{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:35:19Z","timestamp":1792204519489,"version":"4.4.0"},"reference-count":153,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1053\/j.gastro.2016.04.007","type":"journal-article","created":{"date-parts":[[2016,4,17]],"date-time":"2016-04-17T21:23:34Z","timestamp":1460928214000},"page":"351-363.e28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies"],"prefix":"10.1053","volume":"151","author":[{"given":"Amit D.","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Noordam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Chen","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Curhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculata","family":"De Vivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Eicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ellinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Folsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Gala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Haessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L.A.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae H.","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kooperberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Kratzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela L.","family":"Lutsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarwa","family":"Darwish Murad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis R.","family":"Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.","family":"Ridker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda M.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Schafmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rulla M.","family":"Tamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 G.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"V\u00f6lker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janey L.","family":"Wiggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-8933","authenticated-orcid":false,"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan M.","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno H.","family":"Stricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-094X","authenticated-orcid":false,"given":"Alexander","family":"Teumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tybj\u00e6rg-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel I.","family":"Chasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.04.007_bib1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bpg.2006.05.004","article-title":"Gallstone disease: epidemiology of gallbladder stone disease","volume":"20","author":"Shaffer","year":"2006","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.04.007_bib2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1172\/JCI105794","article-title":"The physicochemical basis of cholesterol gallstone formation in man","volume":"47","author":"Admirand","year":"1968","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.04.007_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0022-3476(80)80626-3","article-title":"Incidence of cholelithiasis in sickle cell anemia using the ultrasonic gray-scale technique","volume":"96","author":"Sarnaik","year":"1980","journal-title":"J\u00a0Pediatr"},{"key":"10.1053\/j.gastro.2016.04.007_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2008-1040553","article-title":"Physical-chemical pathogenesis of pigment gallstones","volume":"8","author":"Cahalane","year":"1988","journal-title":"Semin Liver Dis"},{"key":"10.1053\/j.gastro.2016.04.007_bib5","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/S0022-2275(20)37458-7","article-title":"Characterization of crystallization pathways during cholesterol precipitation from human gallbladder biles: identical pathways to corresponding model biles with three predominating sequences","volume":"37","author":"Wang","year":"1996","journal-title":"J\u00a0Lipid Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archinte.1972.03650040142013","article-title":"Bile composition, bile salt metabolism and gallstones","volume":"130","author":"Redinger","year":"1972","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.gastro.2016.04.007_bib7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(06)69044-2","article-title":"Cholesterol gallstone disease","volume":"368","author":"Portincasa","year":"2006","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2016.04.007_bib8","first-page":"138","article-title":"High familial prevalence of gallstones in the first-degree relatives of gallstone patients","volume":"22","author":"Sarin","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.04.007_bib9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ijc.22756","article-title":"Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China","volume":"121","author":"Hsing","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1053\/j.gastro.2016.04.007_bib10","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/00000658-200206000-00012","article-title":"Gallstones: genetics versus environment","volume":"235","author":"Nakeeb","year":"2002","journal-title":"Ann Surg"},{"key":"10.1053\/j.gastro.2016.04.007_bib11","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.20654","article-title":"Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs","volume":"41","author":"Katsika","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.04.007_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/gast.2001.20878","article-title":"Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map","volume":"120","author":"Lammert","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib13","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1053\/j.gastro.2006.10.024","article-title":"Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes","volume":"131","author":"Lyons","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1152\/physiolgenomics.2000.4.1.59","article-title":"Quantitative trait loci mapping for cholesterol gallstones in AKR\/J and C57L\/J strains of mice","volume":"4","author":"Paigen","year":"2000","journal-title":"Physiol Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng2101","article-title":"A\u00a0genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease","volume":"39","author":"Buch","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2350-14-120","article-title":"Lipid trait-associated genetic variation is associated with gallstone disease in the diverse Third National Health and Nutrition Examination Survey (NHANES III)","volume":"14","author":"Goodloe","year":"2013","journal-title":"BMC Med Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib17","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1053\/j.gastro.2010.09.003","article-title":"Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition","volume":"139","author":"Buch","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib18","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1093\/hmg\/ddp202","article-title":"Genome-wide