{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:11:55Z","timestamp":1791321115905,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1053\/j.gastro.2016.06.022","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T15:27:03Z","timestamp":1467041223000},"page":"733-746.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":317,"title":["Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol"],"prefix":"10.1053","volume":"151","author":[{"given":"Khalidur","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirayu","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita S.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie E.","family":"Thorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tekla","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Neish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alton B.","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Nusrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Parkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Anania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.06.022_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cld.2012.05.003","article-title":"Management of nonalcoholic steatohepatitis: an evidence-based approach","volume":"16","author":"Mahady","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1053\/j.gastro.2016.06.022_bib2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1053\/j.gastro.2010.09.038","article-title":"Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study","volume":"140","author":"Williams","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.06.022_bib3","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/hep.22848","article-title":"Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease","volume":"49","author":"Miele","year":"2009","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.06.022_bib4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/gut.48.2.206","article-title":"The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis","volume":"48","author":"Wigg","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.06.022_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1053\/jhep.2003.50116","article-title":"Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats","volume":"37","author":"Lorenzo-Zuniga","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.06.022_bib6","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s10620-010-1447-3","article-title":"Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8","volume":"56","author":"Shanab","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1053\/j.gastro.2016.06.022_bib7","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.06.022_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1055\/s-2001-12927","article-title":"Etiopathogenesis of nonalcoholic steatohepatitis","volume":"21","author":"Chitturi","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1053\/j.gastro.2016.06.022_bib9","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1084\/jem.20071416","article-title":"JAM-A regulates permeability and inflammation in the intestine in\u00a0vivo","volume":"204","author":"Laukoetter","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2016.06.022_bib10","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1091\/mbc.e13-06-0298","article-title":"JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function","volume":"24","author":"Monteiro","year":"2013","journal-title":"Mol Biol Cell"},{"key":"10.1053\/j.gastro.2016.06.022_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/mi.2010.5","article-title":"Multiple facets of intestinal permeability and epithelial handling of dietary antigens","volume":"3","author":"Menard","year":"2010","journal-title":"Mucosal Immunol"},{"key":"10.1053\/j.gastro.2016.06.022_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.immuni.2012.06.017","article-title":"Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis","volume":"37","author":"Khounlotham","year":"2012","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2016.06.022_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.gastro.2008.04.002","article-title":"Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease","volume":"135","author":"Vetrano","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.06.022_bib14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI21231","article-title":"Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice","volume":"114","author":"Cera","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.06.022_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jnutbio.2014.11.002","article-title":"Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis","volume":"26","author":"Mells","year":"2015","journal-title":"J\u00a0Nutr Biochem"},{"key":"10.1053\/j.gastro.2016.06.022_bib16","doi-asserted-by":"crossref","first-page":"G825","DOI":"10.1152\/ajpgi.00145.2011","article-title":"Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition","volume":"301","author":"Charlton","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.06.022_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00024382-199603000-00006","article-title":"The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability","volume":"5","author":"Napolitano","year":"1996","journal-title":"Shock"},{"key":"10.1053\/j.gastro.2016.06.022_bib18","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1038\/srep05437","article-title":"Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice","volume":"4","author":"Rogers","year":"2014","journal-title":"Sci Rep"},{"issue":"Suppl 1","key":"10.1053\/j.gastro.2016.06.022_bib19","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.06.022_bib20","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J"},{"key":"10.1053\/j.gastro.2016.06.022_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4056\/aigs.1443528","article-title":"The Earth Microbiome Project: meeting report of the \u201c1 EMP meeting on sample selection and acquisition\u201d at Argonne National Laboratory October 6 2010","volume":"3","author":"Gilbert","year":"2010","journal-title":"Stand Genomic Sci"},{"key":"10.1053\/j.gastro.2016.06.022_bib22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2016.06.022_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/1471-2105-7-371","article-title":"UniFrac\u2013an online tool for comparing microbial community diversity in a phylogenetic context","volume":"7","author":"Lozupone","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1053\/j.gastro.2016.06.022_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1053\/j.gastro.2016.06.022_bib25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.06.022_bib26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.06.022_bib27","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial\u00a0mutualism in the human