{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:37:35Z","timestamp":1794325055968,"version":"4.9.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1053\/j.gastro.2005.11.061","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T13:22:14Z","timestamp":1147180934000},"page":"1480-1491","source":"Crossref","is-referenced-by-count":3899,"title":["Functional Bowel Disorders"],"prefix":"10.1053","volume":"130","author":[{"given":"George F.","family":"Longstreth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Grant","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Chey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Houghton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermin","family":"Mearin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin C.","family":"Spiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2005.11.061_bib1","first-page":"1910","article-title":"The epidemiology of irritable bowel syndrome in North America","volume":"97","author":"Saito","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2982.2005.00627.x","article-title":"Irritable bowel syndrome in developing countries\u2014a disorder of civilization or colonization?","volume":"17","author":"Gwee","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2005.11.061_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.gtc.2005.02.011","article-title":"Definition and classification of IBS","volume":"34","author":"Longstreth","year":"2005","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1053\/j.gastro.2005.11.061_bib4","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/gast.2002.32392","article-title":"Systematic review of the comorbidity or irritable bowel syndrome with other disorders","volume":"122","author":"Whitehead","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib5","first-page":"24","article-title":"Quality of life in managed care patients with irritable bowel syndrome","volume":"17","author":"Wilson","year":"2004","journal-title":"Manage Care Interface"},{"key":"10.1053\/j.gastro.2005.11.061_bib6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1572-0241.2003.07296.x","article-title":"Irritable bowel syndrome, health care use, and costs","volume":"98","author":"Longstreth","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib7","series-title":"The functional gastrointestinal disorders","article-title":"Functional bowel disorders and functional abdominal pain","author":"Thompson","year":"2000"},{"key":"10.1053\/j.gastro.2005.11.061_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gut.45.2008.ii43","article-title":"Functional bowel disease and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1136\/bmj.300.6722.439","article-title":"Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate","volume":"300","author":"O\u2019Donnell","year":"1990","journal-title":"Br Med J"},{"key":"10.1053\/j.gastro.2005.11.061_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/gut.32.1.73","article-title":"How bad are the symptoms and bowel dysfunction of patients with the irritable bowel syndrome? A prospective, controlled study with emphasis on stool form","volume":"32","author":"Heaton","year":"1991","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00042737-199805000-00011","article-title":"Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome (IBS). Patients\u2019 description of diarrhea, constipation and symptom variation during a prospective 6-week study","volume":"10","author":"Ragnarsson","year":"1998","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1080\/003655299750025093","article-title":"Division of the irritable bowel syndrome into subgroups on the basis of daily recorded symptoms in two outpatients samples","volume":"34","author":"Ragnarsson","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00042737-200302000-00010","article-title":"Irritable bowel syndrome subtypes according to bowel habit","volume":"15","author":"Mearin","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1053\/j.gastro.2004.12.006","article-title":"A prospective assessment of bowel habit in irritable bowel syndrome","volume":"128","author":"Drossman","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib15","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1572-0241.2005.41211.x","article-title":"Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome","volume":"100","author":"Tillisch","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib16","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/j.1572-0241.2005.40674.x","article-title":"Bowel habit subtypes and temporal patterns in irritable bowel syndrome","volume":"100","author":"Guilera","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-2036.1997.00160.x","article-title":"Patient-perceived severity of irritable bowel syndrome in relation to symptoms, health resource utilization and quality of life","volume":"11","author":"Hahn","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S1590-8658(03)00456-0","article-title":"Factor analysis of bowel symptoms in US and Italian populations","volume":"35","author":"Whitehead","year":"2003","journal-title":"Dig Liver Dis"},{"key":"10.1053\/j.gastro.2005.11.061_bib19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/01.AOG.0000135275.63494.3d","article-title":"Prevalence and characteristics of irritable bowel syndrome among women with chronic pelvic pain","volume":"104","author":"Williams","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1053\/j.gastro.2005.11.061_bib20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1572-0241.2003.07233.x","article-title":"Symptoms across the menstrual cycle in women with irritable bowel syndrome","volume":"98","author":"Heitkemper","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib21","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1053\/j.gastro.2004.02.020","article-title":"Irritable bowel syndrome and surgery","volume":"126","author":"Longstreth","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1542-3565(04)00124-7","article-title":"Chronic abdominal wall pain","volume":"2","author":"Costanza","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib23","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/gast.2001.21908","article-title":"Management