association meta-analysis for total serum bilirubin levels","volume":"18","author":"Johnson","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/ejhg.2015.63","article-title":"Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array","volume":"24","author":"Rodriguez","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ije\/dyp394","article-title":"Cohort profile: the study of health in Pomerania","volume":"40","author":"Volzke","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/jwh.1997.6.49","article-title":"The Nurses' Health Study: 20-year contribution to the understanding of health among women","volume":"6","author":"Colditz","year":"1997","journal-title":"J\u00a0Womens Health"},{"key":"10.1053\/j.gastro.2016.04.007_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1373\/clinchem.2007.099366","article-title":"Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy American women","volume":"54","author":"Ridker","year":"2008","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2016.04.007_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/oxfordjournals.aje.a115184","article-title":"The Atherosclerosis Risk in Communities (ARIC) study: design and objectives. The ARIC investigators","volume":"129","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families. The Framingham offspring study","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00145007","article-title":"Determinants of disease and disability in the elderly: the Rotterdam Elderly Study","volume":"7","author":"Hofman","year":"1991","journal-title":"Eur J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10654-015-0082-x","article-title":"The Rotterdam Study: 2016 objectives and design update","volume":"30","author":"Hofman","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib27","first-page":"831","article-title":"[PopGen. A population-based biobank with prospective follow-up of a control group]","volume":"55","author":"Nothlings","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"10.1053\/j.gastro.2016.04.007_bib28","first-page":"55","article-title":"PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships","volume":"9","author":"Krawczak","year":"2006","journal-title":"Community Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ajhg.2010.03.003","article-title":"Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record","volume":"86","author":"Ritchie","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib30","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2016.04.007_bib31","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","article-title":"GCTA: a tool for genome-wide complex trait analysis","volume":"88","author":"Yang","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2307\/3001666","article-title":"The combination of estimates from different experiments","volume":"10","author":"Cochran","year":"1954","journal-title":"Biometrics"},{"key":"10.1053\/j.gastro.2016.04.007_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1053\/j.gastro.2016.04.007_bib34","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btn564","article-title":"SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap","volume":"24","author":"Johnson","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2016.04.007_bib35","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/1471-2164-15-532","article-title":"Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs","volume":"15","author":"Zhang","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib36","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib37","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1161\/CIRCGENETICS.109.907873","article-title":"Genetic regulation of serum phytosterol levels and risk of coronary artery disease","volume":"3","author":"Teupser","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib38","doi-asserted-by":"crossref","first-page":"e1002025","DOI":"10.1371\/journal.pgen.1002025","article-title":"Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms","volume":"7","author":"Zhai","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib39","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1001\/jamainternmed.2013.6465","article-title":"Extreme bilirubin levels as a causal risk factor for symptomatic gallstone disease","volume":"173","author":"Stender","year":"2013","journal-title":"JAMA Intern Med"},{"key":"10.1053\/j.gastro.2016.04.007_bib40","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/ng.2982","article-title":"An atlas of genetic influences on human blood metabolites","volume":"46","author":"Shin","year":"2014","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib41","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.jacc.2013.12.055","article-title":"The ABCG5\/8 cholesterol transporter and myocardial infarction versus gallstone disease","volume":"63","author":"Stender","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib42","doi-asserted-by":"crossref","first-page":"48275","DOI":"10.1074\/jbc.M310223200","article-title":"ABCG5 and ABCG8 are\u00a0obligate heterodimers for protein trafficking and biliary cholesterol excretion","volume":"278","author":"Graf","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.04.007_bib43","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/hep.26009","article-title":"Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5\/8 lithogenic locus","volume":"57","author":"von Kampen","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.04.007_bib44","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000324121","article-title":"The role of cilia in the regulation of bile flow","volume":"29","author":"Larusso","year":"2011","journal-title":"Dig Dis"},{"key":"10.1053\/j.gastro.2016.04.007_bib45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"Teslovich","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib46","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ng.2385","article-title":"Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways","volume":"44","author":"Scott","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","article-title":"Genome-wide association analyses identify 18 new loci associated with\u00a0serum urate concentrations","volume":"45","author":"Kottgen","year":"2013","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib48","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0140-6736(91)91972-W","article-title":"Gallstones: pathogenesis","volume":"338","author":"Paumgartner","year":"1991","journal-title":"Lancet"},{"key":"10.1053\/j.gastro.2016.04.007_bib49","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1172\/JCI0215387","article-title":"Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype","volume":"110","author":"Pullinger","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.04.007_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1096\/fasebj.11.1.9034160","article-title":"Sulfation