{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:10:26Z","timestamp":1793581826206,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital","doi-asserted-by":"publisher","award":["1MS1"],"award-info":[{"award-number":["1MS1"]}],"id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1053\/j.gastro.2013.09.058","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T11:45:47Z","timestamp":1380800747000},"page":"129-137.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Increased Incidence of Gastrointestinal Cancers Among Patients With Pyogenic Liver Abscess: A Population-Based Cohort Study"],"prefix":"10.1053","volume":"146","author":[{"given":"Hsueh\u2013Chou","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2013Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2013Sheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2013Ta","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2013Wei","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2013Yuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2013Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2013Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung\u2013Chang","family":"Sung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2013.09.058_bib1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/CCM.0b013e31816a0a06","article-title":"Clinical outcome and prognostic factors of patients with pyogenic liver abscess requiring intensive care","volume":"36","author":"Chen","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1053\/j.gastro.2013.09.058_bib2","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3201\/eid1410.071254","article-title":"Pyogenic liver abscess as endemic disease, Taiwan","volume":"14","author":"Tsai","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1053\/j.gastro.2013.09.058_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/j.1365-2036.2005.02487.x","article-title":"A\u00a0nationwide study of the incidence and 30-day mortality rate of pyogenic liver abscess in Demark, 1977-2002","volume":"21","author":"Jepsen","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2013.09.058_bib4","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S1542-3565(04)00459-8","article-title":"Population-based study of the epidemiology of and the risk factors for pyogenic liver abscess","volume":"2","author":"Kaplan","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2013.09.058_bib5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1086\/513201","article-title":"Diabetes mellitus and pyogenic liver abscess: risk and prognosis","volume":"44","author":"Tomsen","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1053\/j.gastro.2013.09.058_bib6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1572-0241.2005.40310.x","article-title":"Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics","volume":"100","author":"Lederman","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/00000658-198409000-00010","article-title":"The diagnosis and treatment of pyogenic liver abscess","volume":"200","author":"Miedema","year":"1984","journal-title":"Ann Surg"},{"key":"10.1053\/j.gastro.2013.09.058_bib8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archsurg.1989.01410050051009","article-title":"Liver abscess. The need for complete gastrointestinal evaluation","volume":"124","author":"Cohen","year":"1989","journal-title":"Arch Surg"},{"key":"10.1053\/j.gastro.2013.09.058_bib9","first-page":"176","article-title":"Comparison of pyogenic liver abscess caused by non-Klebsiella pneumoniae and Klebsiella pneumoniae","volume":"37","author":"Yang","year":"2004","journal-title":"J\u00a0Microbiol Immunol Infect"},{"key":"10.1053\/j.gastro.2013.09.058_bib10","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/MCG.0b013e318157e4c1","article-title":"Long-term outcome of pyogenic liver abscess: factors related with abscess recurrence","volume":"42","author":"Cheng","year":"2008","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib11","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1086\/425616","article-title":"Pyogenic liver abscess: recent trends in etiology and mortality","volume":"39","author":"Rahimian","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1053\/j.gastro.2013.09.058_bib12","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1086\/516369","article-title":"Primary liver abscess due to Klebsiella pneumoniae in Taiwan","volume":"26","author":"Wang","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1053\/j.gastro.2013.09.058_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2169\/internalmedicine.48.1550","article-title":"Pyogenic liver abscess complicating early bile duct carcinoma in the middle bile duct: a rare presentation","volume":"48","author":"Chai","year":"2009","journal-title":"Intern Med"},{"key":"10.1053\/j.gastro.2013.09.058_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00004836-199206000-00013","article-title":"Right colon adenocarcinoma presenting as Bacteroides fragilis liver abscess","volume":"14","author":"Lonardo","year":"1992","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib15","first-page":"336","article-title":"Pyogenic liver abscess-an unusual presentation of colonic villous adenoma","volume":"142","author":"Leiba","year":"2003","journal-title":"Harfuah (Israel)"},{"key":"10.1053\/j.gastro.2013.09.058_bib16","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3748\/wjg.v12.i6.990","article-title":"Pyogenic liver abscess associated with large colonic tubulovillous adenoma","volume":"12","author":"Lai","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib17","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1572-0241.2007.01612_1.x","article-title":"Nonmetastatic cancer