{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:16:52Z","timestamp":1793236612636,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1053\/j.gastro.2010.09.005","type":"journal-article","created":{"date-parts":[[2010,9,19]],"date-time":"2010-09-19T04:14:10Z","timestamp":1284869650000},"page":"2028-2037.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":278,"title":["Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach"],"prefix":"10.1053","volume":"139","author":[{"given":"Ki Taek","family":"Nam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk\u2013Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josane F.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria G.","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan L.","family":"O'Neal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Romero\u2013Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Richard M.","family":"Peek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Konieczny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Goldenring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.09.005_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ar.1092360202","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2010.09.005_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/ar.1092360204","article-title":"Dynamics of epithelial cells in the corpus of the mouse stomach","volume":"236","author":"Karam","year":"1993","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2010.09.005_bib3","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa","year":"1988","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2010.09.005_bib4","first-page":"639","article-title":"Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma","volume":"79","author":"Schmidt","year":"1999","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2010.09.005_bib5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/jcp.54.9.679","article-title":"Gastric intestinal metaplasia: subtypes and natural history","volume":"54","author":"El-Zimaity","year":"2001","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.gastro.2010.09.005_bib6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ijc.2910570306","article-title":"Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia","volume":"57","author":"Filipe","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2010.09.005_bib7","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1053\/j.gastro.2008.12.037","article-title":"Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia","volume":"136","author":"Nam","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib8","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/labinvest.3700682","article-title":"Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori","volume":"87","author":"Yoshizawa","year":"2007","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2010.09.005_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0016-5085(00)70361-1","article-title":"Reversible drug-induced oxyntic atrophy in rats","volume":"118","author":"Goldenring","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0016-5085(00)70412-4","article-title":"Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer","volume":"118","author":"Wang","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib11","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1126\/science.1099513","article-title":"Gastric cancer originating from bone marrow-derived cells","volume":"306","author":"Houghton","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.gastro.2010.09.005_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1053\/j.gastro.2004.05.029","article-title":"Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice","volume":"127","author":"Nomura","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1242\/dev.02700","article-title":"The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1","volume":"134","author":"Ramsey","year":"2007","journal-title":"Development"},{"key":"10.1053\/j.gastro.2010.09.005_bib14","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1053\/j.gastro.2007.03.040","article-title":"Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice","volume":"132","author":"Nam","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1053\/j.gastro.2007.11.058","article-title":"A molecular signature of gastric metaplasia arising in response to acute parietal cell loss","volume":"134","author":"Nozaki","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib16","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1053\/j.gastro.2008.12.066","article-title":"Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia","volume":"136","author":"Shi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib17","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/S0016-5085(03)00406-2","article-title":"Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia","volume":"124","author":"Fox","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib18","doi-asserted-by":"crossref","first-page":"G362","DOI":"10.1152\/ajpgi.00160.2004","article-title":"Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild-type and gastrin-deficient mice","volume":"288","author":"Nomura","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2010.09.005_bib19","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.09.005_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ydbio.2008.10.025","article-title":"The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage","volume":"325","author":"Bredemeyer","year":"2009","journal-title":"Dev Biol"},{"key":"10.1053\/j.gastro.2010.09.005_bib21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/gast.1996.v110.pm8536852","article-title":"Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL\/6 mice and p53 hemizygous transgenic mice","volume":"110","author":"Fox","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0016-5085(98)70581-5","article-title":"Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection","volume":"114","author":"Wang","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib23","first-page":"3049","article-title":"Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer","volume":"29","author":"Guzinska-Ustymowicz","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1053\/j.gastro.2010.09.005_bib24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1023\/A:1018897922644","article-title":"Immunohistochemical studies on EGF family growth factors in normal and ulcerated human gastric mucosa","volume":"42","author":"Abe","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2010.09.005_bib25","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1172\/JCI114223","article-title":"Localization of transforming growth factor alpha and its receptor in gastric mucosal cells","volume":"84","author":"Beauchamp","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2010.09.005_bib26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0016-5085(95)90562-6","article-title":"Localization of heparin-binding epidermal growth factor-like growth factor in human gastric mucosa","volume":"109","author":"Murayama","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib27","doi-asserted-by":"crossref","first-page":"15700","DOI":"10.1074\/jbc.M413037200","article-title":"Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells","volume":"280","author":"Stepan","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.09.005_bib28","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2010.04.023","article-title":"Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer","volume":"138","author":"Goldenring","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nature07602","article-title":"Crypt stem cells as the cells-of-origin of intestinal cancer","volume":"457","author":"Barker","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.09.005_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.09.005_bib31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","article-title":"Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro","volume":"6","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1053\/j.gastro.2010.09.005_bib32","doi-asserted-by":"crossref","first-page":"213e3","DOI":"10.1053\/j.gastro.2010.04.008","article-title":"Gene expression profiling of metaplastic lineages identifies CDH17 as a prognostic marker in early stage gastric cancer","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib33","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1053\/j.gastro.2009.01.073","article-title":"Helicobacter pylori in health and disease","volume":"136","author":"Cover","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.09.005_bib34","doi-asserted-by":"crossref","first-page":"18913","DOI":"10.1073\/pnas.0810097105","article-title":"Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice","volume":"105","author":"Habbe","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2010.09.005_bib35","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1242\/dev.01925","article-title":"Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates","volume":"132","author":"Means","year":"2005","journal-title":"Development"},{"key":"10.1053\/j.gastro.2010.09.005_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2353\/ajpath.2007.061176","article-title":"Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia","volume":"171","author":"Zhu","year":"2007","journal-title":"Am J Pathol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510013211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510013211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:55:19Z","timestamp":1758034519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510013211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0016508510013211"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.09.005","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mature Chief Cells Are Cryptic Progenitors for Metaplasia in the Stomach","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}