{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:52:34Z","timestamp":1791186754375,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["08dj1400602"],"award-info":[{"award-number":["08dj1400602"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["09XD1403400"],"award-info":[{"award-number":["09XD1403400"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2012CB524902"],"award-info":[{"award-number":["2012CB524902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070681"],"award-info":[{"award-number":["81070681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81030011"],"award-info":[{"award-number":["81030011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30890043"],"award-info":[{"award-number":["30890043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1053\/j.gastro.2012.08.029","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T22:30:42Z","timestamp":1345674642000},"page":"1630-1640.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor"],"prefix":"10.1053","volume":"143","author":[{"given":"Yan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2012.08.029_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1665-2681(19)32126-X","article-title":"Cholestasis: human disease and experimental animal models","volume":"2","author":"Rodriguez-Garay","year":"2003","journal-title":"Ann Hepatol"},{"key":"10.1053\/j.gastro.2012.08.029_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jhep.2009.05.012","article-title":"New molecular insights into the mechanisms of cholestasis","volume":"51","author":"Wagner","year":"2009","journal-title":"J Hepatol"},{"key":"10.1053\/j.gastro.2012.08.029_bib3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1542\/pir.25-11-388","article-title":"Neonatal cholestasis","volume":"25","author":"Suchy","year":"2004","journal-title":"Pediatr Rev"},{"key":"10.1053\/j.gastro.2012.08.029_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1055\/s-0030-1253224","article-title":"Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy","volume":"30","author":"Pauli-Magnus","year":"2010","journal-title":"Semin Liver Dis"},{"key":"10.1053\/j.gastro.2012.08.029_bib5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1053\/j.gastro.2012.08.029_bib6","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0092-8674(00)00062-3","article-title":"Targeted disruption of the nuclear receptor FXR\/BAR impairs bile acid and lipid homeostasis","volume":"102","author":"Sinal","year":"2000","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2012.08.029_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2012.08.029_bib8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1534-5807(02)00187-9","article-title":"Redundant pathways for negative feedback regulation of bile acid production","volume":"2","author":"Wang","year":"2002","journal-title":"Dev Cell"},{"key":"10.1053\/j.gastro.2012.08.029_bib9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1534-5807(02)00154-5","article-title":"Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis","volume":"2","author":"Kerr","year":"2002","journal-title":"Dev Cell"},{"key":"10.1053\/j.gastro.2012.08.029_bib10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI42846","article-title":"Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis","volume":"121","author":"Anakk","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.029_bib11","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1038\/sj.emboj.7600728","article-title":"Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP","volume":"24","author":"Boulias","year":"2005","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2012.08.029_bib12","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI18945","article-title":"Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis","volume":"112","author":"Liu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.029_bib13","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/hep.21160","article-title":"Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulaton","volume":"43","author":"Demeilliers","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.029_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2007.05.015","article-title":"Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy","volume":"133","author":"Van Mil","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.029_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molmed.2007.06.001","article-title":"Targeting farnesoid X receptor for liver and metabolic disorders","volume":"13","author":"Fiorucci","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.gastro.2012.08.029_bib16","first-page":"S13","article-title":"Pharmacodynamics of glucocorticoids","volume":"29","author":"Strehl","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1053\/j.gastro.2012.08.029_bib17","first-page":"S104","article-title":"The safety of low-dose glucocorticoids in rheumatic diseases","volume":"29","author":"Hwang","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"10.1053\/j.gastro.2012.08.029_bib18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/cs0960513","article-title":"Glucocorticoids and insulin resistance: old hormones, new targets","volume":"96","author":"Andrews","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"10.1053\/j.gastro.2012.08.029_bib19","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cmet.2008.08.001","article-title":"The glucocorticoid receptor controls hepatic dyslipidemia through Hes1","volume":"8","author":"Lemke","year":"2008","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2012.08.029_bib20","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02774711","article-title":"Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis","volume":"20","author":"Yamanishi","year":"1985","journal-title":"Gastroenterol Jpn"},{"key":"10.1053\/j.gastro.2012.08.029_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000084525","article-title":"Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence","volume":"71","author":"V\u00f6lzke","year":"2005","journal-title":"Digestion"},{"key":"10.1053\/j.gastro.2012.08.029_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2007.05.015","article-title":"Glucocorticoids, metabolism and metabolic diseases","volume":"275","author":"Vegiopoulos","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/j.gastro.2012.08.029_bib23","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.pgen.0010016","article-title":"Glucocorticoid receptor-dependent gene regulatory networks","volume":"1","author":"Phuc Le","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2012.08.029_bib24","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/me.2003-0283","article-title":"Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus","volume":"18","author":"Opherk","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.1053\/j.gastro.2012.08.029_bib25","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2337\/diabetes.54.6.1846","article-title":"Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism","volume":"54","author":"Watts","year":"2005","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2012.08.029_bib26","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1101\/gad.827900","article-title":"The glucocorticoid receptor inhibits NF-kappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain","volume":"14","author":"Nissen","year":"2000","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2012.08.029_bib27","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1101\/gad.426007","article-title":"Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression","volume":"21","author":"Engblom","year":"2007","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2012.08.029_bib28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanism for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1053\/j.gastro.2012.08.029_bib29","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1210\/er.2009-0013","article-title":"Cross talk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases","volume":"30","author":"Beck","year":"2009","journal-title":"Endocr