{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:55:17Z","timestamp":1790006117674,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1053\/j.gastro.2006.09.019","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T07:28:23Z","timestamp":1158823703000},"page":"1879-1886","source":"Crossref","is-referenced-by-count":129,"title":["Hepatitis C and Risk of Lymphoma: Results of the European Multicenter Case-Control Study EPILYMPH"],"prefix":"10.1053","volume":"131","author":[{"given":"Alexandra","family":"Nieters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Kallinowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maynadi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Foretova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Cocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Staines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Vornanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Whitby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Sanjos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2006.09.019_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2893.1999.6120139.x","article-title":"Global surveillance and control of hepatitis C","volume":"6","year":"1999","journal-title":"J Viral Hepat"},{"key":"10.1053\/j.gastro.2006.09.019_bib2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1473-3099(05)70216-4","article-title":"Global epidemiology of hepatitis C virus infection","volume":"5","author":"Shepard","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1053\/j.gastro.2006.09.019_bib3","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1053\/jhep.2002.35620","article-title":"Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis","volume":"36","author":"Kayali","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2006.09.019_bib4","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1053\/j.gastro.2003.09.025","article-title":"Prevalence of hepatitis C virus infection in B-cell non-Hodgkin\u2019s lymphoma: systematic review and meta-analysis","volume":"125","author":"Gisbert","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2006.09.019_bib5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1349-7006.2004.tb03256.x","article-title":"Effect of hepatitis C virus infection on the risk of non-Hodgkin\u2019s lymphoma: a meta-analysis of epidemiological studies","volume":"95","author":"Matsuo","year":"2004","journal-title":"Cancer Sci"},{"key":"10.1053\/j.gastro.2006.09.019_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.20205","article-title":"B-cell non-Hodgkin\u2019s lymphoma and hepatitis C virus infection: a systematic review","volume":"111","author":"Negri","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib7","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/annonc\/mdg363","article-title":"Hepatitis C and B-cell lymphoma","volume":"14","author":"Turner","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2006.09.019_bib8","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1182\/blood-2002-01-0226","article-title":"Prospective study of hepatitis C viral infection as a risk factor for subsequent B-cell neoplasia","volume":"99","author":"Rabkin","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1097-0215(19990118)80:2<237::AID-IJC12>3.0.CO;2-I","article-title":"Risk of non-Hodgkin\u2019s lymphoma in patients with hepatitis C virus infection","volume":"80","author":"Ohsawa","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib10","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/hep.20608","article-title":"Non-Hodgkin\u2019s lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection","volume":"41","author":"Duberg","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2006.09.019_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1182\/asheducation-2001.1.194","article-title":"New approaches to lymphoma diagnosis","author":"Harris","year":"2001","journal-title":"Hematology"},{"key":"10.1053\/j.gastro.2006.09.019_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/aje\/kwj187","article-title":"Association between personal use of hair dyes and lymphoid neoplasms in Europe","volume":"164","author":"De Sanjose","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2006.09.019_bib13","series-title":"World Health Organization Classification of Tumours","author":"Jaff\u00e9","year":"2001"},{"key":"10.1053\/j.gastro.2006.09.019_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2893.2001.00280.x","article-title":"Sensitivity and specificity of third-generation hepatitis C virus antibody detection assays: an analysis of the literature","volume":"8","author":"Colin","year":"2001","journal-title":"J Viral Hepat"},{"key":"10.1053\/j.gastro.2006.09.019_bib15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/ijc.20137","article-title":"Non-Hodgkin\u2019s lymphoma and hepatitis C virus: a case-control study from northern and southern Italy","volume":"110","author":"Talamini","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/1055-9965.425.13.3","article-title":"Hepatitis C virus and risk of non-Hodgkin lymphoma: a population-based case-control study among Connecticut women","volume":"13","author":"Morton","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2006.09.019_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ijc.20021","article-title":"Hepatitis C virus infection and non-Hodgkin lymphoma: results of the NCI-SEER multi-center case-control study","volume":"111","author":"Engels","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib18","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1182\/blood.V87.10.4296.bloodjournal87104296","article-title":"Prevalence of hepatitis C virus infection in patients with lymphoproliferative disorders","volume":"87","author":"Silvestri","year":"1996","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1023\/A:1008255830453","article-title":"Clinico-pathological characterization of hepatitis C virus-related B-cell non-Hodgkin\u2019s lymphomas without symptomatic cryoglobulinemia","volume":"9","author":"Luppi","year":"1998","journal-title":"Ann Oncol"},{"key":"10.1053\/j.gastro.2006.09.019_bib20","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1182\/blood.V93.5.1778","article-title":"Hepatitis C virus infection in patients with overt B-cell non-Hodgkin\u2019s lymphoma in a French center","volume":"93","author":"Germanidis","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib21","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1182\/blood-2002-10-3230","article-title":"Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study","volume":"102","author":"Mele","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib22","first-page":"314","article-title":"Hepatitis C virus infection among cryoglobulinemic and non-cryoglobulinemic B-cell non-Hodgkin\u2019s lymphomas","volume":"82","author":"Silvestri","year":"1997","journal-title":"Haematologica"},{"key":"10.1053\/j.gastro.2006.09.019_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1054\/blre.2002.0194","article-title":"Hepatitis