{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:29:16Z","timestamp":1793104156346,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1053\/j.gastro.2010.05.002","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T12:29:55Z","timestamp":1274358595000},"page":"1538-1548","source":"Crossref","is-referenced-by-count":106,"title":["Dynamics of Fat Absorption and Effect of Sham Feeding on Postprandial Lipema"],"prefix":"10.1053","volume":"139","author":[{"given":"Rosa N.","family":"Chavez\u2013Jauregui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Mattes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.05.002_bib1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neubiorev.2006.03.005","article-title":"The neural\/cephalic reflexes in the physiology of nutrition","volume":"30","author":"Zafra","year":"2006","journal-title":"Neurosci Behav Rev"},{"key":"10.1053\/j.gastro.2010.05.002_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0002-8223(97)00101-6","article-title":"Physiologic responses to sensory stimulation by food: nutritional implications","volume":"97","author":"Mattes","year":"1997","journal-title":"J Am Diet Assoc"},{"key":"10.1053\/j.gastro.2010.05.002_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.appet.2007.10.006","article-title":"Anticipatory physiological regulation in feeding biology: cephalic phase responses","volume":"50","author":"Power","year":"2008","journal-title":"Appetite"},{"key":"10.1053\/j.gastro.2010.05.002_bib4","doi-asserted-by":"crossref","first-page":"C1203","DOI":"10.1152\/ajpcell.1997.272.4.C1203","article-title":"Fatty acid modulation of K+ channels in taste receptor cells: gustatory cues for dietary fat","volume":"272","author":"Gilbertson","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib5","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1096\/fj.07-8415com","article-title":"The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse","volume":"22","author":"Gaillard","year":"2008","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2010.05.002_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2007.03.027","article-title":"Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats","volume":"1151","author":"Pittman","year":"2007","journal-title":"Brain Res"},{"key":"10.1053\/j.gastro.2010.05.002_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.physbeh.2006.06.009","article-title":"Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats","volume":"89","author":"Stratford","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0031-9384(98)00299-6","article-title":"The orosensory recognition of long-chain fatty acids in rats","volume":"66","author":"Tsuruta","year":"1999","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0024-3205(00)00614-7","article-title":"Preference for vegetable oils in the two-bottle choice test in mice","volume":"67","author":"Takeda","year":"2000","journal-title":"Life Sci"},{"key":"10.1053\/j.gastro.2010.05.002_bib10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0031-9384(03)00201-4","article-title":"Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats","volume":"79","author":"Hiraoka","year":"2003","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib11","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1172\/JCI25299","article-title":"CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions","volume":"115","author":"Laugerette","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.002_bib12","first-page":"R459","article-title":"Oral stimulation alters digestion of intragastric oil meals in rats","volume":"248","author":"Ramirez","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/chemse\/bjn072","article-title":"Oral detection of short, medium and long chain fatty acids in humans","volume":"34","author":"Mattes","year":"2009","journal-title":"Chem Senses"},{"key":"10.1053\/j.gastro.2010.05.002_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/chemse\/bjm007","article-title":"Evidence for human orosensory (taste?) sensitivity to free fatty acids","volume":"32","author":"Chale-Rush","year":"2007","journal-title":"Chem Senses"},{"key":"10.1053\/j.gastro.2010.05.002_bib15","doi-asserted-by":"crossref","first-page":"G1206","DOI":"10.1152\/ajpgi.00471.2006","article-title":"Multiple routes of chemosensitivity to free fatty acids in humans","volume":"272","author":"Chale-Rush","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1677\/joe.0.1800273","article-title":"Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans","volume":"180","author":"Health","year":"2004","journal-title":"J Endocrinol"},{"key":"10.1053\/j.gastro.2010.05.002_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.physbeh.2006.06.013","article-title":"Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters","volume":"89","author":"Crystal","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0031-9384(01)00578-9","article-title":"The taste of fat elevates postprandial triacylglycerol","volume":"74","author":"Mattes","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib19","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1093\/jn\/132.12.3656","article-title":"Oral fat exposure increases the first phase triacylglycerol concentration due to release of stored lipid in