and sulfotransferases 1: sulfotransferase molecular biology: cDNAs and genes","volume":"11","author":"Weinshilboum","year":"1997","journal-title":"FASEB J"},{"key":"10.1053\/j.gastro.2016.04.007_bib51","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1242\/dev.058693","article-title":"The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration","volume":"138","author":"Anderson","year":"2011","journal-title":"Development"},{"key":"10.1053\/j.gastro.2016.04.007_bib52","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.04.007_bib53","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1373\/clinchem.2007.099366","article-title":"Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy American women","volume":"54","author":"Ridker","year":"2008","journal-title":"Clin Chem"},{"key":"10.1053\/j.gastro.2016.04.007_bib54","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2009.01.042","article-title":"Statin use and the risk of cholecystectomy in women","volume":"136","author":"Tsai","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib55","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ng2075","article-title":"A\u00a0genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer","volume":"39","author":"Hunter","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib56","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/ng.429","article-title":"Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer","volume":"41","author":"Amundadottir","year":"2009","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib57","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1093\/hmg\/ddr382","article-title":"Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA","volume":"20","author":"Wiggs","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00439-013-1369-1","article-title":"Genome-wide association study of endometrial cancer in E2C2","volume":"133","author":"De Vivo","year":"2014","journal-title":"Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib59","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2012.12.020","article-title":"Identification of genetic susceptibility loci for colorectal tumors in a genome-wide meta-analysis","volume":"144","author":"Peters","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib60","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s00439-012-1212-0","article-title":"Genome-wide association study of glioma and meta-analysis","volume":"131","author":"Rajaraman","year":"2012","journal-title":"Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib61","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1093\/hmg\/ddr295","article-title":"Genome-wide association study identifies new prostate cancer susceptibility loci","volume":"20","author":"Schumacher","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib62","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1093\/hmg\/ddq156","article-title":"Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes","volume":"19","author":"Qi","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib63","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCGENETICS.111.960393","article-title":"Protein interaction-based genome-wide analysis of incident coronary heart disease","volume":"4","author":"Jensen","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib64","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1093\/hmg\/dds158","article-title":"Identification of a novel percent mammographic density locus at 12q24","volume":"21","author":"Stevens","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib65","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-11-134","article-title":"ProbABEL package for genome-wide association analysis of imputed data","volume":"11","author":"Aulchenko","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1053\/j.gastro.2016.04.007_bib66","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2105\/AJPH.41.3.279","article-title":"Epidemiological approaches to heart disease: the Framingham Study","volume":"41","author":"Dawber","year":"1951","journal-title":"Am J Public Health Nations Health"},{"key":"10.1053\/j.gastro.2016.04.007_bib67","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/oxfordjournals.aje.a112813","article-title":"An investigation of coronary heart disease in families. The Framingham offspring study","volume":"110","author":"Kannel","year":"1979","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00145007","article-title":"Determinants of disease and disability in the elderly: the Rotterdam Elderly Study","volume":"7","author":"Hofman","year":"1991","journal-title":"Eur J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib69","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1047-2797(01)00260-5","article-title":"Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease. A prospective study","volume":"12","author":"Boland","year":"2002","journal-title":"Ann Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib70","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/gepi.20533","article-title":"MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes","volume":"34","author":"Li","year":"2010","journal-title":"Genet Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib71","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ajhg.2010.03.003","article-title":"Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record","volume":"86","author":"Ritchie","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib72","first-page":"265","article-title":"Visual integration of results from a large DNA biobank (BioVU) using synthesis-view","author":"Pendergrass","year":"2011","journal-title":"Pac Symp Biocomput"},{"key":"10.1053\/j.gastro.2016.04.007_bib73","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/ije\/dyp394","article-title":"Cohort profile: the study of health in Pomerania","volume":"40","author":"Volzke","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib74","first-page":"55","article-title":"PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships","volume":"9","author":"Krawczak","year":"2006","journal-title":"Community Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib75","first-page":"831","article-title":"[PopGen. A population-based biobank with prospective follow-up of a control group]","volume":"55","author":"Nothlings","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"10.1053\/j.gastro.2016.04.007_bib76","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng2101","article-title":"A\u00a0genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease","volume":"39","author":"Buch","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib77","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.3748\/wjg.v11.i43.6800","article-title":"Pregnancy