C and B-cell lymphoma: the hemato-hepatologist linkage","volume":"16","author":"Zuckerman","year":"2002","journal-title":"Blood Rev"},{"key":"10.1053\/j.gastro.2006.09.019_bib24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-117-7-573","article-title":"Hepatitis C virus infection in patients with essential mixed cryoglobulinemia","volume":"117","author":"Misiani","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2006.09.019_bib25","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1182\/blood.V84.9.3047.3047","article-title":"Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia","volume":"84","author":"Pozzato","year":"1994","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3816\/CLM.2003.n.002","article-title":"Nongastric mucosa-associated lymphoid tissue lymphomas","volume":"3","author":"Thieblemont","year":"2003","journal-title":"Clin Lymphoma"},{"key":"10.1053\/j.gastro.2006.09.019_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJMoa013376","article-title":"Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection","volume":"347","author":"Hermine","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2006.09.019_bib28","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.282.5390.938","article-title":"Binding of hepatitis C virus to CD81","volume":"282","author":"Pileri","year":"1998","journal-title":"Science"},{"key":"10.1053\/j.gastro.2006.09.019_bib29","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1182\/blood.V98.13.3745","article-title":"The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis","volume":"98","author":"Quinn","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib30","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1128\/JVI.78.16.8835-8843.2004","article-title":"Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes","volume":"78","author":"Machida","year":"2004","journal-title":"J Virol"},{"key":"10.1053\/j.gastro.2006.09.019_bib31","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.0303971101","article-title":"Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes","volume":"101","author":"Machida","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2006.09.019_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/jhep.2000.9198","article-title":"Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer","volume":"32","author":"Kato","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2006.09.019_bib33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1053\/gast.2002.30983","article-title":"Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein","volume":"122","author":"Okuda","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2006.09.019_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ijc.11303","article-title":"Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma","volume":"107","author":"Chung","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib35","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/sj.gene.6364072","article-title":"An analysis of tumor necrosis factor \u03b1 gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection","volume":"5","author":"Thio","year":"2004","journal-title":"Genes Immun"},{"key":"10.1053\/j.gastro.2006.09.019_bib36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0198-8859(03)00080-6","article-title":"IL-10 and TNF-\u03b1 polymorphisms and the recovery from HCV infection","volume":"64","author":"Lio","year":"2003","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2006.09.019_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cyto.2003.10.005","article-title":"IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection","volume":"25","author":"Mangia","year":"2004","journal-title":"Cytokine"},{"key":"10.1053\/j.gastro.2006.09.019_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(05)70434-4","article-title":"Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium","volume":"7","author":"Rothman","year":"2006","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.gastro.2006.09.019_bib39","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1182\/blood.V91.10.3574","article-title":"Genetic polymorphisms in the tumor necrosis factor locus influence non-Hodgkin\u2019s lymphoma outcome","volume":"91","author":"Warzocha","year":"1998","journal-title":"Blood"},{"key":"10.1053\/j.gastro.2006.09.019_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1080\/1042819021000035590","article-title":"Polymorphisms in the interleukin 10 gene promoter are associated with susceptibility to aggressive non-Hodgkin\u2019s lymphoma","volume":"44","author":"Cunningham","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1053\/j.gastro.2006.09.019_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3748\/wjg.v8.i4.577","article-title":"Hepatitis C and HIV co-infection: a review","volume":"8","author":"Maier","year":"2002","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2006.09.019_bib42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/ijc.20988","article-title":"Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin\u2019s lymphoma: a cohort study","volume":"116","author":"Waters","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2006.09.019_bib43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00126334-200212150-00012","article-title":"Prevalence of hepatitis C virus infection and risk for hepatocellular carcinoma and non-Hodgkin lymphoma in AIDS","volume":"31","author":"Engels","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1053\/j.gastro.2006.09.019_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/(SICI)1096-8652(199706)55:2<77::AID-AJH5>3.0.CO;2-#","article-title":"High prevalence of hepatitis C virus infection in patients with B-cell lymphoproliferative disorders in Italy","volume":"55","author":"De Rosa","year":"1997","journal-title":"Am J Hematol"},{"key":"10.1053\/j.gastro.2006.09.019_bib45","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2036.2005.02395.x","article-title":"Systematic review: regression of lymphoproliferative disorders after treatment for hepatitis C infection","volume":"21","author":"Gisbert","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2006.09.019_bib46","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1080\/104281905001028289","article-title":"Regression of advanced non-splenic marginal zone lymphoma after treatment of hepatitis C virus infection","volume":"46","author":"Svoboda","year":"2005","journal-title":"Leuk Lymphoma"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508506020798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508506020798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T18:52:14Z","timestamp":1683571934000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508506020798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0016508506020798"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2006.09.019","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}