{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:13:17Z","timestamp":1793056397501,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1053\/j.gastro.2015.05.057","type":"journal-article","created":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T01:03:40Z","timestamp":1433639020000},"page":"981-992.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice"],"prefix":"10.1053","volume":"149","author":[{"given":"Christos","family":"Polytarchou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Hommes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Hatziapostolou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Koutsioumpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Koukos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea E.","family":"van der Meulen-de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelos","family":"Oikonomopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Welmoed K.","family":"van Deen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Vorvis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana B.","family":"Serebrennikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Birli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Tsichlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalabos","family":"Pothoulakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein W.","family":"Verspaget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Iliopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2015.05.057_bib1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2015.05.057_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/gutjnl-2013-305304","article-title":"Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease","volume":"63","author":"Ananthakrishnan","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2015.05.057_bib3","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2015.05.057_bib4","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","article-title":"Ulcerative colitis and colorectal cancer. A population-based study","volume":"323","author":"Ekbom","year":"1990","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2015.05.057_bib5","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2009.01.064","article-title":"Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease","volume":"136","author":"Soderlund","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib6","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z","article-title":"Cancer risk in patients with inflammatory bowel disease: a population-based study","volume":"91","author":"Bernstein","year":"2001","journal-title":"Cancer"},{"key":"10.1053\/j.gastro.2015.05.057_bib7","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1053\/j.gastro.2005.12.037","article-title":"Risk of intestinal cancer in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota","volume":"130","author":"Jess","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.MIB.0000217770.21261.ce","article-title":"Risk factors for ulcerative colitis-associated colorectal cancer in a Hungarian cohort of patients with ulcerative colitis: results of a population-based study","volume":"12","author":"Lakatos","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2015.05.057_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/gast.2000.16487","article-title":"Hodgkin's disease risk is increased in patients with ulcerative colitis","volume":"119","author":"Palli","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1053\/j.gastro.2009.12.037","article-title":"AGA medical position statement on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease","volume":"138","author":"Farraye","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1136\/gut.46.4.500","article-title":"A\u00a0decision analysis of surveillance for colorectal cancer in ulcerative colitis","volume":"46","author":"Delco","year":"2000","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2015.05.057_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1046\/j.1365-2168.1999.01133.x","article-title":"DNA aneuploidy as a marker of premalignancy in surveillance of patients with ulcerative colitis","volume":"86","author":"Lindberg","year":"1999","journal-title":"Br J Surg"},{"key":"10.1053\/j.gastro.2015.05.057_bib13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1572-0241.1999.877_f.x","article-title":"Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis","volume":"94","author":"Lashner","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2015.05.057_bib14","first-page":"4841","article-title":"Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers","volume":"54","author":"Suzuki","year":"1994","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2015.05.057_bib15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0016-5085(98)70018-6","article-title":"Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: relation to dysplasia and DNA aneuploidy","volume":"115","author":"Karlen","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ng.549","article-title":"Genome-wide association identifies multiple ulcerative colitis susceptibility loci","volume":"42","author":"McGovern","year":"2010","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2015.05.057_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.05.057_bib18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cgh.2012.11.001","article-title":"Promises, delivery, and challenges of inflammatory bowel disease risk gene discovery","volume":"11","author":"Brant","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2015.05.057_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MOG.0000000000000081","article-title":"Systems biology in inflammatory bowel diseases: ready for prime time","volume":"30","author":"Polytarchou","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1053\/j.gastro.2015.05.057_bib20","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.05.057_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2011.01089.x","article-title":"MicroRNAs, new effectors and regulators of NF-kappaB","volume":"246","author":"Boldin","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1053\/j.gastro.2015.05.057_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.immuni.2009.06.024","article-title":"The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs","volume":"31","author":"Androulidaki","year":"2009","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2015.05.057_bib23","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/ard.2010.139857","article-title":"Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression","volume":"70","author":"Stagakis","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1053\/j.gastro.2015.05.057_bib24","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.cell.2011.10.043","article-title":"An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis","volume":"147","author":"Hatziapostolou","year":"2011","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.05.057_bib25","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: new regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2015.05.057_bib26","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1053\/j.gastro.2008.07.068","article-title":"MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha","volume":"135","author":"Wu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib27","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1053\/j.gastro.2013.07.001","article-title":"MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis","volume":"145","author":"Koukos","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","article-title":"An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation","volume":"139","author":"Iliopoulos","year":"2009","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.05.057_bib29","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tem.2013.03.002","article-title":"miRNAs link metabolic reprogramming to oncogenesis","volume":"24","author":"Hatziapostolou","year":"2013","journal-title":"Trends Endocrinol Metab"},{"key":"10.1053\/j.gastro.2015.05.057_bib30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molcel.2010.07.023","article-title":"STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer","volume":"39","author":"Iliopoulos","year":"2010","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2015.05.057_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ibd.21691","article-title":"MicroRNAs in inflammatory bowel disease","volume":"18","author":"Pekow","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"10.1053\/j.gastro.2015.05.057_bib32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/ni1464","article-title":"PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit","volume":"8","author":"Tanaka","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2015.05.057_bib33","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1158\/0008-5472.CAN-11-0365","article-title":"Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation","volume":"71","author":"Polytarchou","year":"2011","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2015.05.057_bib34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/43474","article-title":"NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling","volume":"401","author":"Romashkova","year":"1999","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2015.05.057_bib35","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1101\/gad.1662308","article-title":"Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK","volume":"22","author":"Dan","year":"2008","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2015.05.057_bib36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1053\/j.gastro.2014.05.034","article-title":"Disruption of Pten\u00a0speeds onset and increases severity of spontaneous\u00a0colitis in Il10 mice","volume":"147","author":"Im","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nmeth.1188","article-title":"Systematic identification of mammalian regulatory motifs' target genes and functions","volume":"5","author":"Warner","year":"2008","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2015.05.057_bib38","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00000441-192508010-00006","article-title":"The sigmoidoscopic picture of chronic ulcerative colitis (non-specific)","volume":"170","author":"Crohn","year":"1925","journal-title":"Am J Med Sci"},{"key":"10.1053\/j.gastro.2015.05.057_bib39","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1053\/j.gastro.2009.12.035","article-title":"AGA technical review on the diagnosis and management of colorectal neoplasia in inflammatory bowel disease","volume":"138","author":"Farraye","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.05.057_bib40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2015.05.057_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gde.2008.01.020","article-title":"NF-kappaB and cancer-identifying targets and mechanisms","volume":"18","author":"Naugler","year":"2008","journal-title":"Curr Opin Genet Dev"},{"key":"10.1053\/j.gastro.2015.05.057_bib42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-kappaB and STAT3\u2013key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res"},{"key":"10.1053\/j.gastro.2015.05.057_bib43","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1126\/science.1178178","article-title":"Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection","volume":"327","author":"Lanford","year":"2010","journal-title":"Science"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515007842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515007842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T16:40:22Z","timestamp":1617468022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508515007842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0016508515007842"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2015.05.057","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2015.05.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}