humans","volume":"132","author":"Mattes","year":"2002","journal-title":"J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib20","doi-asserted-by":"crossref","first-page":"G365","DOI":"10.1152\/ajpgi.90591.2008","article-title":"Brief oral stimulation, but especially oral fat exposure, reliably elevates serum triglycerides in humans","volume":"296","author":"Mattes","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11010-008-9998-8","article-title":"Perilipin A and the control of triacylglycerol metabolism","volume":"326","author":"Brasaemle","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"10.1053\/j.gastro.2010.05.002_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.plefa.2007.10.020","article-title":"New insights into the roles of proteins and lipids in membrane transport of fatty acids","volume":"77","author":"Hamilton","year":"2007","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1053\/j.gastro.2010.05.002_bib23","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1194\/jlr.M800555-JLR200","article-title":"A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging","volume":"50","author":"Zhu","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2010.05.002_bib24","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/oby.2006.129","article-title":"Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification","volume":"14","author":"Getty-Kaushik","year":"2006","journal-title":"Obesity"},{"key":"10.1053\/j.gastro.2010.05.002_bib25","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1074\/jbc.M609088200","article-title":"Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes","volume":"282","author":"Kim","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.05.002_bib26","doi-asserted-by":"crossref","first-page":"G798","DOI":"10.1152\/ajpgi.00512.2002","article-title":"Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans","volume":"284","author":"Feinle","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1172\/JCI102968","article-title":"The effects of eating and of sham feeding upon the absorption of vitamin A palmitate in man","volume":"33","author":"Mendeloff","year":"1954","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.002_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosissup.2008.05.011","article-title":"Postprandial dyslipidemia in insulin resistance: mechanisms and role of intestinal insulin sensitivity","volume":"9","author":"Hsieh","year":"2008","journal-title":"Atheroscler Suppl"},{"key":"10.1053\/j.gastro.2010.05.002_bib29","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1749-6632.1994.tb17340.x","article-title":"Postprandial hyperlipemia and coronary artery disease","volume":"748","author":"Nakamura","year":"1995","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.gastro.2010.05.002_bib30","first-page":"18B","article-title":"Postprandial lipemia: emerging evidence for atherogenicity of remnant lipoproteins","volume":"14","author":"Cohn","year":"1998","journal-title":"Can J Cardiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00041433-199404000-00006","article-title":"Postprandial hyperlipidemia and remnant lipoproteins","volume":"5","author":"Havel","year":"1994","journal-title":"Curr Op Lipid"},{"key":"10.1053\/j.gastro.2010.05.002_bib32","series-title":"Biometric study of basal metabolism in man","author":"Harris","year":"1919"},{"key":"10.1053\/j.gastro.2010.05.002_bib33","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/63.6.911","article-title":"Oral exposure alters postprandial lipid metabolism in humans","volume":"63","author":"Mattes","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib34","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1172\/JCI6572","article-title":"Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production and clearance","volume":"104","author":"Parks","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.002_bib35","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/jn\/131.5.1491","article-title":"Oral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in humans","volume":"131","author":"Mattes","year":"2001","journal-title":"J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib36","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ajcn\/76.1.71","article-title":"Timing of vagal stimulation affects postprandial lipid metabolism in humans","volume":"76","author":"Robertson","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1079\/BJN19970115","article-title":"Metabolic responses to isoenergetic meals containing different proportions of carbohydrate and fat","volume":"78","author":"Whitley","year":"1997","journal-title":"Br J Nutr"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2010.05.002_bib38","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1038\/ijo.2009.15","article-title":"Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery","volume":"33","author":"Cummings","year":"2009","journal-title":"Int J Obes"},{"key":"10.1053\/j.gastro.2010.05.002_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/01.mco.0000214562.14074.fa","article-title":"CD36: taste the difference [editorial]","volume":"9","author":"Calder","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1053\/j.gastro.2010.05.002_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0959-4388(00)00118-5","article-title":"The molecular physiology of taste transduction","volume":"10","author":"Gilbertson","year":"2000","journal-title":"Curr Opin