{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:59Z","timestamp":1790319599056,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1053\/j.gastro.2014.11.042","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T16:40:19Z","timestamp":1417538419000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":275,"title":["Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer"],"prefix":"10.1053","volume":"148","author":[{"given":"Robert C.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Selander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton A.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamini","family":"Selvarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Borgida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Briollais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria M.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Lerner-Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spring","family":"Holter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2014.11.042_bib1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1503\/cmaj.121368","article-title":"Diagnosis and management of pancreatic cancer","volume":"185","author":"Kanji","year":"2013","journal-title":"CMAJ"},{"key":"10.1053\/j.gastro.2014.11.042_bib2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.6004\/jnccn.2012.0073","article-title":"Pancreatic adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines","volume":"10","author":"Tempero","year":"2012","journal-title":"J\u00a0Natl Compr Canc Netw"},{"issue":"64","key":"10.1053\/j.gastro.2014.11.042_bib3","first-page":"9","article-title":"Cancer statistics","volume":"2014","author":"Siegel","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.gastro.2014.11.042_bib4","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jnci\/djj465","article-title":"Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada","volume":"98","author":"Risch","year":"2006","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2014.11.042_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10689-011-9506-2","article-title":"Risk of cancer other than breast or ovarian in individuals with BRCA1 and BRCA2 mutations","volume":"11","author":"Moran","year":"2012","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jmg.2004.028829","article-title":"Cancer risks in BRCA2 families: estimates for sites other than breast and ovary","volume":"42","author":"van Asperen","year":"2005","journal-title":"J\u00a0Med Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1091-255X(98)80105-4","article-title":"Cumulative incidence of colorectal and extracolonic cancers in MLH1 and MSH2 mutation carriers of hereditary nonpolyposis colorectal cancer","volume":"2","author":"Lin","year":"1998","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2014.11.042_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2014.11.042_bib9","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/jnci\/djs351","article-title":"Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome","volume":"104","author":"Win","year":"2012","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2014.11.042_bib10","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1001\/jama.2009.1529","article-title":"Risk of pancreatic cancer in families with Lynch syndrome","volume":"302","author":"Kastrinos","year":"2009","journal-title":"JAMA"},{"key":"10.1053\/j.gastro.2014.11.042_bib11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1136\/jmg.2009.073429","article-title":"TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes","volume":"47","author":"Ruijs","year":"2010","journal-title":"J\u00a0Med Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib12","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.1171202","article-title":"Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene","volume":"324","author":"Jones","year":"2009","journal-title":"Science"},{"key":"10.1053\/j.gastro.2014.11.042_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/2159-8290.CD-11-0194","article-title":"ATM mutations in patients with hereditary pancreatic cancer","volume":"2","author":"Roberts","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1053\/j.gastro.2014.11.042_bib14","first-page":"1417","article-title":"Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer","volume":"31","author":"Fogelman","year":"2011","journal-title":"Anticancer Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib15","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2012.30.4_suppl.217","article-title":"Platinum-based chemotherapy in pancreatic adenocarcinoma associated with BRCA mutations: a translational case series","volume":"30","author":"Tran","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2014.11.042_bib16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11605-011-1781-6","article-title":"Screening for pancreatic cancer in a high-risk cohort: an eight-year experience","volume":"16","author":"Al-Sukhni","year":"2012","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1053\/j.gastro.2014.11.042_bib17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/MPA.0000000000000052","article-title":"Promising outcomes of screening for pancreatic cancer by genetic testing and endoscopic ultrasound","volume":"43","author":"Sud","year":"2014","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2014.11.042_bib18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/AOG.0b013e3181ec5fc1","article-title":"Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer","volume":"116","author":"Berek","year":"2010","journal-title":"Obstetr Gynecol"},{"key":"10.1053\/j.gastro.2014.11.042_bib19","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/jnci\/93.21.1633","article-title":"Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers","volume":"93","author":"Hartmann","year":"2001","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1053\/j.gastro.2014.11.042_bib20","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.suc.2008.04.012","article-title":"Hereditary