{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:26:13Z","timestamp":1790403973791,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK092421"],"award-info":[{"award-number":["R01 DK092421"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1053\/j.gastro.2012.08.051","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T14:56:23Z","timestamp":1348757783000},"page":"1670-1680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Aryl Hydrocarbon Receptor Regulates Pancreatic IL-22 Production and Protects Mice From Acute Pancreatitis"],"prefix":"10.1053","volume":"143","author":[{"given":"Jing","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.C.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Habtezion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2012.08.051_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1159\/000212097","article-title":"Prediction of mortality in acute pancreatitis: a systematic review of the published evidence","volume":"9","author":"Gravante","year":"2009","journal-title":"Pancreatology"},{"key":"10.1053\/j.gastro.2012.08.051_bib2","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1053\/j.gastro.2009.04.023","article-title":"New insights into the mechanisms of pancreatitis","volume":"136","author":"Gaisano","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.051_bib3","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Liang","year":"2006","journal-title":"J Exp Med"},{"key":"10.1053\/j.gastro.2012.08.051_bib4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2012.08.051_bib5","doi-asserted-by":"crossref","first-page":"31335","DOI":"10.1074\/jbc.M005304200","article-title":"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R","volume":"275","author":"Xie","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2012.08.051_bib6","doi-asserted-by":"crossref","first-page":"33676","DOI":"10.1074\/jbc.M204204200","article-title":"Interleukin-22 (IL-22) activates the JAK\/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line","volume":"277","author":"Lejeune","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/j.gastro.2012.08.051_bib7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.intimp.2004.01.016","article-title":"IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues","volume":"4","author":"Gurney","year":"2004","journal-title":"Int Immunopharmacol"},{"key":"10.1053\/j.gastro.2012.08.051_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2012.08.051_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1053\/j.gastro.2011.04.007","article-title":"Aryl hydrocarbon receptorinduced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract","volume":"141","author":"Monteleone","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.051_bib10","doi-asserted-by":"crossref","first-page":"5943","DOI":"10.1073\/pnas.0911755107","article-title":"Notch signaling drives IL-22 secretion in CD4b T cells by stimulating the aryl hydrocarbon receptor","volume":"107","author":"Alam","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2012.08.051_bib11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/gut.2010.217208","article-title":"Panhematin provides a therapeutic benefit in experimental pancreatitis","volume":"60","author":"Habtezion","year":"2011","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2012.08.051_bib12","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1172\/JCI24912","article-title":"Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction","volume":"115","author":"Nakamichi","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.gastro.2012.08.051_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","article-title":"Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKd independent of hydroxylase activity","volume":"138","author":"Xue","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.051_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0076-6879(90)92076-P","article-title":"Dispersed pancreatic acinar cells and pancreatic acini","volume":"192","author":"Menozzi","year":"1990","journal-title":"Methods Enzymol"},{"key":"10.1053\/j.gastro.2012.08.051_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-0378(96)00986-2","article-title":"The lymphocyte and macrophage profile in the pancreas and spleen of NOD mice: percentage of interleukin-2 and prolactin receptors on immunocompetent cell subsets","volume":"32","author":"Hawkins","year":"1996","journal-title":"J Reprod Immunol"},{"key":"10.1053\/j.gastro.2012.08.051_bib16","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/107999001317205178","article-title":"Acinar cells of the pancreas are a target of interleukin-22","volume":"21","author":"Aggarwal","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"10.1053\/j.gastro.2012.08.051_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/jsre.2002.6387","article-title":"Coordinate regulation of secretory stress proteins (PSP\/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis","volume":"105","author":"Graf","year":"2002","journal-title":"J Surg Res"},{"key":"10.1053\/j.gastro.2012.08.051_bib18","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/gut.2006.116087","article-title":"Experimental acute pancreatitis in PAP\/HIP knock-out mice","volume":"56","author":"Gironella","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2012.08.051_bib19","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/MPA.0b013e31815f3933","article-title":"Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis","volume":"36","author":"Lin","year":"2008","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2012.08.051_bib20","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.immuni.2010.12.009","article-title":"CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut","volume":"34","author":"Sonnenberg","year":"2011","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2012.08.051_bib21","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1124\/mol.105.021832","article-title":"Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor","volume":"69","author":"Kim","year":"2006","journal-title":"Mol Pharmacol"},{"key":"10.1053\/j.gastro.2012.08.051_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0014-5793(99)01649-X","article-title":"Different induction of gulonolactone oxidase in aromatic hydrocarbon-responsive or -unresponsive mouse strains","volume":"463","author":"Braun","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2012.08.051_bib23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/abbi.1998.0814","article-title":"Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin","volume":"357","author":"Phelan","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/j.gastro.2012.08.051_bib24","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1136\/gut.2009.186692","article-title":"A novel role for leucocytes in determining the severity of acute pancreatitis","volume":"58","author":"Mayerle","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2012.08.051_bib25","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7150\/ijbs.3967","article-title":"Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway","volume":"8","author":"Feng","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1053\/j.gastro.2012.08.051_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/intimm\/dxr001","article-title":"Recent advances in IL-22 biology","volume":"23","author":"Zenewicz","year":"2011","journal-title":"Int Immunol"},{"key":"10.1053\/j.gastro.2012.08.051_bib27","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0016-5085(00)70265-4","article-title":"CD4(+)T cells play an important role in acute experimental pancreatitis in mice","volume":"118","author":"Demols","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2012.08.051_bib28","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512014448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508512014448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:40:17Z","timestamp":1762162817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508512014448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0016508512014448"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.051","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aryl Hydrocarbon Receptor Regulates Pancreatic IL-22 Production and Protects Mice From Acute Pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2012.08.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}