{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:23:59Z","timestamp":1790313839532,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1053\/j.gastro.2008.02.016","type":"journal-article","created":{"date-parts":[[2008,2,15]],"date-time":"2008-02-15T07:36:24Z","timestamp":1203060984000},"page":"1316-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":275,"title":["Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups"],"prefix":"10.1053","volume":"134","author":[{"given":"Robert C.","family":"Kapel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne K.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saime","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Katzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2008.02.016_bib1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/S0016-5085(82)80011-5","article-title":"Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis","volume":"83","author":"Winter","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2008.02.016_bib2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF01296781","article-title":"Esophageal eosinophilia with dysphagia","volume":"38","author":"Attwood","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2008.02.016_bib3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1148\/radiology.186.3.8430189","article-title":"Idiopathic eosinophilic esophagitis","volume":"186","author":"Vitellas","year":"1993","journal-title":"Radiology"},{"key":"10.1053\/j.gastro.2008.02.016_bib4","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1053\/j.gastro.2005.06.027","article-title":"Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice","volume":"129","author":"Akei","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2008.02.016_bib5","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jaci.2006.07.038","article-title":"Eosinophilic esophagitis: pathogenesis, genetics, and therapy","volume":"118","author":"Blanchard","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2008.02.016_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00042737-200602000-00015","article-title":"Eosinophilic esophagitis in adults: a systematic review","volume":"18","author":"Sgouros","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2008.02.016_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/modpathol.3800498","article-title":"Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients","volume":"19","author":"Parfitt","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1053\/j.gastro.2008.02.016_bib8","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0016-5107(03)02713-5","article-title":"Eosinophilic esophagitis in adults: an emerging problem with unique esophageal features","volume":"59","author":"Potter","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2008.02.016_bib9","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S1542-3565(05)00885-2","article-title":"Eosinophilic esophagitis: a 10-year experience in 381 children","volume":"3","author":"Liacouras","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2008.02.016_bib10","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1067\/S0016-5107(03)01870-4","article-title":"Clinical and endoscopic features of eosinophilic esophagitis in adults","volume":"58","author":"Croese","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2008.02.016_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gie.2005.07.049","article-title":"Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate","volume":"63","author":"Remedios","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"10.1053\/j.gastro.2008.02.016_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/j.1536-4801.2004.tb00869.x","article-title":"Eosinophilic esophagitis in children: symptoms, histology and pH probe results","volume":"39","author":"Sant'Anna","year":"2004","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2008.02.016_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/sim.4780040112","article-title":"A Wilcoxon-type test for trend","volume":"4","author":"Cuzick","year":"1985","journal-title":"Stat Med"},{"key":"10.1053\/j.gastro.2008.02.016_bib14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jaci.2006.10.044","article-title":"Pediatric patients with eosinophilic esophagitis: an 8-year follow-up","volume":"119","author":"Assa'ad","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.gastro.2008.02.016_bib15","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1172\/JCI26679","article-title":"Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis","volume":"116","author":"Blanchard","year":"2006","journal-title":"Am Soc Clin Invest"},{"key":"10.1053\/j.gastro.2008.02.016_bib16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1572-0241.2004.04170.x","article-title":"Correlation between number of eosinophils and reflux index on same day esophageal biopsy and 24 hour esophageal pH monitoring","volume":"99","author":"Steiner","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2008.02.016_bib17","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/adc.2006.100974","article-title":"Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia","volume":"91","author":"Cherian","year":"2006","journal-title":"Arch Dis Childhood"},{"key":"10.1053\/j.gastro.2008.02.016_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.gie.2006.04.037","article-title":"Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis","volume":"64","author":"Gonsalves","year":"2006","journal-title":"Gastrointest Endosc"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508508002485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508508002485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:49:16Z","timestamp":1758034156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508508002485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0016508508002485"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2008.02.016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1111040.568211","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1111040.567011","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eosinophilic Esophagitis: A Prevalent Disease in the United States That Affects All Age Groups","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2008.02.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2008.03.055","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}