of the irritable bowel syndrome","volume":"120","author":"Camilleri","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib24","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1111\/j.1572-0241.2002.07027.x","article-title":"The utility of diagnostic tests in irritable bowel syndrome","volume":"97","author":"Cash","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1542-3565(05)00084-4","article-title":"Severe irritable bowel and functional abdominal pain syndromes","volume":"3","author":"Longstreth","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199507063330101","article-title":"A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance","volume":"333","author":"Suarez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1572-0241.2002.05690.x","article-title":"Celiac disease and irritable bowel-type symptoms","volume":"6","author":"O\u2019Leary","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib28","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1053\/gast.2001.29572","article-title":"Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome","volume":"121","author":"Wahnshaffe","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib29","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1053\/j.gastro.2004.03.012","article-title":"Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea","volume":"126","author":"Spiegel","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib30","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1053\/gast.2002.37095","article-title":"AGA technical review on irritable bowel syndrome","volume":"123","author":"Drossman","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib31","doi-asserted-by":"crossref","first-page":"41S","DOI":"10.1016\/S0002-9343(99)00081-9","article-title":"Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?","volume":"107","author":"Drossman","year":"1999","journal-title":"Am J Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11894-003-0073-z","article-title":"New insights into the psychosocial aspects of irritable bowel syndrome","volume":"5","author":"Lea","year":"2003","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1053\/j.gastro.2005.11.061_bib33","doi-asserted-by":"crossref","first-page":"828","DOI":"10.7326\/0003-4819-113-11-828","article-title":"Sexual and physical abuse in women with functional or organic gastrointestinal disorders","volume":"113","author":"Drossman","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib34","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1365-2036.2004.02256.x","article-title":"The usual medical care for irritable bowel syndrome","volume":"20","author":"Whitehead","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S1542-3565(04)00242-3","article-title":"Self-management for women with irritable bowel syndrome","volume":"2","author":"Heitkemper","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib36","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S1542-3565(04)00241-1","article-title":"Effects of multidisciplinary education on outcomes in patients with irritable bowel syndrome","volume":"2","author":"Saito","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11938-003-0025-6","article-title":"Treatment of irritable bowel syndrome","volume":"6","author":"Spiller","year":"2003","journal-title":"Curr Treat Options Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib38","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1046\/j.1365-2036.2003.01523.x","article-title":"Therapeutic value of a gastroenterology consultation in irritable bowel syndrome","volume":"17","author":"Ilnyckyj","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00042737-200103000-00001","article-title":"Irritable bowel syndrome","volume":"13","author":"Parker","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib40","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1111\/j.1572-0241.2004.40266.x","article-title":"Dietary fructose and gastrointestinal symptoms","volume":"99","author":"Skoog","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib41","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1136\/gut.2003.037697","article-title":"Food elimination based on IgG antibodies in irritable bowel syndrome","volume":"53","author":"Atkinson","year":"2004","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(94)91055-3","article-title":"Bran and irritable bowel syndrome","volume":"344","author":"Francis","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2005.11.061_bib43","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2036.1994.tb00323.x","article-title":"Bran supplementation in the treatment of the irritable bowel syndrome","volume":"8","author":"Snook","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib44","series-title":"Irritable bowel syndrome","author":"Thompson","year":"2003"},{"key":"10.1053\/j.gastro.2005.11.061_bib45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0016-5085(88)90319-8","article-title":"Controlled treatment trials in the irritable bowel syndrome","volume":"95","author":"Klein","year":"1988","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"10.1053\/j.gastro.2005.11.061_bib46","first-page":"S1","article-title":"Evidence-based position statement on the management of irritable bowel syndrome in North America","volume":"97","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib47","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1572-0241.2005.40925.x","article-title":"Efficacy and safety of traditional medical therapies for chronic constipation","volume":"100","author":"Ramkumar","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib48","doi-asserted-by":"crossref","first-page":"136","DOI":"10.7326\/0003-4819-133-2-200007180-00013","article-title":"Pharmacologic treatment of the irritable bowel syndrome","volume":"133","author":"Jailwala","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0016-5085(03)00669-3","article-title":"Cognitive-behavioural therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders","volume":"125","author":"Drossman","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib50","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1572-0241.2005.30375.x","article-title":"Clinical