{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:39:56Z","timestamp":1791405596258,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002910","name":"F\u00e9d\u00e9ration Wallonie-Bruxelles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004744","name":"Innoviris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002749","name":"Belgian Federal Science Policy Office","doi-asserted-by":"publisher","award":["P6\/20"],"award-info":[{"award-number":["P6\/20"]}],"id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1053\/j.gastro.2012.08.024","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T10:16:21Z","timestamp":1345544181000},"page":"1564-1575.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":319,"title":["Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice"],"prefix":"10.1053","volume":"143","author":[{"given":"Regina","family":"Espa\u00f1ol\u2013Su\u00f1er","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Van Hul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Legry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Younes","family":"Achouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Cordi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Jacquemin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lemaigre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle A.","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2012.08.024_bib1","series-title":"Stem cells","first-page":"233","article-title":"Liver stem cells","author":"Grisham","year":"1997"},{"key":"10.1053\/j.gastro.2012.08.024_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0925-4773(02)00338-6","article-title":"The role of hepatocytes and oval cells in liver regeneration and repopulation","volume":"120","author":"Fausto","year":"2003","journal-title":"Mech Dev"},{"key":"10.1053\/j.gastro.2012.08.024_bib3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S0168-8278(02)00013-2","article-title":"Liver stem cells and model systems for liver repopulation","volume":"36","author":"Shafritz","year":"2002","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2012.08.024_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/j.gastro.2009.05.044","article-title":"Stem cells and liver regeneration","volume":"137","author":"Duncan","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.024_bib5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1600-0676.1985.tb00252.x","article-title":"The streaming liver","volume":"5","author":"Zajicek","year":"1985","journal-title":"Liver"},{"key":"10.1053\/j.gastro.2012.08.024_bib6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/hep.22791","article-title":"Locating the stem cell niche and tracing hepatocyte lineages in human liver","volume":"49","author":"Fellous","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ng.722","article-title":"Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine","volume":"43","author":"Furuyama","year":"2011","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2012.08.024_bib8","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1053\/j.gastro.2011.06.049","article-title":"Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells","volume":"141","author":"Carpentier","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.024_bib9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/hep.24398","article-title":"Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice","volume":"54","author":"Iverson","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib10","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1172\/JCI59261","article-title":"Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration","volume":"121","author":"Malato","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.024_bib11","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1172\/JCI59652","article-title":"On the origin of the liver","volume":"121","author":"Friedman","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.024_bib12","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/hep.24613","article-title":"Ductular reactions in human liver: diversity at the interface","volume":"54","author":"Gouw","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.23483","article-title":"The histogenesis of regenerative nodules in human liver cirrhosis","volume":"51","author":"Lin","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib14","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/hep.24122","article-title":"Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem\/progenitor cells in humans","volume":"53","author":"Yoon","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib15","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1101\/gad.2029411","article-title":"Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice","volume":"25","author":"Dorrell","year":"2011","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2012.08.024_bib16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1101\/gad.2027811","article-title":"Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential","volume":"25","author":"Shin","year":"2011","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2012.08.024_bib17","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1242\/dev.031369","article-title":"Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver","volume":"136","author":"Okabe","year":"2009","journal-title":"Development"},{"key":"10.1053\/j.gastro.2012.08.024_bib18","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/hep.22047","article-title":"Identification of adult hepatic progenitor cells capable of repopulating injured rat liver","volume":"47","author":"Yovchev","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1432-0436.2003.7104505.x","article-title":"Differentiation of putative hepatic stem cells derived from adult rats into mature hepatocytes in the presence of epidermal growth factor and hepatocyte growth factor","volume":"71","author":"He","year":"2003","journal-title":"Differentiation"},{"key":"10.1053\/j.gastro.2012.08.024_bib20","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/labinvest.3700474","article-title":"Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin","volume":"86","author":"Leclercq","year":"2006","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2012.08.024_bib21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev Biol"},{"key":"10.1053\/j.gastro.2012.08.024_bib22","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/hep.22820","article-title":"Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury","volume":"49","author":"Van Hul","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib23","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.ajpath.2011.06.042","article-title":"Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury","volume":"179","author":"Van Hul","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1053\/j.gastro.2012.08.024_bib24","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/hep.20178","article-title":"2-acetylaminofluorene dose-dependent differentiation of rat oval cells into hepatocytes: confocal and electron microscopic studies","volume":"39","author":"Paku","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib25","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1053\/j.gastro.2005.03.081","article-title":"Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF\/PHx in rats","volume":"128","author":"Pi","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.024_bib26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/gut.2009.182345","article-title":"Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver","volume":"59","author":"Lorenzini","year":"2010","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2012.08.024_bib27","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/dev.056499","article-title":"Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas","volume":"138","author":"Kopp","year":"2011","journal-title":"Development"},{"key":"10.1053\/j.gastro.2012.08.024_bib28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/dvg.20397","article-title":"A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs","volume":"46","author":"Means","year":"2008","journal-title":"Genesis"},{"key":"10.1053\/j.gastro.2012.08.024_bib29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0168-8278(03)00309-X","article-title":"Regeneration of hepatocyte \u2018buds' in cirrhosis from intrabiliary stem cells","volume":"39","author":"Falkowski","year":"2003","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2012.08.024_bib30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/hep.20600","article-title":"Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury","volume":"41","author":"Michalopoulos","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.cld.2010.08.003","article-title":"Hepatic progenitor cells: an update","volume":"14","author":"Roskams","year":"2010","journal-title":"Clin Liver Dis"},{"key":"10.1053\/j.gastro.2012.08.024_bib32","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/hep.23368","article-title":"Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice","volume":"51","author":"Taura","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib33","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.gastro.2010.05.005","article-title":"Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice","volume":"139","author":"Scholten","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.024_bib34","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/hep.24206","article-title":"Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis","volume":"53","author":"Chu","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.024_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nm.2667","article-title":"Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease","volume":"18","author":"Boulter","year":"2012","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2012.08.024_bib36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1172\/JCI12020","article-title":"Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients","volume":"108","author":"Stratton","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.024_bib37","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1096\/fj.02-0204fje","article-title":"Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras\/MEK\/ERK pathway","volume":"16","author":"Stratton","year":"2002","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2012.08.024_fr1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/2417","article-title":"A new logic for DNA engineering using recombination in Escherichia coli","volume":"20","author":"Zhang","year":"1998","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2012.08.024_fr2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1038\/82449","article-title":"DNA cloning by homologous recombination in Escherichia coli","volume":"18","author":"Zhang","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.gastro.2012.08.024_fr3","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1093\/nar\/gkm163","article-title":"A recombineering based approach for high-throughput conditional knockout targeting vector construction","volume":"35","author":"Chan","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2012.08.024_fr4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/gene.10023","article-title":"Codon-improved Cre recombinase (iCre) expression in the mouse","volume":"32","author":"Shimshek","year":"2002","journal-title":"Genesis"},{"key":"10.1053\/j.gastro.2012.08.024_fr5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/dvg.20664","article-title":"A mouse tool for conditional mutagenesis in ovarian granulosa cells","volume":"48","author":"Grabner","year":"2010","journal-title":"Genesis"},{"key":"10.1053\/j.gastro.2012.08.024_fr6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/geno.2000.6451","article-title":"A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA","volume":"73","author":"Lee","year":"2001","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2012.08.024_fr7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/hep.22820","article-title":"Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury","volume":"49","author":"Van Hul","year":"2009","journal-title":"Hepatology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512012449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512012449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:40:43Z","timestamp":1762162843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508512012449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0016508512012449"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.024","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}