{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:10:18Z","timestamp":1792905018593,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1053\/j.gastro.2011.01.032","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T04:32:51Z","timestamp":1295497971000},"page":"761-765.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":224,"title":["The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome"],"prefix":"10.1053","volume":"140","author":[{"given":"Lin","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2011.01.032_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.31887\/DCNS.2006.8.4\/bmcewen","article-title":"Protective and damaging effects of stress mediators: central role of the brain","volume":"8","author":"McEwen","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"key":"10.1053\/j.gastro.2011.01.032_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM199801153380307","article-title":"Protective and damaging effects of stress mediators","volume":"338","author":"McEwen","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/j.gastro.2011.01.032_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1192\/bjp.156.4.465","article-title":"Mental precursors of myocardial infarction","volume":"156","author":"Appels","year":"1990","journal-title":"Br J Psychiatr"},{"key":"10.1053\/j.gastro.2011.01.032_bib4","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/gast.2002.32392","article-title":"Systemic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?","volume":"122","author":"Whitehead","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_bib5","doi-asserted-by":"crossref","first-page":"G519","DOI":"10.1152\/ajpgi.2001.280.4.G519","article-title":"Stress and the gastrointestinal tract: V. Stress and irritable bowel syndrome","volume":"280","author":"Mayer","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.01.032_fr6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1136\/gut.33.6.825","article-title":"Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction","volume":"33","author":"Whitehead","year":"1992","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/gut.43.2.256","article-title":"Level of chronic life stress predicts clinical outcome in irritable bowel syndrome","volume":"43","author":"Bennett","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1136\/gut.44.3.400","article-title":"The role of psychological and biological factors in postinfective gut dysfunction","volume":"44","author":"Gwee","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ajg.2010.453","article-title":"Abuse, trauma, and GI illness: is there a link?","volume":"106","author":"Drossman","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr10","doi-asserted-by":"crossref","first-page":"74S","DOI":"10.1016\/S0002-9343(99)00083-2","article-title":"The relationship between psychosocial parameters and outcome in the irritable bowel syndrome","volume":"107","author":"Creed","year":"1999","journal-title":"Am J Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00406-005-0624-4","article-title":"The enduring effects of abuse and related adverse experiences in childhood","volume":"256","author":"Anda","year":"2006","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1053\/j.gastro.2011.01.032_fr12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults","volume":"14","author":"Felitti","year":"1998","journal-title":"Am J Prev Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.amepre.2008.02.002","article-title":"Adverse childhood experiences and chronic obstructive pulmonary disease in adults","volume":"34","author":"Anda","year":"2008","journal-title":"Am J Prev Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jpsychores.2008.02.016","article-title":"The relationship between somatisation and outcome in patients with severe irritable bowel syndrome","volume":"64","author":"Creed","year":"2008","journal-title":"J Psychosom Res"},{"key":"10.1053\/j.gastro.2011.01.032_fr15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1572-0241.2007.01722.x","article-title":"Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review","volume":"103","author":"Chitkara","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr16","doi-asserted-by":"crossref","first-page":"828","DOI":"10.7326\/0003-4819-113-11-828","article-title":"Sexual and physical abuse in women with functional or organic gastrointestinal disorders","volume":"113","author":"Drossman","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr17","first-page":"366","article-title":"Self-reported abuse and gastrointestinal disease in outpatients: Association with irritable bowel-type symptoms","volume":"90","author":"Talley","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1021718304633","article-title":"Abuse, dissociation, and somatization in irritable bowel syndrome: towards an explanatory model","volume":"26","author":"Salmon","year":"2003","journal-title":"J Behav Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1300\/J070v14n01_02","article-title":"Childhood sexual abuse and psychosomatic symptoms in irritable bowel syndrome","volume":"14","author":"Ross","year":"2005","journal-title":"J Child Sex Abus"},{"key":"10.1053\/j.gastro.2011.01.032_fr20","first-page":"138","article-title":"Childhood trauma and abuse is associated with an increased vulnerability for multiple somatic symptoms including irritable bowel syndrome (IBS)","author":"Videlock","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2036.2010.04510.x","article-title":"Risk factors for impaired health-related quality of life in functional dyspepsia","volume":"33","author":"Van Oudenhove","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2011.01.032_fr22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/gast.1996.v110.pm8613034","article-title":"Health status by gastrointestinal diagnosis and abuse history","volume":"110","author":"Drossman","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr23","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.47.6.861","article-title":"The neurobiology of stress and gastrointestinal disease","volume":"47","author":"Mayer","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr24","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1053\/j.gastro.2003.09.028","article-title":"Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS","volume":"125","author":"Dunlop","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr25","first-page":"67","article-title":"The emotional motor system","volume":"30","author":"Holstege","year":"1992","journal-title":"Eur J Morphol"},{"key":"10.1053\/j.gastro.2011.01.032_fr26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1196\/annals.1330.011","article-title":"Epigenetic programming of stress responses through variations in maternal care","volume":"1036","author":"Fish","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.gastro.2011.01.032_fr27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0031-6997(25)06673-6","article-title":"Physiology and pharmacology of corticotropin-releasing factor","volume":"43","author":"Owens","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.gastro.2011.01.032_fr28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbi.2009.08.006","article-title":"Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors","volume":"24","author":"Kiank","year":"2010","journal-title":"Brain Behav Immun"},{"key":"10.1053\/j.gastro.2011.01.032_fr29","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.2174\/138161206778743637","article-title":"CRF1 receptors as a therapeutic target for irritable bowel