{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:32:46Z","timestamp":1791999166969,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000149","name":"Canadian Association of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1053\/j.gastro.2014.01.014","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T00:04:01Z","timestamp":1389398641000},"page":"932-940.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions"],"prefix":"10.1053","volume":"146","author":[{"given":"Alexander C.","family":"Ford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premysl","family":"Bercik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Bolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ines","family":"Pintos-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Moayyedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2014.01.014_bib1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/BF01303162","article-title":"U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact","volume":"38","author":"Drossman","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2014.01.014_bib2","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1572-0241.1998.00526.x","article-title":"Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms","volume":"93","author":"Ho","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gut.2006.099846","article-title":"Initial poor quality of life and new onset of dyspepsia: results from a longitudinal 10-year follow-up study","volume":"56","author":"Ford","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/gut.31.4.401","article-title":"Dyspepsia in England and Scotland","volume":"31","author":"Jones","year":"1990","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib5","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.cgh.2010.03.003","article-title":"Functional dyspepsia impacts absenteeism and direct and indirect costs","volume":"8","author":"Brook","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1542-3565(05)00153-9","article-title":"Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study","volume":"3","author":"Camilleri","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0269-2813.2004.01807.x","article-title":"Impact of functional gastrointestinal disorders on health-related quality of life: a population-based case-control study","volume":"19","author":"Halder","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2014.01.014_bib8","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ajg.2010.26","article-title":"Risk factors associated with dyspepsia in a rural Asian population and its impact on quality of life","volume":"105","author":"Mahadeva","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib9","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1365-2036.2010.04270.x","article-title":"Ethnic variation, epidemiological factors and quality of life impairment associated with dyspepsia in urban Malaysia","volume":"31","author":"Mahadeva","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2014.01.014_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/apt.12355","article-title":"Functional dyspepsia: the economic impact to patients","volume":"38","author":"Lacy","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2014.01.014_bib11","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2012.08.002","article-title":"Burden of gastrointestinal disease in the United States: 2012 update","volume":"143","author":"Peery","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/j.gastro.2008.12.015","article-title":"Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases","volume":"136","author":"Everhart","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib13","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/ajg.2010.40","article-title":"Impact of functional gastrointestinal disorders on survival in the community","volume":"105","author":"Chang","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib14","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ajg.2012.69","article-title":"Effect of dyspepsia on survival: a longitudinal 10-year follow-up study","volume":"107","author":"Ford","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib15","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/jama.295.13.1566","article-title":"Can the clinical history distinguish between organic and functional dyspepsia?","volume":"295","author":"Moayyedi","year":"2006","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2014.01.014_bib16","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cgh.2010.05.031","article-title":"What is the prevalence of clinically significant endoscopic findings in subjects with dyspepsia? Systematic review and meta-analysis","volume":"8","author":"Ford","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib17","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0140-6736(88)91364-5","article-title":"Management of dyspepsia: report of a working party","volume":"331","author":"Colin-Jones","year":"1988","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2014.01.014_bib18","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib19","first-page":"145","article-title":"Functional dyspepsia: a classification with guidelines for diagnosis and management","volume":"4","author":"Talley","year":"1991","journal-title":"Gastroenterol Int"},{"issue":"Suppl 2","key":"10.1053\/j.gastro.2014.01.014_bib20","first-page":"37","article-title":"Functional gastroduodenal disorders","volume":"45","author":"Talley","year":"1999","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib21","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2013.08.048","article-title":"Validation of the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care","volume":"145","author":"Ford","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib22","series-title":"Rome III: the functional gastrointestinal disorders","first-page":"835","year":"2006"},{"key":"10.1053\/j.gastro.2014.01.014_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2036.2009.04008.x","article-title":"Meta-analysis: yield of diagnostic tests for coeliac disease in dyspepsia","volume":"30","author":"Ford","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2014.01.014_bib24","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/gut.2005.078634","article-title":"Functional dyspepsia, delayed gastric emptying, and impaired quality of life","volume":"55","author":"Talley","year":"2006","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib25","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1080\/00365520510015845","article-title":"Clinical value of ultrasound in the evaluation of dyspepsia in primary health care","volume":"40","author":"Heikkinen","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-230X-13-84","article-title":"A Rome III survey of functional dyspepsia among the ethnic Malays in a primary care setting","volume":"13","author":"Lee","year":"2013","journal-title":"BMC Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/1319-3767.77244","article-title":"Discriminant value of Rome III questionnaire in dyspeptic patients","volume":"17","author":"Abid","year":"2011","journal-title":"Saudi J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib28","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cgh.2009.03.031","article-title":"Cost of detecting malignant lesions by endoscopy in 2741 primary care dyspeptic patients without alarm symptoms","volume":"7","author":"Vakil","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1053\/gast.2003.50155","article-title":"Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia","volume":"124","author":"Fischler","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/003655202760230874","article-title":"Empiric clustering of dyspepsia into symptom subgroups: a population-based study","volume":"37","author":"Westbrook","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/gut.42.5.690","article-title":"Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population","volume":"42","author":"Talley","year":"1998","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib32","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/gut.2007.137125","article-title":"Relationship between symptoms and ingestion of a meal in functional dyspepsia","volume":"57","author":"Bisschops","year":"2008","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib33","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1053\/j.gastro.2004.08.026","article-title":"The efficacy of proton pump inhibitors in non-ulcer dyspepsia: a systematic review and economic analysis","volume":"127","author":"Moayyedi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.01.014_bib34","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1136\/gutjnl-2011-301454","article-title":"A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia","volume":"61","author":"Matsueda","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.01.014_bib35","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cgh.2012.06.036","article-title":"Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia","volume":"10","author":"Tack","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib36","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/ajg.2013.89","article-title":"Symptom overlap between postprandial distress and epigastric pain syndromes of the Rome III dyspepsia classification","volume":"108","author":"Vakil","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/MCG.0b013e31815591f7","article-title":"Functional dyspepsia: not all roads seem to lead to Rome","volume":"43","author":"van Kerkhoven","year":"2009","journal-title":"J Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2014.01.014_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.5056\/jnm.2011.17.3.279","article-title":"Functional gastrointestinal disorders diagnosed by Rome III questionnaire in Korea","volume":"17","author":"Park","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2014.01.014_bib39","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1365-2036.2010.04282.x","article-title":"Implications of eosinophilia in the normal duodenal biopsy-an association with allergy and functional dyspepsia","volume":"31","author":"Walker","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2014.01.014_bib40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cgh.2008.09.007","article-title":"Relationship between symptoms and dietary patterns in patients with functional dyspepsia","volume":"7","author":"Pilichiewicz","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cgh.2010.04.027","article-title":"Abdominal pain is a frequent symptom of gastroparesis","volume":"8","author":"Cherian","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.01.014_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2011.01859.x","article-title":"Classification of functional dyspepsia based on concomitant bowel symptoms","volume":"24","author":"Matsuzaki","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2014.01.014_bib43","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1365-2982.2011.01703.x","article-title":"Do we have an alternative for the Rome III gastroduodenal symptom-based subgroups in functional gastroduodenal disorders? A cluster analysis approach","volume":"23","author":"van Oudenhove","year":"2011","journal-title":"Neurogastroenterol Motil"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514000274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514000274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:09:25Z","timestamp":1758035365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508514000274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S0016508514000274"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2014.01.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718234635.793491106","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2014.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}