{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:43:46Z","timestamp":1789987426011,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1053\/j.gastro.2015.03.014","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T16:41:33Z","timestamp":1427301693000},"page":"211-222.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes"],"prefix":"10.1053","volume":"149","author":[{"given":"Jittima","family":"Weerachayaphorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jimena","family":"Amaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Spirli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyachat","family":"Chansela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisha A.","family":"Mitchell-Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshisundaram","family":"Ananthanarayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Nathanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2015.03.014_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jhep.2012.10.011","article-title":"The dynamic biliary epithelia: molecules, pathways, and disease","volume":"58","author":"O'Hara","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2015.03.014_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1053\/jhep.2002.34432","article-title":"Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms","volume":"36","author":"Hirata","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.03.014_bib3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0016-5085(03)01201-0","article-title":"Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis","volume":"125","author":"Shibao","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.03.014_bib4","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2007.08.020","article-title":"Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile","volume":"133","author":"Minagawa","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.03.014_bib5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1665-2681(19)31884-8","article-title":"Oxidative stress: a radical way to stop making bile","volume":"7","author":"Roma","year":"2008","journal-title":"Ann Hepatol"},{"key":"10.1053\/j.gastro.2015.03.014_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1053\/j.gastro.2015.03.014_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000324507","article-title":"The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves","volume":"19","author":"Fiedler","year":"2011","journal-title":"Neurosignals"},{"key":"10.1053\/j.gastro.2015.03.014_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1053\/gast.2001.25516","article-title":"Proinflammatory cytokines inhibit secretion in rat bile duct epithelium","volume":"121","author":"Spirli","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.03.014_bib9","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.freeradbiomed.2007.02.017","article-title":"Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin","volume":"42","author":"Tanigawa","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/j.gastro.2015.03.014_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrd3674","article-title":"Epigenetic protein families: a new frontier for drug discovery","volume":"11","author":"Arrowsmith","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1053\/j.gastro.2015.03.014_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.03.014_bib12","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","article-title":"Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region","volume":"91","author":"Moi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.03.014_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(02)00788-6","article-title":"Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors","volume":"294","author":"Motohashi","year":"2002","journal-title":"Gene"},{"key":"10.1053\/j.gastro.2015.03.014_bib14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1080\/01635581.2010.492087","article-title":"The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle","volume":"62","author":"Samuel","year":"2010","journal-title":"Nutr Cancer"},{"key":"10.1053\/j.gastro.2015.03.014_bib15","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1080\/07357900802337191","article-title":"Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt\/beta-catenin signaling pathway","volume":"27","author":"Shan","year":"2009","journal-title":"Cancer Invest"},{"key":"10.1053\/j.gastro.2015.03.014_bib16","doi-asserted-by":"crossref","first-page":"G779","DOI":"10.1152\/ajpgi.00325.2004","article-title":"Purinergic regulation of cholangiocyte secretion: identification of a novel role for P2X receptors","volume":"288","author":"Doctor","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2015.03.014_bib17","doi-asserted-by":"crossref","first-page":"G1059","DOI":"10.1152\/ajpgi.2001.281.4.G1059","article-title":"Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia","volume":"281","author":"Dranoff","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2015.03.014_bib18","first-page":"G86","article-title":"Characterization of cytosolic Ca2+ signaling in rat bile duct epithelia","volume":"271","author":"Nathanson","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2015.03.014_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/23954","article-title":"Type III InsP3 receptor channel stays open in the presence of increased calcium","volume":"396","author":"Hagar","year":"1998","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.03.014_bib20","doi-asserted-by":"crossref","first-page":"10057","DOI":"10.1074\/jbc.M700746200","article-title":"The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves","volume":"282","author":"Hernandez","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.03.014_bib21","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1093\/emboj\/16.11.3078","article-title":"Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor","volume":"16","author":"Sugawara","year":"1997","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2015.03.014_bib22","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1073\/pnas.92.14.6527","article-title":"Isolation of small polarized bile duct units","volume":"92","author":"Mennone","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.03.014_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/gast.2001.26280","article-title":"Bile duct epithelia regulate biliary bicarbonate excretion in normal rat liver","volume":"121","author":"Hirata","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.03.014_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2015.03.014_bib25","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/hep.23883","article-title":"Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes","volume":"52","author":"Woo","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.03.014_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1074\/jbc.M114.587030","article-title":"Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506","volume":"290","author":"Ananthanarayanan","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.03.014_bib27","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/489S4a","article-title":"Biochemistry: a radical treatment","volume":"489","author":"Garber","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.03.014_bib28","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1073\/pnas.0308083100","article-title":"Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network","volume":"101","author":"Sun","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.03.014_bib29","doi-asserted-by":"crossref","first-page":"33627","DOI":"10.1074\/jbc.274.47.33627","article-title":"Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2","volume":"274","author":"Wild","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.03.014_bib30","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1124\/mol.107.039370","article-title":"Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress","volume":"72","author":"Tan","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1053\/j.gastro.2015.03.014_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2004.06.001","article-title":"Mitochondrially-mediated toxicity of bile acids","volume":"203","author":"Palmeira","year":"2004","journal-title":"Toxicology"},{"key":"10.1053\/j.gastro.2015.03.014_bib32","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.1073\/pnas.172398899","article-title":"Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants","volume":"99","author":"Dinkova-Kostova","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.03.014_bib33","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1073\/pnas.0307301101","article-title":"Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers","volume":"101","author":"Wakabayashi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.03.014_bib34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/hep.24723","article-title":"Altered store operated calcium entry increases cyclic 3\u2032,5\u2032-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes","volume":"55","author":"Spirli","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.03.014_bib35","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0168-8278(90)90152-H","article-title":"The use of isolated rat hepatocyte couplets in hepatobiliary physiology","volume":"10","author":"Graf","year":"1990","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2015.03.014_bib36","first-page":"G338","article-title":"Multistep mechanism of polarized Ca2+ wave patterns in hepatocytes","volume":"267","author":"Nathanson","year":"1994","journal-title":"Am J Physiol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515003704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515003704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T11:57:17Z","timestamp":1566475037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508515003704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0016508515003704"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2015.03.014","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuclear Factor, Erythroid 2-Like 2 Regulates Expression of Type 3 Inositol 1,4,5-Trisphosphate Receptor and Calcium Signaling in Cholangiocytes","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2015.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}