{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:12:22Z","timestamp":1791324742915,"version":"4.3.1"},"reference-count":116,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1053\/j.gastro.2016.02.035","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T21:28:32Z","timestamp":1456349312000},"page":"1756-1768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":177,"title":["Linking Pathogenic Mechanisms of Alcoholic Liver Disease With\u00a0Clinical Phenotypes"],"prefix":"10.1053","volume":"150","author":[{"given":"Laura E.","family":"Nagy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Cresci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paramananda","family":"Saikia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay H.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.02.035_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1079\/PNS2003327","article-title":"Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology","volume":"63","author":"Crabb","year":"2004","journal-title":"Proc Nutr Soc"},{"key":"10.1053\/j.gastro.2016.02.035_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/j.gastro.2016.02.035_bib3","doi-asserted-by":"crossref","first-page":"498491","DOI":"10.1155\/2014\/498491","article-title":"Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets","volume":"2014","author":"Li","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1053\/j.gastro.2016.02.035_bib4","doi-asserted-by":"crossref","first-page":"G95","DOI":"10.1152\/ajpgi.00383.2004","article-title":"Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide","volume":"289","author":"Cao","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib5","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1189\/jlb.1005613","article-title":"Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1\/2 activation and TNF-alpha production","volume":"79","author":"Thakur","year":"2006","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI111022","article-title":"Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol","volume":"72","author":"Lange","year":"1983","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.02.035_bib7","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1002\/hep.20957","article-title":"Alcohol and oxidative liver injury","volume":"43","author":"Dey","year":"2006","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI9020","article-title":"NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease","volume":"106","author":"Kono","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.02.035_bib9","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1053\/jhep.2003.50450","article-title":"Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase","volume":"38","author":"Kessova","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib10","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1053\/j.gastro.2003.08.030","article-title":"Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice","volume":"125","author":"McKim","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib11","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.bbabio.2011.09.011","article-title":"Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes","volume":"1807","author":"Zelickson","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2016.02.035_bib12","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.510250422","article-title":"Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in\u00a0vivo","volume":"25","author":"Arteel","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib13","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jhep.2011.07.024","article-title":"HIF-1alpha induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice","volume":"56","author":"Nishiyama","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib14","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/hep.24256","article-title":"Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice","volume":"53","author":"Nath","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jhep.2011.09.009","article-title":"HIF-1alpha is a major and complex player in alcohol induced liver diseases","volume":"56","author":"Mehal","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib16","doi-asserted-by":"crossref","first-page":"e115849","DOI":"10.1371\/journal.pone.0115849","article-title":"Role of hypoxia inducing factor-1beta in alcohol-induced autophagy, steatosis and liver injury in mice","volume":"9","author":"Ni","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.02.035_bib17","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib18","doi-asserted-by":"crossref","first-page":"G892","DOI":"10.1152\/ajpgi.00575.2007","article-title":"Involvement of mammalian sirtuin 1 in the action of ethanol in the liver","volume":"294","author":"You","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib19","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"Ponugoti","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.02.035_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib21","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1002\/hep.26589","article-title":"Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice","volume":"58","author":"Hu","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2016.02.035_bib23","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMP-activated protein kinase in the action of ethanol in the liver","volume":"127","author":"You","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib24","doi-asserted-by":"crossref","first-page":"G833","DOI":"10.1152\/ajpgi.90358.2008","article-title":"Resveratrol alleviates alcoholic fatty liver in mice","volume":"295","author":"Ajmo","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40139-013-0021-z","article-title":"Role of mitochondria in alcoholic liver disease","volume":"1","author":"Garcia-Ruiz","year":"2013","journal-title":"Curr Pathobiol Rep"},{"key":"10.1053\/j.gastro.2016.02.035_bib26","doi-asserted-by":"crossref","first-page":"G265","DOI":"10.1152\/ajpgi.00278.2013","article-title":"Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice","volume":"306","author":"King","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib27","doi-asserted-by":"crossref","first-page":"G324","DOI":"10.1152\/ajpgi.00108.2015","article-title":"Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice","volume":"309","author":"Williams","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib28","doi-asserted-by":"crossref","first-page":"42165","DOI":"10.1074\/jbc.M112.377374","article-title":"Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations","volume":"287","author":"Han","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.02.035_bib29","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0016-5085(03)00276-2","article-title":"Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice","volume":"124","author":"Ji","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib30","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.02.035_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4161\/auto.5190","article-title":"Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome","volume":"4","author":"Ding","year":"2008","journal-title":"Autophagy"},{"key":"10.1053\/j.gastro.2016.02.035_bib32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/hep.510280228","article-title":"Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration","volume":"28","author":"Donohue","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib33","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.jhep.2013.01.011","article-title":"Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice","volume":"58","author":"Lin","year":"2013","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib34","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2010.07.041","article-title":"Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice","volume":"139","author":"Ding","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib35","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4161\/auto.25063","article-title":"Functions