{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:01:34Z","timestamp":1790791294387,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Science Foundation (DFG)","doi-asserted-by":"publisher","award":["BR 3369\/5-1"],"award-info":[{"award-number":["BR 3369\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Science Foundation (DFG)","doi-asserted-by":"publisher","award":["INST 38\/500-1"],"award-info":[{"award-number":["INST 38\/500-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Science Foundation (DFG)","doi-asserted-by":"publisher","award":["INST 38\/498-1"],"award-info":[{"award-number":["INST 38\/498-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["433013"],"award-info":[{"award-number":["433013"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council (NHMRC)","doi-asserted-by":"publisher","award":["541902"],"award-info":[{"award-number":["541902"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["111703"],"award-info":[{"award-number":["111703"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030-138085"],"award-info":[{"award-number":["310030-138085"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Training Group","award":["RTG1331"],"award-info":[{"award-number":["RTG1331"]}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"InViTe"},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["541901"],"award-info":[{"award-number":["541901"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["1058190"],"award-info":[{"award-number":["1058190"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PA00P3_126249"],"award-info":[{"award-number":["PA00P3_126249"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT130100166"],"award-info":[{"award-number":["FT130100166"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Victorian State Government Operational Infrastructure Support"},{"DOI":"10.13039\/501100000925","name":"Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme","doi-asserted-by":"publisher","award":["361646"],"award-info":[{"award-number":["361646"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","gastrojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gastroenterology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1053\/j.gastro.2016.11.019","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T01:31:55Z","timestamp":1479951115000},"page":"867-879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor\u2013Mediated Destruction of Intestinal Epithelial Cells"],"prefix":"10.1053","volume":"152","author":[{"given":"Thomas","family":"Grabinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin J.","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Demgenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eugenia","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feodora","family":"Kostadinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Reinhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Etemadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schweinlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"H\u00e4nggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janin","family":"Knop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Hauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Walles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Silke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Wajant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueli","family":"Nachbur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wong","family":"W. Wei-Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.gastro.2016.11.019_bib1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1084\/jem.190.10.1479","article-title":"Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-\/-) mice upon transfer of CD4(+)CD45RB(hi) T cells","volume":"190","author":"Corazza","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2016.11.019_bib2","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1073\/pnas.1007811108","article-title":"Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology","volume":"108","author":"Roulis","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.11.019_bib3","first-page":"141","article-title":"TNF in the inflammatory response","volume":"74","author":"Mannel","year":"2000","journal-title":"Chem Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1053\/j.gastro.2016.11.019_bib5","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1038\/sj.onc.1209943","article-title":"NF-kappaB and the immune response","volume":"25","author":"Hayden","year":"2006","journal-title":"Oncogene"},{"key":"10.1053\/j.gastro.2016.11.019_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib7","doi-asserted-by":"crossref","first-page":"e100361","DOI":"10.1371\/journal.pone.0100361","article-title":"Anti-TNF treatment response in rheumatoid arthritis patients is associated with genetic variation in the NLRP3-inflammasome","volume":"9","author":"Sode","year":"2014","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.11.019_bib8","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","article-title":"An endotoxin-induced serum factor that causes necrosis of tumors","volume":"72","author":"Carswell","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.11.019_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/excr.2000.4840","article-title":"The CD95 (APO-1\/Fas) and the TRAIL (APO-2L) apoptosis systems","volume":"256","author":"Walczak","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.gastro.2016.11.019_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.274.5288.787","article-title":"Suppression of TNF-alpha-induced apoptosis by NF-kappaB","volume":"274","author":"Van Antwerp","year":"1996","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.11.019_bib11","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.274.5288.782","article-title":"An essential role for NF-kappaB in preventing TNF-alpha-induced cell death","volume":"274","author":"Beg","year":"1996","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.11.019_bib12","first-page":"495","article-title":"TNF-induced enterocyte apoptosis and detachment in mice: induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk","volume":"79","author":"Piguet","year":"1999","journal-title":"Lab Invest"},{"key":"10.1053\/j.gastro.2016.11.019_bib13","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1084\/jem.166.5.1280","article-title":"Tumor necrosis factor\/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease","volume":"166","author":"Piguet","year":"1987","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2016.11.019_bib14","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1172\/JCI2466","article-title":"Apoptosis of human intestinal epithelial cells after bacterial invasion","volume":"102","author":"Kim","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.11.019_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI25608","article-title":"Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8 