{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:47:37Z","timestamp":1782236857079,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1053\/j.gastro.2010.08.047","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T06:36:00Z","timestamp":1283582160000},"page":"2061-2071.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Intracellular Calcium Release and Protein Kinase C Activation Stimulate Sonic Hedgehog Gene Expression During Gastric Acid Secretion"],"prefix":"10.1053","volume":"139","author":[{"given":"Mohamad","family":"El\u2013Zaatari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Zavros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Art","family":"Tessier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghna","family":"Waghray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Lentz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gumucio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Todisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita L.","family":"Merchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.08.047_bib1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/gast.2001.26261","article-title":"Sonic Hedgehog regulates gastric gland morphogenesis in man and mouse","volume":"121","author":"van den Brink","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.08.047_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.regpep.2007.09.020","article-title":"Cyclopamine inhibition of the Sonic Hedgehog pathway in the stomach requires concomitant acid inhibition","volume":"146","author":"El-Zaatari","year":"2008","journal-title":"Regul Pept"},{"key":"10.1053\/j.gastro.2010.08.047_bib3","doi-asserted-by":"crossref","first-page":"G99","DOI":"10.1152\/ajpgi.00389.2007","article-title":"Sonic Hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation","volume":"295","author":"Zavros","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_bib4","doi-asserted-by":"crossref","first-page":"15700","DOI":"10.1074\/jbc.M413037200","article-title":"Regulation and function of the Sonic Hedgehog signal transduction pathway in isolated gastric parietal cells","volume":"280","author":"Stepan","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.08.047_bib5","doi-asserted-by":"crossref","first-page":"33265","DOI":"10.1074\/jbc.M707090200","article-title":"Reduced pepsin A processing of Sonic Hedgehog in parietal cells precedes gastric atrophy and transformation","volume":"282","author":"Zavros","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.08.047_bib6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/j.gastro.2009.10.043","article-title":"Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog","volume":"138","author":"Waghray","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.08.047_bib7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2009.11.002","article-title":"Loss of parietal cell expression of Sonic Hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells","volume":"138","author":"Xiao","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.08.047_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002329900274","article-title":"Signal transduction and activation of acid secretion in the parietal cell","volume":"159","author":"Urushidani","year":"1997","journal-title":"J Membr Biol"},{"key":"10.1053\/j.gastro.2010.08.047_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-5793(88)80391-0","article-title":"Initial and sustained calcium mobilizations in the parietal cell during stimulations with gastrin, inositol trisphosphate, phorbol ester and exogenous diacylglycerol","volume":"232","author":"Tsunoda","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2010.08.047_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2796.1990.tb01466.x","article-title":"HCl secretion and [Ca2+]i in cultured parietal cells","volume":"732","author":"Chew","year":"1990","journal-title":"J Intern Med Suppl"},{"key":"10.1053\/j.gastro.2010.08.047_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-291X(81)91499-6","article-title":"Calcium stimulation of protein kinase C in the absence of added phospholipids","volume":"102","author":"Zabrenetzky","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2010.08.047_bib12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/excr.2002.5527","article-title":"Growth plate chondrocyte maturation is regulated by basal intracellular calcium","volume":"276","author":"Zuscik","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2010.08.047_bib13","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1242\/dev.128.13.2451","article-title":"Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud","volume":"128","author":"Lu","year":"2001","journal-title":"Development"},{"key":"10.1053\/j.gastro.2010.08.047_bib14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1242\/dev.01576","article-title":"Epithelial hedgehog signals pattern the intestinal crypt-villus axis","volume":"132","author":"Madison","year":"2005","journal-title":"Development"},{"key":"10.1053\/j.gastro.2010.08.047_bib15","doi-asserted-by":"crossref","first-page":"G970","DOI":"10.1152\/ajpgi.00461.2005","article-title":"Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice","volume":"290","author":"Lopez-Diaz","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_bib16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MED.0b013e328320a821","article-title":"Sonic Hedgehog in gastric physiology and neoplastic transformation: friend or foe?","volume":"16","author":"El-Zaatari","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.1053\/j.gastro.2010.08.047_bib17","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/MCB.15.4.2294","article-title":"Proteolytic processing yields two secreted forms of Sonic Hedgehog","volume":"15","author":"Bumcrot","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.08.047_bib18","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/35079648","article-title":"A freely diffusible form of Sonic Hedgehog mediates long-range signalling","volume":"411","author":"Zeng","year":"2001","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.08.047_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/path.1763","article-title":"Down-regulation of a morphogen (Sonic Hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils","volume":"206","author":"Suzuki","year":"2005","journal-title":"J Pathol"},{"key":"10.1053\/j.gastro.2010.08.047_bib20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1091\/mbc.2.1.27","article-title":"Thapsigargin potentiates histamine-stimulated HCl secretion in gastric parietal cells but does not mimic cholinergic responses","volume":"2","author":"Chew","year":"1991","journal-title":"Cell Regul"},{"key":"10.1053\/j.gastro.2010.08.047_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000099190","article-title":"Stimulatory pathways of the calcium-sensing receptor on acid secretion in freshly isolated human gastric glands","volume":"19","author":"Remy","year":"2007","journal-title":"Cell Physiol Biochem"},{"key":"10.1053\/j.gastro.2010.08.047_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/bbrc.2000.3955","article-title":"Activation of