response to tricyclic antidepressants in functional bowel disorders is not related to dosage","volume":"100","author":"Halpert","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib51","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/gast.2003.50055","article-title":"The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome","volume":"124","author":"Creed","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib52","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1572-0241.2004.04127.x","article-title":"Paroxetine to treat irritable bowel syndrome not responding to high-fiber diet","volume":"99","author":"Tabas","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1365-2982.2003.00389.x","article-title":"Efficacy of alosetron in irritable bowel syndrome","volume":"15","author":"Cremonini","year":"2003","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2005.11.061_bib54","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1111\/j.1572-0241.2004.30509.x","article-title":"Long-term safety and efficacy of alosetron in women with severe diarrhea-predominant irritable bowel syndrome","volume":"99","author":"Chey","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib55","first-page":"CD003960","article-title":"Tegaserod for the treatment of irritable bowel syndrome","volume":"1","author":"Evans","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.gastro.2005.11.061_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2036.2004.02294.x","article-title":"Tegaserod is effective in the initial and retreatment of irritable bowel syndrome with constipation","volume":"21","author":"Muller-Lissner","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1053\/j.gastro.2004.11.050","article-title":"Lactobacillus and bifidobacterium in irritable bowel syndrome","volume":"128","author":"O\u2019Mahony","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib58","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1001\/jama.292.7.852","article-title":"Small intestinal bacterial overgrowth","volume":"292","author":"Lin","year":"2004","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2005.11.061_bib59","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/j.1572-0241.2005.40795.x","article-title":"Detection of bacterial overgrowth in IBS using the lactulose H2 breath test","volume":"100","author":"Walters","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib60","first-page":"412","article-title":"Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome","volume":"98","author":"Pimentel","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib61","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1572-0241.2002.05428.x","article-title":"Antibiotics increase functional abdominal symptoms","volume":"97","author":"Maxwell","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib62","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2036.2003.01486.x","article-title":"Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome","volume":"17","author":"Lea","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib63","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1136\/gut.52.11.1623","article-title":"Long term benefits of hypnotherapy for irritable bowel syndrome","volume":"52","author":"Gonsalkorale","year":"2003","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib64","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1023\/A:1005554103531","article-title":"Abdominal pain, bloating, and diarrhea in the United States","volume":"45","author":"Sandler","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib65","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/gut.42.5.690","article-title":"Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population","volume":"42","author":"Talley","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1013208713670","article-title":"Functional gastrointestinal disorders in Canada","volume":"47","author":"Thompson","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib67","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1111\/j.1572-0241.2001.05336.x","article-title":"Sensation of bloating and visible abdominal distention in patients with irritable bowel syndrome","volume":"96","author":"Chang","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2982.2005.00666.x","article-title":"Towards a better understanding of abdominal bloating and distention in functional gastrointestinal disorders","volume":"17","author":"Houghton","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2005.11.061_bib69","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3810\/pgm.1997.04.208","article-title":"Belching, bloating and flatulence. How to help patients who have troublesome abdominal gas","volume":"101","author":"Rao","year":"1997","journal-title":"Postgrad Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib70","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1572-0241.1999.00798.x","article-title":"Failure of activated charcoal to reduce the release of gases produced by the colonic flora","volume":"94","author":"Suarez","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib71","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1365-2036.2003.01543.x","article-title":"A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome","volume":"17","author":"Kim","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib72","first-page":"441","article-title":"Does Beano prevent gas? A double-blind, crossover study of oral alpha-galactosidase to treat dietary oligosaccaride intolerance","volume":"39","author":"Ganiats","year":"1994","journal-title":"J Fam Pract"},{"key":"10.1053\/j.gastro.2005.11.061_bib73","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1023\/A:1026675012864","article-title":"Pancreatic supplements reduce symptomatic response of healthy subjects to a high fat meal","volume":"44","author":"Suarez","year":"1999","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib74","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/gut.52.5.671","article-title":"An Asia-Pacific, double-blind, placebo-controlled, randomised