{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:45:44Z","timestamp":1793835944034,"version":"4.6.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1053\/j.gastro.2009.10.051","type":"journal-article","created":{"date-parts":[[2009,11,12]],"date-time":"2009-11-12T05:19:31Z","timestamp":1258003171000},"page":"487-492","source":"Crossref","is-referenced-by-count":190,"title":["Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands"],"prefix":"10.1053","volume":"138","author":[{"given":"Lisette G.","family":"Capelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.T.","family":"Van Grieken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester F.","family":"Lingsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout W.","family":"Steyerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J.","family":"Klokman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans F.A.","family":"Vasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst J.","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2009.10.051_bib1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/0016-5085(93)90368-M","article-title":"Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review","volume":"104","author":"Lynch","year":"1993","journal-title":"Gastroenterology"},{"issue":"Suppl 2","key":"10.1053\/j.gastro.2009.10.051_bib2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2036.2007.03479.x","article-title":"The Lynch syndrome (hereditary nonpolyposis colorectal cancer)","volume":"26","author":"Vasen","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2009.10.051_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1155\/2004\/305058","article-title":"Mutations associated with HNPCC predisposition\u2014update of ICG-HNPCC\/INSiGHT mutation database","volume":"20","author":"Peltomaki","year":"2004","journal-title":"Dis Markers"},{"key":"10.1053\/j.gastro.2009.10.051_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S1470-2045(09)70041-5","article-title":"Management of extracolonic tumours in patients with Lynch syndrome","volume":"10","author":"Koornstra","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.gastro.2009.10.051_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1136\/jmg.2007.048991","article-title":"Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)","volume":"44","author":"Vasen","year":"2007","journal-title":"J Med Genet"},{"key":"10.1053\/j.gastro.2009.10.051_bib6","first-page":"1635","article-title":"The tumor spectrum in HNPCC","volume":"14","author":"Watson","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1053\/j.gastro.2009.10.051_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/1097-0142(19930201)71:3<677::AID-CNCR2820710305>3.0.CO;2-#","article-title":"Extracolonic cancer in hereditary nonpolyposis colorectal cancer","volume":"71","author":"Watson","year":"1993","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/(SICI)1097-0215(19971021)74:5<551::AID-IJC13>3.0.CO;2-9","article-title":"Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome","volume":"74","author":"Aarnio","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1572-0241.2006.00636.x","article-title":"Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database","volume":"101","author":"Maul","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2009.10.051_bib10","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1053\/j.gastro.2005.09.012","article-title":"Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer","volume":"129","author":"Bermejo","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2009.10.051_bib11","first-page":"279","article-title":"Heredity with reference to carcinoma","volume":"9","author":"Warthin","year":"1913","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.gastro.2009.10.051_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0002-9343(89)90296-9","article-title":"Screening for hereditary non-polyposis colorectal cancer: a study of 22 kindreds in The Netherlands","volume":"86","author":"Vasen","year":"1989","journal-title":"Am J Med"},{"key":"10.1053\/j.gastro.2009.10.051_bib13","first-page":"1","article-title":"Statistical methods in cancer research: Volume II: the design and analysis of cohort studies","volume":"82","author":"Breslow","year":"1987","journal-title":"IARC Sci Publ"},{"key":"10.1053\/j.gastro.2009.10.051_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/apm.1965.64.1.31","article-title":"The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. an attempt at a histo-clinical classification","volume":"64","author":"Lauren","year":"1965","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1053\/j.gastro.2009.10.051_bib15","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1002\/1097-0142(197106)27:6<1505::AID-CNCR2820270635>3.0.CO;2-L","article-title":"Cancer family \u201cG\u201d revisited: 1895\u20131970","volume":"27","author":"Lynch","year":"1971","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1155\/2004\/460240","article-title":"Lynch syndrome: history and current status","volume":"20","author":"Lynch","year":"2004","journal-title":"Dis Markers"},{"key":"10.1053\/j.gastro.2009.10.051_bib18","first-page":"2994","article-title":"Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea","volume":"6","author":"Park","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.gastro.2009.10.051_bib19","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/(SICI)1097-0215(19990812)82:4<516::AID-IJC8>3.0.CO;2-U","article-title":"Gene-environment interaction in hereditary nonpolyposis colorectal cancer with implications for diagnosis and genetic testing","volume":"82","author":"Park","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib20","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L","article-title":"Cancer risk in mutation carriers of DNA-mismatch-repair genes","volume":"81","author":"Aarnio","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib21","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ijc.23508","article-title":"The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome","volume":"123","author":"Watson","year":"2008","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1086\/513896","article-title":"Reduced frequency of extracolonic cancers in hereditary nonpolyposis colorectal cancer families with monoallelic hMLH1 expression","volume":"61","author":"Jager","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2009.10.051_bib23","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1200\/JCO.2001.19.20.4074","article-title":"MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families","volume":"19","author":"Vasen","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.gastro.2009.10.051_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10689-007-9164-6","article-title":"Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)","volume":"7","author":"Geary","year":"2008","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2009.10.051_bib25","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1158\/1055-9965.EPI-08-0301","article-title":"Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States","volume":"17","author":"Kastrinos","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2009.10.051_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/13773","article-title":"Familial endometrial cancer in female carriers of MSH6 germline mutations","volume":"23","author":"Wijnen","year":"1999","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2009.10.051_bib27","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1086\/302612","article-title":"Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations","volume":"65","author":"Wu","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2009.10.051_bib28","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/gut.2006.118299","article-title":"Is surveillance of the small bowel indicated for Lynch syndrome families?","volume":"56","author":"ten Kate","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.10.051_bib29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3322\/canjclin.56.4.213","article-title":"Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians","volume":"56","author":"Hendriks","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2009.10.051_bib30","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1001\/jama.296.12.1507","article-title":"Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review","volume":"296","author":"Lindor","year":"2006","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2009.10.051_bib31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0749-3797(02)00593-7","article-title":"Validation of family history data in cancer family registries","volume":"24","author":"Ziogas","year":"2003","journal-title":"Am J Prev Med"},{"key":"10.1053\/j.gastro.2009.10.051_bib32","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/gut.2006.114876","article-title":"Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer?","volume":"56","author":"Gylling","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2009.10.051_bib33","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1200\/JCO.2005.03.7333","article-title":"Genotype-phenotype comparison of German MLH1 and MSH2 mutation carriers clinically affected with Lynch syndrome: a report by the German HNPCC Consortium","volume":"24","author":"Goecke","year":"2006","journal-title":"J Clin Oncol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509019489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509019489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T19:48:05Z","timestamp":1558640885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508509019489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0016508509019489"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2009.10.051","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}