{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:53:00Z","timestamp":1768715580503,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1053\/j.gastro.2008.01.014","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T07:06:31Z","timestamp":1200294391000},"page":"1180-1190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Hepatocyte Growth Factor Suppresses Profibrogenic Signal Transduction via Nuclear Export of Smad3 With Galectin-7"],"prefix":"10.1053","volume":"134","author":[{"given":"Yutaka","family":"Inagaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Kushida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Yu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachie","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiichi","family":"Higashiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johbu","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goshi","family":"Shiota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2008.01.014_bib1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into transforming growth factor-\u03b2 Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2008.01.014_bib2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/oxfordjournals.jbchem.a124958","article-title":"Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats","volume":"118","author":"Matsuda","year":"1995","journal-title":"J Biochem"},{"key":"10.1053\/j.gastro.2008.01.014_bib3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hep.510240328","article-title":"Antifibrotic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats","volume":"24","author":"Yasuda","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.01.014_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats","volume":"5","author":"Ueki","year":"1999","journal-title":"Nature Med"},{"key":"10.1053\/j.gastro.2008.01.014_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-8278(01)00245-8","article-title":"Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cells","volume":"36","author":"Ozaki","year":"2002","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2008.01.014_bib6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0002-9440(10)62323-1","article-title":"Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis","volume":"166","author":"Kim","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2008.01.014_bib7","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2353\/ajpath.2006.050747","article-title":"Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation","volume":"168","author":"Xia","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2008.01.014_bib8","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1096\/fasebj.4.6.2180769","article-title":"Complex and diversified regulatory programs control the expression of vertebrate collagen gene","volume":"4","author":"Ramirez","year":"1990","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2008.01.014_bib9","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Gene Dev"},{"key":"10.1053\/j.gastro.2008.01.014_bib10","doi-asserted-by":"crossref","first-page":"14828","DOI":"10.1016\/S0021-9258(17)36699-1","article-title":"Transforming growth factor-\u03b2 stimulates \u03b12(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site","volume":"269","author":"Inagaki","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib11","first-page":"573","article-title":"Regulation of the \u03b12(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver","volume":"22","author":"Inagaki","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.01.014_bib12","doi-asserted-by":"crossref","first-page":"19738","DOI":"10.1074\/jbc.272.32.19738","article-title":"Sp1 is required for the early response of \u03b12(I) collagen to transforming growth factor-\u03b21","volume":"272","author":"Greenwel","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib13","doi-asserted-by":"crossref","first-page":"39237","DOI":"10.1074\/jbc.M003339200","article-title":"Synergistic cooperation between Sp1 and Smad3\/Smad4 mediates TGF\u03b21 stimulation of \u03b12(I) collagen (COL1A2) transcription","volume":"275","author":"Zhang","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/1097-4652(2001)9999:9999<00::AID-JCP1059>3.0.CO;2-S","article-title":"Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells","volume":"187","author":"Inagaki","year":"2001","journal-title":"J Cell Physiol"},{"key":"10.1053\/j.gastro.2008.01.014_bib15","doi-asserted-by":"crossref","first-page":"16573","DOI":"10.1074\/jbc.M010485200","article-title":"Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific \u03b12(I) collagen gene transcription","volume":"276","author":"Inagaki","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj2850367","article-title":"Eicosanoid-mediated contractility of hepatic stellate cells","volume":"285","author":"Kawada","year":"1992","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2008.01.014_bib17","first-page":"210","article-title":"Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6 and connexin 43","volume":"69","author":"Greenwel","year":"1993","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2008.01.014_bib18","doi-asserted-by":"crossref","first-page":"43470","DOI":"10.1074\/jbc.M302339200","article-title":"Interferon-\u03b3 interferes with transforming growth factor-\u03b2 signaling through direct interaction of YB-1 with Smad3","volume":"278","author":"Higashi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib19","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hep.1840190423","article-title":"Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression","volume":"19","author":"Shiota","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.01.014_bib20","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1083\/jcb.134.5.1333","article-title":"A