intestine","volume":"307","author":"Backhed","year":"2005","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.06.022_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A\u00a0human gut microbial gene catalogue established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.06.022_bib29","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1128\/JCM.01004-06","article-title":"Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis","volume":"44","author":"Gophna","year":"2006","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1053\/j.gastro.2016.06.022_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.chom.2012.07.004","article-title":"Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice","volume":"12","author":"Carvalho","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1053\/j.gastro.2016.06.022_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrgastro.2012.14","article-title":"IBD-what role do Proteobacteria play?","volume":"9","author":"Mukhopadhya","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.06.022_bib32","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature11225","article-title":"Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-\/- mice","volume":"487","author":"Devkota","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.06.022_bib33","doi-asserted-by":"crossref","first-page":"e41079","DOI":"10.1371\/journal.pone.0041079","article-title":"Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity","volume":"7","author":"Gauffin Cano","year":"2012","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.06.022_bib34","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.06.022_bib35","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1046\/j.1523-1755.2003.00284.x","article-title":"Sevelamer hydrochloride attenuates kidney and cardiovascular calcifications in long-term experimental uremia","volume":"64","author":"Cozzolino","year":"2003","journal-title":"Kidney Int"},{"key":"10.1053\/j.gastro.2016.06.022_bib36","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s40265-014-0215-7","article-title":"Sevelamer carbonate: a review in hyperphosphataemia in adults with chronic kidney disease","volume":"74","author":"Perry","year":"2014","journal-title":"Drugs"},{"key":"10.1053\/j.gastro.2016.06.022_bib37","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1159\/000135691","article-title":"Endotoxin-binding affinity of sevelamer hydrochloride","volume":"28","author":"Perianayagam","year":"2008","journal-title":"Am J Nephrol"},{"key":"10.1053\/j.gastro.2016.06.022_bib38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/039463201402700105","article-title":"Clinical efficacy, safety and anti-inflammatory activity of two sevelamer tablet forms in patients on low-flux hemodialysis","volume":"27","author":"Tzanno-Martins","year":"2014","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1053\/j.gastro.2016.06.022_bib39","doi-asserted-by":"crossref","first-page":"e0127991","DOI":"10.1371\/journal.pone.0127991","article-title":"Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease","volume":"10","author":"Machado","year":"2015","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.06.022_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrgastro.2013.149","article-title":"From NAFLD to NASH to cirrhosis-new insights into disease mechanisms","volume":"10","author":"Wree","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.06.022_bib41","doi-asserted-by":"crossref","first-page":"G987","DOI":"10.1152\/ajpgi.90272.2008","article-title":"Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent","volume":"295","author":"Tetri","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.06.022_bib42","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.23719","article-title":"Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites","volume":"52","author":"Neuschwander-Tetri","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.06.022_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cmet.2012.05.012","article-title":"Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling","volume":"16","author":"Imajo","year":"2012","journal-title":"Cell Metab"},{"key":"10.1053\/j.gastro.2016.06.022_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1476-9255-7-15","article-title":"Elevated endotoxin levels in non-alcoholic fatty liver disease","volume":"7","author":"Harte","year":"2010","journal-title":"J\u00a0Inflamm (Lond)"},{"key":"10.1053\/j.gastro.2016.06.022_bib45","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jhep.2009.02.032","article-title":"Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model","volume":"51","author":"Kudo","year":"2009","journal-title":"J\u00a0Hepatol"},{"key":"10.1053\/j.gastro.2016.06.022_bib46","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jcmgh.2015.01.001","article-title":"Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability","volume":"1","author":"Luther","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.06.022_bib47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2016.06.022_bib48","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.gastro.2016.06.022_bib49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tim.2004.01.001","article-title":"Bacterial contributions to mammalian gut development","volume":"12","author":"Hooper","year":"2004","journal-title":"Trends Microbiol"},{"key":"10.1053\/j.gastro.2016.06.022_bib50","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A\u00a0core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.06.022_bib51","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/hep.26093","article-title":"Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous\u00a0alcohol and NASH","volume":"57","author":"Zhu","year":"2013","journal-title":"Hepatology"},{"key":"10.1053\/j.gastro.2016.06.022_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1053\/j.gastro.2016.06.022_bib53","doi-asserted-by":"crossref","first-page":"G225","DOI":"10.1152\/ajpgi.00274.2011","article-title":"Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL\/6J mice fed a Western diet","volume":"302","author":"Mells","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.06.022_bib54","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1128\/JVI.77.8.4911-4927.2003","article-title":"Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment","volume":"77","author":"Wherry","year":"2003","journal-title":"J\u00a0Virol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516346790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516346790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:12:52Z","timestamp":1758035572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516346790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0016508516346790"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.06.022","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the AGA Institute","name":"copyright","label":"Copyright"}]}}