{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:22:34Z","timestamp":1790785354064,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["P42ES010337"],"award-info":[{"award-number":["P42ES010337"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["GM086713"],"award-info":[{"award-number":["GM086713"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1053\/j.gastro.2011.09.045","type":"journal-article","created":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T10:48:39Z","timestamp":1318416519000},"page":"109-118.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-\u03baB Leads to Hyperbilirubinemia"],"prefix":"10.1053","volume":"142","author":[{"given":"Ryoichi","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Tukey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2011.09.045_bib1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.clp.2006.09.002","article-title":"Hyperbilirubinemia and bilirubin toxicity in the late preterm infant","volume":"33","author":"Watchko","year":"2006","journal-title":"Clin Perinatol"},{"key":"10.1053\/j.gastro.2011.09.045_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000113463","article-title":"Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants > or = 35 weeks gestation","volume":"94","author":"Bhutani","year":"2008","journal-title":"Neonatology"},{"key":"10.1053\/j.gastro.2011.09.045_bib3","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.1542\/peds.2006-3499","article-title":"A comparison of alternative risk-assessment strategies for predicting significant neonatal hyperbilirubinemia in term and near-term infants","volume":"121","author":"Keren","year":"2008","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2011.09.045_bib4","first-page":"131","article-title":"Bilirubin UDP-glucuronyltransferase activity in human fetal liver homogenates","volume":"37","author":"Grimmer","year":"1978","journal-title":"Acta Biol Med Ger"},{"key":"10.1053\/j.gastro.2011.09.045_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/bj1960257","article-title":"The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver","volume":"196","author":"Kawade","year":"1981","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2011.09.045_bib6","doi-asserted-by":"crossref","first-page":"17960","DOI":"10.1016\/S0021-9258(17)32403-1","article-title":"Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man","volume":"269","author":"Bosma","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib7","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/S0021-9258(17)40517-5","article-title":"Enzymatic conversion of bilirubin monoglucuronide to diglucuronide by rat liver plasma membranes","volume":"252","author":"Jansen","year":"1977","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib8","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1542\/peds.110.4.e47","article-title":"Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice","volume":"110","author":"Kaplan","year":"2002","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2011.09.045_bib9","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pediatrneurol.2003.09.011","article-title":"Bilirubin toxicity in the developing nervous system","volume":"29","author":"Shapiro","year":"2003","journal-title":"Pediatr Neurol"},{"key":"10.1053\/j.gastro.2011.09.045_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/sj.jp.7211157","article-title":"Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND)","volume":"25","author":"Shapiro","year":"2005","journal-title":"J Perinatol"},{"key":"10.1053\/j.gastro.2011.09.045_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.siny.2009.12.004","article-title":"Chronic bilirubin encephalopathy: diagnosis and outcome","volume":"15","author":"Shapiro","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1053\/j.gastro.2011.09.045_bib12","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1073\/pnas.84.16.5918","article-title":"Antioxidant activity of albumin-bound bilirubin","volume":"84","author":"Stocker","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.09.045_bib13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1542\/peds.28.6.870","article-title":"Diagnosis of kernicterus in the neonatal period","volume":"28","author":"Van","year":"1961","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2011.09.045_bib14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0140-6736(91)90074-Y","article-title":"Variation of initial serum bilirubin rise in newborn infants with type of illness","volume":"338","author":"Benaron","year":"1991","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2011.09.045_bib15","first-page":"296","article-title":"The protective role of bilirubin in oxygen-radical diseases of the preterm infant","volume":"14","author":"Hegyi","year":"1994","journal-title":"J Perinatol"},{"key":"10.1053\/j.gastro.2011.09.045_bib16","first-page":"887","article-title":"Serum bilirubin and 10-year mortality risk in a Belgian population","volume":"12","author":"Temme","year":"2001","journal-title":"Cancer Causes Control"},{"key":"10.1053\/j.gastro.2011.09.045_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0021-9150(01)00601-3","article-title":"Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels","volume":"160","author":"Vitek","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1053\/j.gastro.2011.09.045_bib18","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/clinchem\/40.10.1987","article-title":"Is bilirubin protective against coronary artery disease?","volume":"40","author":"Breimer","year":"1994","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib19","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1542\/peds.32.6.995","article-title":"Hyperbilirubinemia in breast-fed infants","volume":"32","author":"Newman","year":"1963","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2011.09.045_bib20","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1172\/JCI105078","article-title":"Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steriod, pregnane-3(alpha), 20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro","volume":"43","author":"Arias","year":"1964","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2011.09.045_bib21","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1001\/jama.1986.03370230076034","article-title":"Breast milk jaundice in the newborn","volume":"255","author":"Schneider","year":"1986","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2011.09.045_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1203\/PDR.0b013e31809871c9","article-title":"Cytokines in human colostrum and neonatal jaundice","volume":"62","author":"Zanardo","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2011.09.045_bib23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1203\/PDR.0b013e3181ac4a30","article-title":"Breast milk jaundice correlates with high levels of epidermal growth factor","volume":"66","author":"Kumral","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2011.09.045_bib24","doi-asserted-by":"crossref","first-page":"7901","DOI":"10.1074\/jbc.M709244200","article-title":"Disruption of the Ugt1 locus in mice resembles human Crigler-Najjar type I