{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:19:58Z","timestamp":1779236398788,"version":"3.51.4"},"update-to":[{"DOI":"10.1053\/j.gastro.2016.07.029","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000}}],"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK84039"],"award-info":[{"award-number":["R01 DK84039"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK34933"],"award-info":[{"award-number":["P30 DK34933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1053\/j.gastro.2016.07.029","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T17:31:04Z","timestamp":1469727064000},"page":"910-922.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["RETRACTED: Increased Activation of the TRESK K+ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats"],"prefix":"10.1053","volume":"151","author":[{"given":"Gintautas","family":"Grabauskas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lanigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung","family":"Owyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.07.029_bib1","series-title":"Gastrointestinal Function in Diabetes Mellitus","author":"Horowitz","year":"2004"},{"key":"10.1053\/j.gastro.2016.07.029_bib2","first-page":"1","article-title":"Gastrointestinal motor disturbances in diabetes mellitus","volume":"3","author":"Hasler","year":"1997","journal-title":"Mediguide Diabetes"},{"key":"10.1053\/j.gastro.2016.07.029_bib3","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.3748\/wjg.v12.i18.2846","article-title":"Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus","volume":"12","author":"Zhao","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.07.029_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0074-7742(02)50080-5","article-title":"Neuropathology and pathogenesis of diabetic autonomic neuropathy","volume":"50","author":"Schmidt","year":"2002","journal-title":"Int Rev Neurobiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.pain.2007.04.009","article-title":"Gut sensations in diabetic autonomic neuropathy","volume":"131","author":"Frokjaer","year":"2007","journal-title":"Pain"},{"key":"10.1053\/j.gastro.2016.07.029_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000171603","article-title":"Abnormal gastric and small intestinal motor function in diabetes mellitus","volume":"15","author":"Samsom","year":"1997","journal-title":"Dig Dis"},{"key":"10.1053\/j.gastro.2016.07.029_bib7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S1542-3565(03)00130-7","article-title":"Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms","volume":"1","author":"Bredenoord","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.gastro.2016.07.029_bib8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diacare.26.5.1553","article-title":"Diabetic autonomic neuropathy","volume":"26","author":"Vinik","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2016.07.029_bib9","doi-asserted-by":"crossref","first-page":"812","DOI":"10.7326\/0003-4819-59-6-812","article-title":"External pancreatic secretion in diabetes mellitus","volume":"59","author":"Chey","year":"1963","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.07.029_bib10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7326\/0003-4819-61-2-242","article-title":"The exocrine pancreas in diabetes mellitus","volume":"61","author":"Vacca","year":"1964","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.gastro.2016.07.029_bib11","doi-asserted-by":"crossref","first-page":"678","DOI":"10.2337\/diacare.24.4.678","article-title":"Disordered eating, body mass, and glycemic control in adolescents with type 1 diabetes","volume":"24","author":"Meltzer","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1053\/j.gastro.2016.07.029_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1464-5491.2012.03771.x","article-title":"Eating problems in adolescents with type 1 diabetes: a systematic review with meta-analysis","volume":"30","author":"Young","year":"2013","journal-title":"Diabet Med"},{"key":"10.1053\/j.gastro.2016.07.029_bib13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1172\/JCI116583","article-title":"Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion","volume":"92","author":"Li","year":"1993","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.07.029_bib14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0016-5085(88)90546-X","article-title":"There are no morphologic abnormalities of the gastric wall or abdominal vagus in patients with diabetic gastroparesis","volume":"94","author":"Yoshida","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.029_bib15","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1523\/JNEUROSCI.23-16-06460.2003","article-title":"Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons","volume":"23","author":"Meuth","year":"2003","journal-title":"J\u00a0Neurosci"},{"key":"10.1053\/j.gastro.2016.07.029_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.neuron.2006.04.032","article-title":"Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose","volume":"50","author":"Burdakov","year":"2006","journal-title":"Neuron"},{"key":"10.1053\/j.gastro.2016.07.029_bib17","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.2174\/1381612054546824","article-title":"Physiology