{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:51:23Z","timestamp":1780617083281,"version":"3.54.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 DK071626"],"award-info":[{"award-number":["K08 DK071626"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 DK073451"],"award-info":[{"award-number":["K23 DK073451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 DK064539"],"award-info":[{"award-number":["P50 DK064539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK048351"],"award-info":[{"award-number":["R01 DK048351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK07180-34"],"award-info":[{"award-number":["T32 DK07180-34"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1053\/j.gastro.2013.08.016","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:18:53Z","timestamp":1376439533000},"page":"1253-1261.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Impaired Emotional Learning and Involvement of the Corticotropin-Releasing Factor Signaling System in Patients With Irritable Bowel Syndrome"],"prefix":"10.1053","volume":"145","author":[{"given":"Jennifer S.","family":"Labus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine S.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Bueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Ebrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Tillisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Stains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Dukes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Kelleher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Naliboff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fanselow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2013.08.016_bib1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.08.016_bib2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/j.gastro.2011.11.022","article-title":"Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome","volume":"142","author":"Larsson","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.08.016_bib3","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1053\/j.gastro.2005.02.068","article-title":"Brain response to visceral aversive conditioning: a functional magnetic resonance imaging study","volume":"128","author":"Yaguez","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.08.016_bib4","first-page":"22","article-title":"Fear conditioning in an abdominal pain model: neural mechanisms of associative learning and extinction in healthy subjects","volume":"24","author":"Elsenbruch","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2013.08.016_bib5","doi-asserted-by":"crossref","first-page":"G519","DOI":"10.1152\/ajpgi.2001.280.4.G519","article-title":"Stress and the gastrointestinal tract\u2014V. Stress and irritable bowel syndrome","volume":"280","author":"Mayer","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2013.08.016_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2009.83","article-title":"The neurocircuitry of fear, stress, and anxiety disorders","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2013.08.016_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.psych.121208.131631","article-title":"Fear extinction as a model for translational neuroscience: ten years of progress","volume":"63","author":"Milad","year":"2012","journal-title":"Annu Rev Psychol"},{"key":"10.1053\/j.gastro.2013.08.016_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.biopsych.2006.06.004","article-title":"Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research\u2014past, present, and future","volume":"60","author":"Rauch","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.neuron.2004.08.042","article-title":"Extinction learning in humans: role of the amygdala and vmPFC","volume":"43","author":"Phelps","year":"2004","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2013.08.016_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/sj.npp.1301555","article-title":"Neural mechanisms of extinction learning and retrieval","volume":"33","author":"Quirk","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1053\/j.gastro.2013.08.016_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-0173(90)90012-D","article-title":"Physiological and behavioral-responses to corticotropin-releasing factor administration\u2014is Crf a mediator of anxiety or stress responses","volume":"15","author":"Dunn","year":"1990","journal-title":"Brain Res Rev"},{"key":"10.1053\/j.gastro.2013.08.016_bib12","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1126\/science.6267699","article-title":"Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin","volume":"213","author":"Vale","year":"1981","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.08.016_bib13","first-page":"13","article-title":"Neurobiology of posttraumatic stress disorder","volume":"14","author":"Heim","year":"2009","journal-title":"CNS Spectrums"},{"key":"10.1053\/j.gastro.2013.08.016_bib14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1017\/S1092852900016709","article-title":"The potential role of a corticotropin-releasing factor receptor-1 antagonist in psychiatric disorders","volume":"13","author":"Stahl","year":"2008","journal-title":"CNS Spectrums"},{"key":"10.1053\/j.gastro.2013.08.016_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11894-009-0040-4","article-title":"A\u00a0role for corticotropin-releasing factor in functional gastrointestinal disorders","volume":"11","author":"Tach\u00e9","year":"2009","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1053\/j.gastro.2013.08.016_bib16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00535-006-1942-7","article-title":"Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation","volume":"42","author":"Fukudo","year":"2007","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1053\/j.gastro.2013.08.016_bib17","doi-asserted-by":"crossref","first-page":"12491","DOI":"10.1523\/JNEUROSCI.1860-11.2011","article-title":"Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain","volume":"31","author":"Hubbard","year":"2011","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2013.08.016_bib18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ejim.2006.07.011","article-title":"Post-traumatic