{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:05:06Z","timestamp":1792731906988,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1053\/j.gastro.2010.05.005","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T04:21:19Z","timestamp":1277094079000},"page":"987-998","source":"Crossref","is-referenced-by-count":203,"title":["Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice"],"prefix":"10.1053","volume":"139","author":[{"given":"David","family":"Scholten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H.","family":"\u00d6sterreicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Scholten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Iwaisako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kisseleva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.05.005_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1172\/JCI24282","article-title":"Liver fibrosis","volume":"115","author":"Bataller","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mam.2007.09.002","article-title":"Myofibroblast-like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario","volume":"29","author":"Parola","year":"2008","journal-title":"Mol Aspects Med"},{"key":"10.1053\/j.gastro.2010.05.005_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1513\/pats.200711-168DR","article-title":"Fibrogenesis of parenchymal organs","volume":"5","author":"Kisseleva","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1053\/j.gastro.2010.05.005_bib4","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/hep.23196","article-title":"Epithelial-to-mesenchymal transitions in the liver","volume":"50","author":"Choi","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib5","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI36183","article-title":"Biomarkers for epithelial-mesenchymal transitions","volume":"119","author":"Zeisberg","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib7","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ceb.2005.08.001","article-title":"Molecular requirements for epithelial-mesenchymal transition during tumor progression","volume":"17","author":"Huber","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"10.1053\/j.gastro.2010.05.005_bib8","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","article-title":"The basics of epithelial-mesenchymal transition","volume":"119","author":"Kalluri","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib9","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/hep.22397","article-title":"Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways","volume":"48","author":"Nitta","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib10","doi-asserted-by":"crossref","first-page":"23337","DOI":"10.1074\/jbc.M700194200","article-title":"Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition","volume":"282","author":"Zeisberg","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.05.005_bib11","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice","volume":"51","author":"Taura","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib12","first-page":"3331","article-title":"Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans","volume":"118","author":"Omenetti","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib13","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1053\/j.gastro.2009.06.051","article-title":"Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease","volume":"137","author":"Syn","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.05.005_bib14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/dvg.20397","article-title":"A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs","volume":"46","author":"Means","year":"2008","journal-title":"Genesis"},{"key":"10.1053\/j.gastro.2010.05.005_bib15","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1158\/0008-5472.CAN-03-3137","article-title":"A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease","volume":"64","author":"Bhowmick","year":"2004","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2010.05.005_bib16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1053\/j.gastro.2008.03.015","article-title":"Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells","volume":"134","author":"Kuo","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.05.005_bib17","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.22468","article-title":"Surface markers for the murine oval cell response","volume":"48","author":"Dorrell","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.22952","article-title":"CCR2 promotes hepatic fibrosis in mice","volume":"50","author":"Seki","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1440-169X.2008.01070.x","article-title":"Epithelial to mesenchymal transition during gastrulation: an embryological view","volume":"50","author":"Nakaya","year":"2008","journal-title":"Dev Growth Differ"},{"key":"10.1053\/j.gastro.2010.05.005_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.23274","article-title":"Bone marrow transplantation demonstrates medullar origin of CD34(+) fibrocytes and ameliorates hepatic fibrosis in Abcb4(\u2212\/\u2212) mice","volume":"51","author":"Roderfeld","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib21","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.20858","article-title":"Immunohistochemical analysis of cytokeratin 7 expression in resting and proliferating biliary structures of rat liver","volume":"42","author":"Paku","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.05.005_bib22","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.2353\/ajpath.2006.050747","article-title":"Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation","volume":"168","author":"Xia","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2010.05.005_bib23","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/labinvest.3700704","article-title":"Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease","volume":"88","author":"Rygiel","year":"2008","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2010.05.005_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.humpath.2007.05.021","article-title":"Evidence for the epithelial to mesenchymal transition in biliary atresia fibrosis","volume":"39","author":"Diaz","year":"2008","journal-title":"Hum Pathol"},{"key":"10.1053\/j.gastro.2010.05.005_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0022-2836(78)90069-4","article-title":"Miniplasmids of bacteriophage P1","volume":"120","author":"Austin","year":"1978","journal-title":"J Mol Biol"},{"issue":"178","key":"10.1053\/j.gastro.2010.05.005_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-540-35109-2_1","article-title":"Conditional somatic mutagenesis in the mouse using site-specific recombinases","author":"Feil","year":"2007","journal-title":"Handb Exp Pharmacol"},{"key":"10.1053\/j.gastro.2010.05.005_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-60327-019-9_16","article-title":"Site-specific recombinases for manipulation of the mouse genome","volume":"561","author":"Birling","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1053\/j.gastro.2010.05.005_bib28","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1634\/stemcells.2008-0115","article-title":"Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers","volume":"26","author":"Yang","year":"2008","journal-title":"Stem Cells"},{"key":"10.1053\/j.gastro.2010.05.005_bib29","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2006.01.036","article-title":"The bone marrow functionally contributes to liver fibrosis","volume":"130","author":"Russo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.05.005_bib30","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hep.22047","article-title":"Identification of adult hepatic progenitor cells capable of repopulating injured rat liver","volume":"47","author":"Yovchev","year":"2008","journal-title":"Hepatology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650851000733X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650851000733X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T02:26:55Z","timestamp":1544408815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650851000733X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S001650851000733X"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.05.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5279959.5344068","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.5279959.5221058","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}