and pharmacology of two-pore domain potassium channels","volume":"11","author":"Kim","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1053\/j.gastro.2016.07.029_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/35058574","article-title":"Potassium leak channels and the KCNK family of two-P-domain subunits","volume":"2","author":"Goldstein","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1053\/j.gastro.2016.07.029_bib19","doi-asserted-by":"crossref","first-page":"A-94","DOI":"10.1016\/S0016-5085(08)60442-4","article-title":"Hyperpolarization of nodose ganglia in chronic hyperglycemia rats is mediated by activation of the tandem-pore K+ channel TRESK","volume":"134","author":"Grabauskas","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.029_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/jn.2001.86.1.190","article-title":"A\u00a0novel Ca(2+) influx pathway in mammalian primary sensory neurons is activated by caffeine","volume":"86","author":"Hoesch","year":"2001","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0301-0082(02)00004-7","article-title":"Channels underlying neuronal calcium-activated potassium currents","volume":"66","author":"Sah","year":"2002","journal-title":"Prog Neurobiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib22","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1152\/jn.01008.2003","article-title":"Localized IP3-evoked Ca2+ release activates a K+ current in primary vagal sensory neurons","volume":"91","author":"Hoesch","year":"2004","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib23","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1074\/jbc.M602495200","article-title":"Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK","volume":"281","author":"Czirjak","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.07.029_bib24","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1126\/science.285.5436.2129","article-title":"Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A","volume":"285","author":"Aramburu","year":"1999","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.07.029_bib25","doi-asserted-by":"crossref","first-page":"G745","DOI":"10.1152\/ajpgi.00039.2005","article-title":"Secretin activates vagal primary afferent neurons in the rat: evidence from electrophysiological and immunohistochemical studies","volume":"289","author":"Li","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2009.01271.x","article-title":"Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways","volume":"21","author":"Lu","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1053\/j.gastro.2016.07.029_bib27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0002-9343(94)90152-X","article-title":"Diabetes mellitus: a disease of abnormal cellular calcium metabolism?","volume":"96","author":"Levy","year":"1994","journal-title":"Am J Med"},{"key":"10.1053\/j.gastro.2016.07.029_bib28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00424-004-1263-8","article-title":"Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons","volume":"448","author":"Kruglikov","year":"2004","journal-title":"Pflugers Arch"},{"key":"10.1053\/j.gastro.2016.07.029_bib29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-2999(02)01844-7","article-title":"Neuronal Ca2+ disregulation in diabetes mellitus","volume":"447","author":"Biessels","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.gastro.2016.07.029_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/00044067-200401000-00012","article-title":"Diabetes and peripheral sensory neurons: what we don\u2019t know and how it can hurt us","volume":"15","author":"McHugh","year":"2004","journal-title":"AACN Clin Issues"},{"key":"10.1053\/j.gastro.2016.07.029_bib31","doi-asserted-by":"crossref","first-page":"G212","DOI":"10.1152\/ajpgi.00396.2009","article-title":"Expression of transient receptor potential channels and two-pore potassium channels in subtypes of vagal afferent neurons in rat","volume":"298","author":"Zhao","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib32","doi-asserted-by":"crossref","first-page":"C138","DOI":"10.1152\/ajpcell.00629.2005","article-title":"TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons","volume":"291","author":"Kang","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1113\/jphysiol.2007.136150","article-title":"Properties of single two-pore domain TREK-2 channels expressed in mammalian cells","volume":"583","author":"Kang","year":"2007","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib34","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1113\/jphysiol.2007.145649","article-title":"TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones","volume":"585","author":"Dobler","year":"2007","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1744-8069-7-30","article-title":"TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury","volume":"7","author":"Tulleuda","year":"2011","journal-title":"Molecular