{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:17Z","timestamp":1787004797295,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1053\/j.gastro.2011.06.041","type":"journal-article","created":{"date-parts":[[2011,6,26]],"date-time":"2011-06-26T18:36:29Z","timestamp":1309113389000},"page":"1709-1719","source":"Crossref","is-referenced-by-count":16,"title":["Spontaneous, Immune-Mediated Gastric Inflammation in SAMP1\/YitFc Mice, a Model of Crohn's-Like Gastritis"],"prefix":"10.1053","volume":"141","author":[{"given":"Brian K.","family":"Reuter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pastorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Brogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha R.","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Rowlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie C.","family":"Arrieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2013Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik J.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford H.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Mize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cominelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan B.","family":"Meddings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa T.","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2011.06.041_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000083871","article-title":"Treatment of gastroduodenal Crohn's disease","volume":"71","author":"Mottet","year":"2005","journal-title":"Digestion"},{"key":"10.1053\/j.gastro.2011.06.041_bib2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00054725-200111000-00010","article-title":"Proximal Crohn's disease: review of the clinicopathologic features and therapy","volume":"7","author":"van Hogezand","year":"2001","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2011.06.041_bib3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1023\/A:1018870415898","article-title":"Prevalence of upper gastrointestinal lesions and Helicobacter pylori infection in Crohn's disease","volume":"43","author":"D'Inca","year":"1998","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2011.06.041_bib4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/gast.1997.v112.pm9041230","article-title":"Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn's disease","volume":"112","author":"Oberhuber","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.06.041_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/gut.38.3.379","article-title":"High frequency of helicobacter negative gastritis in patients with Crohn's disease","volume":"38","author":"Halme","year":"1996","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.06.041_bib6","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.4049\/jimmunol.149.6.2212","article-title":"Tolerance mechanism in experimental ovarian and gastric autoimmune diseases","volume":"149","author":"Smith","year":"1992","journal-title":"J Immunol"},{"key":"10.1053\/j.gastro.2011.06.041_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/clin.1994.1199","article-title":"Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response","volume":"73","author":"Tung","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1053\/j.gastro.2011.06.041_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature07210","article-title":"T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance","volume":"455","author":"Pesu","year":"2008","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.06.041_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/ibd.21638","article-title":"The SAMP1\/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis","author":"Pizarro","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2011.06.041_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/gut.43.1.71","article-title":"Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1\/Yit strain","volume":"43","author":"Matsumoto","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.06.041_bib11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1172\/JCI10956","article-title":"Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease","volume":"107","author":"Kosiewicz","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2011.06.041_bib12","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1128\/IAI.71.12.7140-7148.2003","article-title":"Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice","volume":"71","author":"Ismail","year":"2003","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2011.06.041_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.gastro.2011.06.041_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01969102","article-title":"Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease","volume":"25","author":"Boughton-Smith","year":"1988","journal-title":"Agents Actions"},{"key":"10.1053\/j.gastro.2011.06.041_bib15","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1128\/JCM.35.6.1620-1623.1997","article-title":"Fecal PCR assay for diagnosis of Helicobacter infection in laboratory rodents","volume":"35","author":"Beckwith","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1053\/j.gastro.2011.06.041_bib16","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/gast.2002.36002","article-title":"Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion","volume":"123","author":"Scott","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.06.041_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5085(98)70636-5","article-title":"Discrimination of site-specific alterations in gastrointestinal permeability in the rat","volume":"114","author":"Meddings","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.06.041_bib18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1091\/mbc.E03-05-0319","article-title":"Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment","volume":"15","author":"Ivanov","year":"2004","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2011.06.041_bib19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1086\/596205","article-title":"CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice","volume":"199","author":"Alam","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1053\/j.gastro.2011.06.041_bib20","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1084\/jem.20050407","article-title":"The primary defect in experimental ileitis originates from a nonhematopoietic source","volume":"203","author":"Olson","year":"2006","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2011.06.041_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.micpath.2004.06.004","article-title":"Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice","volume":"37","author":"Hasegawa","year":"2004","journal-title":"Microb Pathog"},{"key":"10.1053\/j.gastro.2011.06.041_bib22","first-page":"G42","article-title":"Tumor necrosis factor mediation of NSAID-induced gastric damage: role of leukocyte adherence","volume":"270","author":"Appleyard","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2011.06.041_bib23","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1053\/gast.2001.29568","article-title":"Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1\/Yit adoptive transfer model of Crohn's disease in mice","volume":"121","author":"Burns","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.06.041_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1053\/j.gastro.2004.11.053","article-title":"Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation","volume":"128","author":"Bamias","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.06.041_bib25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1007\/s005350170015","article-title":"Prevalence of Helicobacter pylori infection and correlation between severity of upper gastrointestinal lesions and H. pylori infection in Japanese patients with Crohn's disease","volume":"36","author":"Matsumura","year":"2001","journal-title":"J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.06.041_bib26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00535-008-2191-8","article-title":"The clinical significance of focal enhanced gastritis in adults with isolated ileitis of the terminal ileum","volume":"43","author":"Petrolla","year":"2008","journal-title":"J Gastroenterol"},{"key":"10.1053\/j.gastro.2011.06.041_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1517\/17425247.2.3.451","article-title":"Novel drug delivery strategies for the treatment of inflammatory bowel disease","volume":"2","author":"Kesisoglou","year":"2005","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1053\/j.gastro.2011.06.041_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2559.2006.02553.x","article-title":"Pathology of non-infective gastritis","volume":"50","author":"Srivastava","year":"2007","journal-title":"Histopathology"},{"key":"10.1053\/j.gastro.2011.06.041_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ibd.21356","article-title":"Frequent occurrence of gastritis and duodenitis in patients with inflammatory bowel disease","volume":"17","author":"Sonnenberg","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2011.06.041_bib30","doi-asserted-by":"crossref","first-page":"G109","DOI":"10.1152\/ajpgi.00214.2005","article-title":"T cell-induced inflammation of the small and large intestine in immunodeficient mice","volume":"290","author":"Ostanin","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.06.041_bib31","doi-asserted-by":"crossref","first-page":"G135","DOI":"10.1152\/ajpgi.90462.2008","article-title":"T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade","volume":"296","author":"Ostanin","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.06.041_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2011.06.041_bib33","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.134.4.1031","article-title":"Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein","volume":"134","author":"Balda","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2011.06.041_bib34","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1242\/jcs.109.9.2287","article-title":"Occludin is a functional component of the tight junction","volume":"109","author":"McCarthy","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1053\/j.gastro.2011.06.041_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1083\/jcb.153.2.263","article-title":"Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells","volume":"153","author":"Furuse","year":"2001","journal-title":"J Cell Biol"},{"key":"10.1053\/j.gastro.2011.06.041_bib36","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.biocel.2003.08.007","article-title":"Regulation of tight junctions and loss of barrier function in pathophysiology","volume":"36","author":"Harhaj","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1053\/j.gastro.2011.06.041_bib37","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1091\/mbc.11.12.4131","article-title":"Complex phenotype of mice lacking occludin, a component of tight junction strands","volume":"11","author":"Saitou","year":"2000","journal-title":"Mol Biol Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511008201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511008201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T16:10:12Z","timestamp":1686154212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508511008201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0016508511008201"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2011.06.041","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}