{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:23:38Z","timestamp":1777433018348,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","gastrojournal.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1053\/j.gastro.2016.07.025","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T13:01:01Z","timestamp":1469538061000},"page":"407-411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Development of Celiac Disease Therapeutics: Report of the\u00a0Third\u00a0Gastroenterology Regulatory Endpoints and Advancement\u00a0of Therapeutics Workshop"],"prefix":"10.1053","volume":"151","author":[{"given":"Daniel","family":"Leffler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia S.","family":"Kupfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Lebwohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Bugin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Griebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Tait","family":"Lathrop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Mulberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elektra","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli","family":"Tomaino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.07.025_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.07.025_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrgastro.2010.2","article-title":"Mortality in celiac disease","volume":"7","author":"Biagi","year":"2010","journal-title":"Nature reviews. Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.07.025_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.appet.2013.04.016","article-title":"Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey","volume":"68","author":"Hall","year":"2013","journal-title":"Appetite"},{"key":"10.1053\/j.gastro.2016.07.025_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cgh.2006.12.006","article-title":"Etiologies and predictors of diagnosis in nonresponsive celiac disease","volume":"5","author":"Leffler","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.07.025_bib5","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/apt.12510","article-title":"Optimising delivery of care in coeliac disease\u2014comparison of the benefits of repeat biopsy and serological follow-up","volume":"38","author":"Sharkey","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.07.025_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/1756283X13492580","article-title":"Interest in medical therapy for celiac disease","volume":"6","author":"Tennyson","year":"2013","journal-title":"Ther Adv Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib7","volume":"Volume 2016","author":"US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Biologics Evaluation and Research","year":"2014"},{"key":"10.1053\/j.gastro.2016.07.025_bib8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-230X-11-118","article-title":"Delay to celiac disease diagnosis and its implications for health-related quality of life","volume":"11","author":"Norstrom","year":"2011","journal-title":"BMC Gastroenter"},{"key":"10.1053\/j.gastro.2016.07.025_bib9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/gutjnl-2012-302196","article-title":"Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease","volume":"62","author":"Leffler","year":"2013","journal-title":"Gut"},{"key":"10.1053\/j.gastro.2016.07.025_bib10","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2014.02.031","article-title":"Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease","volume":"146","author":"Lahdeaho","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.025_bib11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apt.12164","article-title":"Mucosal healing and mortality in coeliac disease","volume":"37","author":"Lebwohl","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.07.025_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-159-3-201308060-00006","article-title":"Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study","volume":"159","author":"Lebwohl","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.07.025_bib13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/apt.12621","article-title":"Predictors of persistent villous atrophy in coeliac disease: a population-based study","volume":"39","author":"Lebwohl","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.07.025_bib14","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/ajg.2010.10","article-title":"Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet","volume":"105","author":"Rubio-Tapia","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib15","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1038\/ajg.2010.276","article-title":"Update on serologic testing in celiac disease","volume":"105","author":"Leffler","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib16","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1053\/j.gastro.2008.11.040","article-title":"Diagnosing mild enteropathy celiac disease: a randomized, controlled clinical study","volume":"136","author":"Kurppa","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.025_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MCG.0000000000000105","article-title":"Titers of anti-tissue transglutaminase antibody correlate well with severity of villous abnormalities in celiac disease","volume":"49","author":"Singh","year":"2015","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/00365520902718929","article-title":"Coeliac disease-specific tissue transglutaminase autoantibodies are associated with osteoporosis and related fractures in middle-aged women","volume":"44","author":"Agardh","year":"2009","journal-title":"Scand J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1365-2036.2009.04039.x","article-title":"Anti-tissue transglutaminase antibodies in the follow-up of adult coeliac disease","volume":"30","author":"Dipper","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.gastro.2016.07.025_bib20","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1572-0241.2003.07284.x","article-title":"Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease","volume":"98","author":"Vahedi","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.025_bib21","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2015.02.008","article-title":"Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial","volume":"148","author":"Leffler","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.025_bib22","doi-asserted-by":"crossref","first-page":"S351","DOI":"10.1016\/S0016-5085(14)61270-1","article-title":"Sa2001 Celiac disease patients attempting adherence to a gluten-free diet who continue to have moderate or severe symptoms have clinically significant mucosal injury","volume":"146","author":"Adelman","year":"2014","journal-title":"Gastroenterology"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516348211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516348211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T07:24:50Z","timestamp":1536564290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516348211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0016508516348211"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.07.025","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of Celiac Disease Therapeutics: Report of the\u00a0Third\u00a0Gastroenterology Regulatory Endpoints and Advancement\u00a0of Therapeutics Workshop","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the AGA Institute","name":"copyright","label":"Copyright"}]}}