Rev"},{"key":"10.1053\/j.gastro.2012.08.029_bib30","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jc.2003-030871","article-title":"Diagnosis and complications of Cushing's syndrome: a consensus statement","volume":"88","author":"Arnaldi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.gastro.2012.08.029_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/S1807-59322010000100003","article-title":"Screening for Cushing's syndrome in obese patients","volume":"65","author":"Tiryakioglu","year":"2010","journal-title":"Clinics (Sao Paulo)"},{"key":"10.1053\/j.gastro.2012.08.029_bib32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2337\/diabetes.54.1.32","article-title":"Increased glucocorticoid receptor and 11\u03b2-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db\/db mice","volume":"54","author":"Liu","year":"2005","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2012.08.029_bib33","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ijo.2010.34","article-title":"Chronic exposure to a high-fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats","volume":"34","author":"Shin","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"10.1053\/j.gastro.2012.08.029_bib34","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0022-2275(20)37603-3","volume":"37","author":"Wang","year":"1996","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2012.08.029_bib35","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/0016-5085(95)90585-5","article-title":"Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids","volume":"109","author":"Sokol","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.029_bib36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1248\/bpb.32.172","article-title":"Bile acid induced elevated oxidative stress in the absence of farnesoid X receptor","volume":"32","author":"Nomoto","year":"2009","journal-title":"Bio Pharm Bull"},{"key":"10.1053\/j.gastro.2012.08.029_bib37","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/nm1138","article-title":"Prevention of cholesterol gallstone disease by FXR agonists in a mouse model","volume":"10","author":"Moschetta","year":"2004","journal-title":"Nat Med"},{"key":"10.1053\/j.gastro.2012.08.029_bib38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0300-483X(01)00456-5","article-title":"Regulation of biliary drug efflux pump expression by hormones and xenobiotics","volume":"167","author":"Fardel","year":"2001","journal-title":"Toxicology"},{"key":"10.1053\/j.gastro.2012.08.029_bib39","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.bcp.2007.08.014","article-title":"Regulation of hepatic bile acid transporters Ntcp and Bsep expression","volume":"74","author":"Cheng","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/j.gastro.2012.08.029_bib40","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10111","article-title":"A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects","volume":"474","author":"Lee","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2012.08.029_bib41","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1053\/j.gastro.2011.02.055","article-title":"PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts","volume":"140","author":"He","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.029_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1055\/s-2007-1000781","article-title":"Stress induced tyrosine aminotransferase activity via glucocorticoid receptor","volume":"26","author":"Alexandrova","year":"1994","journal-title":"Horm Metab Res"},{"key":"10.1053\/j.gastro.2012.08.029_bib43","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1021\/bi800472w","article-title":"Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression","volume":"47","author":"Tao","year":"2008","journal-title":"Biochemistry"},{"key":"10.1053\/j.gastro.2012.08.029_bib44","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1172\/JCI25604","article-title":"Farnesoid X receptor is essential for normal glucose homeostasis","volume":"116","author":"Ma","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.029_bib45","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1073\/pnas.0506982103","article-title":"Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2012.08.029_bib46","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.addr.2010.09.016","article-title":"Nuclear receptor coregulators as a new paradigm for therapeutic targeting","volume":"62","author":"Hsia","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1053\/j.gastro.2012.08.029_bib47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1210\/er.2007-0012","article-title":"Nuclear receptor coregulators and human disease","volume":"28","author":"Lonard","year":"2007","journal-title":"Endocr Rev"},{"key":"10.1053\/j.gastro.2012.08.029_bib48","doi-asserted-by":"crossref","first-page":"51085","DOI":"10.1074\/jbc.M308321200","article-title":"Farnesoid X receptor activates transcription of the phospholipid pump MDR3","volume":"278","author":"Huang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2012.08.029_bib49","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1101\/gad.1444606","article-title":"Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease","volume":"20","author":"Bilodeau","year":"2006","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2012.08.029_bib50","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/bj2620341","article-title":"Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase","volume":"262","author":"Princen","year":"1989","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2012.08.029_bib51","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1016\/S0022-2275(20)39723-6","article-title":"Hormonal regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7)","volume":"36","author":"Crestani","year":"1995","journal-title":"J Lipid Res"},{"key":"10.1053\/j.gastro.2012.08.029_bib52","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hep.23721","article-title":"Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice","volume":"52","author":"Li","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2012.08.029_bib53","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1093\/nar\/gkl875","article-title":"ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases","volume":"34","author":"Lopez-Garcia","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2012.08.029_bib54","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2011.03.050","article-title":"An ADIOL-ER\u03b2-CtBP transrepression pathway negatively regulates microglia-mediated inflammation","volume":"145","author":"Saijo","year":"2011","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2012.08.029_bib55","doi-asserted-by":"crossref","first-page":"14323","DOI":"10.1073\/pnas.011283598","article-title":"Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP","volume":"97","author":"Zhang","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2012.08.029_bib56","doi-asserted-by":"crossref","first-page":"8549","DOI":"10.1074\/jbc.273.15.8549","article-title":"Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif","volume":"273","author":"Schaeper","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2012.08.029_bib57","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1128\/MCB.00445-06","article-title":"Role of the C-terminal binding protein PXDLS motif binding cleft in protein interactions and transcriptional repression","volume":"26","author":"Quinlan","year":"2006","journal-title":"Mol Cell Biol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512012528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512012528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:02:58Z","timestamp":1758034978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508512012528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0016508512012528"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.029","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717955553.793467069","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}