p42\/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line","volume":"279","author":"Yamaguchi","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2010.08.047_bib23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrm1154","article-title":"Extracellular calcium sensing and signalling","volume":"4","author":"Hofer","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2010.08.047_bib24","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1634\/stemcells.2007-0550","article-title":"Sonic Hedgehog stimulates mouse embryonic stem cell proliferation by cooperation of Ca2+\/protein kinase C and epidermal growth factor receptor as well as Gli1 activation","volume":"25","author":"Heo","year":"2007","journal-title":"Stem Cells"},{"key":"10.1053\/j.gastro.2010.08.047_bib25","first-page":"G246","article-title":"Ca2+-independent protein kinase C isoforms may modulate parietal cell HCl secretion","volume":"272","author":"Chew","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2005.04.003","article-title":"Kinetic analysis of protein production after DNA transfection","volume":"299","author":"Yamada","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1053\/j.gastro.2010.08.047_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1572-0241.2005.41001.x","article-title":"Evidence that loss of Sonic Hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer","volume":"100","author":"Shiotani","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2010.08.047_bib28","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/gut.48.6.782","article-title":"Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C","volume":"48","author":"Beales","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2010.08.047_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0022-3565(25)22386-2","article-title":"The effect of recombinant cytokines on [14C]-aminopyrine accumulation by isolated canine parietal cells","volume":"270","author":"Nompleggi","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2010.08.047_bib30","first-page":"2369","article-title":"Fos and Jun form cell specific protein complexes at the neuropeptide tyrosine promoter","volume":"9","author":"Jalava","year":"1994","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2010.08.047_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gut.49.1.18","article-title":"Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells","volume":"49","author":"Mitsuno","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2010.08.047_bib32","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1462-5822.2006.00743.x","article-title":"Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle","volume":"8","author":"Chang","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1053\/j.gastro.2010.08.047_bib33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0003-9861(89)90094-5","article-title":"Characterization of phospholipase C-mediated polyphosphoinositide hydrolysis in rat heart ventricles","volume":"269","author":"Schwertz","year":"1989","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/j.gastro.2010.08.047_bib34","first-page":"G81","article-title":"Influence of acid secretory state on Cl(-)-base and Na(+)-H+ exchange and pHi in isolated rabbit parietal cells","volume":"262","author":"Seidler","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_bib35","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1242\/jeb.026450","article-title":"Using omeprazole to link the components of the post-prandial alkaline tide in the spiny dogfish, Squalus acanthias","volume":"212","author":"Wood","year":"2009","journal-title":"J Exp Biol"},{"key":"10.1053\/j.gastro.2010.08.047_bib36","doi-asserted-by":"crossref","first-page":"37241","DOI":"10.1074\/jbc.M404520200","article-title":"pH Sensing by the calcium-sensing receptor","volume":"279","author":"Quinn","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.08.047_bib37","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1053\/j.gastro.2009.05.002","article-title":"Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning","volume":"137","author":"Kolterud","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.08.047_bib38","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01972","article-title":"Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours","volume":"425","author":"Berman","year":"2003","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.08.047_bib39","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biocel.2010.04.016","article-title":"Activation of Erk by Sonic Hedgehog independent of canonical hedgehog signalling","volume":"42","author":"Chang","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1053\/j.gastro.2010.08.047_fr1","doi-asserted-by":"crossref","first-page":"G970","DOI":"10.1152\/ajpgi.00461.2005","article-title":"Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice","volume":"290","author":"Lopez-Diaz","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_fr2","doi-asserted-by":"crossref","first-page":"33265","DOI":"10.1074\/jbc.M707090200","article-title":"Reduced pepsin A processing of Sonic Hedgehog in parietal cells precedes gastric atrophy and transformation","volume":"282","author":"Zavros","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.08.047_fr3","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200108062","article-title":"PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1\/2 (ERK1\/2)","volume":"156","author":"Braz","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2010.08.047_fr4","doi-asserted-by":"crossref","first-page":"15700","DOI":"10.1074\/jbc.M413037200","article-title":"Regulation and function of the Sonic Hedgehog signal transduction pathway in isolated gastric parietal cells","volume":"280","author":"Stepan","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.08.047_fr5","first-page":"G558","article-title":"Release of somatostatinlike immunoreactivity from canine fundic mucosal cells in primary culture","volume":"247","author":"Soll","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2010.08.047_fr6","first-page":"2459","article-title":"Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice","volume":"118","author":"Jain","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.08.047_fr7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1242\/dev.01576","article-title":"Epithelial hedgehog signals pattern the intestinal crypt-villus axis","volume":"132","author":"Madison","year":"2005","journal-title":"Development"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510012977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510012977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:55:38Z","timestamp":1758034538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510012977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0016508510012977"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.08.047","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular Calcium Release and Protein Kinase C Activation Stimulate Sonic Hedgehog Gene Expression During Gastric Acid Secretion","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.08.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}