{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:06:31Z","timestamp":1793995591250,"version":"4.8.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DK072237"],"award-info":[{"award-number":["5R01DK072237"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01GM041804"],"award-info":[{"award-number":["5R01GM041804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1053\/j.gastro.2010.03.052","type":"journal-article","created":{"date-parts":[[2010,3,30]],"date-time":"2010-03-30T14:05:35Z","timestamp":1269957935000},"page":"323-334.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":671,"title":["Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1\u03b2 in Mice"],"prefix":"10.1053","volume":"139","author":[{"given":"Kouichi","family":"Miura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schnabl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohide","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold M.","family":"Olefsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekihiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.03.052_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.03.052_bib2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmed.2007.12.003","article-title":"Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis","volume":"14","author":"Marra","year":"2008","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.gastro.2010.03.052_bib3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/hep.22399","article-title":"Beyond insulin resistance: innate immunity in nonalcoholic steatohepatitis","volume":"48","author":"Maher","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"Rivera","year":"2007","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2010.03.052_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.03.052_bib6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.052_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int Immunol"},{"key":"10.1053\/j.gastro.2010.03.052_bib8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/hep.21308","article-title":"Pattern recognition receptors: a contemporary view on liver diseases","volume":"44","author":"Szabo","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","article-title":"Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production","volume":"317","author":"Naugler","year":"2007","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.03.052_bib11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2010.03.052_bib12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.03.052_bib13","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1002\/hep.22083","article-title":"Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis","volume":"47","author":"Frances","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib14","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/hep.21286","article-title":"The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation","volume":"44","author":"Guarner","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib15","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/hep.21867","article-title":"Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9","volume":"46","author":"Watanabe","year":"2007","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib16","first-page":"305","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.03.052_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2008.08.096","article-title":"Role of TLR9 in hepatic stellate cells and experimental liver fibrosis","volume":"376","author":"Gabele","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2010.03.052_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80596-8","article-title":"Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function","volume":"9","author":"Adachi","year":"1998","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2010.03.052_bib19","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1053\/j.gastro.2009.06.045","article-title":"c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice","volume":"137","author":"Kodama","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.052_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1053\/j.gastro.2010.03.052_bib21","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1053\/j.gastro.2008.12.064","article-title":"Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis","volume":"136","author":"Kodama","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.052_bib22","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1053\/j.gastro.2010.03.052_bib24","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jhep.2007.07.024","article-title":"Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB","volume":"47","author":"Miura","year":"2007","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2010.03.052_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2010.03.052_bib26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00042737-200107000-00004","article-title":"Cytokines in the liver","volume":"13","author":"Ramadori","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2010.03.052_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.03.052_bib28","doi-asserted-by":"crossref","first-page":"G518","DOI":"10.1152\/ajpgi.00024.2006","article-title":"Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis","volume":"292","author":"Brun","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.03.052_bib29","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3748\/wjg.14.313","article-title":"Small intestinal bacteria overgrowth decreases small intestinal motility in the NASH rats","volume":"14","author":"Wu","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2010.03.052_bib30","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib31","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1478-3231.2008.01723.x","article-title":"Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis","volume":"28","author":"Farhadi","year":"2008","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2010.03.052_bib32","doi-asserted-by":"crossref","first-page":"7002","DOI":"10.1074\/jbc.M412220200","article-title":"Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice","volume":"280","author":"Isoda","year":"2005","journal-title":"J Biol Chem"},{"issue":"8 suppl proc","key":"10.1053\/j.gastro.2010.03.052_bib33","doi-asserted-by":"crossref","first-page":"106S","DOI":"10.1097\/01.ALC.0000134410.42980.5E","article-title":"Polymorphisms of interleukin-1 beta and beta 3-adrenergic receptor in Japanese patients with nonalcoholic steatohepatitis","volume":"28","author":"Nozaki","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2010.03.052_bib34","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/hep.20425","article-title":"Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats","volume":"40","author":"Parsons","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib35","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1053\/jhep.2000.20521","article-title":"Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model","volume":"32","author":"Yoshiji","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib36","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1053\/jhep.2002.35625","article-title":"Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse","volume":"36","author":"Yoshiji","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2567.2005.02211.x","article-title":"Differential effects of CpG-DNA in Toll-like receptor-2\/-4\/-9 tolerance and cross-tolerance","volume":"116","author":"Dalpke","year":"2005","journal-title":"Immunology"},{"key":"10.1053\/j.gastro.2010.03.052_bib38","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.4049\/jimmunol.0901031","article-title":"Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages","volume":"183","author":"De Nardo","year":"2009","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2010.03.052_bib39","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.166.4.2651","article-title":"Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta","volume":"166","author":"Seki","year":"2001","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2010.03.052_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jhep.2009.03.027","article-title":"Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice","volume":"51","author":"Imamura","year":"2009","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2010.03.052_bib41","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1073\/pnas.0909781107","article-title":"Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis","volume":"107","author":"Inokuchi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2010.03.052_bib42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1053\/jhep.2002.30692","article-title":"NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome","volume":"35","author":"Chitturi","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/jhep.2002.34738","article-title":"Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?","volume":"36","author":"Chitturi","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/hep.20519","article-title":"Impact of steatosis on progression of fibrosis in patients with mild hepatitis C","volume":"41","author":"Fartoux","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/hep.20983","article-title":"Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C","volume":"43","author":"Camma","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib46","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.gastro.2006.10.014","article-title":"Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis","volume":"132","author":"Ota","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.03.052_bib47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00535-006-1948-","article-title":"Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease","volume":"42","author":"Sakurai","year":"2007","journal-title":"J Gastroenterol"},{"key":"10.1053\/j.gastro.2010.03.052_bib48","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2010.03.052_bib49","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.2337\/db09-0279","article-title":"Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene","volume":"58","author":"Kantartzis","year":"2009","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2010.03.052_bib50","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1074\/jbc.M109.064501","article-title":"A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis","volume":"285","author":"He","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.03.052_bib51","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/hep.23622","article-title":"Homozygosity for the patatin-like phospholipase-3\/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease","volume":"51","author":"Valenti","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.03.052_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0959-9673.2006.00465.x","article-title":"Mouse models in non-alcoholic fatty liver disease and steatohepatitis research","volume":"87","author":"Anstee","year":"2006","journal-title":"Int J Exp Pathol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510004853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510004853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:39:10Z","timestamp":1762162750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510004853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0016508510004853"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.03.052","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3485957.3180055","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1\u03b2 in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.03.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}