{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:28:03Z","timestamp":1790400483955,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["3967\/3-1"],"award-info":[{"award-number":["3967\/3-1"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["691405"],"award-info":[{"award-number":["691405"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["DFG-EI\/ZUK2\/I3TM\/SF_15_5_17"],"award-info":[{"award-number":["DFG-EI\/ZUK2\/I3TM\/SF_15_5_17"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["TR 285\/10-1"],"award-info":[{"award-number":["TR 285\/10-1"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007210","name":"RWTH Aachen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009379","name":"Interdisziplin\u00e4res Zentrum f\u00fcr Klinische Forschung, Universit\u00e4tsklinikum W\u00fcrzburg","doi-asserted-by":"publisher","award":["SFB\/TRR57"],"award-info":[{"award-number":["SFB\/TRR57"]}],"id":[{"id":"10.13039\/501100009379","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1053\/j.gastro.2015.12.019","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T23:32:46Z","timestamp":1450481566000},"page":"968-981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury"],"prefix":"10.1053","volume":"150","author":[{"given":"Francisco Javier","family":"Cubero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Eugenio","family":"Zoubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia A.","family":"Nevzorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Al Masaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars P.","family":"Bechmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark V.","family":"Boekschoten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Preisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Gassler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali E.","family":"Canbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Luedde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Liedtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2015.12.019_bib1","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect Immun"},{"key":"10.1053\/j.gastro.2015.12.019_bib2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/j.2040-4603.2013.tb00507.x","article-title":"Apoptosis and necrosis in the liver","volume":"3","author":"Guicciardi","year":"2013","journal-title":"Compr Physiol"},{"key":"10.1053\/j.gastro.2015.12.019_bib3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1084\/jem.20011508","article-title":"c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation","volume":"195","author":"Conze","year":"2002","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2015.12.019_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0092-8674(00)00116-1","article-title":"Signal transduction by the JNK group of MAP kinases","volume":"103","author":"Davis","year":"2000","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.12.019_bib5","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1073\/pnas.0502143102","article-title":"Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes","volume":"102","author":"Jaeschke","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.12.019_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/jpet.104.075945","article-title":"Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes","volume":"312","author":"Reid","year":"2005","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1053\/j.gastro.2015.12.019_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1056\/NEJMct0708278","article-title":"Acetylcysteine for acetaminophen poisoning","volume":"359","author":"Heard","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2015.12.019_bib8","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1053\/jhep.2003.50230","article-title":"Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes","volume":"37","author":"Matsumaru","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib9","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1074\/jbc.M708916200","article-title":"Role of JNK\u00a0translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury","volume":"283","author":"Hanawa","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.12.019_bib10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/j.gastro.2009.09.015","article-title":"Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition","volume":"138","author":"Kluwe","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.12.019_bib11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1136\/gutjnl-2013-305507","article-title":"Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis","volume":"63","author":"Zhao","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2015.12.019_bib12","doi-asserted-by":"crossref","first-page":"15759","DOI":"10.1073\/pnas.0707782104","article-title":"Suppression of p53-dependent senescence by the JNK signal transduction pathway","volume":"104","author":"Das","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2015.12.019_bib13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cell.2008.11.017","article-title":"Induction of hepatitis by JNK-mediated expression of TNF-alpha","volume":"136","author":"Das","year":"2009","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2015.12.019_bib14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib15","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","article-title":"Role of CYP2E1 in the hepatotoxicity of acetaminophen","volume":"271","author":"Lee","year":"1996","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.12.019_bib16","doi-asserted-by":"crossref","first-page":"24609","DOI":"10.1074\/jbc.M110.121822","article-title":"Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress","volume":"285","author":"Bansal","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2015.12.019_bib17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/hep.25711","article-title":"Hepatic activation of IKK\/NF-kappaB signaling induces liver fibrosis via macrophage-mediated chronic inflammation","volume":"56","author":"Sunami","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib18","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.febslet.2008.01.063","article-title":"Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology","volume":"582","author":"Xu","year":"2008","journal-title":"FEBS Lett"},{"key":"10.1053\/j.gastro.2015.12.019_bib19","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/hep.26625","article-title":"Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways","volume":"59","author":"Saberi","year":"2014","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1053\/j.gastro.2012.06.004","article-title":"A\u00a0liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches","volume":"143","author":"Seki","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.12.019_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/hep.20277","article-title":"Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease","volume":"40","author":"Toivola","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib22","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/hep.20437","article-title":"Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes","volume":"40","author":"Kon","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hep.24690","article-title":"Activation of autophagy protects against acetaminophen-induced hepatotoxicity","volume":"55","author":"Ni","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib24","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/hep.26547","article-title":"Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice","volume":"58","author":"Ramachandran","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2015.12.019_bib25","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jhep.2011.12.019","article-title":"Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity","volume":"56","author":"Antoine","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2015.12.019_bib26","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2015.12.019_bib27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2006.03.045","article-title":"c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity","volume":"131","author":"Gunawan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2015.12.019_bib28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/gut.2006.104372","article-title":"Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure","volume":"56","author":"Henderson","year":"2007","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2015.12.019_bib29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1101\/gad.1989311","article-title":"The role of JNK in the development of hepatocellular carcinoma","volume":"25","author":"Das","year":"2011","journal-title":"Genes Dev"},{"key":"10.1053\/j.gastro.2015.12.019_bib30","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.4049\/jimmunol.172.4.2569","article-title":"Inhibition of c-Jun\u00a0NH2-terminal kinase activity improves ischemia\/reperfusion injury in rat lungs","volume":"172","author":"Ishii","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2015.12.019_bib31","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/hep.27939","article-title":"Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis","volume":"62","author":"Dara","year":"2015","journal-title":"Hepatology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515018144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508515018144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:13:38Z","timestamp":1758035618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508515018144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0016508515018144"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2015.12.019","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2015.12.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}