{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:59:24Z","timestamp":1792677564473,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","gastrojournal.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1053\/j.gastro.2015.02.053","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:38:04Z","timestamp":1425429484000},"page":"1417-1426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":136,"title":["\u03b3\u03b4 Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice"],"prefix":"10.1053","volume":"148","author":[{"given":"Karen L.","family":"Edelblum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurminder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Odenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amulya","family":"Lingaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"El Bissati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne I.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrold R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2015.02.053_bib1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1084\/jem.170.5.1569","article-title":"Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function","volume":"170","author":"Goodman","year":"1989","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2015.02.053_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cellimm.2012.09.012","article-title":"Protective function of an unconventional gammadelta T cell subset against malaria infection in apoptosis inhibitor deficient mice","volume":"279","author":"Li","year":"2012","journal-title":"Cell Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib3","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1053\/j.gastro.2006.06.003","article-title":"Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection","volume":"131","author":"Dalton","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.02.053_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"\u03b3\u03b4 T cells exhibit multifunctional and protective memory in intestinal tissues","volume":"39","author":"Sheridan","year":"2013","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2015.02.053_bib5","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1073\/pnas.1019574108","article-title":"Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface","volume":"108","author":"Ismail","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.02.053_bib6","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1073\/pnas.1112519109","article-title":"Dynamic migration of \u03b3\u03b4 intraepithelial lymphocytes requires occludin","volume":"109","author":"Edelblum","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.02.053_bib7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/eji.1830250333","article-title":"Recognition of E-cadherin on epithelial cells by the mucosal T cell integrin alpha M290 beta 7 (alpha E beta 7)","volume":"25","author":"Karecla","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1083\/jcb.140.1.197","article-title":"Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin","volume":"140","author":"Higgins","year":"1998","journal-title":"J\u00a0Cell Biol"},{"key":"10.1053\/j.gastro.2015.02.053_bib9","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.4049\/jimmunol.162.11.6641","article-title":"Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice","volume":"162","author":"Schon","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0092-8674(93)90112-4","article-title":"T\u00a0cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes","volume":"72","author":"Itohara","year":"1993","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.02.053_bib11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ni1371","article-title":"Visualization of the earliest steps of gammadelta T cell development in the adult thymus","volume":"7","author":"Prinz","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib12","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1091\/mbc.11.12.4131","article-title":"Complex phenotype of mice lacking occludin, a component of tight junction strands","volume":"11","author":"Saitou","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2015.02.053_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humimm.2011.10.006","article-title":"Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-\u03b3 and reduces parasite burden in HLA-B*0702 mice","volume":"73","author":"Cong","year":"2012","journal-title":"Hum Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib14","doi-asserted-by":"crossref","first-page":"e14057","DOI":"10.1371\/journal.pone.0014057","article-title":"T.\u00a0gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest","volume":"5","author":"Hutson","year":"2010","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2015.02.053_bib15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2011.01.004","article-title":"The epithelial barrier is maintained by in\u00a0vivo tight junction expansion during pathologic intestinal epithelial shedding","volume":"140","author":"Marchiando","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.02.053_bib16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200902153","article-title":"Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in\u00a0vivo","volume":"189","author":"Marchiando","year":"2010","journal-title":"J\u00a0Cell Biol"},{"key":"10.1053\/j.gastro.2015.02.053_bib17","doi-asserted-by":"crossref","first-page":"52300","DOI":"10.1074\/jbc.M409175200","article-title":"The expression of lactate dehydrogenase is important for the cell cycle of Toxoplasma gondii","volume":"279","author":"Al-Anouti","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.02.053_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1462-5822.2005.00486.x","article-title":"Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2","volume":"7","author":"Barragan","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1053\/j.gastro.2015.02.053_bib19","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1056\/NEJM195706132562402","article-title":"Clinical manifestations of salmonellosis in man; an evaluation of 7779 human infections identified at the New York Salmonella Center","volume":"256","author":"Saphra","year":"1957","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2015.02.053_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"\u03b3\u03b4 T cells: first line of defense and beyond","volume":"32","author":"Chien","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib21","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.00218.2013","article-title":"\u03b3\u03b4 T-cell-deficient mice show alterations in mucin expression, glycosylation, and goblet cells but maintain an intact mucus layer","volume":"306","author":"Kober","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2015.02.053_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1749-6632.2012.06534.x","article-title":"The protozoan pathogen Toxoplasma gondii targets the paracellular pathway to invade the intestinal epithelium","volume":"1258","author":"Weight","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1053\/j.gastro.2015.02.053_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/mi.2013.32","article-title":"Protection against colitis by CD100-dependent modulation of intraepithelial gammadelta T lymphocyte function","volume":"7","author":"Meehan","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib24","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11242","article-title":"HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria","volume":"488","author":"Shui","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.02.053_bib25","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.7973709","article-title":"Modulation of epithelial cell growth by intraepithelial gamma delta T cells","volume":"266","author":"Boismenu","year":"1994","journal-title":"Science"},{"key":"10.1053\/j.gastro.2015.02.053_bib26","doi-asserted-by":"crossref","first-page":"14338","DOI":"10.1073\/pnas.212290499","article-title":"Protection of the intestinal mucosa by intraepithelial gamma delta T cells","volume":"99","author":"Chen","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.02.053_bib27","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.4049\/jimmunol.173.2.1390","article-title":"Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation","volume":"173","author":"Inagaki-Ohara","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib28","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1128\/IAI.02024-05","article-title":"Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection","volume":"74","author":"Inagaki-Ohara","year":"2006","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2015.02.053_bib29","doi-asserted-by":"crossref","first-page":"e84553","DOI":"10.1371\/journal.pone.0084553","article-title":"Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge","volume":"8","author":"Walker","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2015.02.053_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coi.2014.03.002","article-title":"Visualization and dynamic analysis of host-pathogen interactions","volume":"29C","author":"Mandl","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib31","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.4049\/jimmunol.0802705","article-title":"Reciprocal interactions between commensal bacteria and gamma delta intraepithelial lymphocytes during mucosal injury","volume":"182","author":"Ismail","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2015.02.053_bib32","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1194598","article-title":"Salmonella pathogenesis and processing of secreted effectors by caspase-3","volume":"330","author":"Srikanth","year":"2010","journal-title":"Science"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515003029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515003029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T15:26:36Z","timestamp":1732116396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508515003029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0016508515003029"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2015.02.053","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b3\u03b4 Intraepithelial Lymphocyte Migration Limits Transepithelial Pathogen Invasion and Systemic Disease in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2015.02.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}