Pain"},{"key":"10.1053\/j.gastro.2016.07.029_bib36","doi-asserted-by":"crossref","first-page":"e87029","DOI":"10.1371\/journal.pone.0087029","article-title":"Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors","volume":"9","author":"Guo","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.07.029_bib37","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/nprot.2006.276","article-title":"In\u00a0vivo electroporation in the embryonic mouse central nervous system","volume":"1","author":"Saito","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1053\/j.gastro.2016.07.029_bib38","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1053\/j.gastro.2004.05.002","article-title":"New insights into neurohormonal regulation of pancreatic secretion","volume":"127","author":"Owyang","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.07.029_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0196-9781(88)90171-4","article-title":"Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety","volume":"9","author":"South","year":"1988","journal-title":"Peptides"},{"key":"10.1053\/j.gastro.2016.07.029_bib40","first-page":"G242","article-title":"Cholecystokinin inhibits gastric motility and emptying by a capsaicin-sensitive vagal afferent pathway in rats","volume":"255","author":"Raybould","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1172\/JCI110588","article-title":"Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini","volume":"70","author":"Otsuki","year":"1982","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.07.029_bib42","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2337\/db10-1507","article-title":"Diabetic visceral hypersensitivity is associated with activation of mitogen-activated kinase in rat dorsal root ganglia","volume":"60","author":"Grabauskas","year":"2011","journal-title":"Diabetes"},{"key":"10.1053\/j.gastro.2016.07.029_bib43","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1113\/jphysiol.2004.064816","article-title":"Serotonin and cholecystokinin synergistically stimulate rat vagal primary afferent neurones","volume":"559","author":"Li","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1469-7793.2001.0431k.x","article-title":"Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat","volume":"530","author":"Zhu","year":"2001","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib45","series-title":"Anatomy of the laboratory rat","author":"Hebel","year":"1976"},{"key":"10.1053\/j.gastro.2016.07.029_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1172\/JCI116583","article-title":"Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion","volume":"92","author":"Li","year":"1993","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.07.029_bib47","first-page":"G489","article-title":"Action of pancreatic polypeptide on rat pancreatic secretion: in\u00a0vivo and vitro","volume":"249","author":"Louie","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/ng1117","article-title":"A\u00a0lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference","volume":"33","author":"Rubinson","year":"2003","journal-title":"Nat Genet"},{"key":"10.1053\/j.gastro.2016.07.029_bib49","first-page":"G1012","article-title":"Secretin at physiological doses inhibits gastric motility via a vagal afferent pathway","volume":"268","author":"Lu","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib50","doi-asserted-by":"crossref","first-page":"G394","DOI":"10.1152\/ajpgi.00493.2010","article-title":"Inhibition of gastric motility by hyperglycemia is mediated by nodose ganglia KATP channels","volume":"300","author":"Zhou","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib51","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1113\/jphysiol.2009.182147","article-title":"Electrophysiological identification of glucose-sensing neurons in rat nodose ganglia","volume":"588","author":"Grabauskas","year":"2010","journal-title":"J\u00a0Physiol"},{"key":"10.1053\/j.gastro.2016.07.029_bib52","doi-asserted-by":"crossref","first-page":"11707","DOI":"10.1074\/jbc.M110.198945","article-title":"Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways: Implications for leptin as a regulator of short term satiety","volume":"286","author":"Heldsinger","year":"2011","journal-title":"J\u00a0Biol Chem"}],"updated-by":[{"DOI":"10.1053\/j.gastro.2024.01.003","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"record-id":"51128"},{"DOI":"10.1053\/j.gastro.2024.01.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000}},{"DOI":"10.1053\/j.gastro.2016.07.029","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000}}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516348259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516348259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:14:34Z","timestamp":1758035674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516348259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0016508516348259"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.07.029","relation":{},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Increased Activation of the TRESK K+ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the AGA Institute","name":"copyright","label":"Copyright"}]}}