of autophagy in normal and diseased liver","volume":"9","author":"Czaja","year":"2013","journal-title":"Autophagy"},{"key":"10.1053\/j.gastro.2016.02.035_bib36","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/hep.22014","article-title":"Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking","volume":"47","author":"Joseph","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1530-0277.1998.tb03866.x","article-title":"Ethanol oxidation mediates impaired hepatic receptor-mediated enocytosis","volume":"22","author":"Clemens","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib38","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1006\/bbrc.1993.2161","article-title":"Chronic ethanol administration impairs ATP-dependent acidification of endosomes in rat liver","volume":"195","author":"Casey","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.gastro.2016.02.035_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0304-4165(95)00121-2","article-title":"Ethanol consumption reduces the proteolytic capacity and protease activities of hepatic lysosomes","volume":"1245","author":"Kharbanda","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2016.02.035_bib40","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib41","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.00061.2009","article-title":"Hepatocyte death: a clear and present danger","volume":"90","author":"Malhi","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1053\/j.gastro.2016.02.035_bib42","doi-asserted-by":"crossref","first-page":"49S","DOI":"10.1111\/j.1530-0277.2001.tb02373.x","article-title":"Alcoholic liver disease and apoptosis","volume":"25","author":"Casey","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib43","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.2741\/1765","article-title":"Apoptosis in alcoholic and nonalcoholic steatohepatitis","volume":"10","author":"Feldstein","year":"2005","journal-title":"Front Biosci"},{"key":"10.1053\/j.gastro.2016.02.035_bib44","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib45","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib46","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2009.05.037","article-title":"Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation","volume":"137","author":"Cho","year":"2009","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib47","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nrm3143","article-title":"Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death","volume":"12","author":"Vucic","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.molcel.2014.11.001","article-title":"The two faces of receptor interacting protein kinase-1","volume":"56","author":"Weinlich","year":"2014","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib50","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pronecrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.molcel.2011.06.006","article-title":"The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs","volume":"43","author":"Tenev","year":"2011","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib52","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cell.2014.04.018","article-title":"RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3","volume":"157","author":"Dillon","year":"2014","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.02.035_bib53","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1530-0277.2011.01720.x","article-title":"Inhibition of apoptosis protects mice from ethanol-mediated acceleration of early markers of CCl4 -induced fibrosis but not steatosis or inflammation","volume":"36","author":"Roychowdhury","year":"2012","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib54","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.26200","article-title":"Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury","volume":"57","author":"Roychowdhury","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.redox.2013.08.005","article-title":"Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver","volume":"1","author":"Ni","year":"2013","journal-title":"Redox Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib56","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1158\/0008-5472.CAN-10-4475","article-title":"Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1","volume":"71","author":"Li","year":"2011","journal-title":"Cancer Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib57","doi-asserted-by":"crossref","first-page":"700","DOI":"10.15252\/embr.201439496","article-title":"RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis","volume":"16","author":"Yonekawa","year":"2015","journal-title":"EMBO Rep"},{"key":"10.1053\/j.gastro.2016.02.035_bib58","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/nure.12027","article-title":"Ethanol metabolism and its effects on the intestinal epithelial barrier","volume":"71","author":"Elamin","year":"2013","journal-title":"Nutr Rev"},{"key":"10.1053\/j.gastro.2016.02.035_bib59","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1053\/j.gastro.2016.02.073","article-title":"Changes in intestinal microbiome and alcoholic and nonalcoholic liver diseases: causes or effects?","volume":"150","author":"Betrapally","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib60","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.23009","article-title":"Endotoxemia and gut barrier dysfunction in alcoholic liver disease","volume":"50","author":"Rao","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib61","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alcohol.2008.12.009","article-title":"Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis","volume":"43","author":"Forsyth","year":"2009","journal-title":"Alcohol"},{"key":"10.1053\/j.gastro.2016.02.035_bib62","doi-asserted-by":"crossref","first-page":"14660","DOI":"10.3748\/wjg.v20.i40.14660","article-title":"Alcoholism: a systemic proinflammatory condition","volume":"20","author":"Gonzalez-Reimers","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.035_bib63","doi-asserted-by":"crossref","first-page":"e0134044","DOI":"10.1371\/journal.pone.0134044","article-title":"Protection