disease","volume":"283","author":"Nguyen","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib25","doi-asserted-by":"crossref","first-page":"37547","DOI":"10.1074\/jbc.M506683200","article-title":"Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus","volume":"280","author":"Chen","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib26","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.1073\/pnas.0913290107","article-title":"Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus","volume":"107","author":"Fujiwara","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.09.045_bib27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1542\/peds.96.4.730","article-title":"Kernicterus in otherwise healthy, breast-fed term newborns","volume":"96","author":"Maisels","year":"1995","journal-title":"Pediatrics"},{"key":"10.1053\/j.gastro.2011.09.045_bib28","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0026-895X(24)12086-X","article-title":"Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR","volume":"61","author":"Ueda","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1053\/j.gastro.2011.09.045_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/35019116","article-title":"Humanized xenobiotic response in mice expressing nuclear receptor SXR","volume":"406","author":"Xie","year":"2000","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.09.045_bib30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nm849","article-title":"The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion","volume":"9","author":"Chen","year":"2003","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2011.09.045_bib31","doi-asserted-by":"crossref","first-page":"15001","DOI":"10.1074\/jbc.M300645200","article-title":"Involvement of the xenobiotic response element (XRE) in a receptor-mediated induction of human UDP-glucuronosyltransferase 1A1","volume":"278","author":"Yueh","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2011.09.045_bib32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1124\/mol.104.007161","volume":"67","author":"Sugatani","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1053\/j.gastro.2011.09.045_bib33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/dmd.106.013243","article-title":"Expression of the human UGT1 locus in transgenic mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor {alpha} activation","volume":"35","author":"Senekeo-Effenberger","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1053\/j.gastro.2011.09.045_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jbt.2570050403","article-title":"Differential enzyme induction of mouse liver and lung following a single low or high dose of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)","volume":"5","author":"Beebe","year":"1990","journal-title":"J Biochem Toxicol"},{"key":"10.1053\/j.gastro.2011.09.045_bib35","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/35038112","article-title":"The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism","volume":"407","author":"Wei","year":"2000","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.09.045_bib36","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.09.045_bib37","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0022-3565(24)35029-3","article-title":"Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent","volume":"290","author":"Barclay","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2011.09.045_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1203\/01.PDR.0000085169.87948.B6","article-title":"Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain","volume":"54","author":"Hanko","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1053\/j.gastro.2011.09.045_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.109.002014","article-title":"Xenobiotic, bile acid, and cholesterol transporters: function and regulation","volume":"62","author":"Klaassen","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.gastro.2011.09.045_bib40","doi-asserted-by":"crossref","first-page":"C1404","DOI":"10.1152\/ajpcell.00471.2003","article-title":"Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-kappaB signaling in human intestinal cells","volume":"287","author":"Minekawa","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1053\/j.gastro.2011.09.045_bib41","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1073\/pnas.0306734101","article-title":"IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium","volume":"101","author":"Egan","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.09.045_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cyto.2007.02.011","article-title":"Cadmium induces interleukin-8 production via NF-kappaB activation in the human intestinal epithelial cell, Caco-2","volume":"37","author":"Hyun","year":"2007","journal-title":"Cytokine"},{"key":"10.1053\/j.gastro.2011.09.045_bib43","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.bbrc.2004.05.218","article-title":"Cadmium stimulates the expression of ICAM-1 via NF-kappaB activation in cerebrovascular endothelial cells","volume":"320","author":"Jeong","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2011.09.045_bib44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccr.2004.08.012","article-title":"Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression","volume":"6","author":"Luo","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2011.09.045_bib45","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1042\/bj1840705","article-title":"Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver","volume":"184","author":"Onishi","year":"1979","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2011.09.045_bib46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/MPG.0b013e31819f1e05","article-title":"Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition","volume":"49","author":"Agostoni","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.gastro.2011.09.045_bib47","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2337\/diab.37.12.1625","article-title":"Reduced risk of IDDM among breast-fed children","volume":"37","author":"Mayer","year":"1988","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2011.09.045_bib48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0140-6736(96)12103-6","article-title":"Breastfeeding and incidence of non-insulin-dependent diabetes mellitus in Pima Indians","volume":"350","author":"Pettitt","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2011.09.045_bib49","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0140-6736(95)91742-X","article-title":"Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old","volume":"346","author":"Saarinen","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2011.09.045_bib50","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jpeds.2009.03.017","article-title":"Systematic review: the role of breastfeeding in the development of pediatric inflammatory bowel disease","volume":"155","author":"Barclay","year":"2009","journal-title":"J Pediatr"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511013710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511013710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T14:57:52Z","timestamp":1758034672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508511013710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0016508511013710"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2011.09.045","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13489058.14866183","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Expression of UGT1A1 in Intestines of Humanized UGT1 Mice via Inactivation of NF-\u03baB Leads to Hyperbilirubinemia","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2011.09.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}