Neurobiol"},{"key":"10.1053\/j.gastro.2010.05.002_bib41","doi-asserted-by":"crossref","first-page":"7.1","DOI":"10.1146\/annurev-nutr-080508-141108","article-title":"Is there a fatty acid taste?","volume":"29","author":"Mattes","year":"2009","journal-title":"Ann Rev Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib42","doi-asserted-by":"crossref","first-page":"E789","DOI":"10.1152\/ajpendo.00557.2004","article-title":"Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes","volume":"288","author":"Ravikumar","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1053\/j.gastro.2010.05.002_bib43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00394-004-0538-3","article-title":"Meal ingestion provokes entry of lipoproteins containing fat from the previous meal: possible metabolic implications","volume":"44","author":"Renuka","year":"2005","journal-title":"Eur J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib44","first-page":"S55","article-title":"Oro-sensory stimulation prior to fat ingestion impairs postprandial fat tolerance","volume":"24","author":"Robertson","year":"2000","journal-title":"Int J Obes"},{"key":"10.1053\/j.gastro.2010.05.002_bib45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajcn\/67.1.31","article-title":"Effects of graded amounts (0\u201350 g) of dietary fat on postprandial lipemia and lipoproteins in normolipidemic adults","volume":"67","author":"Dubois","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib46","author":"Parks"},{"key":"10.1053\/j.gastro.2010.05.002_bib47","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.2337\/diabetes.54.9.2694","article-title":"Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men","volume":"54","author":"Timlin","year":"2005","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2010.05.002_bib48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/ajcn\/63.1.36","article-title":"Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals","volume":"63","author":"Fielding","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1079\/BJN19980072","article-title":"Rapid chylomicron clearance following sequential meals: effects of second meal composition","volume":"79","author":"Evans","year":"1998","journal-title":"Br J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib50","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/ajcn\/75.3.505","article-title":"Extended effects of evening meal carbohydrate-to-fat ratio on fasting and postprandial substrate metabolism","volume":"75","author":"Robertson","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib51","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(63)91500-9","article-title":"The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus","volume":"1","author":"Randle","year":"1963","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2010.05.002_bib52","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/CIRCULATIONAHA.107.739888","article-title":"Both intestinal and hepatic production are stimulated by an acute elevation in plasma free fatty acids in humans","volume":"117","author":"Duez","year":"2008","journal-title":"Circulation"},{"key":"10.1053\/j.gastro.2010.05.002_bib53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1079\/BJN2000226","article-title":"Second meal effect: modified sham feeding does not provoke release of stored triacylglycerol from a previous high-fat meal","volume":"85","author":"Jackson","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0031-9384(01)00644-8","article-title":"Effect of orosensory stimulation on postprandial thermogenesis in humans","volume":"75","author":"Tittelbach","year":"2002","journal-title":"Physiol Behav"},{"key":"10.1053\/j.gastro.2010.05.002_bib55","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12078-009-9062-4","article-title":"Oral fat exposure pattern and lipid loading effects on the serum triacylglycerol concentration of humans","volume":"2","author":"Mattes","year":"2009","journal-title":"Chemosens Percept"},{"key":"10.1053\/j.gastro.2010.05.002_bib56","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s11883-001-0036-5","article-title":"Recent findings in the study of postprandial lipemia","volume":"3","author":"Parks","year":"2001","journal-title":"Curr Atheroscler Rep"},{"key":"10.1053\/j.gastro.2010.05.002_bib57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0007114599001245","article-title":"Postprandial lipoprotein, glucose and insulin responses after two consecutive meals containing rapeseed oil, sunflower oil or palm oil with or without glucose at the first meal","volume":"82","author":"Pedersen","year":"1999","journal-title":"Br J Nutr"},{"key":"10.1053\/j.gastro.2010.05.002_bib58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1017\/S0007114500002853","article-title":"Fatty acid composition of an oral load affects chylomicron size in human subjects","volume":"77","author":"Sakr","year":"1997","journal-title":"Br J Nutr"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510007298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510007298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:54:09Z","timestamp":1740099249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510007298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0016508510007298"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.05.002","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}