{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:38:13Z","timestamp":1790267893520,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1053\/j.gastro.2010.07.046","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T10:45:34Z","timestamp":1280832334000},"page":"1730-1739.e1","source":"Crossref","is-referenced-by-count":47,"title":["Stress Signaling in the Methionine-Choline\u2013Deficient Model of Murine Fatty Liver Disease"],"prefix":"10.1053","volume":"139","author":[{"suffix":"Jr","given":"Russell K.","family":"Soon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim S.","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Grenert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn J.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.07.046_bib1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.07.046_bib2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI32752","article-title":"Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents","volume":"118","author":"Ota","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.07.046_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep.22960","article-title":"Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance","volume":"50","author":"Su","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.07.046_bib4","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1126\/science.1158042","article-title":"Regulation of hepatic lipogenesis by the transcription factor XBP1","volume":"320","author":"Lee","year":"2008","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.07.046_bib5","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI37007","article-title":"GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice","volume":"119","author":"Kammoun","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.07.046_bib6","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.07.046_bib7","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cmet.2008.04.011","article-title":"Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice","volume":"7","author":"Oyadomari","year":"2008","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2010.07.046_bib8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.devcel.2008.10.015","article-title":"UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators","volume":"15","author":"Rutkowski","year":"2008","journal-title":"Dev Cell"},{"key":"10.1053\/j.gastro.2010.07.046_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","article-title":"Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2010.07.046_bib10","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1194\/jlr.M700181-JLR200","article-title":"Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury","volume":"48","author":"Lee","year":"2007","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2010.07.046_bib11","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1194\/jlr.M900022-JLR200","article-title":"Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis","volume":"50","author":"Pickens","year":"2009","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2010.07.046_bib12","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1091\/mbc.8.9.1805","article-title":"The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane","volume":"8","author":"Cox","year":"1997","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2010.07.046_bib13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ncb1035","article-title":"The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages","volume":"5","author":"Feng","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.gastro.2010.07.046_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1046\/j.1432-1327.1999.00780.x","article-title":"Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase","volume":"265","author":"Berlanga","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1053\/j.gastro.2010.07.046_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2010.07.046_bib16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","article-title":"Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1","volume":"287","author":"Urano","year":"2000","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.07.046_bib17","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1128\/MCB.16.8.4273","article-title":"Signals from the stressed endoplasmic reticulum induce C\/EBP-homologous protein (CHOP\/GADD153)","volume":"16","author":"Wang","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.07.046_bib18","doi-asserted-by":"crossref","first-page":"13935","DOI":"10.1074\/jbc.M010677200","article-title":"Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress","volume":"276","author":"Yoneda","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.07.046_bib19","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1371\/journal.pbio.0040374","article-title":"Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins","volume":"4","author":"Rutkowski","year":"2006","journal-title":"PLoS Biol"},{"key":"10.1053\/j.gastro.2010.07.046_bib20","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/01.alc.0000174691.03751.11","article-title":"Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding","volume":"29","author":"Ji","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2010.07.046_bib21","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.07.046_bib22","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1194\/jlr.M600198-JLR200","article-title":"Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1","volume":"47","author":"Rizki","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2010.07.046_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"Calfon","year":"2002","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.07.046_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cmet.2009.11.002","article-title":"Circadian clock-coordinated 12 hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver","volume":"11","author":"Cretenet","year":"2010","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2010.07.046_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev Cell"},{"key":"10.1053\/j.gastro.2010.07.046_bib26","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/sj.emboj.7600596","article-title":"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death","volume":"24","author":"Ohoka","year":"2005","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2010.07.046_bib27","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1101\/gad.1250704","article-title":"CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum","volume":"18","author":"Marciniak","year":"2004","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.07.046_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2007.01.001","article-title":"The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid","volume":"5","author":"Guo","year":"2007","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2010.07.046_bib29","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2010.07.046_bib30","doi-asserted-by":"crossref","first-page":"16314","DOI":"10.1073\/pnas.0808517105","article-title":"PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation","volume":"105","author":"Bobrovnikova-Marjon","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2010.07.046_bib31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/jhep.2003.50307","article-title":"Central role of PPAR-a-dependent hepatic lipid turnover in dietary steatohepatitis in mice","volume":"38","author":"Ip","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.07.046_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bcp.2008.10.004","article-title":"Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells","volume":"77","author":"Penna","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/j.gastro.2010.07.046_bib33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.07.046_bib34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/hep.20999","article-title":"JNK1 but not JNK2 promotes the development of steatohepatitis in mice","volume":"43","author":"Schattenberg","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.07.046_bib35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hep.22578","article-title":"Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance","volume":"49","author":"Singh","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.07.046_bib36","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.metabol.2008.06.019","article-title":"The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis","volume":"57","author":"Ariyama","year":"2008","journal-title":"Metabolism"},{"key":"10.1053\/j.gastro.2010.07.046_bib37","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI34587","article-title":"Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes","volume":"118","author":"Song","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.07.046_bib38","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cmet.2009.03.003","article-title":"Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe\u2212\/\u2212 and Ldlr\u2212\/\u2212 mice lacking CHOP","volume":"9","author":"Thorp","year":"2009","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2010.07.046_bib39","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/j.1478-3231.2006.01314.x","article-title":"Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis","volume":"26","author":"Rangnekar","year":"2006","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2010.07.046_bib40","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1038\/oby.2007.197","article-title":"Chop-deficient mice showed increased adiposity but no glucose intolerance","volume":"15","author":"Ariyama","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.1053\/j.gastro.2010.07.046_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription","volume":"6","author":"Ron","year":"1992","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.07.046_bib42","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1002\/j.1460-2075.1995.tb00147.x","article-title":"Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153)","volume":"14","author":"Batchvarova","year":"1995","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2010.07.046_bib43","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/j.gastro.2007.10.039","article-title":"Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease","volume":"134","author":"Puri","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.07.046_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1101\/gad.964702","article-title":"IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response","volume":"16","author":"Lee","year":"2002","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.07.046_bib45","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/physiolgenomics.90396.2008","article-title":"eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver","volume":"38","author":"Dang Do","year":"2009","journal-title":"Physiol Genomics"},{"key":"10.1053\/j.gastro.2010.07.046_bib46","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800042-JLR200","article-title":"Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet","volume":"49","author":"Rinella","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2010.07.046_bib47","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep"},{"key":"10.1053\/j.gastro.2010.07.046_bib48","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/MCB.21.4.1249-1259.2001","article-title":"Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state","volume":"21","author":"McCullough","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.07.046_bib49","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1101\/gad.12.7.982","article-title":"CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum","volume":"12","author":"Zinszner","year":"1998","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2010.07.046_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1172\/JCI0214550","article-title":"Targeted disruption of the CHOP gene delays endoplasmic reticulum stress-mediated diabetes","volume":"109","author":"Oyadomari","year":"2002","journal-title":"J Clin Invest"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510011418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510011418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T05:23:28Z","timestamp":1559366608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510011418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0016508510011418"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.07.046","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}