stress disorder and other co-morbidities in a sample population of patients with irritable bowel syndrome","volume":"17","author":"Cohen","year":"2006","journal-title":"Eur J Intern Med"},{"key":"10.1053\/j.gastro.2013.08.016_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4088\/JCP.v57n1204","article-title":"Comorbidity of posttraumatic stress disorder and irritable bowel syndrome","volume":"57","author":"Irwin","year":"1996","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.pharmthera.2010.08.011","article-title":"Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: evidence from animal models","volume":"128","author":"Kehne","year":"2010","journal-title":"Pharmacol Ther"},{"issue":"Suppl 20","key":"10.1053\/j.gastro.2013.08.016_bib21","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J\u00a0Clin Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib22","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/jm800744m","article-title":"Synthesis and pharmacological characterization of novel druglike corticotropin-releasing factor 1 antagonists","volume":"51","author":"Di Fabio","year":"2008","journal-title":"J\u00a0Med Chem"},{"key":"10.1053\/j.gastro.2013.08.016_bib23","first-page":"84","article-title":"A\u00a0randomised double blind placebo (PLA) controlled crossover study to evaluate the efficacy and safety of the corticotrophin releasing factor 1 (CRF1) receptor antagonist (RA) GW876008 in irritable bowel syndrome (IBS) patients (Pts)","volume":"21","author":"Dukes","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2013.08.016_bib24","first-page":"85","article-title":"The selective CRF-1 receptor antagonist GW876008 attenuates stress induced rectal hypersensitivity in patients with irritable bowel syndrome (IBS)","volume":"21","author":"Thoua","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2013.08.016_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0959-4388(00)00078-7","article-title":"Classical fear conditioning in functional neuroimaging","volume":"10","author":"Buchel","year":"2000","journal-title":"Curr Opin Neurobiol"},{"key":"10.1053\/j.gastro.2013.08.016_bib26","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1523\/JNEUROSCI.19-24-10869.1999","article-title":"Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging","volume":"19","author":"Buchel","year":"1999","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2013.08.016_bib27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.neuron.2008.06.029","article-title":"Neural circuitry underlying the regulation of conditioned fear and its relation to extinction","volume":"59","author":"Delgado","year":"2008","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2013.08.016_bib28","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.biopsych.2003.11.008","article-title":"Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents","volume":"55","author":"May","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib29","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/cercor\/bhp155","article-title":"Uncertainty during anticipation modulates neural responses to aversion in human insula and amygdala","volume":"20","author":"Sarinopoulos","year":"2010","journal-title":"Cereb Cortex"},{"key":"10.1053\/j.gastro.2013.08.016_bib30","first-page":"4","article-title":"Human fear conditioning and extinction in neuroimaging: a systematic review","author":"Sehlmeyer","year":"2009","journal-title":"Plos One"},{"key":"10.1053\/j.gastro.2013.08.016_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.biopsych.2006.03.042","article-title":"An insular view of anxiety","volume":"60","author":"Paulus","year":"2006","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1523\/JNEUROSCI.2500-07.2008","article-title":"Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome","volume":"28","author":"Berman","year":"2008","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2013.08.016_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1212\/01.wnl.0000295509.30630.10","article-title":"Cortical thinning in IBS: implications for homeostatic, attention, and pain processing","volume":"70","author":"Davis","year":"2008","journal-title":"Neurology"},{"issue":"Suppl","key":"10.1053\/j.gastro.2013.08.016_bib34","doi-asserted-by":"crossref","first-page":"S547","DOI":"10.1016\/S0016-5085(12)62102-7","article-title":"Cortical thinning in female patients with irritable bowel syndrome","volume":"142","author":"Jiang","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.08.016_bib35","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2006.10.011","article-title":"Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert","volume":"62","author":"Milad","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib36","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1053\/j.gastro.2013.08.016_bib37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1364-6613(03)00197-9","article-title":"Persistent activity in the prefrontal cortex during working memory","volume":"7","author":"Curtis","year":"2003","journal-title":"Trends Cogn Sci"},{"key":"10.1053\/j.gastro.2013.08.016_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/026999398379646","article-title":"Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition","volume":"12","author":"Drevets","year":"1998","journal-title":"Cognition Emotion"},{"key":"10.1053\/j.gastro.2013.08.016_bib39","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1126\/science.288.5472.1835","article-title":"Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control","volume":"288","author":"MacDonald","year":"2000","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.08.016_bib40","first-page":"119S","article-title":"Neural correlates of sexual abuse-related PTSD","volume":"45","author":"Bremner","year":"1999","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib41","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1176\/ajp.156.11.1787","article-title":"Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder","volume":"156","author":"Bremner","year":"1999","journal-title":"Am J Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/scnp.2001.21837","article-title":"Prefrontal-subcortical and limbic circuit