{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:13:57Z","timestamp":1768788837170,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007571","name":"Fondazione Cassa di Risparmio di Civitavecchia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1053\/j.gastro.2009.01.004","type":"journal-article","created":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T04:20:43Z","timestamp":1231993243000},"page":"341-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis"],"prefix":"10.1053","volume":"137","author":[{"given":"Marco","family":"Domenicali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Caraceni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Giannone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Pertosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Principe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Zambruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Trevisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Croci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2009.01.004_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/pr.58.3.2","article-title":"The endocannabinoid system as an emerging target of pharmacotherapy","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.gastro.2009.01.004_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1042\/bj3460835","article-title":"Functional CB1 cannabinoid receptors in human vascular endothelial cells","volume":"346","author":"Liu","year":"2000","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2009.01.004_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/00005344-200304000-00020","article-title":"Cannabinoids acting on CB1-receptors decrease contractile performance in human atrial muscle","volume":"41","author":"Bonz","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/j.gastro.2009.01.004_bib4","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1007\/BF02854900","article-title":"Cannabinoid receptors and endocannabinoids: evidence for new players","volume":"8","author":"Mackie","year":"2006","journal-title":"AAPS J"},{"key":"10.1053\/j.gastro.2009.01.004_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","article-title":"CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2009.01.004_bib6","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/89953","article-title":"Endocannabinoids acting at vascular CB1-receptors mediate the vasodilated state in advanced liver cirrhosis","volume":"7","author":"B\u00e1tkai","year":"2001","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2009.01.004_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/gast.2002.30305","article-title":"Endogenous cannabinoids: a new system involved in the homeostasis of arterial pressure in experimental cirrhosis in the rat","volume":"122","author":"Ros","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.01.004_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gut.2004.051599","article-title":"Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors","volume":"54","author":"Domenicali","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.01.004_bib9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/MOG.0b013e3280b0841f","article-title":"Portal hypertension and its complications","volume":"23","author":"Blei","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2009.01.004_bib10","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1002\/hep.20993","article-title":"The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule","volume":"43","author":"Iwakiri","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.01.004_bib11","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/hep.1840080532","article-title":"Peripheral vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis","volume":"8","author":"Schrier","year":"1988","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.01.004_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/hep.1840050215","article-title":"Temporal relationship between hyperaldosteronism, sodium retention and ascites formation in rats with experimental cirrhosis","volume":"5","author":"Jim\u00e9nez","year":"1985","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.01.004_bib13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jhep.2005.01.034","article-title":"A novel sodium overload test predicting ascites decompensation in rats with CCl4-induced cirrhosis","volume":"43","author":"Domenicali","year":"2005","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2009.01.004_bib14","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1440-1746.1992.tb00940.x","article-title":"Carbon tetrachloride induced cirrhosis in rats: a useful tool for investigating the pathogenesis of ascites in chronic liver disease","volume":"7","author":"Jim\u00e9nez","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2009.01.004_bib15","first-page":"F175","article-title":"Validation of miniature transit-time probes for measurement of renal blood flow in rats","volume":"268","author":"Welch","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2009.01.004_bib16","series-title":"Histological and histochemical methods: theory and practice","author":"Kiernan","year":"1999"},{"key":"10.1053\/j.gastro.2009.01.004_bib17","series-title":"Image cytometry","author":"Chieco","year":"2001"},{"key":"10.1053\/j.gastro.2009.01.004_bib18","first-page":"14","article-title":"Rapid and reliable assessment of volume percentage of epithelium in borderline and invasive ovarian tumors","volume":"20","author":"Brugghe","year":"1997","journal-title":"Anal Quant Histol Cytol"},{"key":"10.1053\/j.gastro.2009.01.004_bib19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0014-5793(94)00773-X","article-title":"SR141716A, a potent and selective antagonist of the brain cannabinoid receptor","volume":"350","author":"Rinaldi-Carmona","year":"1994","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2009.01.004_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1210\/er.2005-0009","article-title":"The emerging role of the endocannabinoid system in endocrine regulation and energy balance","volume":"27","author":"Pagotto","year":"2006","journal-title":"Endocr Rev"},{"key":"10.1053\/j.gastro.2009.01.004_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0024-3205(98)00322-1","article-title":"Appetite suppression and weight loss after the cannabinoid antagonist SR 141716","volume":"63","author":"Colombo","year":"1998","journal-title":"Life Sci"},{"key":"10.1053\/j.gastro.2009.01.004_bib22","series-title":"The liver and the kidney","first-page":"43","article-title":"The renin-angiotensin-aldosterone system in cirrhosis","author":"Bernardi","year":"2005"},{"key":"10.1053\/j.gastro.2009.01.004_bib23","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1053\/jhep.2002.33714","article-title":"Renal sodium retention in pre-ascitic cirrhosis: expanding knowledge, enduring uncertainties","volume":"35","author":"Bernardi","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.01.004_bib24","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/0016-5085(92)91451-9","article-title":"Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition","volume":"103","author":"Pizcueta","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.01.004_bib25","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/sj.bjp.0706928","article-title":"Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors","volume":"149","author":"Moezi","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.gastro.2009.01.004_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0706331","article-title":"Role of endocannabinoids in the pathogenesis of cirrhotic cardiomiopathy in bile duct-ligated rats","volume":"146","author":"Gaskari","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10.1053\/j.gastro.2009.01.004_bib27","doi-asserted-by":"crossref","first-page":"H1689","DOI":"10.1152\/ajpheart.00538.2007","article-title":"Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats","volume":"293","author":"Batkai","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1053\/j.gastro.2009.01.004_bib28","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1097\/01.ASN.0000130561.82631.BC","article-title":"Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys","volume":"15","author":"Koura","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/j.gastro.2009.01.004_bib29","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1097\/01.hjh.0000249706.42230.a8","article-title":"Differential mechanisms mediating depressor and diuretic effects of anandamide","volume":"24","author":"Li","year":"2006","journal-title":"J Hypertens"},{"key":"10.1053\/j.gastro.2009.01.004_bib30","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/sj.ki.5002540","article-title":"Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats","volume":"72","author":"Janiak","year":"2007","journal-title":"Kidney Int"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:52:06Z","timestamp":1758034326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508509000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0016508509000080"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2009.01.004","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2009.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}