is not a risk factor for gallstone disease: results of a randomly selected population sample","volume":"11","author":"Walcher","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.04.007_bib78","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.jacc.2013.12.055","article-title":"The ABCG5\/8 cholesterol transporter and myocardial infarction versus gallstone disease","volume":"63","author":"Stender","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib79","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1308027","article-title":"Loss-of-function mutations in APOC3 and risk of ischemic vascular disease","volume":"371","author":"Jorgensen","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl","key":"10.1053\/j.gastro.2016.04.007_bib80","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/S1047-2797(03)00042-5","article-title":"The Women\u2019s Health Initiative recruitment methods and results","volume":"13","author":"Hays","year":"2003","journal-title":"Ann Epidemiol"},{"key":"10.1053\/j.gastro.2016.04.007_bib81","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ajhg.2012.07.023","article-title":"Genome-wide association and population genetic analysis of C-reactive\u00a0protein in African American and Hispanic American women","volume":"91","author":"Reiner","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib82","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/hmg\/ddr489","article-title":"Genome-wide association study of body height in African Americans: the Women\u2019s Health Initiative SNP Health Association Resource (SHARe)","volume":"21","author":"Carty","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib83","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib84","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ng2119","article-title":"Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes","volume":"39","author":"Goring","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib85","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng.495","article-title":"Geographical genomics of human leukocyte gene expression variation in southern Morocco","volume":"42","author":"Idaghdour","year":"2010","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-2-1","article-title":"Complex nature of SNP genotype effects on gene expression in primary human leucocytes","volume":"2","author":"Heap","year":"2009","journal-title":"BMC Med Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib87","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nature06758","article-title":"Genetics of gene expression and its effect on disease","volume":"452","author":"Emilsson","year":"2008","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib88","doi-asserted-by":"crossref","first-page":"e1002197","DOI":"10.1371\/journal.pgen.1002197","article-title":"Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA","volume":"7","author":"Fehrmann","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib89","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ejhg.2012.106","article-title":"Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood","volume":"21","author":"Mehta","year":"2013","journal-title":"Eur J Human Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib90","doi-asserted-by":"crossref","first-page":"e1003594","DOI":"10.1371\/journal.pgen.1003594","article-title":"DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts","volume":"9","author":"Zhernakova","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib91","doi-asserted-by":"crossref","first-page":"e54967","DOI":"10.1371\/journal.pone.0054967","article-title":"Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population","volume":"8","author":"Sasayama","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib92","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ygeno.2013.07.006","article-title":"Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II","volume":"102","author":"Landmark-Hoyvik","year":"2013","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib93","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"Westra","year":"2013","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib94","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1186\/1471-2164-13-636","article-title":"Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects","volume":"13","author":"van Eijk","year":"2012","journal-title":"BMC Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib95","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","year":"2013","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib96","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1101\/gr.155192.113","article-title":"Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals","volume":"24","author":"Battle","year":"2014","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib97","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ajhg.2013.11.004","article-title":"Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits","volume":"93","author":"Benton","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib98","doi-asserted-by":"crossref","first-page":"e100924","DOI":"10.1371\/journal.pone.0100924","article-title":"Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants","volume":"9","author":"Narahara","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib99","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fgene.2014.00026","article-title":"Genomic architecture of sickle cell disease in West African children","volume":"5","author":"Quinlan","year":"2014","journal-title":"Front Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib100","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.2951","article-title":"Heritability and genomics of gene expression in peripheral blood","volume":"46","author":"Wright","year":"2014","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib101","doi-asserted-by":"crossref","first-page":"e93844","DOI":"10.1371\/journal.pone.0093844","article-title":"Mapping the genetic architecture of gene regulation in whole blood","volume":"9","author":"Schramm","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib102","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ng2109","article-title":"A\u00a0genome-wide association study of global gene expression","volume":"39","author":"Dixon","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib103","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1101\/gr.142521.112","article-title":"A\u00a0cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines","volume":"23","author":"Liang","year":"2013","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib104","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ng2142","article-title":"Population genomics of human gene