{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:49:51Z","timestamp":1794124191584,"version":"4.8.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1053\/j.gastro.2010.12.038","type":"journal-article","created":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T04:31:32Z","timestamp":1294115492000},"page":"1314-1321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function"],"prefix":"10.1053","volume":"140","author":[{"given":"Yuki","family":"Hitomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth T.","family":"Cirulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Fellay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"McHutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis E.","family":"Gumbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin V.","family":"Shianna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2010.12.038_bib1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1478-3231.2008.01934.x","article-title":"The global burden of hepatitis C","volume":"29","author":"Lavanchy","year":"2009","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2010.12.038_bib2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa0808010","article-title":"Peginterferon \u03b1-2b or \u03b1-2a with ribavirin for treatment of hepatitis C infection","volume":"361","author":"McHutchison","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2010.12.038_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08825","article-title":"ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C","volume":"464","author":"Fellay","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.12.038_bib4","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1053\/j.gastro.2010.06.016","article-title":"Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction","volume":"139","author":"Thompson","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2010.12.038_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s00439-002-0798-z","article-title":"Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency","volume":"111","author":"Sumi","year":"2002","journal-title":"Hum Genet"},{"key":"10.1053\/j.gastro.2010.12.038_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s100380200095","article-title":"DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency","volume":"47","author":"Cao","year":"2002","journal-title":"J Hum Genet"},{"key":"10.1053\/j.gastro.2010.12.038_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ymgme.2005.03.011","article-title":"Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency in the Japanese population","volume":"85","author":"Maeda","year":"2005","journal-title":"Mol Genet Metab"},{"key":"10.1053\/j.gastro.2010.12.038_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1373\/clinchem.2005.059501","article-title":"Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasian population","volume":"52","author":"Shipkova","year":"2006","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2010.12.038_bib9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbadis.2006.10.006","article-title":"The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene","volume":"1772","author":"Arenas","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2010.12.038_bib10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/FTD.0b013e3180308554","article-title":"Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6","volume":"29","author":"Atanasova","year":"2007","journal-title":"Ther Drug Monit"},{"key":"10.1053\/j.gastro.2010.12.038_bib11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jmb.2009.07.051","article-title":"Functional study of the P32T ITPA variant associated with drug sensitivity in humans","volume":"392","author":"Stepchenkova","year":"2009","journal-title":"J Mol Biol"},{"key":"10.1053\/j.gastro.2010.12.038_bib12","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1053\/he.2000.5789","article-title":"Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage","volume":"31","author":"De Franceschi","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.12.038_bib13","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/hep.20208","article-title":"Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C","volume":"39","author":"Grattagliano","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.12.038_bib14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0020-711X(90)90140-X","article-title":"The metabolism of ribavirin in erythrocytes and nucleated cells","volume":"22","author":"Page","year":"1990","journal-title":"Int J Biochem"},{"key":"10.1053\/j.gastro.2010.12.038_bib15","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1248\/bpb.32.1940","article-title":"Morphological transformation and phosphatidylserine exposure in erythrocytes treated with ribavirin","volume":"32","author":"Homma","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1053\/j.gastro.2010.12.038_bib16","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1016\/S0021-9258(19)42102-9","article-title":"Human adenylosuccinate synthetase","volume":"249","author":"Van der Weyden","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.12.038_bib17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1053\/jhep.2002.32672","article-title":"Mechanism of action of ribavirin in the combination treatment of chronic HCV Infection","volume":"35","author":"Lau","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2010.12.038_bib18","doi-asserted-by":"crossref","first-page":"24046","DOI":"10.1016\/S0021-9258(19)51045-6","article-title":"Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5\u2032-triphosphate to xanthosine 5\u2032-triphosphate","volume":"269","author":"Kang","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2010.12.038_bib19","first-page":"650","article-title":"Adenylosuccinate synthetase of the yeast Saccharomyces cerevisiae: purification and properties","volume":"63","author":"Ryzhova","year":"1998","journal-title":"Biochemistry (Mosc)"},{"key":"10.1053\/j.gastro.2010.12.038_bib20","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMp0806284","article-title":"Common genetic variation and human traits","volume":"360","author":"Goldstein","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2010.12.038_bib21","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg2779","article-title":"Uncovering the roles of rare variants in common disease through whole-genome sequencing","volume":"11","author":"Cirulli","year":"2010","journal-title":"Nat Rev Genet"},{"key":"10.1053\/j.gastro.2010.12.038_bib22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance","volume":"461","author":"Ge","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2010.12.038_bib23","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","article-title":"IL28B is associated with response to chronic hepatitis C interferon-\u03b1 and ribavirin therapy","volume":"41","author":"Suppiah","year":"2009","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2010.12.038_bib24","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-\u03b1 and ribavirin therapy for chronic hepatitis C","volume":"41","author":"Tanaka","year":"2009","journal-title":"Nat Genet"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510018834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508510018834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:56:23Z","timestamp":1758034583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508510018834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0016508510018834"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2010.12.038","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inosine Triphosphate Protects Against Ribavirin-Induced Adenosine Triphosphate Loss by Adenylosuccinate Synthase Function","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2010.12.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}