colorectal cancer syndromes: familial adenomatous polyposis and lynch syndrome","volume":"88","author":"Al-Sukhni","year":"2008","journal-title":"Surg Clin North Am"},{"key":"10.1053\/j.gastro.2014.11.042_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1503\/cjs.026409","article-title":"Management of pancreatic adenocarcinoma in Ontario, Canada: a population-based study using novel case ascertainment","volume":"54","author":"Borgida","year":"2011","journal-title":"Can J Surg"},{"key":"10.1053\/j.gastro.2014.11.042_bib22","first-page":"231","article-title":"An EM composite likelihood approach for multistage sampling of family data","volume":"21","author":"Choi","year":"2011","journal-title":"Stat Sinica"},{"key":"10.1053\/j.gastro.2014.11.042_bib23","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2014.11.042_bib24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib25","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2014.11.042_bib27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/nar\/29.1.308","article-title":"dbSNP: the NCBI database of genetic variation","volume":"29","author":"Sherry","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.21629","article-title":"Classification of missense substitutions in the BRCA genes: a database dedicated to Ex-UVs","volume":"33","author":"Vallee","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1053\/j.gastro.2014.11.042_bib29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/ng.2854","article-title":"Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database","volume":"46","year":"2014","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsdottir","year":"2013","journal-title":"Brief Bioinform"},{"key":"10.1053\/j.gastro.2014.11.042_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1479-7364-7-11","article-title":"Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer","volume":"7","author":"Grant","year":"2013","journal-title":"Hum Genomics"},{"key":"10.1053\/j.gastro.2014.11.042_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1525-1578(10)60577-6","article-title":"Tumor microsatellite instability in early onset gastric cancer","volume":"7","author":"Bacani","year":"2005","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1053\/j.gastro.2014.11.042_bib33","series-title":"Complex surveys: a guide to analysis using R","author":"Lumley","year":"2010"},{"key":"10.1053\/j.gastro.2014.11.042_bib34","first-page":"1","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley","year":"2004","journal-title":"J\u00a0Stat Software"},{"key":"10.1053\/j.gastro.2014.11.042_bib35","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/cncr.26424","article-title":"Annual screening strategies in BRCA1 and BRCA2 gene mutation carriers: a comparative effectiveness analysis","volume":"118","author":"Lowry","year":"2012","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.bjc.6600064","article-title":"Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations","volume":"86","author":"Duffy","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib37","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1136\/gutjnl-2012-304356","article-title":"Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts","volume":"62","author":"Vasen","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2014.11.042_bib38","unstructured":"NHS Cancer Screening Programs. Protocols for the surveillance of women at higher risk of developing breast cancer, version 4. Volume 74.\u00a02013."},{"key":"10.1053\/j.gastro.2014.11.042_bib39","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/j.gastro.2009.06.055","article-title":"Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer","volume":"137","author":"Tischkowitz","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2014.11.042_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/cncr.26191","article-title":"Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer","volume":"118","author":"Stadler","year":"2012","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10689-010-9329-6","article-title":"Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families","volume":"9","author":"Slater","year":"2010","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0597-17","article-title":"Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients","volume":"16","author":"Ozcelik","year":"1997","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib43","first-page":"3789","article-title":"Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%","volume":"62","author":"Murphy","year":"2002","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib44","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1158\/1078-0432.CCR-12-3020","article-title":"High prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions","volume":"19","author":"Lucas","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib45","doi-asserted-by":"crossref","first-page":"645","DOI":"10.20452\/pamw.512","article-title":"Is there any relationship between BRCA1 gene mutation and pancreatic cancer development?","volume":"118","author":"Lawniczak","year":"2008","journal-title":"Pol Arch Med Wewn"},{"key":"10.1053\/j.gastro.2014.11.042_bib46","first-page":"409","article-title":"Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations","volume":"60","author":"Lal","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib47","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10689-011-9507-1","article-title":"The founder Ashkenazi Jewish mutations in the MSH2 and MSH6 genes in Israeli patients with gastric and pancreatic cancer","volume":"11","author":"Laitman","year":"2012","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib48","first-page":"5360","article-title":"Germline BRCA2\u00a0gene\u00a0mutations in patients with apparently sporadic pancreatic