expression","volume":"39","author":"Stranger","year":"2007","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib105","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ng.2007.57","article-title":"Genome-wide analysis of transcript isoform variation in humans","volume":"40","author":"Kwan","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib106","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1126\/science.1174148","article-title":"Common regulatory variation impacts gene expression in a cell type-dependent manner","volume":"325","author":"Dimas","year":"2009","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.04.007_bib107","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/hmg\/dds021","article-title":"The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes","volume":"21","author":"Cusanovich","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib108","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ng.2394","article-title":"Mapping cis- and trans-regulatory effects across multiple tissues in twins","volume":"44","author":"Grundberg","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib109","doi-asserted-by":"crossref","first-page":"e00523","DOI":"10.7554\/eLife.00523","article-title":"Passive and active DNA methylation and the interplay with genetic variation in gene regulation","volume":"2","author":"Gutierrez-Arcelus","year":"2013","journal-title":"eLife"},{"key":"10.1053\/j.gastro.2016.04.007_bib110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nature12508","article-title":"A\u00a0statin-dependent QTL for GATM expression is associated with statin-induced myopathy","volume":"502","author":"Mangravite","year":"2013","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib111","doi-asserted-by":"crossref","first-page":"e1004461","DOI":"10.1371\/journal.pgen.1004461","article-title":"Cis and trans effects of human genomic variants on gene expression","volume":"10","author":"Bryois","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib112","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ng.2205","article-title":"Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles","volume":"44","author":"Fairfax","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib113","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1093\/hmg\/ddq392","article-title":"Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes","volume":"19","author":"Murphy","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib114","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1371\/journal.pbio.1000001","article-title":"Tissue-specific genetic control of splicing: implications for the study of complex traits","volume":"6","author":"Heinzen","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1053\/j.gastro.2016.04.007_bib115","doi-asserted-by":"crossref","first-page":"e10693","DOI":"10.1371\/journal.pone.0010693","article-title":"Genetics and beyond\u2013the transcriptome of human monocytes and disease susceptibility","volume":"5","author":"Zeller","year":"2010","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib116","doi-asserted-by":"crossref","first-page":"1246949","DOI":"10.1126\/science.1246949","article-title":"Innate immune activity conditions the effect of regulatory variants upon\u00a0monocyte gene expression","volume":"343","author":"Fairfax","year":"2014","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.04.007_bib117","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1073\/pnas.1115761109","article-title":"Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection","volume":"109","author":"Barreiro","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.04.007_bib118","doi-asserted-by":"crossref","first-page":"1246980","DOI":"10.1126\/science.1246980","article-title":"Common genetic variants modulate pathogen-sensing responses in human dendritic cells","volume":"343","author":"Lee","year":"2014","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.04.007_bib119","doi-asserted-by":"crossref","first-page":"692","DOI":"10.4161\/rna.8.4.16029","article-title":"Population differences in microRNA expression and biological implications","volume":"8","author":"Huang","year":"2011","journal-title":"RNA Biol"},{"key":"10.1053\/j.gastro.2016.04.007_bib120","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10808","article-title":"DNase I sensitivity QTLs are a major determinant of human expression variation","volume":"482","author":"Degner","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib121","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1101\/gr.112821.110","article-title":"A\u00a0survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort","volume":"21","author":"Greenawalt","year":"2011","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib122","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1755-8794-4-6","article-title":"Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer","volume":"4","author":"Kompass","year":"2011","journal-title":"BMC Med Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib123","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2012.12.034","article-title":"Integrative eQTL-based analyses reveal the biology of breast cancer risk loci","volume":"152","author":"Li","year":"2013","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.04.007_bib124","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.pbio.0060107","article-title":"Mapping the genetic architecture of gene expression in human liver","volume":"6","author":"Schadt","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1053\/j.gastro.2016.04.007_bib125","doi-asserted-by":"crossref","first-page":"e1002078","DOI":"10.1371\/journal.pgen.1002078","article-title":"Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue","volume":"7","author":"Innocenti","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/tpj.2011.44","article-title":"Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver","volume":"13","author":"Schroder","year":"2013","journal-title":"Pharmacogenomics J"},{"key":"10.1053\/j.gastro.2016.04.007_bib127","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1136\/jmedgenet-2013-102045","article-title":"Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population","volume":"51","author":"Wang","year":"2014","journal-title":"J\u00a0Med Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib128","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1101\/gr.095224.109","article-title":"Population genomics in a disease targeted primary cell model","volume":"19","author":"Grundberg","year":"2009","journal-title":"Genome Res"},{"key":"10.1053\/j.gastro.2016.04.007_bib129","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1053\/j.gastro.2013.03.001","article-title":"Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine","volume":"144","author":"Kabakchiev","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.04.007_bib130","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature13602","article-title":"Putative