{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:54Z","timestamp":1791216594528,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1053\/j.gastro.2009.07.048","type":"journal-article","created":{"date-parts":[[2009,7,25]],"date-time":"2009-07-25T14:53:24Z","timestamp":1248533604000},"page":"2084-2095.e3","source":"Crossref","is-referenced-by-count":225,"title":["The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli"],"prefix":"10.1053","volume":"137","author":[{"given":"Stuart M.","family":"Brierley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Y.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey A.","family":"O'Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole J.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Liebregts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Holtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigori Y.","family":"Rychkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Ashley","family":"Blackshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2009.07.048_bib1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(94)90809-5","article-title":"Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome","volume":"107","author":"Lembo","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib2","first-page":"105","article-title":"Pain from distention of the pelvic colon by inflating a balloon in the irritable bowel syndrome","volume":"6","author":"Ritchie","year":"1973","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.07.048_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2982.2006.00875.x","article-title":"Mechanisms of hypersensitivity in IBS and functional disorders","volume":"19","author":"Azpiroz","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2009.07.048_bib4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","article-title":"Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome","volume":"126","author":"Barbara","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib5","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/j.1572-0241.2003.07542.x","article-title":"Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome","volume":"98","author":"Dunlop","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2009.07.048_bib6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.47.6.804","article-title":"Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome","volume":"47","author":"Spiller","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.07.048_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2004.04.008","article-title":"Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice","volume":"127","author":"Brierley","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib8","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jn.00785.2001","article-title":"Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus","volume":"87","author":"Page","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1053\/j.gastro.2009.07.048_bib9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1053\/j.gastro.2008.01.074","article-title":"Selective role for TRPV4 ion channels in visceral sensory pathways","volume":"134","author":"Brierley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/gut.2008.170811","article-title":"Post-inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses","author":"Hughes","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.07.048_bib11","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2009.02.061","article-title":"Identification of medium\/high threshold extrinsic mechanosensitive afferent nerves to the gastrointestinal tract","author":"Song","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib12","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S1471-4892(02)00211-4","article-title":"The pharmacology of gastrointestinal nociceptive pathways","volume":"2","author":"Blackshaw","year":"2002","journal-title":"Curr Opin Pharmacol"},{"key":"10.1053\/j.gastro.2009.07.048_bib13","doi-asserted-by":"crossref","first-page":"G1288","DOI":"10.1152\/ajpgi.00002.2008","article-title":"Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia","volume":"294","author":"Sipe","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_bib14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1053\/j.gastro.2008.05.024","article-title":"Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms","volume":"135","author":"Cenac","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_bib15","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.0013-05.2005","article-title":"Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing","volume":"25","author":"Nagata","year":"2005","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2009.07.048_bib16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2009.07.048_bib17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2009.07.048_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2006.03.042","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan","year":"2006","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2009.07.048_bib19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2009.07.048_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1113\/jphysiol.2007.133231","article-title":"Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization","volume":"583","author":"Akopian","year":"2007","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_bib21","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI25437","article-title":"TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury","volume":"115","author":"Obata","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2009.07.048_bib22","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/cne.21204","article-title":"Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia","volume":"500","author":"Hughes","year":"2007","journal-title":"J Comp Neurol"},{"key":"10.1053\/j.gastro.2009.07.048_bib23","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-2982.2005.00710.x","article-title":"Activation of splanchnic and pelvic colonic afferents by bradykinin in mice","volume":"17","author":"Brierley","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2009.07.048_bib24","doi-asserted-by":"crossref","first-page":"G255","DOI":"10.1152\/ajpgi.90530.2008","article-title":"TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus","volume":"296","author":"Yu","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_bib25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2006.121111","article-title":"Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia","volume":"578","author":"Grant","year":"2006","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_bib26","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI30951","article-title":"Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain","volume":"117","author":"Dai","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2009.07.048_bib27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1523\/JNEUROSCI.3791-08.2009","article-title":"TPRV1 expression defines functionally distinct pelvic colon afferents","volume":"29","author":"Malin","year":"2009","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2009.07.048_bib28","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1136\/gut.2005.071084","article-title":"Different contributions of ASIC channels 1a, 2 and 3 in gastrointestinal mechanosensory function","volume":"54","author":"Page","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.07.048_bib29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/nrn2149","article-title":"TRP channels in mechanosensation: direct or indirect activation?","volume":"8","author":"Christensen","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2009.07.048_bib30","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/brain\/awn060","article-title":"Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain","volume":"131","author":"Wang","year":"2008","journal-title":"Brain"},{"key":"10.1053\/j.gastro.2009.07.048_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00424-008-0493-6","article-title":"Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators","volume":"457","author":"Karashima","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1053\/j.gastro.2009.07.048_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1113\/jphysiol.2005.089714","article-title":"Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice","volume":"567","author":"Brierley","year":"2005","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_fr1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2004.04.008","article-title":"Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice","volume":"127","author":"Brierley","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_fr2","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1152\/jn.00785.2001","article-title":"Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus","volume":"87","author":"Page","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1053\/j.gastro.2009.07.048_fr3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","article-title":"Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin","volume":"41","author":"Bandell","year":"2004","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2009.07.048_fr4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1365-2982.2005.00710.x","article-title":"Activation of splanchnic and pelvic colonic afferents by bradykinin in mice","volume":"17","author":"Brierley","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2009.07.048_fr5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1113\/jphysiol.2005.089714","article-title":"Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice","volume":"567","author":"Brierley","year":"2005","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_fr6","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI30951","article-title":"Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain","volume":"117","author":"Dai","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2009.07.048_fr7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.2006.121111","article-title":"Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia","volume":"578","author":"Grant","year":"2006","journal-title":"J Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_fr8","doi-asserted-by":"crossref","first-page":"G1288","DOI":"10.1152\/ajpgi.00002.2008","article-title":"Transient Receptor Potential Vanilloid 4 Mediates Protease Activated Receptor 2-Induced Sensitization of Colonic Afferent Nerves and Visceral Hyperalgesia","volume":"294","author":"Sipe","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2009.07.048_fr9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1053\/j.gastro.2008.01.074","article-title":"Selective role for TRPV4 ion channels in visceral sensory pathways","volume":"134","author":"Brierley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.07.048_fr10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jpain.2005.09.003","article-title":"Assessment of Visceral Pain-Related Pseudo-Affective Responses to Colorectal Distension in Mice by Intracolonic Manometric Recordings","volume":"7","author":"Arvidsson","year":"2006","journal-title":"J Pain"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509012475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509012475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T13:58:53Z","timestamp":1558447133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508509012475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0016508509012475"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2009.07.048","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1752956.1275054","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}