{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:01:55Z","timestamp":1791291715248,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1053\/j.gastro.2011.04.049","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T15:29:34Z","timestamp":1304782174000},"page":"565-575.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine"],"prefix":"10.1053","volume":"141","author":[{"given":"Daniel P.","family":"Poole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Pelayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiore","family":"Cattaruzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yien\u2013Ming","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Gai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon V.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romke","family":"Bron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Furness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen F.","family":"Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel W.","family":"Bunnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2011.04.049_bib1","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.04.049_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.04.049_bib3","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2011.04.049_bib4","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.0705924104","article-title":"TRPA1 mediates formalin-induced pain","volume":"104","author":"McNamara","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.04.049_bib5","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2011.04.049_bib6","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0705923104","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.04.049_bib7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-8069-4-30","article-title":"Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1","volume":"4","author":"Cruz-Orengo","year":"2008","journal-title":"Mol Pain"},{"key":"10.1053\/j.gastro.2011.04.049_bib8","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1073\/pnas.0802354105","article-title":"Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1","volume":"105","author":"Materazzi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.04.049_bib9","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/brain\/awn060","article-title":"Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain","volume":"131","author":"Wang","year":"2008","journal-title":"Brain"},{"key":"10.1053\/j.gastro.2011.04.049_bib10","doi-asserted-by":"crossref","first-page":"G81","DOI":"10.1152\/ajpgi.00221.2009","article-title":"Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice","volume":"298","author":"Cattaruzza","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.04.049_bib11","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI30951","article-title":"Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain","volume":"117","author":"Dai","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2011.04.049_bib12","doi-asserted-by":"crossref","first-page":"G34","DOI":"10.1152\/ajpgi.00068.2009","article-title":"TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus","volume":"297","author":"Yu","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.04.049_bib13","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.0013-05.2005","article-title":"Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing","volume":"25","author":"Nagata","year":"2005","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2011.04.049_bib14","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2011.04.049_bib15","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1053\/j.gastro.2009.07.048","article-title":"The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli","volume":"137","author":"Brierley","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.04.049_bib16","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1136\/gut.2008.175901","article-title":"Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats","volume":"58","author":"Kondo","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.04.049_bib17","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1523\/JNEUROSCI.5380-08.2009","article-title":"TRPA1 modulates mechanotransduction in cutaneous sensory neurons","volume":"29","author":"Kwan","year":"2009","journal-title":"J Neurosci"},{"key":"10.1053\/j.gastro.2011.04.049_bib18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.freeradbiomed.2006.06.005","article-title":"4-Hydroxynonenal modifies IgA in rat intestine after lipopolysaccharide injection","volume":"41","author":"Kimura","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/j.gastro.2011.04.049_bib19","doi-asserted-by":"crossref","first-page":"58S","DOI":"10.1007\/BF01538132","article-title":"Role of eicosanoids in human and experimental colitis","volume":"33","author":"Schumert","year":"1988","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2011.04.049_bib20","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1073\/pnas.0805323106","article-title":"TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells","volume":"106","author":"Nozawa","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.04.049_bib21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ejphar.2007.08.015","article-title":"Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine","volume":"576","author":"Penuelas","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2011.04.049_bib22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2982.2007.00939.x","article-title":"Stimulation of neuronal receptors, neuropeptides and cytokines during experimental oil of mustard colitis","volume":"19","author":"Kimball","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.04.049_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neulet.2008.04.007","article-title":"TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons","volume":"438","author":"Anand","year":"2008","journal-title":"Neurosci Lett"},{"key":"10.1053\/j.gastro.2011.04.049_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00210-009-0435-7","article-title":"TRPA1 agonists delay gastric emptying in rats through serotonergic pathways","volume":"380","author":"Doihara","year":"2009","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1053\/j.gastro.2011.04.049_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1566-0702(02)00179-0","article-title":"The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system","volume":"101","author":"Poole","year":"2002","journal-title":"Auton Neurosci"},{"key":"10.1053\/j.gastro.2011.04.049_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-008-0684-7","article-title":"Immunohistochemical analysis of neuron types in the mouse small intestine","volume":"334","author":"Qu","year":"2008","journal-title":"Cell Tissue Res"},{"key":"10.1053\/j.gastro.2011.04.049_bib27","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1091\/mbc.9.8.2305","article-title":"Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq\/11, G-protein receptor kinase-2\/3, and beta-arrestin-1\/2","volume":"9","author":"McConalogue","year":"1998","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2011.04.049_bib28","doi-asserted-by":"crossref","first-page":"G887","DOI":"10.1152\/ajpgi.00222.2006","article-title":"PKC delta-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle","volume":"292","author":"Poole","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.04.049_bib29","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/hmg\/ddq038","article-title":"Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes","volume":"19","author":"Kuo","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2011.04.049_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuron.2006.04.009","article-title":"Numbing the senses: role of TRPA1 in mechanical and cold sensation","volume":"50","author":"Story","year":"2006","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2011.04.049_bib31","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0024-3205(99)00663-3","article-title":"Stimulatory effect of trans-cinnamaldehyde on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals","volume":"66","author":"Cheng","year":"2000","journal-title":"Life Sci"},{"key":"10.1053\/j.gastro.2011.04.049_bib32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuron.2009.09.030","article-title":"Nociceptive signals induce trafficking of TRPA1 to the plasma membrane","volume":"64","author":"Schmidt","year":"2009","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2011.04.049_bib33","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","volume":"129","author":"Atoyan","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.gastro.2011.04.049_bib34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2009.06.038","article-title":"Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs","volume":"617","author":"Doihara","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2011.04.049_bib35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000236524","article-title":"Characterization of two models of drug-induced constipation in mice and evaluation of mustard oil in these models","volume":"84","author":"Kojima","year":"2009","journal-title":"Pharmacology"},{"key":"10.1053\/j.gastro.2011.04.049_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2982.2004.00618.x","article-title":"Role of oxidative stress in the pathogenesis of septic ileus in mice","volume":"17","author":"de Winter","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2011.04.049_bib37","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0024-3205(95)02006-5","article-title":"4-Hydroxynonenal formation during ischemia and reperfusion of rat small intestine","volume":"57","author":"Siems","year":"1995","journal-title":"Life Sci"},{"key":"10.1053\/j.gastro.2011.04.049_bib38","doi-asserted-by":"crossref","first-page":"G238","DOI":"10.1152\/ajpgi.2000.279.1.G238","article-title":"Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis","volume":"279","author":"Ajuebor","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.04.049_bib39","first-page":"G132","article-title":"Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon","volume":"266","author":"Frieling","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2011.04.049_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.physiol.61.1.117","article-title":"The enteric nervous system and regulation of intestinal motility","volume":"61","author":"Kunze","year":"1999","journal-title":"Annu Rev Physiol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511006044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511006044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:59:24Z","timestamp":1758034764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508511006044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0016508511006044"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2011.04.049","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2011.04.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}