{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:20:10Z","timestamp":1791134410562,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 48351"],"award-info":[{"award-number":["DK 48351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 073451-01"],"award-info":[{"award-number":["DK 073451-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AT 00268"],"award-info":[{"award-number":["AT 00268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 64530"],"award-info":[{"award-number":["DK 64530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 071626-04"],"award-info":[{"award-number":["DK 071626-04"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 084169-01"],"award-info":[{"award-number":["DK 084169-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1053\/j.gastro.2010.03.049","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T14:05:35Z","timestamp":1269957935000},"page":"48-57.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":255,"title":["Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome"],"prefix":"10.1053","volume":"139","author":[{"given":"David A.","family":"Seminowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Labus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Bueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Tillisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Naliboff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Catherine","family":"Bushnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.03.049_bib1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.049_bib2","series-title":"Functional pain syndromes: presentation and pathophysiology","first-page":"185","article-title":"Anxiety in functional pain disorders","author":"Naliboff","year":"2009"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2010.03.049_bib3","first-page":"80","article-title":"Brain response during pelvic visceral distension in healthy controls and patients with irritable bowel syndrome: a quantitative meta analysis","volume":"21","author":"Labus","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2010.03.049_bib4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jpain.2009.09.001","article-title":"How neuroimaging studies have challenged us to rethink: is chronic pain a disease?","volume":"10","author":"Tracey","year":"2009","journal-title":"J Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib5","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.0098-07.2007","article-title":"Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?","volume":"27","author":"Kuchinad","year":"2007","journal-title":"J Neurosci"},{"issue":"suppl","key":"10.1053\/j.gastro.2010.03.049_bib6","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/j.pain.2007.05.010","article-title":"Striatal grey matter increase in patients suffering from fibromyalgia - A voxel-based morphometry study","volume":"132","author":"Schmidt-Wilcke","year":"2007","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib7","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1002\/art.24070","article-title":"White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion-tensor and volumetric imaging study","volume":"58","author":"Lutz","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1053\/j.gastro.2010.03.049_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.pain.2009.03.017","article-title":"No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder","volume":"143","author":"Hsu","year":"2009","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib9","doi-asserted-by":"crossref","first-page":"10410","DOI":"10.1523\/JNEUROSCI.2541-04.2004","article-title":"Chronic back pain is associated with decreased prefrontal and thalamic gray matter density","volume":"24","author":"Apkarian","year":"2004","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pain.2006.05.004","article-title":"Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients","volume":"125","author":"Schmidt-Wilcke","year":"2006","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib11","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1212\/01.wnl.0000183067.94400.80","article-title":"Gray matter decrease in patients with chronic tension type headache","volume":"65","author":"Schmidt-Wilcke","year":"2005","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2010.03.049_bib12","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1212\/01.wnl.0000291618.32247.2d","article-title":"Thickening in the somatosensory cortex of patients with migraine","volume":"69","author":"DaSilva","year":"2007","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2010.03.049_bib13","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1468-2982.2008.01550.x","article-title":"Regional grey matter changes in patients with migraine: a voxel-based morphometry study","volume":"28","author":"Kim","year":"2008","journal-title":"Cephalalgia"},{"key":"10.1053\/j.gastro.2010.03.049_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pain.2008.09.014","article-title":"Increased gray matter density in young women with chronic vulvar pain","volume":"140","author":"Schweinhardt","year":"2008","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib15","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1073\/pnas.0611721104","article-title":"An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus","volume":"104","author":"Pereira","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2010.03.049_bib16","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neuroimage.2008.05.044","article-title":"Changes in brain gray matter due to repetitive painful stimulation","volume":"42","author":"Teutsch","year":"2008","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_bib17","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1523\/JNEUROSCI.4628-05.2006","article-title":"Temporal and spatial dynamics of brain structure changes during extensive learning","volume":"26","author":"Draganski","year":"2006","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/hipo.20547","article-title":"Aerobic fitness is associated with hippocampal volume in elderly humans","volume":"19","author":"Erickson","year":"2009","journal-title":"Hippocampus"},{"key":"10.1053\/j.gastro.2010.03.049_bib19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1212\/01.wnl.0000295509.30630.10","article-title":"Cortical thinning in IBS: implications for homeostatic, attention, and pain processing","volume":"70","author":"Davis","year":"2008","journal-title":"Neurology"},{"key":"10.1053\/j.gastro.2010.03.049_bib20","doi-asserted-by":"crossref","unstructured":"Blankstein U, Chen J, Diamant NE, Davis KD. Altered brain structure in IBS: potential contributions of pre-existing and disease-driven factors [published online ahead of print January 4, 2010]. Gastroenterology doi:10.1053\/j.gastro.2009.12.043.","DOI":"10.1053\/j.gastro.2009.12.043"},{"key":"10.1053\/j.gastro.2010.03.049_bib21","series-title":"The Brief Symptom Inventory: administration, scoring, and procedures manual","author":"Derogatis","year":"1993"},{"key":"10.1053\/j.gastro.2010.03.049_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1053\/j.gastro.2010.03.049_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0016-5085(97)70219-1","article-title":"Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome","volume":"112","author":"Munakata","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.049_bib24","doi-asserted-by":"crossref","first-page":"II43","DOI":"10.1136\/gut.45.2008.ii43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2010.03.049_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O","article-title":"A unified statistical approach for determining significant signals in images of cerebral activation","volume":"4","author":"Worsley","year":"1996","journal-title":"Human Brain Mapping"},{"key":"10.1053\/j.gastro.2010.03.049_bib26","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1526-4610.2008.01133.x","article-title":"Attack