of gastrointestinal mucosa from acute heavy alcohol consumption: the effect of berberine and its correlation with TLR2, 4\/IL1beta-TNFalpha signaling","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.02.035_bib64","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1521-6918(03)00034-9","article-title":"Effect of alcohol consumption on the gut","volume":"17","author":"Bode","year":"2003","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.035_bib65","first-page":"315","article-title":"Damage-associated molecular patterns control neutrophil recruitment","volume":"5","author":"Pittman","year":"2013","journal-title":"J\u00a0Innate Immun"},{"key":"10.1053\/j.gastro.2016.02.035_bib66","doi-asserted-by":"crossref","first-page":"G838","DOI":"10.1152\/ajpgi.00151.2013","article-title":"HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury","volume":"305","author":"Seo","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib67","doi-asserted-by":"crossref","first-page":"22672","DOI":"10.1074\/jbc.M114.552141","article-title":"High mobility group box-1 (HMGB1) participates in the pathogenesis of alcoholic liver disease (ALD)","volume":"289","author":"Ge","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.02.035_bib68","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1053\/j.gastro.2010.05.074","article-title":"Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in\u00a0vivo","volume":"139","author":"Jiang","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib69","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1189\/jlb.3AB1214-590R","article-title":"Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease","volume":"98","author":"Petrasek","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib70","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrgastro.2015.94","article-title":"Inflammasome activation and function in liver disease","volume":"12","author":"Szabo","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib71","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/acer.12157","article-title":"Genetic resistance to liver fibrosis on A\/J mouse chromosome 17","volume":"37","author":"DeSantis","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib72","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/hep.24599","article-title":"An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice","volume":"54","author":"Mandrekar","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib73","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/path.4494","article-title":"22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto\/paracrine activation of MCP-1 mediated by LXRalpha","volume":"235","author":"Na","year":"2015","journal-title":"J\u00a0Pathol"},{"key":"10.1053\/j.gastro.2016.02.035_bib74","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1038\/srep09991","article-title":"Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS","volume":"5","author":"Momen-Heravi","year":"2015","journal-title":"Sci Rep"},{"key":"10.1053\/j.gastro.2016.02.035_bib75","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","article-title":"Alcohol stimulates macrophage activation through caspase dependent hepatocyte derived release of CD40L containing extracellular vesicles","volume":"64","author":"Verma","year":"2016","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib76","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrd3978","article-title":"Extracellular vesicles: biology and emerging therapeutic opportunities","volume":"12","author":"El Andaloussi","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1053\/j.gastro.2016.02.035_bib77","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev-nutr-072610-145138","article-title":"Inflammation in alcoholic liver disease","volume":"32","author":"Wang","year":"2012","journal-title":"Annu Rev Nutr"},{"key":"10.1053\/j.gastro.2016.02.035_bib78","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O'Connell","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.02.035_bib79","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1074\/jbc.M110.145870","article-title":"Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease","volume":"286","author":"Bala","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.02.035_bib80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000341126","article-title":"Innate immunity and alcoholic liver disease","volume":"30","author":"Szabo","year":"2012","journal-title":"Dig Dis"},{"key":"10.1053\/j.gastro.2016.02.035_bib81","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/hep.26607","article-title":"M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease","volume":"59","author":"Wan","year":"2014","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib82","doi-asserted-by":"crossref","first-page":"13460","DOI":"10.1074\/jbc.M110.204644","article-title":"Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin","volume":"286","author":"Mandal","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.02.035_bib83","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI76468","article-title":"NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation","volume":"125","author":"Xu","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.02.035_bib84","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.coi.2004.09.008","article-title":"Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation","volume":"16","author":"Schmidt-Weber","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib85","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/ni1274","article-title":"Limiting inflammatory responses during activation of innate immunity","volume":"6","author":"Han","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib86","first-page":"G98","article-title":"Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells","volume":"276","author":"Aldred","year":"1999","journal-title":"Am J Physiol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.02.035_bib87","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1111\/j.1440-1746.2007.05284.x","article-title":"Mechanisms for the anti-inflammatory effects of adiponectin in macrophages","volume":"23","author":"Huang","year":"2008","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib88","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.4049\/jimmunol.1002060","article-title":"Adiponectin and heme oxygenase-1 suppress