{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:19:43Z","timestamp":1790450383236,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1053\/j.gastro.2013.10.045","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T23:19:59Z","timestamp":1382656799000},"page":"520-529.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":128,"title":["Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas"],"prefix":"10.1053","volume":"146","author":[{"given":"Manish K.","family":"Gala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long P.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Moriichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y.","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Bardeesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2013.10.045_bib1","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1038\/ctg.2011.5","article-title":"Prevalence of different subtypes of serrated polyps and risk of synchronous advanced colorectal neoplasia in average-risk population undergoing first-time colonoscopy","volume":"3","author":"Buda","year":"2012","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1053\/j.gastro.2013.10.045_bib2","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/modpathol.2012.98","article-title":"Proximal colon cancers and the serrated pathway: a systematic analysis of precursor histology and BRAF mutation status","volume":"25","author":"Patil","year":"2012","journal-title":"Mod Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib3","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1053\/j.gastro.2009.12.066","article-title":"Role of the serrated pathway in colorectal cancer pathogenesis","volume":"138","author":"Leggett","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.10.045_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2010.06.002","article-title":"Update on the serrated pathway to colorectal carcinoma","volume":"42","author":"Snover","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/jclinpath-2011-200602","article-title":"Wnt signalling pathway in the serrated neoplastic pathway of the colorectum: possible roles and epigenetic regulatory mechanisms","volume":"65","author":"Fu","year":"2012","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib6","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/01.pas.0000213313.36306.85","article-title":"Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points","volume":"30","author":"O'Brien","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib7","first-page":"157073","article-title":"Serrated polyposis: an enigmatic model of colorectal cancer predisposition","volume":"2011","author":"Rosty","year":"2011","journal-title":"Patholog Res Int"},{"key":"10.1053\/j.gastro.2013.10.045_bib8","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1007\/s10350-004-0709-6","article-title":"Hyperplastic polyposis and the risk of colorectal cancer","volume":"47","author":"Hyman","year":"2004","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.gastro.2013.10.045_bib9","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/1055-9965.EPI-06-0359","article-title":"Somatic BRAF-V600E mutations in familial colorectal cancer","volume":"15","author":"Vandrovcova","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2013.10.045_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MEG.0b013e3283598506","article-title":"Serrated polyposis: prospective study of first-degree relatives","volume":"25","author":"Oquinena","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2013.10.045_bib11","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1136\/gut.2009.200741","article-title":"Increased colorectal cancer risk in first-degree relatives of patients with hyperplastic polyposis syndrome","volume":"59","author":"Boparai","year":"2010","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2013.10.045_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ajg.2012.52","article-title":"Cancer risks for relatives of patients with serrated polyposis","volume":"107","author":"Win","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.10.045_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.gastro.2006.03.046","article-title":"Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH","volume":"131","author":"Chow","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.10.045_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10689-010-9408-8","article-title":"Linkage to chromosome 2q32.2-q33.3 in familial serrated neoplasia (Jass syndrome)","volume":"10","author":"Roberts","year":"2011","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2013.10.045_bib15","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1053\/j.gastro.2008.09.020","article-title":"Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis","volume":"135","author":"Boparai","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.10.045_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/emmm.201000099","article-title":"V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a","volume":"2","author":"Carragher","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1053\/j.gastro.2013.10.045_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2010.06.013","article-title":"Ink4a\/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis","volume":"18","author":"Bennecke","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2013.10.045_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ccr.2013.05.014","article-title":"A\u00a0genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention","volume":"24","author":"Rad","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2013.10.045_bib19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature05268","article-title":"Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints","volume":"444","author":"Bartkova","year":"2006","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib20","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/modpathol.2011.43","article-title":"Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps\/adenomas indicates a senescence barrier in the serrated route to colon cancer","volume":"24","author":"Kriegl","year":"2011","journal-title":"Mod Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib21","series-title":"World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system","article-title":"Serrated polyps of the colon and rectum and serrated