carcinomas","volume":"56","author":"Goggins","year":"1996","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2014.11.042_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10689-011-9483-5","article-title":"Contribution of\u00a0germline mutations in the BRCA and PALB2 genes to\u00a0pancreatic cancer in Italy","volume":"11","author":"Ghiorzo","year":"2012","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib50","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/jmedgenet-2011-100281","article-title":"CDKN2A is the main susceptibility gene in Italian pancreatic cancer families","volume":"49","author":"Ghiorzo","year":"2012","journal-title":"J\u00a0Med Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib51","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10689-009-9285-1","article-title":"Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome","volume":"8","author":"Gargiulo","year":"2009","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib52","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1158\/1055-9965.EPI-06-0783","article-title":"The prevalence of BRCA2 mutations in familial pancreatic cancer","volume":"16","author":"Couch","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.gastro.2014.11.042_bib53","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/cbt.8.2.7136","article-title":"Absence of germline BRCA1 mutations in familial pancreatic cancer patients","volume":"8","author":"Axilbund","year":"2009","journal-title":"Cancer Biol Ther"},{"key":"10.1053\/j.gastro.2014.11.042_bib54","doi-asserted-by":"crossref","first-page":"e67538","DOI":"10.1371\/journal.pone.0067538","article-title":"Analysis of PALB2 gene in BRCA1\/BRCA2 negative Spanish hereditary breast\/ovarian cancer families with pancreatic cancer cases","volume":"8","author":"Blanco","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2014.11.042_bib55","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ejhg.2011.226","article-title":"Routine testing for PALB2 mutations in familial pancreatic cancer families and breast cancer families with pancreatic cancer is not indicated","volume":"20","author":"Harinck","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib56","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10689-011-9447-9","article-title":"Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer","volume":"10","author":"Yang","year":"2011","journal-title":"Fam Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib57","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/MPA.0b013e3181da91dd","article-title":"Impact of race, age, and socioeconomic status on participation in pancreatic cancer clinical trials","volume":"39","author":"El-Rayes","year":"2010","journal-title":"Pancreas"},{"key":"10.1053\/j.gastro.2014.11.042_bib58","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1200\/JCO.2013.53.6607","article-title":"Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment","volume":"32","author":"Kurian","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2014.11.042_bib59","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1200\/JCO.2012.46.9403","article-title":"Multiplex genetic testing for cancer susceptibility: out on the high wire without a net?","volume":"31","author":"Domchek","year":"2013","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2014.11.042_bib60","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1200\/JCO.2013.53.6607","article-title":"Clinical evaluation of a multiple-gene sequencing panel for hereditary cancer risk assessment","volume":"32","author":"Kurian","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1053\/j.gastro.2014.11.042_bib61","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1073\/pnas.1115052108","article-title":"Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing","volume":"108","author":"Walsh","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2014.11.042_bib62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/cncr.29010","article-title":"Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel","volume":"121","author":"Tung","year":"2015","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2014.11.042_bib63","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.6004\/jnccn.2014.0127","article-title":"Genetic\/familial high-risk assessment: breast and ovarian, version 1.2014","volume":"12","author":"Daly","year":"2014","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1053\/j.gastro.2014.11.042_bib64","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1073\/pnas.0511301103","article-title":"Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population","volume":"103","author":"Simchoni","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2014.11.042_bib65","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2014.11.042_bib66","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/humu.22262","article-title":"Cancer risks for MLH1 and MSH2 mutation carriers","volume":"34","author":"Dowty","year":"2013","journal-title":"Hum Mutat"},{"key":"10.1053\/j.gastro.2014.11.042_bib67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature11547","article-title":"Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes","volume":"491","author":"Biankin","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2014.11.042_bib68","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1158\/1055-9965.EPI-05-0734","article-title":"Pancreatic cancer genetic epidemiology consortium","volume":"15","author":"Petersen","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514014796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508514014796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:09:59Z","timestamp":1758035399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508514014796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0016508514014796"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2014.11.042","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2014.11.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}