syndrome","volume":"12","author":"Martinez","year":"2006","journal-title":"Curr Pharm Des"},{"key":"10.1053\/j.gastro.2011.01.032_fr30","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/0016-5085(88)90006-6","article-title":"Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome","volume":"94","author":"Welgan","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1572-0241.2003.07156.x","article-title":"Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress","volume":"98","author":"Dickhaus","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/00006842-200109000-00014","article-title":"Psychological and physiological responses to postprandial mental stress in women with the irritable bowel syndrome","volume":"63","author":"Elsenbruch","year":"2001","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr33","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1136\/gut.2003.017962","article-title":"Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress","volume":"53","author":"Posserud","year":"2004","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00006842-198503000-00005","article-title":"The effect of stress on colon motor and electrical activity in irritable bowel syndrome","volume":"47","author":"Welgan","year":"1985","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1023\/A:1005487821063","article-title":"Role of anger in antral motor activity in irritable bowel syndrome","volume":"45","author":"Welgan","year":"2000","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2011.01.032_fr36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0889-8553(21)00551-3","article-title":"Motility disorders in the irritable bowel syndrome","volume":"20","author":"Lind","year":"1991","journal-title":"Gastroenterol Clin North Am"},{"key":"10.1053\/j.gastro.2011.01.032_fr37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/00365529209011167","article-title":"Effects of acute psychologic stress on small-intestinal motility in health and the irritable bowel syndrome","volume":"27","author":"Kellow","year":"1992","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr38","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/gut.42.6.845","article-title":"Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome","volume":"42","author":"Fukudo","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr39","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1053\/j.gastro.2004.08.057","article-title":"Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome","volume":"127","author":"Murray","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr40","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","article-title":"Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes","volume":"101","author":"Dunlop","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pain.2009.06.017","article-title":"Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome","volume":"146","author":"Zhou","year":"2009","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2011.01.032_fr42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/gut.2007.140806","article-title":"Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators","volume":"58","author":"Piche","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.gastro.2006.11.039","article-title":"Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome","volume":"132","author":"Barbara","year":"2007","journal-title":"Gastroenterology"},{"issue":"Suppl 7","key":"10.1053\/j.gastro.2011.01.032_fr44","first-page":"33","article-title":"Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications","volume":"60","author":"Larauche","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"10.1053\/j.gastro.2011.01.032_fr45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.gastro.2008.03.036","article-title":"Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation","volume":"135","author":"Alonso","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr46","first-page":"3","article-title":"Evolving pathophysiological model of functional gastrointestinal disorders: Implications for treatment","volume":"168","author":"Mayer","year":"2002","journal-title":"Eur J Surg Suppl"},{"key":"10.1053\/j.gastro.2011.01.032_fr47","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s11894-005-0019-8","article-title":"New insights into the pathophysiology of irritable bowel syndrome: implications for future treatments","volume":"7","author":"Crowell","year":"2005","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1053\/j.gastro.2011.01.032_fr48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.gastro.2011.01.032_fr49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1034\/j.1600-0773.2003.t01-1-920301.x","article-title":"The enteric nervous system I: organisation and classification","volume":"92","author":"Hansen","year":"2003","journal-title":"Pharmacol Toxicol"},{"key":"10.1053\/j.gastro.2011.01.032_fr50","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cgh.2008.02.060","article-title":"Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome","volume":"6","author":"Camilleri","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2011.01.032_fr51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2982.2006.00877.x","article-title":"Heart rate variability is related to pain severity and predominant bowel pattern in women with irritable bowel syndrome","volume":"19","author":"Cain","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.01.032_fr52","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1023\/A:1018871617483","article-title":"Evidence for autonomic nervous system imbalance in women with irritable bowel syndrome","volume":"43","author":"Heitkemper","year":"1998","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2011.01.032_fr53","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1136\/gut.2004.058685","article-title":"Sex-specific alterations in autonomic function among patients with irritable bowel syndrome","volume":"54","author":"Tillisch","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.01.032_fr54","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1023\/A:1010671514618","article-title":"Autonomic nervous system function in women with irritable bowel syndrome","volume":"46","author":"Heitkemper","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2011.01.032_fr55","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0016-5085(94)90753-6","article-title":"Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities","volume":"106","author":"Aggarwal","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr56","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1111\/j.1572-0241.2002.07112.x","article-title":"Autonomic functioning during REM sleep differentiates IBS symptom subgroups","volume":"97","author":"Thompson","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr57","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/109980040000200203","article-title":"Comparison of autonomic nervous system indices based on abdominal pain reports in women with irritable bowel syndrome","volume":"2","author":"Burr","year":"2000","journal-title":"Biol Res Nurs"},{"key":"10.1053\/j.gastro.2011.01.032_fr58","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/01.mcg.0000135362.35665.49","article-title":"Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome","volume":"38","author":"Waring","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr59","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1111\/j.1572-0241.2006.00837.x","article-title":"Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome","volume":"101","author":"Elsenbruch","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2982.2008.01171.x","article-title":"Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome","volume":"21","author":"Chang","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.01.032_fr61","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1053\/j.gastro.2009.08.058","article-title":"Childhood