T cell-mediated, TNF-dependent immunopathology","volume":"116","author":"Liu","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.11.019_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/intimm\/dxu051","article-title":"Pleiotropic functions of TNF-alpha in the regulation of the intestinal epithelial response to inflammation","volume":"26","author":"Leppkes","year":"2014","journal-title":"Intl Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/eji.1830270722","article-title":"Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice","volume":"27","author":"Neurath","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrc2889","article-title":"IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer","volume":"10","author":"Gyrd-Hansen","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.gastro.2016.11.019_bib19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/B978-0-12-801430-1.00002-0","article-title":"IAP family of cell death and signaling regulators","volume":"545","author":"Silke","year":"2014","journal-title":"Methods Enzymol"},{"key":"10.1053\/j.gastro.2016.11.019_bib20","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1073\/pnas.0711122105","article-title":"Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation","volume":"105","author":"Mahoney","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.11.019_bib21","doi-asserted-by":"crossref","first-page":"ra22","DOI":"10.1126\/scisignal.2001878","article-title":"Cellular inhibitors of apoptosis are global regulators of NF-kappaB and MAPK activation by members of the TNF family of receptors","volume":"5","author":"Varfolomeev","year":"2012","journal-title":"Sci Signal"},{"key":"10.1053\/j.gastro.2016.11.019_bib22","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2008.05.014","article-title":"cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination","volume":"30","author":"Bertrand","year":"2008","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib23","doi-asserted-by":"crossref","first-page":"35906","DOI":"10.1074\/jbc.M109.072256","article-title":"TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis","volume":"284","author":"Vince","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.11.019_bib24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1098231","article-title":"A\u00a0small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death","volume":"305","author":"Li","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.gastro.2016.11.019_bib25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cell.2007.10.037","article-title":"IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis","volume":"131","author":"Vince","year":"2007","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.10.030","article-title":"IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis","volume":"131","author":"Varfolomeev","year":"2007","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.semcdb.2014.12.004","article-title":"IAP gene deletion and conditional knockout models","volume":"39","author":"Silke","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1053\/j.gastro.2016.11.019_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1083\/jcb.200801010","article-title":"TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha","volume":"182","author":"Vince","year":"2008","journal-title":"J\u00a0Cell Biol"},{"key":"10.1053\/j.gastro.2016.11.019_bib29","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/cdd.2009.80","article-title":"TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling","volume":"16","author":"Wicovsky","year":"2009","journal-title":"Cell Death Differ"},{"key":"10.1053\/j.gastro.2016.11.019_bib30","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08229","article-title":"XIAP discriminates between type I and type II FAS-induced apoptosis","volume":"460","author":"Jost","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/emboj.2012.18","article-title":"IAPs limit activation of RIP kinases by TNF receptor 1 during development","volume":"31","author":"Moulin","year":"2012","journal-title":"EMBO J"},{"key":"10.1053\/j.gastro.2016.11.019_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1073\/pnas.90.2.587","article-title":"Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice","volume":"90","author":"Whitehead","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.gastro.2016.11.019_bib33","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.4049\/jimmunol.0903555","article-title":"Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway","volume":"185","author":"Roos","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib34","doi-asserted-by":"crossref","first-page":"e21556","DOI":"10.1371\/journal.pone.0021556","article-title":"SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells","volume":"6","author":"Muller-Sienerth","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.gastro.2016.11.019_bib35","doi-asserted-by":"crossref","first-page":"e1228","DOI":"10.1038\/cddis.2014.183","article-title":"Ex\u00a0vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy","volume":"5","author":"Grabinger","year":"2014","journal-title":"Cell Death Dis"},{"key":"10.1053\/j.gastro.2016.11.019_bib36","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/ten.tec.2016.0101","article-title":"Development of an advanced primary human in\u00a0vitro model of the small intestine","volume":"22","author":"Schweinlin","year":"2016","journal-title":"Tissue Eng Part C Methods"},{"key":"10.1053\/j.gastro.2016.11.019_bib37","doi-asserted-by":"crossref","first-page":"17525","DOI":"10.1074\/jbc.M109.087635","article-title":"Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding","volume":"285","author":"Feltham","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1053\/j.gastro.2016.11.019_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ymeth.2007.11.004","article-title":"Detection of apoptosis in\u00a0vivo using antibodies against caspase-induced neo-epitopes","volume":"44","author":"Jakob","year":"2008","journal-title":"Methods"},{"key":"10.1053\/j.gastro.2016.11.019_bib39","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/j.1572-0241.2002.05914.x","article-title":"Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease","volume":"97","author":"Suenaert","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.gastro.2016.11.019_bib40","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4049\/jimmunol.160.2.943","article-title":"TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation","volume":"160","author":"Peschon","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib42","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3499::AID-IMMU3499>3.0.CO;2-Q","article-title":"TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53","volume":"28","author":"Piguet","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib43","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20090849","article-title":"TNF