{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:18:16Z","timestamp":1793409496417,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1053\/j.gastro.2016.02.011","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T05:15:32Z","timestamp":1462079732000},"page":"1380-1392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1403,"title":["Gastroduodenal Disorders"],"prefix":"10.1053","volume":"150","author":[{"given":"Vincenzo","family":"Stanghellini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis K.L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Hasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Malagelada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.02.011_bib1","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/apt.12865","article-title":"Review article: adherence to Rome criteria in therapeutic trials in functional dyspepsia","volume":"40","author":"Stanghellini","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.02.011_bib3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/apt.12855","article-title":"The use of pictograms improves symptom evaluation by patients with functional dyspepsia","volume":"40","author":"Tack","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.02.011_bib4","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3748\/wjg.v12.i17.2661","article-title":"Epidemiology of functional dyspepsia: a global perspective","volume":"12","author":"Mahadeva","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib5","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1111\/j.1572-0241.2004.40052.x","article-title":"The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States","volume":"99","author":"Shaib","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2982.2009.01262.x","article-title":"Dyspeptic symptoms in the general population: a factor and cluster analysis of symptom groupings","volume":"21","author":"Piessevaux","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nrgastro.2013.14","article-title":"Functional dyspepsia\u2014symptoms, definitions and validity of the Rome III criteria","volume":"10","author":"Tack","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib8","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/gut.2007.137125","article-title":"Relationship between symptoms and ingestion of a meal in functional dyspepsia","volume":"57","author":"Bisschops","year":"2008","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.02.011_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/nmo.12305","article-title":"The gastric accommodation response to meal intake determines the occurrence of transient lower esophageal sphincter relaxations and reflux events in patients with gastro-esophageal reflux disease","volume":"26","author":"Pauwels","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1053\/gast.1996.v110.pm8612991","article-title":"Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia","volume":"110","author":"Stanghellini","year":"1996","journal-title":"Gastroenterology"},{"issue":"Suppl","key":"10.1053\/j.gastro.2016.02.011_bib11","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/S0016-5085(14)60637-5","article-title":"Uninvestigated dyspepssia in the US general population resutls from the Rome Normative Gastrointestinal Symptoms Survey (RNGSS)","volume":"146","author":"Palsson","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/nrgastro.2012.255","article-title":"Changes in gastrointestinal tract function and structure in functional dyspepsia","volume":"10","author":"Vanheel","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib13","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1136\/gutjnl-2013-306084","article-title":"Gastroparesis: separate entity or just a part of dyspepsia?","volume":"63","author":"Stanghellini","year":"2014","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.02.011_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/gut.35.3.327","article-title":"Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients","volume":"35","author":"Troncon","year":"1994","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.02.011_bib15","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0016-5085(98)70012-5","article-title":"Role of impaired gastric accommodation to a meal in functional dyspepsia","volume":"115","author":"Tack","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/MCG.0b013e31818e37ab","article-title":"Prolonged recording of duodenal acid exposure in patients with functional dyspepsia and controls using a radiotelemetry pH monitoring system","volume":"43","author":"Bratten","year":"2009","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib17","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional dyspepsia","volume":"373","author":"Talley","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1053\/j.gastro.2016.02.011_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrgastro.2013.9","article-title":"Helicobacter pylori infection in functional dyspepsia","volume":"10","author":"Suzuki","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/jgh.12419","article-title":"Duodenal eosinophilia and early satiety in functional dyspepsia: confirmation of a positive association in an Australian cohort","volume":"29","author":"Walker","year":"2014","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1053\/j.gastro.2005.04.012","article-title":"Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year follow-up cohort study","volume":"129","author":"Mearin","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1053\/j.gastro.2014.03.013","article-title":"Salmonella gastroenteritis during childhood is a risk factor for irritable bowel syndrome in adulthood","volume":"147","author":"Cremon","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2009.01320.x","article-title":"Novel associations with dyspepsia: a community-based study of familial aggregation, sleep dysfunction and somatization","volume":"21","author":"Gathaiya","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/01.PSY.0000075977.90337.E7","article-title":"Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review","volume":"65","author":"Henningsen","year":"2003","journal-title":"Psychosom Med"},{"key":"10.1053\/j.gastro.2016.02.011_bib24","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1136\/gutjnl-2012-302371","article-title":"Investigating the directionality of the brain\u2212gut mechanism in functional gastrointestinal disorders","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.02.011_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrgastro.2013.11","article-title":"Current management strategies and emerging treatments for functional dyspepsia","volume":"10","author":"Camilleri","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrgastro.2015.158","article-title":"Helicobacter pylori: Helicobacter pylori gastritis-a novel distinct disease