TLR4\/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure","volume":"185","author":"Mandal","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib89","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2014.06.007","article-title":"Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice","volume":"61","author":"Bakhautdin","year":"2014","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib90","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1002\/hep.26169","article-title":"Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis","volume":"57","author":"Barnes","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib91","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1189\/jlb.3A0614-280R","article-title":"Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis","volume":"97","author":"Barnes","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1053\/j.gastro.2016.02.035_bib92","doi-asserted-by":"crossref","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.02.035_bib93","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.27921","article-title":"Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1","volume":"62","author":"Chang","year":"2015","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib94","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26419","article-title":"Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin","volume":"58","author":"Bertola","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib95","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1530-0277.2008.00842.x","article-title":"A\u00a0recent perspective on alcohol, immunity, and host defense","volume":"33","author":"Szabo","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib96","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12263-009-0151-4","article-title":"Immune mechanisms in alcoholic liver disease","volume":"5","author":"Albano","year":"2010","journal-title":"Genes Nutr"},{"key":"10.1053\/j.gastro.2016.02.035_bib97","series-title":"Ethanol and the liver: mechanisms and management","first-page":"206","article-title":"Cytokines and alcohol liver disease","author":"Laso","year":"2002"},{"key":"10.1053\/j.gastro.2016.02.035_bib98","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/acer.12095","article-title":"Decreased peripheral blood CD4+\/CD25+ regulatory T cells in patients with alcoholic hepatitis","volume":"37","author":"Almeida","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib99","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/j.gastro.2006.11.016","article-title":"Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction","volume":"132","author":"Aloman","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib100","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1128\/CVI.05029-11","article-title":"Ethanol inhibits antigen presentation by dendritic cells","volume":"18","author":"Eken","year":"2011","journal-title":"Clin Vaccine Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib101","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.4049\/jimmunol.173.5.3398","article-title":"Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production","volume":"173","author":"Mandrekar","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib102","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbadis.2012.09.008","article-title":"Natural killer and natural killer T cells in liver fibrosis","volume":"1832","author":"Gao","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/j.gastro.2016.02.035_bib103","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.4049\/jimmunol.0800973","article-title":"TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells","volume":"182","author":"Jiang","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib104","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/cmi.2015.06","article-title":"Invariant natural killer\u00a0T cells contribute to chronic-plus-binge ethanol-mediated\u00a0liver injury by promoting hepatic neutrophil infiltration","volume":"13","author":"Mathews","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib105","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nri3623","article-title":"Liver fibrosis and repair: immune regulation of wound healing in a solid organ","volume":"14","author":"Pellicoro","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2016.02.035_bib106","first-page":"1509","article-title":"Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice","volume":"35","author":"Inokuchi","year":"2011","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/j.gastro.2016.02.035_bib107","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib108","doi-asserted-by":"crossref","first-page":"G516","DOI":"10.1152\/ajpgi.00537.2010","article-title":"Innate immunity in alcoholic liver disease","volume":"300","author":"Gao","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.02.035_bib109","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","article-title":"Vascular endothelial growth factor promotes fibrosis resolution and repair in mice","volume":"146","author":"Yang","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.02.035_bib110","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/hep.27632","article-title":"Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice","volume":"61","author":"Maricic","year":"2015","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.02.035_bib111","doi-asserted-by":"crossref","first-page":"G491","DOI":"10.1152\/ajpgi.00140.2015","article-title":"Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: role of exosomes in horizontal transfer of Twist1","volume":"309","author":"Chen","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.02.035_bib112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jgh.12030","article-title":"Alcoholic liver disease: pathogenesis, management, and novel targets for therapy","volume":"28","author":"Orman","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.02.035_bib113","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.jhep.2015.03.006","article-title":"Trends in the management and burden of alcoholic liver disease","volume":"62","author":"Mathurin","year":"2015","journal-title":"J\u00a0Hepatol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.02.035_bib114","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/jgh.12032","article-title":"Hepatoprotective and anti-fibrotic functions of interleukin-22: therapeutic potential for the treatment of alcoholic liver disease","volume":"28","author":"Kong","year":"2013","journal-title":"J\u00a0Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.02.035_bib115","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.clinre.2015.05.008","article-title":"Combination therapy: new hope for alcoholic hepatitis?","volume":"39","author":"Gao","year":"2015","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1053\/j.gastro.2016.02.035_bib116","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1055\/s-0035-1562951","article-title":"Pharmacotherapy for nonalcoholic fatty liver disease","volume":"35","author":"Gawrieh","year":"2015","journal-title":"Semin Liver Dis"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516002262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516002262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T15:42:30Z","timestamp":1718379750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516002262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":116,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0016508516002262"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.02.035","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking Pathogenic Mechanisms of Alcoholic Liver Disease With\u00a0Clinical Phenotypes","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the AGA Institute","name":"copyright","label":"Copyright"}]}}