of the colon associated with pyogenic liver abscess","volume":"103","author":"Lee","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1440-1746.2004.03509.x","article-title":"Silent colorectal carcinoma and pyogenic liver abscess","volume":"19","author":"Lim","year":"2004","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"suppl II","key":"10.1053\/j.gastro.2013.09.058_bib19","first-page":"A145","article-title":"Do diabetes patients with Klebsiella pneumonia liver abscess need further evaluation of the colon for presence of neoplasm in Taiwan (abstr)","volume":"58","author":"Lai","year":"2009","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.09.058_bib20","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1478-3231.2010.02327.x","article-title":"Cryptogenic pyogenic liver abscess as a sign of colorectal cancer: a population-based 5-year follow-up study","volume":"30","author":"Lai","year":"2010","journal-title":"Liver Int"},{"key":"10.1053\/j.gastro.2013.09.058_bib21","first-page":"821","article-title":"Liver abscess caused by Streptococcus anginosus","volume":"87","author":"Gil Lasa","year":"1995","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1053\/j.gastro.2013.09.058_bib22","series-title":"Six countries, six reform models: the health reform experience of Israel, The Netherlands, New Zealand, Singapore, Switzerland and Taiwan","first-page":"171","article-title":"Taiwan's National health insurance system: high value for the dollar","author":"Cheng","year":"2009"},{"key":"10.1053\/j.gastro.2013.09.058_bib23","unstructured":"Taiwan Cancer Registry. http:\/\/tcr.cph.ntu.edu.tw\/uploadimages\/Top%2010%20cancer%20in%20Taiwan%202008. Accessed July\u00a02012."},{"key":"10.1053\/j.gastro.2013.09.058_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2036.2012.05212.x","article-title":"Cancer risk in patients with pyogenic liver abscess: a nationwide cohort study","volume":"36","author":"Kao","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2013.09.058_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-1746.2011.06851.x","article-title":"Cryptogenic pyogenic liver abscess as the herald of colon cancer","volume":"27","author":"Jeong","year":"2012","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2013.09.058_bib26","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.3748\/wjg.v18.i23.2948","article-title":"Pyogenic liver abscesses associated with nonmetastatic colorectal cancers: an increasing problem in Eastern Asia","volume":"18","author":"Qu","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/ijc.25354","article-title":"Increased risk of colorectal cancer among patients with biliary tract inflammation: a 5-year follow-up study","volume":"128","author":"Lin","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2013.09.058_bib28","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.3748\/wjg.15.3329","article-title":"Bile acids as endogenous etiologic agents in gastrointestinal cancer","volume":"15","author":"Bernstein","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.09.058_bib29","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1664::AID-CNCR4>3.0.CO;2-O","article-title":"Colonic mucosal proliferation is related to serum deoxycholic acid levels","volume":"85","author":"OchsenKuhn","year":"1999","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2013.09.058_bib30","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s11605-007-0282-0","article-title":"Trends in\u00a0survival after surgery for cholangiocarcinoma: a 30-year population-based SEER database analysis","volume":"11","author":"Nathan","year":"2007","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2013.09.058_bib31","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjc.6603127","article-title":"Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001","volume":"94","author":"West","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2013.09.058_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/1097-0142(19950101)75:1+<171::AID-CNCR2820751306>3.0.CO;2-2","article-title":"Liver, gallbladder, extrahepatic bile ducts, and pancreas","volume":"75","author":"Carriaga","year":"1995","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2013.09.058_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2013.09.058_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000319414","article-title":"Pancreatic cancer: epidemiology and risk factors","volume":"28","author":"Krejs","year":"2010","journal-title":"Dig Dis"},{"key":"10.1053\/j.gastro.2013.09.058_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/SLA.0b013e31818e4641","article-title":"Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 years","volume":"249","author":"Bilimoria","year":"2009","journal-title":"Ann Surg"},{"key":"10.1053\/j.gastro.2013.09.058_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-78-2-271","article-title":"Influence of gastric acidity on bacterial and parasitic enteric infections","volume":"78","author":"Giannella","year":"1973","journal-title":"Ann Intern Med"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513014194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513014194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:41:06Z","timestamp":1762162866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508513014194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0016508513014194"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2013.09.058","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Incidence of Gastrointestinal Cancers Among Patients With Pyogenic Liver Abscess: A Population-Based Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2013.09.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}