{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:44:15Z","timestamp":1791981855978,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-06-PHYSIO-022"],"award-info":[{"award-number":["ANR-06-PHYSIO-022"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1053\/j.gastro.2009.12.008","type":"journal-article","created":{"date-parts":[[2009,12,22]],"date-time":"2009-12-22T04:08:24Z","timestamp":1261454904000},"page":"1546-1556.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Neutrophil Migration During Liver Injury Is Under Nucleotide-Binding Oligomerization Domain 1 Control"],"prefix":"10.1053","volume":"138","author":[{"given":"S\u00e9bastien","family":"Dharancy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Body\u2013Malapel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Berrebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gantier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gosset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Viala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Hollebecque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana J.","family":"Philpott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen E.","family":"Girardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J.","family":"Sansonetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Desreumaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dubuquoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2009.12.008_bib1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3748\/wjg.v12.i10.1493","article-title":"Gut flora and bacterial translocation in chronic liver disease","volume":"12","author":"Almeida","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2009.12.008_bib2","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1053\/jhep.2000.19621","article-title":"Exacerbation of alcoholic liver injury by enteral endotoxin in rats","volume":"32","author":"Mathurin","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.12.008_bib3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/hep.20632","article-title":"Bacterial translocation (BT) in cirrhosis","volume":"41","author":"Wiest","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.12.008_bib4","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/hep.21138","article-title":"Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver","volume":"43","author":"Gustot","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.12.008_bib5","doi-asserted-by":"crossref","first-page":"12955","DOI":"10.1074\/jbc.274.19.12955","article-title":"Human CARD4 protein is a novel CED-4\/Apaf-1 cell death family member that activates NF-kappaB","volume":"274","author":"Bertin","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib6","doi-asserted-by":"crossref","first-page":"41702","DOI":"10.1074\/jbc.M307198200","article-title":"Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib7","doi-asserted-by":"crossref","first-page":"41701","DOI":"10.1074\/jbc.M206473200","article-title":"Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation","volume":"277","author":"Gutierrez","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib8","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib9","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2","volume":"278","author":"Inohara","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib10","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2009.12.008_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2009.12.008_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/labinvest.3700716","article-title":"NOD2: a potential target for regulating liver injury","volume":"88","author":"Body-Malapel","year":"2008","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2009.12.008_bib13","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/ni945","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","author":"Chamaillard","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2009.12.008_bib14","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1126\/science.1084677","article-title":"Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan","volume":"300","author":"Girardin","year":"2003","journal-title":"Science"},{"key":"10.1053\/j.gastro.2009.12.008_bib15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1084\/jem.20051229","article-title":"Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo","volume":"203","author":"Masumoto","year":"2006","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2009.12.008_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0741-8329(02)00206-9","article-title":"Neutrophilic infiltration in alcoholic hepatitis","volume":"27","author":"Bautista","year":"2002","journal-title":"Alcohol"},{"key":"10.1053\/j.gastro.2009.12.008_bib17","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning","volume":"284","author":"Jaeschke","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2009.12.008_bib18","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.4049\/jimmunol.180.10.6439","article-title":"The physiology of leukocyte recruitment: an in vivo perspective","volume":"180","author":"Petri","year":"2008","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2009.12.008_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1083\/jcb.200202114","article-title":"An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients","volume":"159","author":"Heit","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2009.12.008_bib20","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1164\/ajrccm.162.2.9907014","article-title":"CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus","volume":"162","author":"Tillie-Leblond","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/j.gastro.2009.12.008_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jim.2006.02.019","article-title":"Isolation of neutrophils from mouse liver: a novel method to study effector leukocytes during inflammation","volume":"312","author":"Cotter","year":"2006","journal-title":"J Immunol Methods"},{"key":"10.1053\/j.gastro.2009.12.008_bib22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/hep.20827","article-title":"Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia\/reperfusion injury in