{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:33:07Z","timestamp":1793406787564,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK66423"],"award-info":[{"award-number":["R01-DK66423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1053\/j.gastro.2011.12.017","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T04:21:41Z","timestamp":1324009301000},"page":"918-927.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":384,"title":["Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats"],"prefix":"10.1053","volume":"142","author":[{"given":"Guanhua","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roscoe D.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Kanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Gaarde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie D.","family":"DeLeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2011.12.017_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/hep.1840070117","article-title":"Alcoholic liver injury: defenestration in noncirrhotic livers-a scanning electron microscopic study","volume":"7","author":"Horn","year":"1987","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib2","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2353\/ajpath.2008.070720","article-title":"Prevention of hepatic fibrosis in a murine model of metabolic syndrome with non-alcoholic steatohepatitis","volume":"173","author":"DeLeve","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2011.12.017_bib3","doi-asserted-by":"crossref","first-page":"G757","DOI":"10.1152\/ajpgi.00017.2004","article-title":"Rat liver sinusoidal endothelial cell phenotype is under paracrine and autocrine control","volume":"287","author":"DeLeve","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.12.017_bib4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.22351","article-title":"Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence","volume":"48","author":"DeLeve","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0016-5085(63)80130-4","article-title":"Capillarization of hepatic sinusoids in man","volume":"44","author":"Schaffner","year":"1963","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.12.017_bib6","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0002-9440(10)63487-6","article-title":"Capillarization of hepatic sinusoid by liver endothelial cell-reactive autoantibodies in patients with cirrhosis and chronic hepatitis","volume":"163","author":"Xu","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2011.12.017_bib7","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0676.1985.tb00253.x","article-title":"Early alcoholic liver injury: changes of the Disse space in acinar zone 3","volume":"5","author":"Horn","year":"1985","journal-title":"Liver"},{"key":"10.1053\/j.gastro.2011.12.017_bib8","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/hep.1840140519","article-title":"The role of capillarization in hepatic failure: studies in carbon tetrachloride-induced cirrhosis","volume":"14","author":"Martinez-Hernandez","year":"1991","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib9","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/hep.1840170520","article-title":"Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis","volume":"17","author":"Mori","year":"1993","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jhep.2006.08.022","article-title":"Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis","volume":"46","author":"Warren","year":"2007","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2011.12.017_bib11","first-page":"2683","article-title":"A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular endothelial growth factor and Flt tyrosine kinase receptor family (Flt-1 and KDR\/Flk-1)","volume":"9","author":"Yamane","year":"1994","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2011.12.017_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/oxfordjournals.eurheartj.a061753","article-title":"Studies of endothelium-derived relaxant factor (EDRF), its nature and mode of action","volume":"6","author":"Griffith","year":"1985","journal-title":"Eur Heart J"},{"key":"10.1053\/j.gastro.2011.12.017_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrm1569","article-title":"Protein S-nitrosylation: purview and parameters","volume":"6","author":"Hess","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2011.12.017_bib14","first-page":"71","article-title":"Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis","volume":"58","author":"Knorr","year":"2008","journal-title":"Arzneimittelforschung"},{"key":"10.1053\/j.gastro.2011.12.017_bib15","doi-asserted-by":"crossref","first-page":"G1187","DOI":"10.1152\/ajpgi.00229.2006","article-title":"Rat liver endothelial cells isolated by anti-CD31 immunomagnetic sorting lack fenestrae and sieve plates","volume":"291","author":"DeLeve","year":"2006","journal-title":"Am J Physiology Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.12.017_bib16","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/hep.1840060505","article-title":"Phagocytosis, an unrecognized property of murine endothelial liver cells","volume":"6","author":"Steffan","year":"1986","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1042\/bj2180081","article-title":"Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells","volume":"218","author":"Blomhoff","year":"1984","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2011.12.017_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0014-4827(84)90714-6","article-title":"Preparation of isolated liver endothelial cells and Kupffer cells in high yield by means of an enterotoxin","volume":"150","author":"Blomhoff","year":"1984","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2011.12.017_bib19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/bj2580511","article-title":"Intracellular transport of formaldehyde-treated serum albumin in liver endothelial cells after uptake via scavenger receptors","volume":"258","author":"Eskild","year":"1989","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2011.12.017_bib20","doi-asserted-by":"crossref","first-page":"G1204","DOI":"10.1152\/ajpgi.00302.2010","article-title":"Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity","volume":"299","author":"Xie","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.12.017_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/hep.23618","article-title":"Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1","volume":"52","author":"G\u00e9raud","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib22","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1089\/ten.2006.0437","article-title":"Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds","volume":"13","author":"Sellaro","year":"2007","journal-title":"Tissue