{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:55:15Z","timestamp":1791284115931,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1053\/j.gastro.2010.01.007","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T05:10:51Z","timestamp":1264482651000},"page":"1920-1930.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":108,"title":["Proliferative Suppression by CDK4\/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells"],"prefix":"10.1053","volume":"138","author":[{"given":"Dayana B.","family":"Rivadeneira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N.","family":"Mayhew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chellappagounder","family":"Thangavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sotillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Gra\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik S.","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.01.007_bib1","first-page":"74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2010.01.007_bib2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/01.TP.0000046938.50680.C4","article-title":"Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506","volume":"75","author":"Yang","year":"2003","journal-title":"Transplantation"},{"key":"10.1053\/j.gastro.2010.01.007_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1634\/theoncologist.11-7-790","article-title":"Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be?","volume":"11","author":"Zhu","year":"2006","journal-title":"Oncologist"},{"key":"10.1053\/j.gastro.2010.01.007_bib4","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1038\/sj.onc.1209547","article-title":"Genetics of hepatocellular tumors","volume":"25","author":"Laurent-Puig","year":"2006","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2010.01.007_bib5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng0802-339","article-title":"Molecular pathogenesis of human hepatocellular carcinoma","volume":"31","author":"Thorgeirsson","year":"2002","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2010.01.007_bib6","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/153537020623100713","article-title":"Retinoblastoma tumor suppressor: where cancer meets the cell cycle","volume":"231","author":"Knudsen","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1053\/j.gastro.2010.01.007_bib7","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/sj.onc.1208619","article-title":"Pocket proteins and cell cycle control","volume":"24","author":"Cobrinik","year":"2005","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2010.01.007_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ceb.2007.10.003","article-title":"E2F-associated chromatin modifiers and cell cycle control","volume":"19","author":"Blais","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"10.1053\/j.gastro.2010.01.007_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/400_002","article-title":"The retinoblastoma gene family in cell cycle regulation and suppression of tumorigenesis","volume":"42","author":"Dannenberg","year":"2006","journal-title":"Results Probl Cell Differ"},{"key":"10.1053\/j.gastro.2010.01.007_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0959-437X(98)80057-9","article-title":"Control of pRB phosphorylation","volume":"8","author":"Mittnacht","year":"1998","journal-title":"Curr Opin Genet Dev"},{"key":"10.1053\/j.gastro.2010.01.007_bib11","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1101\/gad.813200","article-title":"The Rb\/E2F pathway: expanding roles and emerging paradigms","volume":"14","author":"Harbour","year":"2000","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.01.007_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0065-230X(08)60834-9","article-title":"The retinoblastoma tumor suppressor protein","volume":"64","author":"Wang","year":"1994","journal-title":"Adv Cancer Res"},{"key":"10.1053\/j.gastro.2010.01.007_bib13","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/sj.onc.1207503","article-title":"Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents","volume":"23","author":"Mayhew","year":"2004","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2010.01.007_bib14","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1128\/MCB.20.20.7751-7763.2000","article-title":"RB-dependent S-phase response to DNA damage","volume":"20","author":"Knudsen","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.01.007_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1172\/JCI28803","article-title":"The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer","volume":"117","author":"Bosco","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.01.007_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/375503a0","article-title":"Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16","volume":"375","author":"Lukas","year":"1995","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.01.007_bib17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1083\/jcb.125.3.625","article-title":"DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1","volume":"125","author":"Lukas","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2010.01.007_bib18","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1021\/jm049354h","article-title":"Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4\/6","volume":"48","author":"Toogood","year":"2005","journal-title":"J Med Chem"},{"key":"10.1053\/j.gastro.2010.01.007_bib19","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","article-title":"Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts","volume":"3","author":"Fry","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"10.1053\/j.gastro.2010.01.007_bib20","doi-asserted-by":"crossref","first-page":"27632","DOI":"10.1074\/jbc.274.39.27632","article-title":"Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest","volume":"274","author":"Knudsen","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.01.007_bib21","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/334168a0","article-title":"A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products","volume":"334","author":"Moran","year":"1988","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.01.007_bib22","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1101\/gad.12.15.2278","article-title":"Inhibition of DNA synthesis by RB: effects on G1\/S transition and S-phase progression","volume":"12","author":"Knudsen","year":"1998","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.01.007_bib23","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1158\/0008-5472.CAN-04-4221","article-title":"Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy","volume":"65","author":"Mayhew","year":"2005","journal-title":"Cancer Research"},{"key":"10.1053\/j.gastro.2010.01.007_bib24","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1021\/jm049355+","article-title":"Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4","volume":"48","author":"VanderWel","year":"2005","journal-title":"J Med Chem"},{"key":"10.1053\/j.gastro.2010.01.007_bib25","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1128\/JVI.74.7.3166-3176.2000","article-title":"E1A blocks hyperphosphorylation of p130 and p107 without affecting the phosphorylation status of the retinoblastoma protein","volume":"74","author":"Parreno","year":"2000","journal-title":"J Virol"},{"key":"10.1053\/j.gastro.2010.01.007_bib26","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1158\/0008-5472.CAN-06-4753","article-title":"Retinoblastoma deficiency increases chemosensitivity in lung cancer","volume":"67","author":"Zagorski","year":"2007","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2010.01.007_bib27","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1101\/gad.843200","article-title":"Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization","volume":"14","author":"Sage","year":"2000","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.01.007_bib28","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1242\/dev.01148","article-title":"Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis","volume":"131","author":"Ruiz","year":"2004","journal-title":"Development"},{"key":"10.1053\/j.gastro.2010.01.007_bib29","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1158\/0008-5472.CAN-04-4221","article-title":"Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy","volume":"65","author":"Mayhew","year":"2005","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2010.01.007_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510000442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510000442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:55:01Z","timestamp":1758034501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510000442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0016508510000442"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.01.007","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proliferative Suppression by CDK4\/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}