study to evaluate the efficacy, safety, and tolerability of tegaserod in patient with irritable bowel syndrome","volume":"52","author":"Kellow","year":"2003","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib75","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1111\/j.1572-0241.2001.05259.x","article-title":"An epidemiological survey of constipation in Canada","volume":"96","author":"Pare","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib76","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1136\/gut.35.10.1455","article-title":"Evidence for the ambiguity of the word constipation","volume":"35","author":"Probert","year":"1994","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib77","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2982.2004.00526.x","article-title":"Investigation of the utility of colorectal function tests and Rome II criteria in dyssynergic defecation (Anismus)","volume":"16","author":"Rao","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2005.11.061_bib78","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJMra020995","article-title":"Chronic constipation","volume":"349","author":"Lembo","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib79","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0889-8553(03)00026-8","article-title":"Constipation","volume":"32","author":"Rao","year":"2003","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1053\/j.gastro.2005.11.061_bib80","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/0016-5085(89)91500-X","article-title":"Psychological and physiological characteristics of patients with severe idiopathic constipation","volume":"97","author":"Wald","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib81","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1572-0241.2005.40885.x","article-title":"Myths and misconceptions about chronic constipation","volume":"100","author":"Muller-Lissner","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib82","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1023\/A:1020131126397","article-title":"Lack of objective evidence of efficacy of laxatives in chronic constipation","volume":"47","author":"Jones","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib83","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9343(90)90177-F","article-title":"Cost-effective treatment of constipation in the elderly","volume":"89","author":"Lederle","year":"1990","journal-title":"Am J Med"},{"key":"10.1053\/j.gastro.2005.11.061_bib84","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1542-3565(04)00356-8","article-title":"Effect of tegaserod in chronic constipation","volume":"2","author":"Johanson","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2005.11.061_bib85","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1572-0241.2005.40749.x","article-title":"Tegaserod for the treatment of chronic constipation","volume":"100","author":"Kamm","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2005.11.061_bib86","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(91)90717-Y","article-title":"Epidemiology of colonic symptoms and the irritable bowel syndrome","volume":"101","author":"Talley","year":"1991","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1053\/j.gastro.2005.11.061_bib87","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/BF01537261","article-title":"A longitudinal survey of self-reported bowel habits in the United States","volume":"34","author":"Everhart","year":"1989","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib88","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gut.46.1.78","article-title":"Irritable bowel syndrome in general practice","volume":"46","author":"Thompson","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib89","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/BF01296706","article-title":"Bowel habits in young adults not seeking health care","volume":"32","author":"Sandler","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2005.11.061_bib90","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/0016-5085(95)90134-5","article-title":"Determinants of decreased fecal consistency in patients with diarrhea","volume":"108","author":"Wenzl","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib91","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.1365-2036.1998.00388.x","article-title":"Idiopathic bile acid malabsorption","volume":"12","author":"Sinha","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2005.11.061_bib92","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/0016-5085(91)90080-5","article-title":"Effect of eating on colonic motility and transit in patients with functional diarrhea","volume":"101","author":"Bazzocchi","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib93","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1136\/gut.24.3.236","article-title":"Psychological stress and the passage of a standard meal through the stomach and small intestine in man","volume":"24","author":"Cann","year":"1983","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2005.11.061_bib94","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/0016-5085(80)90924-5","article-title":"Double blind cross-over study comparing loperamide, codeine and diphenoxylate in chronic diarrhea","volume":"79","author":"Palmer","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2005.11.061_bib95","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1056\/NEJM199212243272605","article-title":"The self-limited nature of chronic idiopathic diarrhoea","volume":"327","author":"Afzalpurkar","year":"1992","journal-title":"N Engl J Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508506005129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508506005129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T12:34:42Z","timestamp":1586867682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508506005129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":95,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0016508506005129"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2005.11.061","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}