Engineering"},{"key":"10.1053\/j.gastro.2011.12.017_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0016-5085(98)70487-1","article-title":"Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension","volume":"114","author":"Rockey","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.12.017_bib24","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/hep.22758","article-title":"Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats","volume":"49","author":"Mejias","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/gut.2010.220913","article-title":"Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver","volume":"60","author":"Gracia-Sancho","year":"2011","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2011.12.017_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.21673","article-title":"Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA\/Rho-kinase and activation of endothelial nitric oxide synthase","volume":"46","author":"Trebicka","year":"2007","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib27","first-page":"S1","article-title":"Hepatic stellate cells revert to a quiescent phenotype during liver fibrosis regression and do not undergo mesenchymal-epithelial transition","volume":"54","author":"Tr\u00f6ger","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib28","first-page":"S1","article-title":"Hepatic stellate cells revert to an inactive phenotype during regression of fibrosis","volume":"52","author":"Kisseleva","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1006\/bbrc.1996.1786","article-title":"Smooth muscle [alpha]-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production","volume":"229","author":"Kawada","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2011.12.017_bib30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/gast.2000.9354","article-title":"Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells","volume":"119","author":"Failli","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.12.017_bib31","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrm1911","article-title":"VEGF receptor signalling-in control of vascular function","volume":"7","author":"Olsson","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2011.12.017_bib32","first-page":"180","article-title":"Structure and dynamics of the fenestrae-associated cytoskeleton of rat sinusoidal endothelial cells","volume":"21","author":"Braet","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib33","doi-asserted-by":"crossref","first-page":"13635","DOI":"10.1073\/pnas.95.23.13635","article-title":"A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide","volume":"95","author":"Braet","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2011.12.017_bib34","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/hep.23767","article-title":"p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration","volume":"52","author":"Tazaki","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib35","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hep.510280405","article-title":"Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats","volume":"28","author":"Gupta","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2011.12.017_bib36","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0016-5085(99)70408-7","article-title":"Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat","volume":"117","author":"Shah","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2011.12.017_bib37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.exger.2003.07.002","article-title":"Hepatic sinusoidal pseudocapillarization with aging in the non-human primate","volume":"38","author":"Cogger","year":"2003","journal-title":"Exp Gerontol"},{"key":"10.1053\/j.gastro.2011.12.017_bib38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/path.1328","article-title":"Age-related pseudocapillarization of the human liver","volume":"200","author":"McLean","year":"2003","journal-title":"J Pathol"},{"key":"10.1053\/j.gastro.2011.12.017_bib39","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/ar.20661","article-title":"Old age and the hepatic sinusoid","volume":"291","author":"Le Couteur","year":"2008","journal-title":"Anat Rec"},{"key":"10.1053\/j.gastro.2011.12.017_bib40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/BST0350437","article-title":"Introduction to the Biochemical Society Focused Meeting on Diet and Cardiovascular Health: chylomicron remnants and their emerging roles in vascular dysfunction in atherosclerosis","volume":"35","author":"Botham","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.1053\/j.gastro.2011.12.017_bib41","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/gerona\/glq108","article-title":"Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells","volume":"65","author":"Simon-Santamaria","year":"2010","journal-title":"J Gerontol Series A Biol Sci Med Sci"},{"key":"10.1053\/j.gastro.2011.12.017_bib42","doi-asserted-by":"crossref","first-page":"G71","DOI":"10.1152\/ajpgi.00215.2010","article-title":"Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins","volume":"300","author":"Li","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2011.12.017_bib43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","article-title":"Endothelial\/pericyte interactions","volume":"97","author":"Armulik","year":"2005","journal-title":"Circ Res"},{"key":"10.1053\/j.gastro.2011.12.017_bib44","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature09522","article-title":"Pericytes regulate the blood-brain barrier","volume":"468","author":"Armulik","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.12.017_bib45","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood\u2013brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2011.12.017_bib46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0966-3274(97)80034-2","article-title":"Cell-cell interactions in vessel assembly: a model for the fundamentals of vascular remodelling","volume":"5","author":"Hirschi","year":"1997","journal-title":"Transplant Immunol"},{"key":"10.1053\/j.gastro.2011.12.017_bib47","first-page":"4","article-title":"Mechanisms of ocular angiogenesis and its molecular mediators","volume":"46","author":"Siemerink","year":"2010","journal-title":"Dev Opthalmol"},{"key":"10.1053\/j.gastro.2011.12.017_fr1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/01.RES.87.11.999","article-title":"Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide\/cGMP signaling and endothelial dysfunction","volume":"87","author":"Oelze","year":"2000","journal-title":"Circ Res"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511016994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508511016994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:39:44Z","timestamp":1762162784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508511016994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0016508511016994"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2011.12.017","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2011.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}