potent far-upstream enhancer in the mouse pro\u03b12(I) collagen gene regulates expression of reporter genes in transgenic mice","volume":"134","author":"Bou-Gharios","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2008.01.014_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2005.03.088","article-title":"Cell type-specific intervention of TGF-\u03b2\/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice","volume":"129","author":"Inagaki","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2008.01.014_bib22","first-page":"890","article-title":"Interferon \u03b1 down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice","volume":"38","author":"Inagaki","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.01.014_bib23","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1074\/jbc.M208724200","article-title":"Y-box-binding protein YB-1 mediates transcriptional repression of human \u03b12(I) collagen gene expression by interferon-\u03b3","volume":"278","author":"Higashi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib24","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1074\/jbc.M109360200","article-title":"Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release","volume":"277","author":"Kuwabara","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib26","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1101\/gad.13.7.804","article-title":"A mechanism of repression of TGF\u03b2\/Smad signaling by oncogenic Ras","volume":"13","author":"Kretzschmar","year":"1999","journal-title":"Gene Dev"},{"key":"10.1053\/j.gastro.2008.01.014_bib27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1006\/bbrc.1998.9387","article-title":"Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor \u03b21 expression and DNA synthesis","volume":"250","author":"Ikeda","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2008.01.014_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0304-4165(02)00313-6","article-title":"Intracellular functions of galectins","volume":"1572","author":"Liu","year":"2002","journal-title":"Biochem Biophys Acta"},{"key":"10.1053\/j.gastro.2008.01.014_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbagen.2004.03.013","article-title":"Nucleocytoplasmic lectins","volume":"1673","author":"Wang","year":"2004","journal-title":"Biochem Biophys Acta"},{"key":"10.1053\/j.gastro.2008.01.014_bib30","doi-asserted-by":"crossref","first-page":"18938","DOI":"10.1074\/jbc.M209673200","article-title":"Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways","volume":"278","author":"Maeda","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.01.014_bib31","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1073\/pnas.0511167103","article-title":"Galectin-3 regulates myofibroblast activation and hepatic fibrosis","volume":"103","author":"Henderson","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2008.01.014_bib32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/sj.ki.4491416","article-title":"Reciprocal balance of hepatocyte growth factor and transforming growth factor-\u03b21 in renal fibrosis in mice","volume":"57","author":"Mizuno","year":"2000","journal-title":"Kidney Int"},{"key":"10.1053\/j.gastro.2008.01.014_bib33","doi-asserted-by":"crossref","first-page":"F7","DOI":"10.1152\/ajprenal.00451.2003","article-title":"Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action","volume":"287","author":"Liu","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1053\/j.gastro.2008.01.014_bib34","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0002-9440(10)63689-9","article-title":"Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction","volume":"163","author":"Yang","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2008.01.014_bib35","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1097\/01.ASN.0000130568.53923.FD","article-title":"Hepatocyte growth factor antagonizes the profibrogenic action of TGF-\u03b21 in mesangial cells by stabilizing Smad transcriptional corepressors TGIF","volume":"15","author":"Dai","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.gastro.2008.01.014_bib36","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1681\/ASN.2003090795","article-title":"A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition","volume":"16","author":"Yang","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.gastro.2008.01.014_bib37","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1128\/MCB.26.4.1318-1332.2006","article-title":"The mechanism of nuclear export of Smad3 involves exportin 4 and Ran","volume":"26","author":"Kurisaki","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2008.01.014_bib38","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1158\/0008-5472.CAN-05-0134","article-title":"A novel function for galectin-7: promoting tumorigenesis by up-regulating MMP-9 gene expression","volume":"65","author":"Demers","year":"2005","journal-title":"Cancer Res"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850800053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650850800053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:36:19Z","timestamp":1762162579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650850800053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S001650850800053X"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2008.01.014","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte Growth Factor Suppresses Profibrogenic Signal Transduction via Nuclear Export of Smad3 With Galectin-7","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2008.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}