{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:15:49Z","timestamp":1791296149742,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011103","name":"Sixth Framework Programme","doi-asserted-by":"publisher","award":["LSHB-CT-2005-518167"],"award-info":[{"award-number":["LSHB-CT-2005-518167"]}],"id":[{"id":"10.13039\/100011103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1053\/j.gastro.2008.02.055","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T16:57:38Z","timestamp":1204822658000},"page":"1459-1469.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Obesity-Induced Lymphocyte Hyperresponsiveness to Chemokines: A New Mechanism of Fatty Liver Inflammation in Obese Mice"],"prefix":"10.1053","volume":"134","author":[{"given":"Am\u00e9lie E.","family":"Bigorgne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bouchet\u2013Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Naveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Pr\u00e9vot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Durand\u2013Gasselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Couderc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Valet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Emilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Perlemuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2008.02.055_bib1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncpendmet0505","article-title":"Nonalcoholic fatty liver disease: from pathogenesis to patient care","volume":"3","author":"Perlemuter","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1053\/j.gastro.2008.02.055_bib2","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2008.02.055_bib3","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits?\u201d","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2008.02.055_bib4","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.hepres.2005.09.020","article-title":"Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases","volume":"33","author":"Seki","year":"2005","journal-title":"Hepatol Res"},{"key":"10.1053\/j.gastro.2008.02.055_bib5","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJM200011163432007","article-title":"Cytokines in alcoholic and nonalcoholic steatohepatitis","volume":"343","author":"Tilg","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2008.02.055_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-2001-12925","article-title":"Nonalcoholic steatohepatitis: definition and pathology","volume":"21","author":"Brunt","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1053\/j.gastro.2008.02.055_bib7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0016-5085(90)90833-M","article-title":"Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth","volume":"98","author":"Lichtman","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2008.02.055_bib8","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1073\/pnas.94.6.2557","article-title":"Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis","volume":"94","author":"Yang","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2008.02.055_bib9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/bega.2002.0332","article-title":"Animal models of steatohepatitis","volume":"16","author":"Koteish","year":"2002","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2008.02.055_bib10","first-page":"R136","article-title":"Leptin deficiency enhances sensitivity to endotoxin-induced lethality","volume":"276","author":"Faggioni","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2008.02.055_bib11","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/01.ALC.0000167744.60838.4A","article-title":"Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression","volume":"29","author":"Romics","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2008.02.055_bib12","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1189\/jlb.0603297","article-title":"Critical role of CXC chemokines in endotoxemic liver injury in mice","volume":"75","author":"Li","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.gastro.2008.02.055_bib13","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1073\/pnas.96.15.8585","article-title":"Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis: expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells","volume":"96","author":"Coulomb-L'Hermin","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2008.02.055_bib14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.187.4.655","article-title":"B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1\/CXCR5","volume":"187","author":"Legler","year":"1998","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2008.02.055_bib15","doi-asserted-by":"crossref","first-page":"9576","DOI":"10.1158\/0008-5472.CAN-06-1507","article-title":"The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver","volume":"66","author":"Meijer","year":"2006","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2008.02.055_bib16","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.02.055_bib17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.it.2005.08.005","article-title":"Intrahepatic immunity: a tale of two sites?","volume":"26","author":"Bowen","year":"2005","journal-title":"Trends Immunol"},{"key":"10.1053\/j.gastro.2008.02.055_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-065X.2006.00435.x","article-title":"Cellular and molecular mechanisms of liver tolerance","volume":"213","author":"Crispe","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1053\/j.gastro.2008.02.055_bib19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00001574-200311000-00009","article-title":"Innate immunity in the liver","volume":"19","author":"Li","year":"2003","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1053\/j.gastro.2008.02.055_bib20","doi-asserted-by":"crossref","first-page":"G518","DOI":"10.1152\/ajpgi.00024.2006","article-title":"Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis","volume":"292","author":"Brun","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2008.02.055_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/gut.48.2.206","article-title":"The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor \u03b1 in the pathogenesis of non-alcoholic steatohepatitis","volume":"48","author":"Wigg","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2008.02.055_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1096\/fsb2fasebj.12.1.57","article-title":"Leptin regulates proinflammatory immune responses","volume":"12","author":"Loffreda","year":"1998","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2008.02.055_bib23","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.20320","article-title":"Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis","volume":"40","author":"Li","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.02.055_bib24","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/hep.510310313","article-title":"Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage","volume":"31","author":"Guebre-Xabier","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.02.055_bib25","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/hep.20826","article-title":"Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease","volume":"42","author":"Li","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.02.055_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/path.1950","article-title":"Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob\/ob mice and is associated with intrahepatic CD8 trapping","volume":"209","author":"Elinav","year":"2006","journal-title":"J Pathol"},{"key":"10.1053\/j.gastro.2008.02.055_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature03408","article-title":"Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections","volume":"434","author":"Mattner","year":"2005","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2008.02.055_bib28","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1172\/JCI24798","article-title":"Attenuated liver fibrosis in the absence of B cells","volume":"115","author":"Novobrantseva","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2008.02.055_bib29","doi-asserted-by":"crossref","first-page":"35760","DOI":"10.1074\/jbc.M508234200","article-title":"The chemokine SDF-1\/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes","volume":"280","author":"Balabanian","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2008.02.055_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.molimm.2004.06.040","article-title":"Chemokine-mediated control of T-cell traffic in lymphoid and peripheral tissues","volume":"42","author":"Ebert","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1053\/j.gastro.2008.02.055_bib31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jlb.65.1.6","article-title":"Chemokines: signal lamps for trafficking of T and B cells for development and effector function","volume":"65","author":"Kim","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.gastro.2008.02.055_bib32","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/hep.20302","article-title":"Hepatic microvascular dysfunction during evolution of dietary steatohepatitis in mice","volume":"40","author":"McCuskey","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2008.02.055_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2007.01.011","article-title":"A key role of leptin in the control of regulatory T-cell proliferation","volume":"26","author":"De Rosa","year":"2007","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2008.02.055_bib34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nri1350","article-title":"The weight of leptin in immunity","volume":"4","author":"La Cava","year":"2004","journal-title":"Nat Rev Immunol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508508003430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508508003430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:37:09Z","timestamp":1762162629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508508003430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0016508508003430"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2008.02.055","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obesity-Induced Lymphocyte Hyperresponsiveness to Chemokines: A New Mechanism of Fatty Liver Inflammation in Obese Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2008.02.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}