{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:07:48Z","timestamp":1790737668812,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK084567"],"award-info":[{"award-number":["P30DK084567"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005979","name":"Lustgarten Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005979","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1053\/j.gastro.2013.07.049","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T22:00:25Z","timestamp":1375394425000},"page":"1098-1109.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":187,"title":["Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor"],"prefix":"10.1053","volume":"145","author":[{"given":"Stephen J.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven N.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joema Felipe","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Kipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Klebig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Winters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Szabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce W.","family":"Eckloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria M.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Gibbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"McWilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Vasmatzis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J.","family":"Couch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2013.07.049_bib1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MPA.0b013e318163a329","article-title":"Changing incidence of pancreatic neoplasms: a 16-year review of statewide tumor registry","volume":"37","author":"Fitzgerald","year":"2008","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2013.07.049_bib2","first-page":"91","article-title":"Pancreas cancer (non-endocrine)","volume":"8","author":"Cubilla","year":"2008","journal-title":"Clin Bull"},{"key":"10.1053\/j.gastro.2013.07.049_bib3","first-page":"225","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2013.07.049_bib4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00423-004-0476-9","article-title":"Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist?","volume":"390","author":"Smeenk","year":"2005","journal-title":"Langenbecks Arch Surg"},{"key":"10.1053\/j.gastro.2013.07.049_bib5","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S1091-255X(00)80105-5","article-title":"Resected adenocarcinoma of\u00a0the\u00a0pancreas-616 patients: results, outcomes, and prognostic indicators","volume":"4","author":"Sohn","year":"2000","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2013.07.049_bib6","series-title":"Ductal adenocarcinoma of the pancreas, WHO classification of tumors: pathology and genetics of the digestive system","author":"Kloppel","year":"2000"},{"key":"10.1053\/j.gastro.2013.07.049_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/01.pas.0000126675.59108.80","article-title":"An illustrated consensus on the classification of PanIN and intraductal papillary mucinous neoplasms","volume":"28","author":"Hruban","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2013.07.049_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Hingorani","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2013.07.049_bib9","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1136\/gut.2005.083063","article-title":"Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins","volume":"55","author":"Kim","year":"2006","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.07.049_bib10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/dnares\/dss021","article-title":"Mate-pair sequencing of WGA DNA following LCM of prostate cancer","volume":"19","author":"Murphy","year":"2012","journal-title":"DNA Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib11","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a\u00a0MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/bioinformatics\/btr612","article-title":"TREAT: a bioinformatics tool for variant annotations and visualizations in targeted and exome sequencing data","volume":"28","author":"Asmann","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2013.07.049_bib13","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/bioinformatics\/btr665","article-title":"SomaticSniper: identification of somatic point mutations in whole genome sequencing data","volume":"28","author":"Larson","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2013.07.049_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.genom.7.080505.115630","article-title":"Predicting the effects of amino-acid substitutions on protein function","volume":"7","author":"Ng","year":"2006","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"10.1053\/j.gastro.2013.07.049_bib16","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1093\/nar\/gkq045","article-title":"Bayesian: model-based gene set analysis of genome-scale data","volume":"38","author":"Bauer","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib17","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","volume":"321","author":"Jones","year":"2008","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.07.049_bib18","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1158\/0008-5472.CAN-10-0192","article-title":"Genomic and biological characterization of exon 4 KRAS mutations in human cancer","volume":"70","author":"Janakiraman","year":"2010","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/BJ20110240","article-title":"Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP","volume":"440","author":"Mukherjee","year":"2011","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2013.07.049_bib20","first-page":"41","article-title":"ATM mutations in patients with hereditary pancreatic cancer cancer","volume":"2","author":"Roberts","year":"2012","journal-title":"Discovery"},{"key":"10.1053\/j.gastro.2013.07.049_bib21","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.yexcr.2008.01.013","article-title":"A\u00a0cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95","volume":"314","author":"Sugiura","year":"2008","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2013.07.049_bib22","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1096\/fj.12-205419","article-title":"Loss of giant obscurins promotes breast epithelial cell survival through apoptotic resistance","volume":"26","author":"Perry","year":"2012","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2013.07.049_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/1471-2407-10-503","article-title":"Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer","volume":"10","author":"Waalkes","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1053\/j.gastro.2013.07.049_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0888-7543(89)90344-3","article-title":"Mapping and characterization of an X-linked processed gene related to MYCL1","volume":"4","author":"Morton","year":"1989","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2013.07.049_bib25","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nrendo.2011.142","article-title":"Molecular genetics and diagnosis of thyroid cancer","volume":"7","author":"Nikiforov","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"10.1053\/j.gastro.2013.07.049_bib26","doi-asserted-by":"crossref","first-page":"9040","DOI":"10.1073\/pnas.94.17.9040","article-title":"A\u00a0thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein","volume":"94","author":"Chang","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.07.049_bib27","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/j.1742-4658.2010.07606.x","article-title":"Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing","volume":"277","author":"Ansari","year":"2010","journal-title":"FEBS J"},{"key":"10.1053\/j.gastro.2013.07.049_bib28","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/gb-2012-13-9-r52","article-title":"Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3","volume":"13","author":"Frietz","year":"2012","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2013.07.049_bib29","doi-asserted-by":"crossref","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","volume":"3","author":"Wu","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1053\/j.gastro.2013.07.049_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nrc2251","article-title":"CHK2 kinase: cancer susceptibility and cancer therapy- two sides of the same coin?","volume":"7","author":"Antoni","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2013.07.049_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature11547","article-title":"Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes","volume":"491","author":"Biankin","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.07.049_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10549-009-0500-4","article-title":"Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma","volume":"121","author":"Kamal","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1053\/j.gastro.2013.07.049_bib33","first-page":"1491","article-title":"Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment","volume":"31","author":"Adamsen","year":"2007","journal-title":"Int J\u00a0Oncol"},{"key":"10.1053\/j.gastro.2013.07.049_bib34","doi-asserted-by":"crossref","first-page":"E451","DOI":"10.1002\/humu.20927","article-title":"Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes","volume":"30","author":"Bleeker","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1053\/j.gastro.2013.07.049_bib35","doi-asserted-by":"crossref","first-page":"e46887","DOI":"10.1371\/journal.pone.0046887","article-title":"Insights into pancreatic cancer etiology from pathway analysis of genome-wide association study data","volume":"7","author":"Wei","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2013.07.049_bib36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00000658-200007000-00011","article-title":"Disruption of TGFbeta signaling pathways in human pancreatic cancer cells","volume":"232","author":"Simeone","year":"2000","journal-title":"Ann Surg"},{"key":"10.1053\/j.gastro.2013.07.049_bib37","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1136\/gut.2005.083063","article-title":"Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins","volume":"55","author":"Kim","year":"2006","journal-title":"Gut"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513011396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513011396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:41:12Z","timestamp":1762162872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508513011396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0016508513011396"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2013.07.049","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2013.07.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}