{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:21Z","timestamp":1787004801324,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1053\/j.gastro.2013.06.038","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T00:15:45Z","timestamp":1371860145000},"page":"730-739","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Central Obesity in Asymptomatic Volunteers Is Associated With Increased Intrasphincteric Acid Reflux and Lengthening of the Cardiac Mucosa"],"prefix":"10.1053","volume":"145","author":[{"given":"Elaine V.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Derakhshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela A.","family":"Wirz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Yeh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Paul","family":"Seenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Hanvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Kelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Going","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.L.","family":"McColl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2013.06.038_bib1","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1158\/1055-9965.EPI-09-0265","article-title":"Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition","volume":"18","author":"Steffen","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2013.06.038_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7326\/0003-4819-143-3-200508020-00006","article-title":"Meta-analysis: Obesity and the risk for gastroesophageal reflux disease and its complications","volume":"143","author":"Hampel","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2013.06.038_bib3","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1572-0241.2008.01909.x","article-title":"Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with hiatal hernia, body mass index, and esophageal acid exposure","volume":"103","author":"de Vries","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.06.038_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1053\/j.gastro.2005.12.016","article-title":"Obesity: a challenge to\u00a0esophagogastric junction integrity","volume":"130","author":"Pandolfino","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.06.038_bib5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/gutjnl-2011-300633","article-title":"Mechanism of association between BMI and dysfunction of the gastro-oesophageal barrier in patients with normal endoscopy","volume":"61","author":"Derakhshan","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.06.038_bib6","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/bjs.7072","article-title":"Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma","volume":"97","author":"Howard","year":"2010","journal-title":"Br J Surg"},{"key":"10.1053\/j.gastro.2013.06.038_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/aje\/kwr117","article-title":"Population attributable fractions of adenocarcinoma of the esophagus and gastroesophageal junction","volume":"174","author":"Olsen","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2013.06.038_bib8","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/ajg.2009.159","article-title":"Receipt of previous diagnoses and endoscopy and outcome from esophageal adenocarcinoma: a population-based study with temporal trends","volume":"104","author":"Cooper","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.06.038_bib9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1053\/gast.2002.31879","article-title":"Surveillance and survival in Barrett's adenocarcinomas: a population-based study","volume":"122","author":"Corley","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.06.038_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/ije\/29.4.645","article-title":"Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries","volume":"29","author":"Botterweck","year":"2000","journal-title":"Int J Epidemiol"},{"key":"10.1053\/j.gastro.2013.06.038_bib11","first-page":"669","article-title":"Trends in incidence of oesophageal and stomach cancer subtypes in Europe","volume":"22","author":"Steevens","year":"2010","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2013.06.038_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1442-2050.2004.00371.x","article-title":"Cancer of the esophagus and gastric cardia: recent advances","volume":"17","author":"Tytgat","year":"2004","journal-title":"Dis Esophagus"},{"key":"10.1053\/j.gastro.2013.06.038_bib13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/gut.2006.114504","article-title":"Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status","volume":"56","author":"Hansen","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.06.038_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/gut.2007.137364","article-title":"Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer","volume":"57","author":"Derakhshan","year":"2008","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.06.038_bib15","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1056\/NEJM199903183401101","article-title":"Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma","volume":"340","author":"Lagergren","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2013.06.038_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00000478-200102000-00013","article-title":"Carditis: a manifestation of gastroesophageal reflux disease","volume":"25","author":"Der","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2013.06.038_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1572-0241.1999.00768.x","article-title":"Barrett's esophagus: the long and the short of it","volume":"94","author":"Nandurkar","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.06.038_bib18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/gut.2006.109421","article-title":"Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket","volume":"57","author":"Clarke","year":"2008","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.06.038_bib19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/00365521.2012.658854","article-title":"Effect of nitrite delivered in saliva on postprandial gastro-esophageal function","volume":"47","author":"Seenan","year":"2012","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.06.038_bib20","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1097\/00000478-200208000-00008","article-title":"Morphology of the cardia and significance of carditis in pediatric patients","volume":"26","author":"Glickman","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2013.06.038_bib21","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/PAS.0b013e3181f06990","article-title":"The histologic squamo-oxyntic gap: an accurate and reproducible diagnostic marker of gastroesophageal reflux disease","volume":"34","author":"Chandrasoma","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2013.06.038_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1365-2559.2005.02088.x","article-title":"Controversies of the cardiac mucosa and Barrett's oesophagus","volume":"46","author":"Chandrasoma","year":"2005","journal-title":"Histopathology"},{"key":"10.1053\/j.gastro.2013.06.038_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/ajcn\/63.1.4","article-title":"Predicting body composition by densitometry from simple anthropometric measurements","volume":"63","author":"Lean","year":"1996","journal-title":"Am J Clin Nutr"},{"key":"10.1053\/j.gastro.2013.06.038_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2982.2011.01817.x","article-title":"High-resolution esophageal manometry: addressing thermal drift of the manoscan system","volume":"24","author":"Robertson","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2013.06.038_bib25","first-page":"375","article-title":"Morphometric analysis of the relationships between intervertebral disc and vertebral body heights: an anatomical and radiographic study of the human thoracic spine","volume":"219","author":"Kunkel","year":"2011","journal-title":"J\u00a0Anat"},{"key":"10.1053\/j.gastro.2013.06.038_bib26","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1111\/j.1572-0241.1999.01513.x","article-title":"Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastroesophageal reflux disease. The Central Finland Endoscopy Study Group","volume":"94","author":"Voutilainen","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.06.038_bib27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-2036.2003.01702.x","article-title":"Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal relfux disease","volume":"18","author":"Cicala","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2013.06.038_bib28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.humpath.2008.06.008","article-title":"Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma","volume":"40","author":"Takubo","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1053\/j.gastro.2013.06.038_bib29","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1080\/00365520701420735","article-title":"Barrett's oesophagus: intestinal metaplasia is not essential for cancer risk","volume":"42","author":"Kelty","year":"2007","journal-title":"Scand J Gastroenterol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513009402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513009402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:40:47Z","timestamp":1762162847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508513009402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0016508513009402"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2013.06.038","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central Obesity in Asymptomatic Volunteers Is Associated With Increased Intrasphincteric Acid Reflux and Lengthening of the Cardiac Mucosa","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2013.06.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}