polyposis","author":"Snover","year":"2010"},{"key":"10.1053\/j.gastro.2013.10.045_bib22","first-page":"317","article-title":"Nomenclature, molecular genetics and clinical significance of the precursor lesions in the serrated polyp pathway of colorectal carcinoma","volume":"1","author":"Liang","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.1219240","article-title":"Evolution and functional impact of rare coding variation from deep sequencing of human exomes","volume":"337","author":"Tennessen","year":"2012","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.10.045_bib24","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1073\/pnas.1001613107","article-title":"Pattern of retinoblastoma pathway inactivation dictates response to CDK4\/6 inhibition in GBM","volume":"107","author":"Wiedemeyer","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.10.045_bib25","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1073\/pnas.94.19.10199","article-title":"Effects of p53 mutations on apoptosis in mouse intestinal and human colonic adenomas","volume":"94","author":"Fazeli","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.10.045_bib26","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1093\/hmg\/ddq365","article-title":"Loss-of-function variants in the genomes of healthy humans","volume":"19","author":"MacArthur","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2013.10.045_bib27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature10945","article-title":"De novo mutations revealed by whole-exome sequencing are strongly associated with autism","volume":"485","author":"Sanders","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1968411","article-title":"Gene inactivation and its implications for annotation in the era of personal genomics","volume":"25","author":"Balasubramanian","year":"2011","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2013.10.045_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1215040","article-title":"A\u00a0systematic survey of loss-of-function variants in human protein-coding genes","volume":"335","author":"MacArthur","year":"2012","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.10.045_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/emmm.201000070","article-title":"Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine","volume":"2","author":"Dias-Santagata","year":"2010","journal-title":"EMBO Mol Med"},{"key":"10.1053\/j.gastro.2013.10.045_bib31","doi-asserted-by":"crossref","first-page":"e1001273","DOI":"10.1371\/journal.pgen.1001273","article-title":"Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology","volume":"7","author":"Rossin","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2013.10.045_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mrfmmm.2006.09.003","article-title":"A\u00a0strategy to discover genes that carry multi-allelic or mono-allelic risk for common diseases: a cohort allelic sums test (CAST)","volume":"615","author":"Morgenthaler","year":"2007","journal-title":"Mutat Res"},{"key":"10.1053\/j.gastro.2013.10.045_bib33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/jcp.2010.075507","article-title":"Sessile serrated adenomas: prevalence of dysplasia and carcinoma in 2139 patients","volume":"63","author":"Lash","year":"2010","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1053\/j.gastro.2013.10.045_bib34","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib35","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1186\/bcr2919","article-title":"Rare variants in the ATM gene and risk of breast cancer","volume":"13","author":"Goldgar","year":"2011","journal-title":"Breast Cancer Res"},{"key":"10.1053\/j.gastro.2013.10.045_bib36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/2159-8290.CD-11-0194","article-title":"ATM mutations in patients with hereditary pancreatic cancer","volume":"2","author":"Roberts","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2013.10.045_bib37","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2007.10.052","article-title":"Tel2 regulates the stability of PI3K-related protein kinases","volume":"131","author":"Takai","year":"2007","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2013.10.045_bib38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1074\/jbc.M509053200","article-title":"The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium","volume":"281","author":"Haigis","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2013.10.045_bib39","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1128\/MCB.26.4.1170-1182.2006","article-title":"The retinoblastoma protein is required for Ras-induced oncogenic transformation","volume":"26","author":"Williams","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.gastro.2013.10.045_bib40","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/carcin\/bgp155","article-title":"Identification of XAF1 as a\u00a0novel cell cycle regulator through modulating G(2)\/M checkpoint and interaction with checkpoint kinase 1 in\u00a0gastrointestinal cancer","volume":"30","author":"Wang","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1053\/j.gastro.2013.10.045_bib41","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1053\/j.gastro.2007.04.024","article-title":"Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses","volume":"132","author":"Chung","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2013.10.045_bib42","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.3748\/wjg.v18.i22.2844","article-title":"XAF1 is frequently methylated in human esophageal cancer","volume":"18","author":"Chen","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2013.10.045_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1349-7006.2009.01396.x","article-title":"XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer","volume":"101","author":"Huang","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1053\/j.gastro.2013.10.045_bib44","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1158\/0008-5472.CAN-10-4404","article-title":"Suppression of apoptosis by PIF1 helicase in human tumor cells","volume":"71","author":"Gagou","year":"2011","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2013.10.045_bib45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature12149","article-title":"Pif1 family helicases suppress genome instability at G-quadruplex