenitor Cell Transplantation Improves the Survival Following Liver Injury in Mice"],"prefix":"10.1053","volume":"130","author":[{"given":"Eitaro","family":"Taniguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Kin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Torimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Kumemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Hisamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Maeyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryukichi","family":"Kumashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takato","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisao","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Sata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2005.10.050_bib1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jnci\/6.1.73","article-title":"Vascular reactions of normal and malignant tissues in vivo: 1. vascular reactions of mice to wounds and to normal and neoplastic transplants","volume":"6","author":"Algire","year":"1945","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2005.10.050_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2005.10.050_bib3","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1053\/j.gastro.2005.10.050_bib4","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1073\/pnas.97.7.3422","article-title":"Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2005.10.050_bib5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1172\/JCI8296","article-title":"Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization","volume":"105","author":"Murohara","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2005.10.050_bib6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.CIR.103.5.634","article-title":"Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia","volume":"103","author":"Kawamoto","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2005.10.050_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.CIR.0000046450.89986.50","article-title":"Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia","volume":"107","author":"Kawamoto","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2005.10.050_bib8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(02)09670-8","article-title":"Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells","volume":"360","author":"Tateishi-Yuyama","year":"2002","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.10.050_bib9","first-page":"349","article-title":"Proliferation of mononuclear phagocytes (Kupffer cells) and endothelial cells in regenerating rat liver","volume":"80","author":"Widmann","year":"1975","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2005.10.050_bib10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0168-8278(99)80147-0","article-title":"Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats","volume":"30","author":"Assy","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2005.10.050_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/002215540104900112","article-title":"Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats","volume":"49","author":"Taniguchi","year":"2001","journal-title":"J Histochem Cytochem"},{"key":"10.1053\/j.gastro.2005.10.050_bib12","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1053\/jhep.2001.29624","article-title":"Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver","volume":"34","author":"Ross","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2005.10.050_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0168-8278(00)00055-6","article-title":"Vascular endothelial growth factor secreted by replicating hepatocytes induces sinusoidal endothelial cell proliferation during regeneration after partial hepatectomy in rats","volume":"34","author":"Shimizu","year":"2001","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2005.10.050_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0168-8278(00)00109-4","article-title":"Sinusoidal endothelial cell proliferation and expression of angiopoietin\/Tie family in regenerating rat liver","volume":"34","author":"Sato","year":"2001","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2005.10.050_bib15","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0168-8278(02)00043-0","article-title":"Contribution of bone marrow cells to liver regeneration after partial hepatectomy in mice","volume":"36","author":"Fujii","year":"2002","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2005.10.050_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/eji.1830010114","article-title":"Immunological unresponsiveness of genetically thymus less (nude) mice","volume":"1","author":"Kindred","year":"1971","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2005.10.050_bib17","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/sj.ki.4491416","article-title":"Reciprocal balance of hepatocyte growth factor and transforming growth factor-\u03b2 1 in renal fibrosis in mice","volume":"57","author":"Mizuno","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.gastro.2005.10.050_bib18","first-page":"233","article-title":"Vascular permeability factor\/vascular endothelial growth factor","volume":"79","author":"Brown","year":"1997","journal-title":"EXS"},{"key":"10.1053\/j.gastro.2005.10.050_bib19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1053\/j.gastro.2005.10.050_bib20","first-page":"2683","article-title":"A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR\/Flk-1)","volume":"9","author":"Yamane","year":"1994","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2005.10.050_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0140-6736(92)92396-W","article-title":"Prediction of outcome in fulminant hepatic failure by serum human hepatocyte growth factor","volume":"340","author":"Tsubouchi","year":"1992","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.10.050_bib22","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/hep.1840160520","article-title":"Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo","volume":"16","author":"Ishiki","year":"1992","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2005.10.050_bib23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.1840190423","article-title":"Hepatocyte growth factor in transgenic mice","volume":"19","author":"Shiota","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2005.10.050_bib24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/bbrc.1994.1004","article-title":"Heparin-binding EGF-like growth factor is a potent mitogen for rat hepatocytes","volume":"198","author":"Ito","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2005.10.050_bib25","first-page":"1584","article-title":"Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy","volume":"22","author":"Kiso","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2005.10.050_bib26","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/hep.1840180622","article-title":"Transforming growth factor-\u03b1 expression during liver regeneration after partial hepatectomy and toxic injury, and potential interactions between transforming growth factor-\u03b1 and hepatocyte growth factor","volume":"18","author":"Webber","year":"1993","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2005.10.050_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1098-2744(199603)15:3<183::AID-MC4>3.0.CO;2-J","article-title":"Liver regeneration and hepatocarcinogenesis in transforming growth factor-\u03b1-targeted mice","volume":"15","author":"Russell","year":"1996","journal-title":"Mol Carcinog"},{"key":"10.1053\/j.gastro.2005.10.050_bib28","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1182\/blood.V97.10.3075","article-title":"Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine\/paracrine manner","volume":"97","author":"Majka","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2005.10.050_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.1063889","article-title":"Liver organogenesis promoted by endothelial cells prior to vascular function","volume":"294","author":"Matsumoto","year":"2001","journal-title":"Science"},{"key":"10.1053\/j.gastro.2005.10.050_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/bbrc.1996.1329","article-title":"Increased expressions of vascular endothelial growth factor and its receptors, flt-1 and KDR\/flk-1, in regenerating rat liver","volume":"226","author":"Mochida","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2005.10.050_bib31","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1093\/emboj\/18.14.3964","article-title":"VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells","volume":"18","author":"Asahara","year":"1999","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2005.10.050_bib32","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/01.RES.86.12.1198","article-title":"Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects","volume":"86","author":"Kalka","year":"2000","journal-title":"Circ Res"},{"key":"10.1053\/j.gastro.2005.10.050_bib33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0003-4975(00)01633-7","article-title":"VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease","volume":"70","author":"Kalka","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.gastro.2005.10.050_bib34","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/hc2301.092122","article-title":"Mobilization of endothelial progenitor cells in patients with acute myocardial infarction","volume":"103","author":"Shintani","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2005.10.050_bib35","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/hh1301.093953","article-title":"Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease","volume":"89","author":"Vasa","year":"2001","journal-title":"Circ Res"},{"key":"10.1053\/j.gastro.2005.10.050_bib36","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/hc0602.103673","article-title":"Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration","volume":"105","author":"Iwaguro","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2005.10.050_bib37","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1182\/blood.V93.4.1253","article-title":"Maturation of embryonic stem cells into endothelial cells in an in vitro model of vasculogenesis","volume":"93","author":"Hirashima","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2005.10.050_bib38","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1182\/blood-2002-06-1877","article-title":"Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage","volume":"101","author":"Yurugi-Kobayashi","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2005.10.050_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.LAB.0000050761.67879.E4","article-title":"Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization","volume":"83","author":"Akita","year":"2003","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2005.10.050_bib40","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000027584.85865.B4","article-title":"Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells","volume":"106","author":"Murasawa","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2005.10.050_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1172\/JCI200113152","article-title":"HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase\/Akt pathway","volume":"108","author":"Dimmeler","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2005.10.050_bib42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1172\/JCI200113131","article-title":"HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells","volume":"108","author":"Llevadot","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2005.10.050_bib43","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/01.RES.0000070067.64040.7C","article-title":"HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes","volume":"92","author":"Assmus","year":"2003","journal-title":"Circ Res"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505022304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508505022304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T13:18:35Z","timestamp":1736255915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508505022304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0016508505022304"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2005.10.050","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10034.467523","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}