suppresses acute intestinal inflammation by inducing local glucocorticoid synthesis","volume":"207","author":"Noti","year":"2010","journal-title":"J\u00a0Exp Med"},{"key":"10.1053\/j.gastro.2016.11.019_bib44","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.celrep.2014.05.008","article-title":"XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation","volume":"7","author":"Yabal","year":"2014","journal-title":"Cell Rep"},{"key":"10.1053\/j.gastro.2016.11.019_bib45","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1053\/j.gastro.2011.08.040","article-title":"Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis","volume":"141","author":"Kawashima","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.gastro.2016.11.019_bib46","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/mi.2013.10","article-title":"TWEAK\/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice","volume":"6","author":"Son","year":"2013","journal-title":"Mucosal Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib47","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1083\/jcb.200904158","article-title":"Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment","volume":"187","author":"Geserick","year":"2009","journal-title":"J\u00a0Cell Biol"},{"key":"10.1053\/j.gastro.2016.11.019_bib48","article-title":"Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation. Cold Spring Harbor Perspect Biol","volume":"5","author":"Silke","year":"2013"},{"key":"10.1053\/j.gastro.2016.11.019_bib49","first-page":"3","article-title":"New strategies for treatment of inflammatory bowel disease","volume":"1","author":"Nielsen","year":"2014","journal-title":"Front Med (Lausanne)"},{"key":"10.1053\/j.gastro.2016.11.019_bib50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/mi.2008.7","article-title":"New therapeutic strategies for treatment of inflammatory bowel disease","volume":"1","author":"Atreya","year":"2008","journal-title":"Mucosal Immunol"},{"key":"10.1053\/j.gastro.2016.11.019_bib51","doi-asserted-by":"crossref","first-page":"G422","DOI":"10.1152\/ajpgi.00412.2004","article-title":"Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression","volume":"288","author":"Ma","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/j.gastro.2016.11.019_bib52","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1172\/JCI65624","article-title":"Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium","volume":"123","author":"Van Hauwermeiren","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1053\/j.gastro.2016.11.019_bib53","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09857","article-title":"RIP3 mediates the embryonic lethality of caspase-8-deficient mice","volume":"471","author":"Kaiser","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib54","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cell.2014.04.018","article-title":"RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3","volume":"157","author":"Dillon","year":"2014","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib55","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature10273","article-title":"FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation","volume":"477","author":"Welz","year":"2011","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib56","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2014.04.019","article-title":"RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis","volume":"157","author":"Rickard","year":"2014","journal-title":"Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature13608","article-title":"RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis","volume":"513","author":"Dannappel","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature13706","article-title":"RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis","volume":"513","author":"Takahashi","year":"2014","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib59","doi-asserted-by":"crossref","first-page":"13282","DOI":"10.1074\/jbc.M110.216226","article-title":"In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8","volume":"286","author":"Gentle","year":"2011","journal-title":"The Journal of biological chemistry"},{"key":"10.1053\/j.gastro.2016.11.019_bib60","first-page":"221","article-title":"Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity","volume":"11","author":"Damgaard","year":"2011","journal-title":"Discov Med"},{"key":"10.1053\/j.gastro.2016.11.019_bib61","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.molcel.2012.04.014","article-title":"The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity","volume":"46","author":"Damgaard","year":"2012","journal-title":"Mol Cell"},{"key":"10.1053\/j.gastro.2016.11.019_bib62","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A\u00a0frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"10.1053\/j.gastro.2016.11.019_bib63","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.molmed.2014.09.006","article-title":"Inhibitors of apoptosis (IAPs) regulate intestinal immunity and inflammatory bowel disease (IBD) inflammation","volume":"20","author":"Pedersen","year":"2014","journal-title":"Trends Mol Med"},{"key":"10.1053\/j.gastro.2016.11.019_bib64","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.immuni.2009.04.011","article-title":"Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2","volume":"30","author":"Bertrand","year":"2009","journal-title":"Immunity"},{"key":"10.1053\/j.gastro.2016.11.019_bib65","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1189\/jlb.0112042","article-title":"The TWEAK\/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases: focus on inflammatory bowel diseases","volume":"92","author":"Dohi","year":"2012","journal-title":"J\u00a0Leukocyte Biol"}],"container-title":["Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516353884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0016508516353884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T15:14:00Z","timestamp":1758035640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0016508516353884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0016508516353884"],"URL":"https:\/\/doi.org\/10.1053\/j.gastro.2016.11.019","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727033323.793553380","asserted-by":"object"}]},"ISSN":["0016-5085"],"issn-type":[{"value":"0016-5085","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor\u2013Mediated Destruction of Intestinal Epithelial Cells","name":"articletitle","label":"Article Title"},{"value":"Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.gastro.2016.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the AGA Institute","name":"copyright","label":"Copyright"}]}}