mice","volume":"42","author":"Kuzumoto","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2009.12.008_bib23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4049\/jimmunol.179.1.514","article-title":"Nod1\/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells","volume":"179","author":"Park","year":"2007","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2009.12.008_bib24","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni1131","article-title":"Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island","volume":"5","author":"Viala","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2009.12.008_bib25","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1172\/JCI119468","article-title":"A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature","volume":"99","author":"Wong","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2009.12.008_bib26","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1189\/jlb.0806528","article-title":"Neutrophil transepithelial migration in response to the chemoattractant fMLP but not C5a is phospholipase D-dependent and related to the use of CD11b\/CD18","volume":"82","author":"Carrigan","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.gastro.2009.12.008_bib27","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1242\/jcs.02632","article-title":"Fundamentally different roles for LFA-1, Mac-1 and alpha4-integrin in neutrophil chemotaxis","volume":"118","author":"Heit","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1053\/j.gastro.2009.12.008_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0741-8329(02)00200-8","article-title":"Neutrophil-mediated tissue injury in alcoholic hepatitis","volume":"27","author":"Jaeschke","year":"2002","journal-title":"Alcohol"},{"key":"10.1053\/j.gastro.2009.12.008_bib29","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.4049\/jimmunol.144.7.2702","article-title":"Mac-1 (CD11b\/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils","volume":"144","author":"Shappell","year":"1990","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2009.12.008_bib30","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20071765","article-title":"Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids","volume":"205","author":"McDonald","year":"2008","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2009.12.008_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0378-4274(01)00284-3","article-title":"Role of inflammation in chemical-induced hepatotoxicity","volume":"120","author":"Luster","year":"2001","journal-title":"Toxicol Lett"},{"key":"10.1053\/j.gastro.2009.12.008_bib32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol Ther"},{"key":"10.1053\/j.gastro.2009.12.008_bib33","doi-asserted-by":"crossref","first-page":"G1083","DOI":"10.1152\/ajpgi.00568.2005","article-title":"Mechanisms of liver injury","volume":"290","author":"Jaeschke","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2009.12.008_bib34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1164\/rccm.200608-1103OC","article-title":"Selective NOD1 agonists cause shock and organ injury\/dysfunction in vivo","volume":"175","author":"Cartwright","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/j.gastro.2009.12.008_bib35","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","article-title":"CARD4\/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri","volume":"2","author":"Girardin","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1053\/j.gastro.2009.12.008_bib36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/IAI.72.3.1487-1495.2004","article-title":"Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by Toll-like receptors","volume":"72","author":"Kim","year":"2004","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2009.12.008_bib37","doi-asserted-by":"crossref","first-page":"36714","DOI":"10.1074\/jbc.M501649200","article-title":"Nod1 participates in the innate immune response to Pseudomonas aeruginosa","volume":"280","author":"Travassos","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2009.12.008_bib38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/sj.embor.7400552","article-title":"Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin","volume":"6","author":"Magalhaes","year":"2005","journal-title":"EMBO Rep"},{"key":"10.1053\/j.gastro.2009.12.008_bib39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature07450","article-title":"Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis","volume":"456","author":"Bouskra","year":"2008","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2009.12.008_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2007.03.009","article-title":"Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity","volume":"26","author":"Fritz","year":"2007","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2009.12.008_bib41","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1084\/jem.20082818","article-title":"Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection","volume":"206","author":"Robinson","year":"2009","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2009.12.008_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1107\/S1744309106051955","article-title":"Purification, crystallization and preliminary crystallographic characterization of the caspase-recruitment domain of human Nod1","volume":"63","author":"Srimathi","year":"2007","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"10.1053\/j.gastro.2009.12.008_bib43","doi-asserted-by":"crossref","first-page":"e4931","DOI":"10.1371\/journal.pone.0004931","article-title":"Evaluation of Nod-like receptor (NLR) effector domain interactions","volume":"4","author":"Wagner","year":"2009","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2009.12.008_fr1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0014-5793(01)02614-X","article-title":"15-Deoxy-delta12,14-PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways","volume":"501","author":"Boyault","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2009.12.008_fr2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni1131","article-title":"Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island","volume":"5","author":"Viala","year":"2004","journal-title":"Nat Immunol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509021465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508509021465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:37:38Z","timestamp":1762162658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508509021465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0016508509021465"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2009.12.008","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil Migration During Liver Injury Is Under Nucleotide-Binding Oligomerization Domain 1 Control","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2009.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}