cis-regulatory drivers in colorectal cancer","volume":"512","author":"Ongen","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib131","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2337\/db13-1301","article-title":"Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity","volume":"63","author":"Keildson","year":"2014","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.04.007_bib132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.molonc.2013.11.008","article-title":"The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors","volume":"8","author":"Quigley","year":"2014","journal-title":"Mol Oncol"},{"key":"10.1053\/j.gastro.2016.04.007_bib133","doi-asserted-by":"crossref","first-page":"e1003029","DOI":"10.1371\/journal.pgen.1003029","article-title":"Lung eQTLs to help reveal the molecular underpinnings of asthma","volume":"8","author":"Hao","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib134","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/bioinformatics\/btt690","article-title":"HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors","volume":"30","author":"Gao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1053\/j.gastro.2016.04.007_bib135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ajhg.2010.10.024","article-title":"Gene expression in skin and lymphoblastoid cells: refined statistical method reveals extensive overlap in cis-eQTL signals","volume":"87","author":"Ding","year":"2010","journal-title":"Am J Human Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib136","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/gb-2014-15-2-r37","article-title":"The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts","volume":"15","author":"Wagner","year":"2014","journal-title":"Genome Biol"},{"key":"10.1053\/j.gastro.2016.04.007_bib137","doi-asserted-by":"crossref","first-page":"e24395","DOI":"10.1371\/journal.pone.0024395","article-title":"Genetics of sputum gene expression in chronic obstructive pulmonary disease","volume":"6","author":"Qiu","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib138","doi-asserted-by":"crossref","first-page":"13924","DOI":"10.1073\/pnas.1402665111","article-title":"Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism","volume":"111","author":"Fadista","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.04.007_bib139","doi-asserted-by":"crossref","first-page":"e97380","DOI":"10.1371\/journal.pone.0097380","article-title":"Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart","volume":"9","author":"Koopmann","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib140","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.hrthm.2013.10.051","article-title":"Gene expression and genetic variation in human atria","volume":"11","author":"Lin","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1053\/j.gastro.2016.04.007_bib141","doi-asserted-by":"crossref","first-page":"e27338","DOI":"10.1371\/journal.pone.0027338","article-title":"MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven","volume":"6","author":"Rantalainen","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.04.007_bib142","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1186\/1471-2164-14-395","article-title":"A\u00a0genome-wide integrative study of microRNAs in human liver","volume":"14","author":"Gamazon","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib143","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1093\/hmg\/ddu228","article-title":"Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types","volume":"23","author":"Li","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib144","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2009.03.011","article-title":"Genetic control of human brain transcript expression in Alzheimer disease","volume":"84","author":"Webster","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib145","doi-asserted-by":"crossref","first-page":"e1002707","DOI":"10.1371\/journal.pgen.1002707","article-title":"Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants","volume":"8","author":"Zou","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib146","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/nn.3801","article-title":"Genetic variability in the regulation of gene expression in ten regions of the human brain","volume":"17","author":"Ramasamy","year":"2014","journal-title":"Nat Neurosci"},{"key":"10.1053\/j.gastro.2016.04.007_bib147","doi-asserted-by":"crossref","first-page":"e1000952","DOI":"10.1371\/journal.pgen.1000952","article-title":"Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain","volume":"6","author":"Gibbs","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1053\/j.gastro.2016.04.007_bib148","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/mp.2011.174","article-title":"Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants","volume":"18","author":"Gamazon","year":"2013","journal-title":"Mol Psychiatry"},{"key":"10.1053\/j.gastro.2016.04.007_bib149","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1038\/tp.2012.42","article-title":"Association between SNPs and gene expression in multiple regions of the human brain","volume":"2","author":"Kim","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1053\/j.gastro.2016.04.007_bib150","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.04.007_bib151","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ygeno.2014.02.005","article-title":"An eQTL analysis of the human glioblastoma multiforme genome","volume":"103","author":"Shpak","year":"2014","journal-title":"Genomics"},{"key":"10.1053\/j.gastro.2016.04.007_bib152","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature10524","article-title":"Temporal dynamics and genetic control of transcription in the human prefrontal cortex","volume":"478","author":"Colantuoni","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.04.007_bib153","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/mp.2009.128","article-title":"Whole-genome association mapping of gene expression in the human prefrontal cortex","volume":"15","author":"Liu","year":"2010","journal-title":"Mol Psychiatry"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650851630110X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001650851630110X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T20:22:26Z","timestamp":1655497346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001650851630110X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":153,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S001650851630110X"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.04.007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726299538.793550810","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the AGA Institute","name":"copyright","label":"Copyright"}]}}