motifs","volume":"497","author":"Paeschke","year":"2013","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib46","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ng.993","article-title":"Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk","volume":"44","author":"Broderick","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2013.10.045_bib47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.519709","article-title":"Autophagy mediates the mitotic senescence transition","volume":"23","author":"Young","year":"2009","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2013.10.045_bib48","doi-asserted-by":"crossref","first-page":"e11824","DOI":"10.1371\/journal.pone.0011824","article-title":"Genome-wide association study of pancreatic cancer in Japanese population","volume":"5","author":"Low","year":"2010","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2013.10.045_bib49","doi-asserted-by":"crossref","first-page":"21188","DOI":"10.1073\/pnas.1118046108","article-title":"Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways","volume":"108","author":"Wu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.10.045_bib50","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nature11308","article-title":"Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors","volume":"488","author":"Koo","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature11019","article-title":"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner","volume":"485","author":"Hao","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbrc.2010.11.082","article-title":"RNF43 interacts with NEDL1 and regulates p53-mediated transcription","volume":"404","author":"Shinada","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2013.10.045_bib53","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ng.f.136","article-title":"Common and rare variants in multifactorial susceptibility to common diseases","volume":"40","author":"Bodmer","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2013.10.045_bib54","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.1217283","article-title":"Recent explosive human population growth has resulted in an excess of rare genetic variants","volume":"336","author":"Keinan","year":"2012","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.10.045_bib55","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature11690","article-title":"Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants","volume":"493","author":"Fu","year":"2013","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib56","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/ng.2344","article-title":"Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis","volume":"44","author":"Emond","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2013.10.045_bib57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.2303","article-title":"Exome sequencing and the genetic basis of complex traits","volume":"44","author":"Kiezun","year":"2012","journal-title":"Nat Genet"},{"issue":"suppl 8","key":"10.1053\/j.gastro.2013.10.045_bib58","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1471-2164-13-S8-S8","article-title":"Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data","volume":"13","author":"Liu","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1053\/j.gastro.2013.10.045_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12561-012-9060-y","article-title":"Single nucleotide polymorphism (SNP) detection and genotype calling from massively parallel sequencing (MPS) data","author":"Li","year":"2012","journal-title":"Stat Biosci"},{"key":"10.1053\/j.gastro.2013.10.045_bib60","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.1215040","article-title":"A\u00a0systematic survey of loss-of-function variants in human protein-coding genes","volume":"335","author":"MacArthur","year":"2012","journal-title":"Science"},{"key":"10.1053\/j.gastro.2013.10.045_bib61","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature10945","article-title":"De novo mutations revealed by whole-exome sequencing are strongly associated with autism","volume":"485","author":"Sanders","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2013.10.045_bib62","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.1073\/pnas.0910672106","article-title":"Genetic diagnosis by whole exome capture and massively parallel DNA sequencing","volume":"106","author":"Choi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2013.10.045_bib63","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2147","article-title":"Evolutionary diagnosis method for variants in personal exomes","volume":"9","author":"Kumar","year":"2012","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2013.10.045_bib64","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00428-009-0731-0","article-title":"Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis","volume":"454","author":"Caruso","year":"2009","journal-title":"Virchows Arch"},{"key":"10.1053\/j.gastro.2013.10.045_bib65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/sj.onc.1209778","article-title":"Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis","volume":"26","author":"Laiho","year":"2007","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2013.10.045_bib66","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Hingorani","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1053\/j.gastro.2013.10.045_bib67","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0076-6879(05)07055-2","article-title":"Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems","volume":"407","author":"Agbunag","year":"2006","journal-title":"Methods Enzymol"},{"key":"10.1053\/j.gastro.2013.10.045_bib68","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cell.2005.02.034","article-title":"Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1\/CXCL12 secretion","volume":"121","author":"Orimo","year":"2005","journal-title":"Cell"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513015199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508513015199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:08:09Z","timestamp":1758035289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508513015199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0016508513015199"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2013.10.045","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2013.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}