frequency and disease duration as indicators for brain damage in migraine","volume":"48","author":"Schmitz","year":"2008","journal-title":"Headache"},{"key":"10.1053\/j.gastro.2010.03.049_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1523\/JNEUROSCI.2500-07.2008","article-title":"Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome","volume":"28","author":"Berman","year":"2008","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib28","series-title":"Rome III: the functional gastrointestinal disorders","first-page":"557","article-title":"Functional abdominal pain syndrome","author":"Clouse","year":"2006"},{"key":"10.1053\/j.gastro.2010.03.049_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neuroimage.2007.08.042","article-title":"Detection of cortical thickness correlates of cognitive performance: reliability across MRI scan sessions, scanners, and field strengths","volume":"39","author":"Dickerson","year":"2008","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel?","volume":"3","author":"Craig","year":"2002","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tics.2008.05.005","article-title":"Neurocognitive aspects of pain perception","volume":"12","author":"Wiech","year":"2008","journal-title":"Trends Cogn Sci"},{"key":"10.1053\/j.gastro.2010.03.049_bib32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuroimage.2004.01.037","article-title":"The neural correlates of placebo effects: a disruption account","volume":"22","author":"Lieberman","year":"2004","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_bib33","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.pain.2005.03.023","article-title":"Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis","volume":"115","author":"Mayer","year":"2005","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2010.03.049_bib34","doi-asserted-by":"crossref","first-page":"6167","DOI":"10.1523\/JNEUROSCI.4654-08.2009","article-title":"Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia","volume":"29","author":"Seifert","year":"2009","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1126\/science.1060952","article-title":"Regional mu opioid receptor regulation of sensory and affective dimensions of pain","volume":"293","author":"Zubieta","year":"2001","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.03.049_bib36","doi-asserted-by":"crossref","first-page":"12165","DOI":"10.1523\/JNEUROSCI.3576-06.2006","article-title":"Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain","volume":"26","author":"Baliki","year":"2006","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib37","doi-asserted-by":"crossref","first-page":"13746","DOI":"10.1523\/JNEUROSCI.3687-09.2009","article-title":"Brain gray matter decrease in chronic pain is the consequence and not the cause of pain","volume":"29","author":"Rodriguez-Raecke","year":"2009","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib38","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1161\/01.STR.0000226589.00599.4d","article-title":"Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study","volume":"37","author":"Rocca","year":"2006","journal-title":"Stroke"},{"key":"10.1053\/j.gastro.2010.03.049_bib39","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.3748\/wjg.v13.i27.3699","article-title":"Abnormal endogenous pain modulation and somatic and visceral hypersensitivity in female patients with irritable bowel syndrome","volume":"13","author":"Wilder-Smith","year":"2007","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2010.03.049_bib40","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1523\/JNEUROSCI.1100-05.2005","article-title":"A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging","volume":"25","author":"Dunckley","year":"2005","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2010.03.049_bib41","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.neuroimage.2009.05.059","article-title":"The influence of negative emotions on pain: behavioral effects and neural mechanisms","volume":"47","author":"Wiech","year":"2009","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr1","article-title":"The CIVET image-processing environment: a fully automated comprehensive pipeline for anatomical neuroimaging research","author":"Ad-Dab'bagh","year":"2006"},{"key":"10.1053\/j.gastro.2010.03.049_fr2","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1109\/TMI.2002.806283","article-title":"Automatic \u201cpipeline\u201d analysis of 3-D MRI data for clinical trials: application to multiple sclerosis","volume":"21","author":"Zijdenbos","year":"2002","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1053\/j.gastro.2010.03.049_fr3","unstructured":"Fahim C, Yoon U, Das S, et al. Somatosensory-motor bodily representation cortical thinning in Tourette: effects of tic severity, age and gender. Cortex (in press, corrected proof)."},{"key":"10.1053\/j.gastro.2010.03.049_fr4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1109\/42.668698","article-title":"A nonparametric method for automatic correction of intensity nonuniformity in MRI data","volume":"17","author":"Sled","year":"1998","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1053\/j.gastro.2010.03.049_fr5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00004728-199403000-00005","article-title":"Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space","volume":"18","author":"Collins","year":"1994","journal-title":"J Comput Assist Tomogr"},{"key":"10.1053\/j.gastro.2010.03.049_fr6","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/hbm.460030304","article-title":"Automatic 3-D model-based neuroanatomical segmentation","volume":"3","author":"Collins","year":"1995","journal-title":"Human Brain Mapping"},{"key":"10.1053\/j.gastro.2010.03.049_fr7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroimage.2004.05.007","article-title":"Fast and robust parameter estimation for statistical partial volume models in brain MRI","volume":"23","author":"Tohka","year":"2004","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/nimg.2000.0652","article-title":"Measurement of cortical thickness using an automated 3-D algorithm: a validation study","volume":"13","author":"Kabani","year":"2001","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuroimage.2005.03.036","article-title":"Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification","volume":"27","author":"Kim","year":"2005","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/nimg.1999.0534","article-title":"Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI","volume":"12","author":"MacDonald","year":"2000","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr11","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.neuroimage.2006.10.041","article-title":"An unbiased iterative group registration template for cortical surface analysis","volume":"34","author":"Lyttelton","year":"2007","journal-title":"Neuroimage"},{"key":"10.1053\/j.gastro.2010.03.049_fr12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S1053-8119(02)00017-4","article-title":"Deformation-based surface morphometry applied to gray matter deformation","volume":"18","author":"Chung","year":"2003","journal-title":"Neuroimage"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510004828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510004828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:54:32Z","timestamp":1758034472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510004828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0016508510004828"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.03.049","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional Gray Matter Density Changes in Brains of Patients With Irritable Bowel Syndrome","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.03.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}