trauma is associated with hypothalamic-pituitary-adrenal axis responsiveness in irritable bowel syndrome","volume":"137","author":"Videlock","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr62","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2005.11.033","article-title":"Hypothalmic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential marker?","volume":"130","author":"Dinan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.01.032_fr63","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF03343838","article-title":"Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS)","volume":"24","author":"Patacchioli","year":"2001","journal-title":"J Endocrinol Invest"},{"key":"10.1053\/j.gastro.2011.01.032_fr64","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/01.psy.0000157064.72831.ba","article-title":"Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls","volume":"67","author":"Bohmelt","year":"2005","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr65","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2009.01351.x","article-title":"Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome","volume":"21","author":"Burr","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.01.032_fr66","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1572-0241.2001.03526.x","article-title":"Diarrhea- and constipation-predominant IBS patients differ in postprandial autonomic and cortisol responses","volume":"96","author":"Elsenbruch","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr67","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.pain.2009.12.005","article-title":"Central and peripheral hypersensitivity in the irritable bowel syndrome","volume":"148","author":"Zhou","year":"2010","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2011.01.032_fr68","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1177\/0193945909339320","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis dysregulation in women with irritable bowel syndrome in response to acute physical stress","volume":"31","author":"FitzGerald","year":"2009","journal-title":"West J Nurs Res"},{"key":"10.1053\/j.gastro.2011.01.032_fr69","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1572-0241.2004.04138.x","article-title":"Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome?","volume":"99","author":"Elsenbruch","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr70","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1176\/appi.ajp.158.4.575","article-title":"Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse","volume":"158","author":"Heim","year":"2001","journal-title":"Am J Psychiatr"},{"key":"10.1053\/j.gastro.2011.01.032_fr71","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.284.5.592","article-title":"Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood","volume":"284","author":"Heim","year":"2000","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2011.01.032_fr72","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.biopsych.2008.01.011","article-title":"Childhood parental loss and adult hypothalamic-pituitary-adrenal function","volume":"63","author":"Tyrka","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2011.01.032_fr73","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.biopsych.2008.05.012","article-title":"Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents","volume":"64","author":"Rao","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2011.01.032_fr74","doi-asserted-by":"crossref","first-page":"G307","DOI":"10.1152\/ajpgi.00240.2001","article-title":"Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat","volume":"282","author":"Coutinho","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.01.032_fr75","doi-asserted-by":"crossref","first-page":"G198","DOI":"10.1152\/ajpgi.00392.2006","article-title":"Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability","volume":"293","author":"Gareau","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.01.032_fr76","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1203\/01.pdr.0000190577.62426.45","article-title":"Neonatal maternal separation causes colonic dysfunction in rat pups including impaired host resistance","volume":"59","author":"Gareau","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2011.01.032_fr77","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/endo.137.4.8625891","article-title":"Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation","volume":"137","author":"Ladd","year":"1996","journal-title":"Endocrinology"},{"key":"10.1053\/j.gastro.2011.01.032_fr78","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1126\/science.277.5332.1659","article-title":"Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress","volume":"277","author":"Liu","year":"1997","journal-title":"Science"},{"key":"10.1053\/j.gastro.2011.01.032_fr79","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.molmed.2007.05.003","article-title":"Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health","volume":"13","author":"Meaney","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.gastro.2011.01.032_fr80","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.yfrne.2005.10.002","article-title":"Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat","volume":"26","author":"Szyf","year":"2005","journal-title":"Frontiers in Neuroendocrinology"},{"key":"10.1053\/j.gastro.2011.01.032_fr81","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat Neurosci"},{"key":"10.1053\/j.gastro.2011.01.032_fr82","first-page":"906","article-title":"Increased urine catecholamines and cortisol in women with irritable bowel syndrome","volume":"91","author":"Heitkemper","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.01.032_fr83","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2982.2006.00833.x","article-title":"Pre-experimental stress in patients with irritable bowel syndrome: high cortisol values already before symptom provocation with rectal distensions","volume":"18","author":"Walter","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.01.032_fr84","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1365-2826.2008.01711.x","article-title":"The neuroendocrinology of stress: a never ending story","volume":"20","author":"Lightman","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1053\/j.gastro.2011.01.032_fr85","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrn2639","article-title":"Effects of stress throughout the lifespan on the brain, behaviour and cognition","volume":"10","author":"Lupien","year":"2009","journal-title":"Nat Rev Neurosci"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511000874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511000874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:57:53Z","timestamp":1758034673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508511000874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0016508511000874"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2011.01.032","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.8118957.8516055","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2011.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}