entity","volume":"12","author":"Suzuki","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"9","key":"10.1053\/j.gastro.2016.02.011_bib27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.02.011_bib28","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1053\/j.gastro.2015.04.020","article-title":"Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study","volume":"149","author":"Talley","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib29","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/ajg.2014.165","article-title":"The pathophysiology, diagnosis and treatment of excessive belching symptoms","volume":"109","author":"Kessing","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib30","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.1111\/nmo.12024","article-title":"Mechanisms of gastric and supragastric belching: a study using concurrent high-resolution manometry and impedance monitoring","volume":"24","author":"Kessing","year":"2012","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib31","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1111\/j.1572-0241.2006.00917.x","article-title":"Psychological factors affect the frequency of belching in patients with aerophagia","volume":"101","author":"Bredenoord","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/WNN.0b013e318165a9b9","article-title":"Aerophagia and belching after herpes simplex encephalitis","volume":"21","author":"Scheid","year":"2008","journal-title":"Cogn Behav Neurol"},{"key":"10.1053\/j.gastro.2016.02.011_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/0145445504264746","article-title":"Behavioral treatment of chronic belching due to aerophagia in a normal adult","volume":"30","author":"Cigrang","year":"2006","journal-title":"Behav Modif"},{"key":"10.1053\/j.gastro.2016.02.011_bib34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2982.2009.01371.x","article-title":"Speech therapy in patients with excessive supragastric belching\u2014a pilot study","volume":"22","author":"Hemmink","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib35","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cgh.2011.10.042","article-title":"Baclofen improves symptoms and reduces postprandial flow events in patients with rumination and supragastric belching","volume":"10","author":"Blondeau","year":"2012","journal-title":"Clini Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000121347","article-title":"The Rome III Classification of dyspepsia: will it help research?","volume":"26","author":"Talley","year":"2008","journal-title":"Digest Dis"},{"key":"10.1053\/j.gastro.2016.02.011_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2036.2011.04721.x","article-title":"Review article: cyclic vomiting syndrome in adults\u2014rediscovering and redefining an old entity","volume":"34","author":"Hejazi","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.02.011_bib38","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2982.2011.01679.x","article-title":"Autonomic nerve function in adult patients with cyclic vomiting syndrome","volume":"23","author":"Hejazi","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.02.011_bib39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1445-5994.2009.02047.x","article-title":"Cannabinoid hyperemesis","volume":"39","author":"Sannarangappa","year":"2009","journal-title":"Intern Med J"},{"key":"10.1053\/j.gastro.2016.02.011_bib40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1468-2982.2008.01793.x","article-title":"Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome","volume":"29","author":"Zaki","year":"2009","journal-title":"Cephalalgia"},{"key":"10.1053\/j.gastro.2016.02.011_bib41","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/MEG.0b013e328354fc83","article-title":"Cyclic vomiting syndrome in 28 patients: demographics, features and outcomes","volume":"24","author":"Lee","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.011_bib42","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/MPG.0b013e318173ed39","article-title":"North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition consensus statement on the diagnosis and management of cyclic vomiting syndrome","volume":"47","author":"Li","year":"2008","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"1049","key":"10.1053\/j.gastro.2016.02.011_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/postgradmedj-2012-131284","article-title":"Sensory neuromodulators in functional nausea and vomiting: predictors of response","volume":"89","author":"Patel","year":"2013","journal-title":"Postgrad Med J"},{"key":"10.1053\/j.gastro.2016.02.011_bib44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/j.gastro.2010.10.015","article-title":"Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity","volume":"140","author":"Parkman","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.011_bib45","first-page":"1621","article-title":"Voluntary induction of transient lower esophageal sphincter relaxations in an adult patient with the rumination syndrome","volume":"85","author":"Smout","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib46","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.3109\/00365521.2011.605467","article-title":"Impedance measurements and high-resolution manometry help to better define rumination episodes","volume":"46","author":"Kessing","year":"2011","journal-title":"Scandi J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib47","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0025-6196(11)63571-4","article-title":"Rumination syndrome","volume":"72","author":"Malcolm","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"10.1053\/j.gastro.2016.02.011_bib48","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ajg.2013.428","article-title":"Objective manometric criteria for the rumination syndrome","volume":"109","author":"Kessing","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.011_bib49","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1365-2036.2011.04584.x","article-title":"Review article: the pathophysiology, differential diagnosis and management of rumination syndrome","volume":"33","author":"Tack","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.02.011_bib50","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/00005176-199811000-00019","article-title":"Behavioral\u00a0intervention for the treatment of rumination","volume":"27","author":"Wagaman","year":"1998","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516001773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516001773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:37:02Z","timestamp":1718498222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516001773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0016508516001773"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.02.011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726334922.793536953","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastroduodenal Disorders","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The AGA Institute.","name":"copyright","label":"Copyright"}]}}