{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:11:15Z","timestamp":1791223875068,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1053\/j.gastro.2014.11.027","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T20:55:13Z","timestamp":1416516913000},"page":"579-589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells"],"prefix":"10.1053","volume":"148","author":[{"given":"Stephanie S.","family":"Tseng-Rogenski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hamaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Y.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Carethers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2014.11.027_bib1","first-page":"5248","article-title":"A\u00a0National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland","year":"1998","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.027_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1053\/j.gastro.2008.07.076","article-title":"Genomic and epigenetic instability in colorectal cancer pathogenesis","volume":"135","author":"Grady","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1056\/NEJMoa043146","article-title":"Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)","volume":"352","author":"Hampel","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2014.11.027_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cgh.2013.12.007","article-title":"DNA Testing and molecular screening for colon cancer","volume":"12","author":"Carethers","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2014.11.027_bib5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/j.gastro.2014.01.041","article-title":"Differentiating Lynch-like from Lynch syndrome","volume":"146","author":"Carethers","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib6","doi-asserted-by":"crossref","first-page":"6870","DOI":"10.1073\/pnas.95.12.6870","article-title":"Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma","volume":"95","author":"Herman","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2014.11.027_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1200\/JCO.2005.01.086","article-title":"Systematic review of microsatellite instability and colorectal cancer prognosis","volume":"23","author":"Popat","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2014.11.027_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1053\/j.gastro.2003.12.023","article-title":"Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer","volume":"126","author":"Carethers","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ijc.20455","article-title":"Different types of microsatellite instability in ovarian carcinoma","volume":"112","author":"Singer","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2014.11.027_bib10","first-page":"2488","article-title":"Microsatellite instability at selected tetranucleotide repeats is associated with p53 mutations in non-small cell lung cancer","volume":"60","author":"Ahrendt","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.027_bib11","doi-asserted-by":"crossref","first-page":"8699","DOI":"10.1038\/sj.onc.1206964","article-title":"Distinct patterns of microsatellite instability are seen in tumours of the urinary tract","volume":"22","author":"Catto","year":"2003","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2014.11.027_bib12","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1158\/0008-5472.CAN-08-0002","article-title":"Genetic instability\u00a0caused by loss of MutS homologue 3 in human colorectal cancer","volume":"68","author":"Haugen","year":"2008","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.027_bib13","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/j.gastro.2010.08.001","article-title":"Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias","volume":"139","author":"Lee","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib14","first-page":"551","article-title":"Microsatellite instability at tetranucleotide repeats in sporadic colorectal\u00a0cancer in Japan","volume":"23","author":"Yamada","year":"2010","journal-title":"Oncol Rep"},{"key":"10.1053\/j.gastro.2014.11.027_bib15","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s11605-010-1340-6","article-title":"Relationship of EMAST and microsatellite instability among patients with rectal cancer","volume":"14","author":"Devaraj","year":"2010","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2014.11.027_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10620-011-1825-5","article-title":"Microsatellite instability, EMAST, and morphology associations with T cell infiltration in colorectal neoplasia","volume":"57","author":"Lee","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2014.11.027_bib17","doi-asserted-by":"crossref","first-page":"e50616","DOI":"10.1371\/journal.pone.0050616","article-title":"Oxidative stress induces nuclear-to-cytosol shift of hMSH3, a potential mechanism for EMAST in colorectal cancer cells","volume":"7","author":"Tseng-Rogenski","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2014.11.027_bib18","doi-asserted-by":"crossref","first-page":"e50541","DOI":"10.1371\/journal.pone.0050541","article-title":"MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells","volume":"7","author":"Campregher","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2014.11.027_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/j.gastro.2012.03.034","article-title":"Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability","volume":"143","author":"Garcia","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1755-5922.2010.00218.x","article-title":"Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy","volume":"30","author":"Elmarakby","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1053\/j.gastro.2014.11.027_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"10.1053\/j.gastro.2014.11.027_bib22","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.7150\/ijbs.4989","article-title":"IL6 trans-signaling via the soluble IL6 receptor: importance for the pro-inflammatory activities of IL6","volume":"8","author":"Rose-John","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1053\/j.gastro.2014.11.027_bib23","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1053\/j.gastro.2009.11.052","article-title":"Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in\u00a0vitro","volume":"138","author":"Roig","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-4598-4-2","article-title":"Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells","volume":"4","author":"Huang","year":"2005","journal-title":"Mol Cancer"},{"key":"10.1053\/j.gastro.2014.11.027_bib25","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/cncr.25445","article-title":"Evidence for an hMSH3 defect in familial hamartomatous polyps","volume":"117","author":"Huang","year":"2011","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2014.11.027_bib26","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1053\/j.gastro.2009.12.064","article-title":"Microsatellite instability in colorectal cancer","volume":"138","author":"Boland","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.027_bib27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.mrfmmm.2012.11.003","article-title":"Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?","volume":"743-744","author":"Hile","year":"2013","journal-title":"Mutat Res"},{"key":"10.1053\/j.gastro.2014.11.027_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00109-005-0012-6","article-title":"Tetranucleotide repeats in coding regions: no evidence for involvement in EMAST carcinogenesis","volume":"84","author":"Kloor","year":"2006","journal-title":"J\u00a0Mol Med (Berl)"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514014590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514014590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:10:11Z","timestamp":1758035411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508514014590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0016508514014590"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2014.11.027","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2014.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}