mediation of major depressive disorder","volume":"6","author":"Brody","year":"2001","journal-title":"Semin Clin Neuropsychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib43","doi-asserted-by":"crossref","first-page":"125S","DOI":"10.1016\/S0006-3223(00)00680-6","article-title":"Interactive effects in the anterior cingulate of sadness and selective attention: a pet study","volume":"47","author":"Liotti","year":"2000","journal-title":"Biol Psychiatry"},{"key":"10.1053\/j.gastro.2013.08.016_bib44","first-page":"S79","article-title":"Investigating the emotions behind investment decisions: fMRI evidence that subliminal affective cues can empty your wallet","volume":"47","author":"Hall","year":"2010","journal-title":"Psychophysiology"},{"key":"10.1053\/j.gastro.2013.08.016_bib45","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1053\/j.gastro.2010.06.054","article-title":"Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli","volume":"139","author":"Elsenbruch","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.08.016_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(77)90377-8","article-title":"Ascending projections of locus coeruleus in rat .1. Axonal-transport in central noradrenaline neurons","volume":"127","author":"Jones","year":"1977","journal-title":"Brain Res"},{"key":"10.1053\/j.gastro.2013.08.016_bib47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0306-4522(86)90155-7","article-title":"Efferent projections of nucleus locus-coeruleus\u2014topographic organization of cells of origin demonstrated by 3-dimensional reconstruction","volume":"18","author":"Loughlin","year":"1986","journal-title":"Neuroscience"},{"key":"10.1053\/j.gastro.2013.08.016_bib48","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1073\/pnas.83.6.1921","article-title":"Distribution of corticotropin-releasing factor receptors in primate brain","volume":"83","author":"Millan","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.08.016_bib49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<365::AID-CNE5>3.0.CO;2-N","article-title":"Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain","volume":"408","author":"Sanchez","year":"1999","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2013.08.016_bib50","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1097\/PSY.0b013e318186d858","article-title":"Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat","volume":"70","author":"Naliboff","year":"2008","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2013.08.016_bib51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.biopsycho.2010.02.012","article-title":"Sex-related differences in prepulse inhibition of startle in irritable bowel syndrome (IBS)","volume":"84","author":"Kilpatrick","year":"2010","journal-title":"Biol Psychol"},{"key":"10.1053\/j.gastro.2013.08.016_bib52","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1007\/s10620-007-0066-0","article-title":"Autonomic function at rest and in response to emotional and rectal stimuli in women with irritable bowel syndrome","volume":"53","author":"Spetalen","year":"2008","journal-title":"Digest Dis Sci"},{"key":"10.1053\/j.gastro.2013.08.016_bib53","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/cne.902050306","article-title":"Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal-cord in the rat","volume":"205","author":"Sawchenko","year":"1982","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2013.08.016_bib54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1096-9861(20001211)428:2<191::AID-CNE1>3.0.CO;2-U","article-title":"Distribution of mRNAs encoding CRF receptors in brain and pituitary of bat and mouse","volume":"428","author":"Van Pett","year":"2000","journal-title":"J\u00a0Comp Neurol"},{"key":"10.1053\/j.gastro.2013.08.016_bib55","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/apt.12171","article-title":"Randomised clinical trial: symptoms of the irritable bowel syndrome are improved by a psycho-education group intervention","volume":"37","author":"Labus","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2013.08.016_bib56","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.brat.2005.05.002","article-title":"Cognitive therapy for irritable bowel syndrome is associated with reduced limbic activity, GI symptoms, and anxiety","volume":"44","author":"Lackner","year":"2006","journal-title":"Behav Res Ther"},{"key":"10.1053\/j.gastro.2013.08.016_bib57","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1001\/archinte.164.16.1773","article-title":"Clinical determinants of health-related quality of life in patients with irritable bowel syndrome","volume":"164","author":"Spiegel","year":"2004","journal-title":"Arch Inter Med"},{"key":"10.1053\/j.gastro.2013.08.016_bib58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopsycho.2006.01.006","article-title":"Extending animal models of fear conditioning to humans","volume":"73","author":"Delgado","year":"2006","journal-title":"Biol Psychol"},{"key":"10.1053\/j.gastro.2013.08.016_bib59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00008877-199711000-00003","article-title":"Animal models of \u2018anxiety\u2019: where next?","volume":"8","author":"Rodgers","year":"1997","journal-title":"Behav Pharmacol"},{"key":"10.1053\/j.gastro.2013.08.016_bib60","first-page":"109","article-title":"Do IBS patients without rectal hypersensitivity adapt to repeated aversive rectal distensions?","volume":"24","author":"Larsson","year":"2012","journal-title":"Neurogastroenterol Motil"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513011621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513011621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:05:35Z","timestamp":1758035135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508513011621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0016508513011621"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2013.08.016","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired Emotional Learning and Involvement of the Corticotropin-Releasing Factor Signaling System in Patients With Irritable Bowel Syndrome","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2013.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}